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"That the automobile has practically reached the limit of its development is suggested by the fact that during the past year no improvements of a radical nature have been introduced."
Scientific American ; Jan. 2 edition, 1909
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| Number | Title | Issue Date |
| 8188151 | Methods for treating diabetes The subject invention provides compositions and methods for treating diabetes in patients. In a preferred embodiment, the invention provides compositions methods for treating diabetes and/or preventing or alleviating complications associated with diabetes. Specifica... | 05/29/2012 |
| 8138227 | Method for inhibiting or reversing non-enzymatic glycation The present invention relates to a method for inhibiting or reversing non-enzymatic glycation of the first intermediate of a biological moiety using an α-thiolamine. By inhibiting or reversing non-enzymatic glycation of the biological moiety, conditions such as agi... | 03/20/2012 |
| 8129433 | Enterically coated cysteamine, cystamine and derivatives thereof The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The formulations provide controlled release compositions that improve quality of life and reduced side-effects. ... | 03/06/2012 |
| 8114913 | Systemic administration of NAC as an adjunct in the treatment of bioterror exposures such as smallpox and use in combination with DHEA for the treatment of smallpox The invention is for the combination and related methods of N-acetyl-cysteine oral, inhaled, or intravenous, or glutathione inhaled or intravenous, generally in combination with antibiotic and/or antiviral therapy to ameliorate the toxic effects of infection with ma... | 02/14/2012 |
| 8026284 | Enterically coated cystamine, cysteamine and derivatives thereof The disclosure provides oral cysteamine and cystamine formulations useful for treating cystinosis and neurodegenerative diseases and disorders. The formulations provide controlled release compositions that improve quality of life and reduced side-effects. ... | 09/27/2011 |
| 7994226 | Methods of treating non-alcoholic steatohepatitis (NASH) using cysteamine products The disclosure relates, in general, to treatment of fatty liver disorders comprising administering compositions comprising cysteamine products. The disclosure provides administration of enterically coated cysteamine compositions to treat fatty liver disorders, such ... | 08/09/2011 |
| 7893113 | Materials and methods for modulating metabolism The subject invention provides materials and methods for modulating a variety of biological factors to treat biological conditions associated with the factors. In one embodiment of the invention, a cysteamine compound is administered to a patient to treat hyperchole... | 02/22/2011 |
| 7803843 | Materials and methods for improving alcohol metabolism and alleviating the effects of hangovers The subject invention provides materials and methods for improving alcohol metabolism in animals. In a preferred embodiment, the invention provides methods for increasing the ability of people to consume alcohol while reducing hangovers or other effects of intoxicat... | 09/28/2010 |
| 7786174 | Methods and compounds for inhibiting amyloid deposits Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid... | 08/31/2010 |
| 7759398 | Methods for modulating metabolism The subject invention provides materials and methods for modulating a variety of biological factors to treat biological conditions associated with the factors. In one embodiment of the invention, a cysteamine compound is administered to a patient to treat hyperchole... | 07/20/2010 |
| 7745493 | Methods of treating tardive dyskinesia and other movement disorders The present invention describes a novel treatment for movement disorders, including tardive dyskinesia, tic disorders, Tourette's syndrome, and blepharospasm, and other focal dystonias. The treatment of the present invention utilizes agents that simultaneously act a... | 06/29/2010 |
| 7652070 | Treatment method for MMP-implicated pathologies A treatment method for pathologies in which increased levels of MMP production are implicated in pathogenesis. Examples of such pathologies include pterygium, kerataconus, and macular degeneration. Treatment is based on administration of cysteamine in therapeuticall... | 01/26/2010 |
| 7498361 | Methods of treating tardive dyskinesia and other movement disorders The present invention describes a novel treatment for movement disorders, including tardive dyskinesia, tic disorders, Tourette's syndrome, and blepharospasm, and other focal dystonias. The treatment of the present invention utilizes agents that simultaneously act a... | 03/03/2009 |
| 7442720 | Compositions and methods for treating diabetes The subject invention provides compositions and methods for treating diabetes in patients. In a preferred embodiment, the invention provides compositions methods for treating diabetes and/or preventing or alleviating complications associated with diabetes. Specifica... | 10/28/2008 |
| 7414154 | Polyamine compounds and compositions for use in conjunction with cancer therapy The invention provides novel polyamine compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-effects of chemoth... | 08/19/2008 |
| 7393875 | Methods and compounds for inhibiting amyloid deposits Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid... | 07/01/2008 |
| 7368440 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy or chemotherapy in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compound... | 05/06/2008 |
| 7314959 | Amino thiol compounds and compositions for use in conjunction with cancer therapy The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adverse side-ef... | 01/01/2008 |
| 7291599 | Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis and to an inflammatory reaction magnifying the damage, by the isolated ... | 11/06/2007 |
