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| Number | Title | Issue Date |
| 8124656 | Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the C-ring This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture ... | 02/28/2012 |
| 7307071 | RAF-MEK-ERK pathway inhibitors to treat cancer Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia, and which cancer is preferably resistant to the inhibition of the Bc... | 12/11/2007 |
| 7202279 | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activi... | 04/10/2007 |
| 7173019 | Linked cyclitols and their polysulfated derivatives The invention relates to compounds of the following formula (I). In these compounds, R1, R2, R3 and R4 are each independently a substituted or unsubstituted cyclitol with a ring comprising six carbon atoms, or hydrogen, su... | 02/06/2007 |
| 7101916 | Exo-S-mecamylamine formulation and use in treatment A pharmaceutical composition includes a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine in combination with a pharmaceutically acceptable carrier. Preferably the amount is... | 09/05/2006 |
| 6979698 | Method of treating cognitive deficits in learning and memory The treatment of learning, memory, and age-related memory disorders includes administration of a nicotine antagonist. The preferred nicotine antagonists are mecamylamine, a mecamylamine analog, or a mecamylamine stereoisomer. The effective amount of the nicotine ant... | 12/27/2005 |
| 6794545 | Conformationally restricted polyamine analogs as disease therapies Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of d... | 09/21/2004 |
| 6756504 | Sphingolipids The invention relates to compounds of the general formula (I), as defined, and to pharmaceutical compositions containing them. The compounds of formula (I) are inhibitors of various lipid-related enzymes. They can be used in reducing accumulation of sphingoli... | 06/29/2004 |
| 6605645 | Linear polyamine compounds and polyamine-based anti-tumor agents Nobel polyamine compounds and polyamine compounds having carcinostatic action are provided. There are also provided anticancer agents containing as active ingredient at least one of polyamine compounds represented by the following Formula (I) or (III) and... | 08/12/2003 |
| 6551614 | Antimalarial N,N'-substituted biguanides derived from hydroxylamines Compounds of the formulae ##STR1## are disclosed. A method of protecting subjects from infections caused by an organism of the group: Plasmodium sp., Mycobacterium sp., P. falciparum, M. avium complex, M. tuberculosis, M. kanasii and Pneumocystis carinii ... | 04/22/2003 |
| 6384083 | USE OF ADAMANTANE AMINES OR STRUCTURALLY SIMILAR COMPOUNDS FOR COMBATING BORNA DISEASE VIRUS AND FOR THE PREVENTION AND TREATMENT OF AFFECTIVE DISEASES AND OTHER DISORDERS ASSOCIATED WITH BDV INFECTIONS IN HUMANS AND ANIMALS The invention concerns the use of 1-adamantane amines (amantadines) or structurally similar compounds for combating borna disease virus infections and for treating affective diseases and disorders associated with borna disease virus infections in humans a... | 05/07/2002 |
| 6380267 | Composition and method for decreasing neurologic symptomatology A method of decreasing the signs or symptomatology in a patient with a neurologic condition or disease, or in a patient due to effects of exposure to an exogenous substance, such as a pharmaceutical agent, comprising selecting a patient having at least on... | 04/30/2002 |
| 6271264 | Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polyme... | 08/07/2001 |
| 6228890 | Use of alicyclic diamines as immunomodulators The invention discloses the use of a compound of general structural formula (I) R-NH-K-Q-K-NH-R, wherein Q is a divalent radical of formulae (II) to (V), K is a methylene group, or, when Q is a group of formula (II), K is a binding valency. R is a radical... | 05/08/2001 |
| 6197827 | Nicotine addiction treatment The present invention encompasses methods of treating patients for tobacco addiction and nicotine addiction, for palliating the effects of nicotine withdrawal, for providing or facilitating the effects of smoking cessation therapies and as long-term smoki... | 03/06/2001 |
| 6159960 | Steroid sulphatase inhibitors A method of inhibiting steroid sulphatase activity in a subject in need of same is described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring ... | 12/12/2000 |
| 6114392 | Agmatine, and polyaminoguanidine-bound heterocyclic compounds for neurotrauma and neurodegenerative diseases The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia). The invention further provides novel compounds of general formula I... | 09/05/2000 |
| 6083962 | Agonist-anatagonist combination to reduce the use of nicotine and other drugs A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the ... | 07/04/2000 |
| 5939462 | NPY5 receptor antagonists and methods for using same -alkoxy and -thioalkoxyamide compositions and methods of administering the compositions to mammals to treat disorders such as obesity that are mediated by NPY and especially those mediated by NPY via the Y5 receptor.... | 08/17/1999 |
| 5935975 | Agonist-antagonist combination to reduce the use of nicotine and other drugs A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or an agonist of the drug in an amount which would normally provide the desir... | 08/10/1999 |
| 5886051 | Methods and compositions for the treatment of neurodegeneration Methods and pharmaceutical compositions in unit dosage form for treating neurodegeneration in a human or non-human animal afflicted therewith wherein the active agent is a therapeutically effective amount of a polyamine having the formula: ##STR1## ... | 03/23/1999 |
