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| Number | Title | Issue Date |
| 8044103 | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activi... | 10/25/2011 |
| 7619006 | Conjugated psychotropic drugs and uses thereof Novel chemical conjugates of psychotropic drugs and organic acids, uses thereof in the treatment of psychotic and/or proliferative disorders and diseases and as chemosensitizing agents, and their syntheses are disclosed. The organic acids are selected to reduce side... | 11/17/2009 |
| 7390821 | Methods of reducing angiogenesis The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a nicotinic acetyl choline receptor antagonist. The methods are useful to treat conditions associat... | 06/24/2008 |
| 7365096 | Methods for selectively inhibiting Janus tyrosine kinase 3 (Jak3) Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e.g., T-cells, B-cells). A Mannich base compound, or a der... | 04/29/2008 |
| 7335644 | Anti-hypertensive molecules and process for preparation thereof The present invention relates to novel anti-hypertensive molecules. The present invention also provides a process for the preparation of novel antihypertensive molecules. The present invention particularly relates to the preparation of novel Angiotensin Converting E... | 02/26/2008 |
| 7326730 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and composi... | 02/05/2008 |
| 7314890 | Sulfonamides The present invention provides wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5; R2 | 01/01/2008 |
| 7279502 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as compositions... | 10/09/2007 |
| 7261706 | Package for an ostomy appliance A package for a disposable ostomy receiving bag, the package including a first compartment capable of accommodating a fresh ostomy receiving bag and a second compartment capable of accommodating a used ostomy receiving bag. The second compartment is sealable so as t... | 08/28/2007 |
| 7243375 | Protection gear against harmful insects Provided is protection gear against harmful insects that enables controlling and capturing of harmful insects in addition to protection against harmful insects. The protection gear against harmful insects includes a protection net made of ventilative cloth, woven fa... | 07/17/2007 |
| 7202279 | Cyclic dipeptides and azetidinone compounds and their use in treating CNS injury and neurodegenerative disorders The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activi... | 04/10/2007 |
| 7160865 | Cancer treatment including glycolytic inhibitors Glycolytic inhibitors are useful in the treatment of solid tumors by attacking anaerobic cells at the center on the tumor. 2-deoxyglucose, oxamate and various analogs thereof are identified as having a natural selective toxicity toward anaerobic cells, and will sign... | 01/09/2007 |
| 7087648 | Methods for modulating macrophage proliferation using polyamine analogs Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated ... | 08/08/2006 |
| 7074833 | Use of the (1S,2R) enantiomer of milnacipran for the preparation of a drug A method for treating or preventing a disorder or a condition by double inhibition of serotonin (5-HT) and noradrenaline (NA) reuptake in a subject in need thereof, while limiting the risks of cardiovascular disturbances and/or organ and/or tissue toxicity, comprisi... | 07/11/2006 |
| 7045534 | Methods of reducing angiogenesis The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a nicotinic acetyl choline receptor antagonist. The methods are useful to treat conditions associat... | 05/16/2006 |
| 7026514 | Compounds used to treat alcoholism N,N′-bis(3-aminopropyl)cyclohexane-1,4-diamine, of formula (I), is a new compound that is prepared by hydrogenation with Raney nickel catalyst of N,N′-bis(2-cyanoethyl)-cyclohexane-1,4-diamine, the latter being prepared by reaction between 1,4-cyclohexanediamine... | 04/11/2006 |
| 7022739 | Substituted 1-aminobutan-3-ol compounds Substituted 1-aminobutane-3-ol compounds, methods for producing them, pharmaceutical compounds containing them, and the use of substituted 1-aminobutane-3-ol compounds for producing pharmaceutical compounds. ... | 04/04/2006 |
| 7005452 | Use of the dextrogyral enantiomer of milnacipran for the preparation of a drug The present invention concerns the use of a mixture of enantiomers enriched in the dextrogyral enantiomer of milnacipran and/or of at least one of its metabolites, as well as their pharmaceutically-acceptable salts, for the preparation of a drug intended to prevent ... | 02/28/2006 |
| 6881748 | Drug targeting A bioreductive conjugate comprises a bioreductive moiety with at least one therapeutic agent linked thereto and physiologically acceptable derivatives thereof. The bioreductive moiety incorporates an aromatic ring substituted with a nitro group and the conjugate is ... | 04/19/2005 |
| 6828318 | 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission Compounds of formula (1): wherein R1, R2, R3, R4, R5 and R6 are independently selected from hydrogen, alkyl, aryl and... | 12/07/2004 |
| 6828462 | Unsaturated 1-amino-alkylcyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists Unsaturated 1-Amino-alkylcyclohexane compounds which are systemically-active as NMDA, 5HT3, and nicotinic receptor antagonists, pharmaceutical compositions comprising the same, method of preparation thereof, and method of treating CNS disorders which invo... | 12/07/2004 |
| 6794545 | Conformationally restricted polyamine analogs as disease therapies Novel conformationally restricted polyamine analogs are provided, as well as compositions comprising these novel polyamine analogs. Methods of using the novel polyamine analogs in treatment of diseases such as cancer are also provided. Also provided is a method of d... | 09/21/2004 |