| 7273889 | NMDA receptor antagonist formulation with reduced neurotoxicity The present invention is directed to pharmaceutical compositions of effective amounts of NMDA receptor antagonists and preservative for the administration to a patient in need of effective analgesia and anesthesia. The compositions of the invention advantageously do... | 09/25/2007 |
| 7250157 | Dermatological compositions and methods Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds,... | 07/31/2007 |
| 7229969 | Combinations of enzyme inhibitors and the use thereof Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase (aminopeptidase N, APN) and of enzymes having the same substrate specificity (... | 06/12/2007 |
| 7217739 | Method for inducing cell death with carbonyl scavengers Carbonyl scavengers, which have been recognized for their ability to react with reactive carbonyl species, have been implicated as agents that can accelerate or induce the death of abnormal cells without having a parallel effect on normal cells. As such, they are us... | 05/15/2007 |
| 7160913 | Methods and kit for treating Parkinson's disease The efficacy of levodopa therapy in patients being treated for Parkinson's disease is enhanced by administering high doses of a partial glycine agonist. The frequency and severity of levodopa-induced side effects in Parkinson's disease patients are also reduced by a... | 01/09/2007 |
| 7151094 | Topical administration of amifostine and related compounds The present invention is directed to methods of treating or protecting mucosal tissue from damage associated with radiation and/or chemotherapeutic treatment of cancers, by the topical application of amifostine and related compounds. These methods avoid the side eff... | 12/19/2006 |
| 7105575 | Methods for the treatment of neuro- disorders using aminothiol compounds The present invention relates to new uses of S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by therapeutic agents, radiation treatment or diabetes. In particular, the inve... | 09/12/2006 |
| 7102013 | Methods of making amidino compounds useful as nitric oxide synthase inhibitors Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: | 09/05/2006 |
| 7078047 | Cosmetic or pharmaceutical compositions comprising homopolymers and salts thereof Use of at least one material chosen from homopolymers and salts thereof of formula (I), defined herein, for moisturizing the skin, mucous membranes and/or keratin fibres, and/or as a moisturizer and/or emollient, for the skin, mucous membranes and/or keratin fibres.... | 07/18/2006 |
| 7067508 | Diaminedithiol derivatives and radiorhenium or radiotechnetium complex thereof; a liver cancer-treating composition comprising the radiorhenium complex and lipiodol; and a kit for preparation of the liver cancer-treating composition The present invention relates to a novel diaminedithiol derivative or a pharmaceutically acceptable salt thereof; radiorhenium or radiotechneticum complex thereof; a composition for treating liver cancer comprising the radiorhenium complex and lipiodol; and, a prepa... | 06/27/2006 |
| 7053072 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compounds as compared wi... | 05/30/2006 |
| 7022315 | Administration of a thiol-based chemoprotectant compound A method of administration of a thiol-based chemoprotectant agent including NAC (N-acetylcysteine) and STS (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for t... | 04/04/2006 |
| 7008545 | Synergistic biocidal mixtures Synergistic mixtures of biocides and their use to control the growth of microorganisms in aqueous systems are disclosed. The method of using the synergistic mixtures entails adding an effective amount of a nitrogenous compound activated by an oxidant and at least on... | 03/07/2006 |
| 6974568 | Treatment for cough The invention discloses the existence of cannabinoid receptors in the airways, which are functionally linked to inhibition of cough. Locally acting cannabinoid agents can be administered to the airways of a subject to ameliorate cough, without causing the psychoacti... | 12/13/2005 |
| 6955804 | Dermatological compositions and methods Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; by administration of various compounds,... | 10/18/2005 |
| 6955812 | Health food and preparation having an anti-obesity effect The present invention discloses an anti-obesity agent comprising: D-cysteinolic acid represented by Formula I, as an active ingredient: Formula I: | 10/18/2005 |
| 6929685 | Alkylamine derivatives as antifouling agents The invention relates to methods for preventing the attachment of aquatic organisms to surfaces that are submerged for extension periods of time in water. More particularly, this invention relates to the protection of submerged surfaces with alkylamine derivatives a... | 08/16/2005 |
| 6924391 | Alpha-amino,-thio,-oxo substituted ketones as phospholipase inhibitors Inhibitors of the cytosolic phospholypase A2 enzymes are provided which are of use in controlling a wide variety of inflammatory diseases. The inhibitors of the present invention have the general formula wherein X, Z, ... | 08/02/2005 |
| 6919379 | Compounds useful in reflux disease Novel compounds of formula (I) wherein R1 represents hydrogen; R2 represents hydroxy, fluoro, or an oxo group; R3 represents hydrogen; R4 represents hydrogen; and pharmaceutically acceptable salts, solvates, and the stereo... | 07/19/2005 |
| 6812251 | Taurine compounds The invention provides a method of inhibiting tumor growth by contacting the tumor with a composition containing a taurine compound. The composition is administered to directly contact a tumor cell at a dose sufficient to induce cell death. ... | 11/02/2004 |
| 6809117 | Therapeutic uses of nitric oxide inhibitors The present invention is based on the discovery that nitric oxide (NO) is an important growth regulator in an intact developing organism. In particular, the present invention relates to a method of increasing in a mammal a population of hematopoietic stem cells in b... | 10/26/2004 |
