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| Number | Title | Issue Date |
| 8138226 | Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety diso... | 03/20/2012 |
| 8093299 | Methods of treating bowel disorders The present invention relates to methods for treating bowel disorders using calcimimetics. ... | 01/10/2012 |
| 7501453 | Cyclopropanes with central nervous system activity Disclosed are aromatic cyclopropane compounds with CNS activity. These compounds can be used for alleviating symptoms of CNS disorders. ... | 03/10/2009 |
| 7429679 | Sulphonic acid salt of sibutramine Disclosed is a novel sulphonic acid salt of sibutramine, which has good physicochemical properties. Also disclosed are a method of preparing the compound and a pharmaceutical composition comprising the compound. ... | 09/30/2008 |
| 7417169 | Amino alcohol derivatives, medicinal composition containing the same, and use of these The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independentl... | 08/26/2008 |
| 7407990 | Therapeutic Agents Substituted cycloalkyl compounds with 3 to 6 carbon atoms in the ring, one carbon linked to each of two side groups R and R′, and pharmaceutically acceptable salts thereof in which R is phenyl optionally substituted by one or more halo substituents or R is naphthy... | 08/05/2008 |
| 7342133 | Substituted amino compounds as 5-HT/NA uptake inhibitors The invention relates to substituted amino compounds, to processes for their preparation, to pharmaceutical formulations containing these compounds and to the use of these substances in the preparation of pharmaceutical formulations, especially for the treatment or ... | 03/11/2008 |
| 7319171 | Sertraline hydrochloride form II and methods for the preparation thereof The present invention is directed to Form II of sertraline hydrochloride and novel methods for its preparation. According to the present invention, sertraline hydrochloride Form II may be produced directly form sertraline base or sertraline mandelate. It may also be... | 01/15/2008 |
| 7273889 | NMDA receptor antagonist formulation with reduced neurotoxicity The present invention is directed to pharmaceutical compositions of effective amounts of NMDA receptor antagonists and preservative for the administration to a patient in need of effective analgesia and anesthesia. The compositions of the invention advantageously do... | 09/25/2007 |
| 7273952 | Substituted C-cyclohexylmethylamine derivatives Substituted C-cyclohexylmethylamine derivatives, methods for the production thereof, pharmaceuticals containing said compounds, the use of substituted C-cyclohexylmethylamine derivatives for producing pharmaceuticals, and method of pain treatment using the pharmaceu... | 09/25/2007 |
| 7256185 | Control of selective estrogen receptor modulators The treatment of an estrogen sensitive condition by the administration of a selective estrogen receptor modulator is improved by additionally administering a progestationally active compound to the recipient. The additional agent can express both progestational and ... | 08/14/2007 |
| 7220783 | Para-terphenyl compounds The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which do... | 05/22/2007 |
| 7169817 | Bis-aromatic alkanols The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them. Compounds according to the present invention are based upon the chemical formula: | 01/30/2007 |
| 7135497 | Treating neural conditions resulting from spinal cord contusions and other causes β2-agonists, such as clenbuterol and salbutamol can enhance the recovery of locomotive function and/or neuromuscular strength following spinal cord injuries or as a result of degenerative neural conditions such as Mnd. Pharmacological compositions for tr... | 11/14/2006 |
| 7105701 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 09/12/2006 |
| 7101915 | P-terphenyl compounds The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which do... | 09/05/2006 |
| RE39221 | Composition comprising a tramadol material and acetaminophen and its use This invention relates to a composition comprising a tramadol material and acetaminophen, and its use. As used herein tramadol refers to various forms of tramadol. The compositions are pharmacologically useful in treating pain and tussive conditions. The composition... | 08/01/2006 |
| 7074836 | Para-terphenyl compounds The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which do... | 07/11/2006 |
| 7071234 | Methods of treating or preventing erectile dysfunction Methods are disclosed for the treatment and prevention of disorders and conditions including, but are not limited to, erectile dysfunction, affective disorders, weight gain, cerebral functional disorders, pain, obsessive-compulsive disorder, substance abuse, chronic... | 07/04/2006 |