| 6787164 | Composition and method for treating the effects of diseases and maladies An improved medicinal composition includes an effective amount of a pain relieving and anti-inflammatory pharmaceutical and an effective amount of a nutraceutical in a pharmaceutically acceptable base. At least one of the pharmaceutical and the nutraceutical treats ... | 09/07/2004 |
| 6723749 | Fatty acid synthase inhibitors This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH. ... | 04/20/2004 |
| 6710081 | Erection insufficiency remedies Therapeutic agents for erectile dysfunction containing as the active ingredient prostaglandin derivatives of formula (I) (wherein symbols have the same meanings as described in the description), nontoxic salts thereof, o... | 03/23/2004 |
| 6649587 | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases Peptide conjugates in which cytocidal and cytostatic agents, such as polyamine analogs or naphthoquinones, are conjugated to a polypeptide recognized and cleaved by enzymes such as prostate-specific antigen (PSA) and cathepsin B are provided, as well as c... | 11/18/2003 |
| 6602862 | 1-Amino-alkylcyclohexanes as trypanocidal agents Certain 1-aminoalkylcyclohexanes are anti-trypanosomiasis agents and trypanocides. Pharmaceutical compositions thereof for such purpose and method of making same, as well as a method-of-treating trypanosomiasis therewith.... | 08/05/2003 |
| 6576636 | Method of treating a liver disorder with fatty acid-antiviral agent conjugates The invention provides conjugates of fatty acids and antiviral agents useful in treating liver disorders.... | 06/10/2003 |
| 6576267 | Composition and method for treating the effects of diseases and maladies An improved medicinal composition includes an effective amount of a decongestant pharmaceutical and an effective amount of a nutraceutical in a pharmaceutically acceptable base. At least one of the pharmaceutical and the nutraceutical treats a condition c... | 06/10/2003 |
| 6462076 | Beta-amino acid nitrile derivatives as cathepsin K inhibitors The present invention relates to beta-amino acid nitrile derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are cysteine protease inhibitors useful for the treatment of diseases associated wi... | 10/08/2002 |
| 6228890 | Use of alicyclic diamines as immunomodulators The invention discloses the use of a compound of general structural formula (I) R-NH-K-Q-K-NH-R, wherein Q is a divalent radical of formulae (II) to (V), K is a methylene group, or, when Q is a group of formula (II), K is a binding valency. R is a radical... | 05/08/2001 |
| 6211229 | Treatment of transient and short term insomnia The invention is directed to a method for the treatment of a patient suffering from transient or short term insomnia. The claimed method comprises the administration of a compound selected from the group consisting of the pharmaceutically acceptable forms... | 04/03/2001 |
| 6180677 | Tyrosine-derived compounds as calcium channel antagonists The present invention provides compounds that block calcium channels and have the Formula I: ##STR1## and pharmaceutically acceptable salts, esters, and pro-drugs thereof, wherein R1 and R2 are independently H, phenylcyclopentylcarbo... | 01/30/2001 |
| 6121289 | Method for enhanced brain delivery of nicotinic antagonist This invention provides methods of treatment of addiction to tobacco comprising intranasal administration of nicotinic antagonists.... | 09/19/2000 |
| 6114392 | Agmatine, and polyaminoguanidine-bound heterocyclic compounds for neurotrauma and neurodegenerative diseases The invention relates to the use of agmatine, in the treatment of acute neurotrauma (such as stroke) and degenerative disorders of the central and peripheral nervous system (such as dementia). The invention further provides novel compounds of general formula I... | 09/05/2000 |
| 6071966 | 1-amino-alkylcyclohexane NMDA receptor antagonists Certain 1-aminoalkylcyclohexanes are systemically-active uncompetitive NMDA receptor antagonists having rapid blocking/unblocking kinetics and strong voltage-dependency and are therefore useful in the alleviation of conditions resulting from disturbances ... | 06/06/2000 |
| 6056966 | Method and compositions for treating impotence Pharmaceutical compositions in topical or parenteral form containing specific organic mono- or dinitrates, some of them novel compounds, are effective in treating male impotence and erectile dysfunction through topical or intracavernosal administration to... | 05/02/2000 |
| 6034134 | 1-Amino-alkylcyclohexane NMDA receptor antagonists Certain 1-aminoalkylcyclohexanes are systemically-active uncompetitive NMDA receptor antagonists having rapid blocking/unblocking kinetics and strong voltage-dependency and are therefore useful in the alleviation of conditions resulting from disturbances ... | 03/07/2000 |
| 6017906 | Polyamine conjugates for treatment of infection The present invention relates to methods of preventing or treating an infection or disease caused by an infectious agent. The present invention also relates to the augmentation of the efficacy of existing anti-infective agents by the co-administration of ... | 01/25/2000 |
| 5972964 | Aminomethylindans, -benzofurans and -benzothiophenes Compounds of formula I ##STR1## wherein R1.dbd.(cyclo)alk(en)yl, aralkyl, alkyl(oxy)carbonyl, CONH2, etc.; R2.dbd.H, (cyclo)alk(en)yl, aralkyl, etc.; R3-R5.dbd.H, halo, alkyl, alkoxy, etc.; R6,R7.dbd.H, alkyl; R6R7.dbd.atoms to complete a ring; ... | 10/26/1999 |