| 5861422 | Agonist-antagonist combination to reduce the use of nicotine and other drugs A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the ... | 01/19/1999 |
| 5849802 | Fungicidal spirocyclic amines New antimicrobial spirocarbocyclic compounds are described, having the general formula I, ##STR1## or an acid-addition salt thereof, in which R1 represents an optionally substituted alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, cycloalk... | 12/15/1998 |
| 5726190 | Agonist-antagonist combination to reduce the use of nicotine and other drugs A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine, or an agonist of the drug in an amount which would normally provide the desi... | 03/10/1998 |
| 5703101 | Agonist-antagonist combination to reduce the use of nicotine and other drugs A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the ... | 12/30/1997 |
| 5627215 | Unsaturate amino compounds for use as anticancer and antiprotozoic agent The invention relates to compounds of formula (I), R1 and R2, each independently of the other, are selected from lower alkyl that is unsubstituted or substituted by one or more fluorine atoms which are not linked to the carbon atom o... | 05/06/1997 |
| 5574052 | Agonist-antagonist combination to reduce the use of nicotine and other drugs A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the ... | 11/12/1996 |
| 5316759 | Agonist-antagonist combination to reduce the use of nicotine and other drugs A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the ... | 05/31/1994 |
| 5166173 | Method of treating herpes simplex virus infection A method of inhibiting cell infection by herpes simplex virus-1 or -2. The method includes contacting the virus with a macrocyclic chromotropic acid compound, in an amount effective to inhibit cell infectivity of the virus.... | 11/24/1992 |
| 5086073 | Composition for treating depression with aralkyl amines The invention concerns compounds having formula: ##STR1## or a salt thereof, wherein E represents hydrogen, lower alkyl or a group Ar1 --A1 ; Ar and Ar1 are the same or different aryl groups (including heteroaryl) whi... | 02/04/1992 |
| 5032616 | 4-substituted cyclohexylamine derivatives, fungicides containing these and a method of controlling fungi 4-trans-substituted cyclohexylamine derivatives of the formula ##STR1## where R1 is the group CR5 R6 R7, in which R5, R6 and R7 are hydrogen, unsubstituted or substituted alkyl, ... | 07/16/1991 |
| 4997854 | Anti-fibrotic agents and methods for inhibiting the activity of lysyl oxidase in-situ using adjacently positioned diamine analogue substrates A class of anti-fibrotic agents and methods for their use as effective inhibitor substrate analogues of lysyl oxidase in-situ are provided. The inhibitory substrate analogues comprise adjacently positioned diamine compositions which may be employed in-viv... | 03/05/1991 |
| 4996236 | Therapeutic composition for hepatic encephalopathy A pharmaceutical composition for the treatment of hyperammonemia which comprises a valiolamine compound of the formula ##STR1## wherein A means an acyclic hydrocarbon group of 1 to 10 carbon atoms which may optionally be substituted by hydroxy, pheno... | 02/26/1991 |
| 4897425 | Fungicidal cyclohexylamines Cyclohexylamines of the formula ##STR1## where X is a single bond or an alkylene chain, Y is hydrogen or an aryl, cyclohexyl, 4-cyclohexylcyclohexyl, perhydro-1- or 2-naphthyl or piperidyl radical, R1 and R2 are hydrogen, alkyl,... | 01/30/1990 |
| 4774229 | Modification of plant extracts from zygophyllaceae and pharmaceutical use therefor A mixture of an extract from a plant belonging to the Zygophyllaceae family containing phenolic compositions and a nonalkali metal salt is useful as a pharmaceutical agent, for example, in the treatment of cancer, nonmalignant tumors, osteomyelitis, psori... | 09/27/1988 |
| 4230726 | Control of parasitic mites with alkyl amines Certain secondary and tertiary straight and branched chain amines and amides are found to be highly effective for controlling scabies mites and other parasitic mites.... | 10/28/1980 |
| 4169896 | Control of coccidial diseases by treatment of animal excreta with secondary amines Compositions effective against coccidial oocysts and eggs of Ascaris suum, Ascaridia galli and Toxocara canis as active ingredient at least one secondary amine of the general formula I wherein R represents a straight-chain or branched alkyl radical of 5 to 18 ... | 10/02/1979 |
| 4138497 | Indanpentol derivatives for treating hypertension Compounds are provided having the structure ##STR1## wherein n is 1, 2 or 3, m is 0, 1 or 2, R1 R2, R3, R4 and R5 may be the same or different and can be hydrogen, lower alkyl, halo-lower alkyl, ... | 02/06/1979 |
| 4092432 | Mixtures having antimicrobial or pesticidal effect The present invention relates to mixtures of guanidated aliphatic polyamines, or their acid addition salts, having antimicrobial or pesticidal effect. More particularly the invention relates to such mixtures which have a total degree of guanidation exceed... | 05/30/1978 |
| 4049559 | Composition for secondary and tertiary oil recovery An antimicrobial composition for secondary and tertiary oil recovery comprising a flooding composition consisting of displacement and driving fluids having incorporated therein an antimicrobially effective amount of a di-bicyclo[3.1.1] or [2.2.1] heptyl o... | 09/20/1977 |