| 7030160 | Propanolaminotetralines, preparation thereof and compositions containing same The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action. ... | 04/18/2006 |
| 6984664 | Tertiary amino compounds having opioid receptor affinity Disclosed are compounds of the formula (I) wherein R1, R2 R3 R4 R5, R6 and N are as disclosed herein. The compounds are useful for the treatment of chron... | 01/10/2006 |
| 6974840 | Therapeutic agents Compounds of formula (I) and pharmaceutically acceptable salts thereof in which m is 0, 1 or 2; n is 2, 3, 4 or 5; X is carbonyl or a group of formula (II) in which R5 is H or alkyl; Y is an alkylene chain optionally substituted by one or more alkyl group... | 12/13/2005 |
| 6974839 | Method of delaying ejaculation The invention provides a method of delaying ejaculation. The method comprises administering an effective amount of a tramadol material to a human male prior to sexual intercourse. The method is particularly useful for treating premature ejaculation. ... | 12/13/2005 |
| 6974837 | Compositions comprising sibutramine metabolites in combination with phosphodiesterase inhibitors Pharmaceutical compositions and dosage forms are disclosed that comprise a racemic or optically pure sibutramine metabolite and a phosphodiesterase inhibitor. ... | 12/13/2005 |
| 6919482 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2-adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 07/19/2005 |
| 6919317 | Pharmaceutical composition comprising squalene epoxidase inhibitor and macrolide immunomodulator Synergistic combinations of a squalene epoxidase inhibitor such as terbinafine and a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro, 33-desoxyascomycin are provided, which are useful in particular in the treatment of diseases involving fu... | 07/19/2005 |
| 6908914 | Antipsychotic cyclic N-aralkylamines The invention relates to benzene derivatives, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of psychotic disorders. ... | 06/21/2005 |
| 6881748 | Drug targeting A bioreductive conjugate comprises a bioreductive moiety with at least one therapeutic agent linked thereto and physiologically acceptable derivatives thereof. The bioreductive moiety incorporates an aromatic ring substituted with a nitro group and the conjugate is ... | 04/19/2005 |
| 6872852 | Polyamine analogues as cytotoxic agents Cytotoxic polyamine analogues are provided that are useful for treating diseases where it is desired to inhibit cell growth and/or proliferation, for example cancer and post-angioplasty injury. ... | 03/29/2005 |
| 6846492 | Use of phenylethylamine derivatives for the antimicrobial treatment of surfaces The use of compounds of formula (1) is described, in which compounds R1, R2 and R3 are each independently of the others hydrogen; C1-C20alkyl; C3-C7cycloalkyl; C2-C20a... | 01/25/2005 |
| 6835386 | Collar containing a novel gel formulation to control arthropod infestation of animals The present invention provides a device, preferably a collar or ear tag, capable of the controlled, sustained release of an effective amount of an active ingredient that can protect an animal against arthropod pests, comprising a reservoir containing a novel gel for... | 12/28/2004 |
| 6828318 | 2-adamantylethylamines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission Compounds of formula (1): wherein R1, R2, R3, R4, R5 and R6 are independently selected from hydrogen, alkyl, aryl and... | 12/07/2004 |
| 6756508 | Cinnamic acid salts, processes for their preparation, and their use as medicaments The present invention relates to new cinnamic acid salts of salmeterol, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions. ... | 06/29/2004 |
| 6730329 | Zinc containing compositions for anti-viral use One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Anoth... | 05/04/2004 |
| 6710080 | Substituted 2-dialkylaminoalkylbiphenyl derivatives Substituted 2-dialkylaminoalkylbiphenyl derivatives, processes for their preparation, pharmaceutical compositions comprising these compounds and methods using these compounds for the preparation of medicaments and for the treatment of diseases. ... | 03/23/2004 |
| 6624201 | HIGH PURITY (1R,2S,4R)-(-)-2-[(2'-{N,N-DIMETHYLAMINO}-ETHOXY)]-2-[PHENYL]-1,7,7 -TRI-[METHYL]-BICYCLO [2.2.1]HEPTANE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF AND A PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AS WELL AS MEDICAMENTS CONTAINING 1 OR MORE OF THESE COMPOUNDS AND THEIR USE The invention relates to high purity (1R,2S,4R)-(-)-2-[(2'-{N,N-dimethylamino}-ethoxy)]-2-[phenyl]-1,7,7-tri-[m ethyl]-bicyclo[2.2.1]heptane and pharmaceutically acceptable acid addition salts thereof containing not more than 0.2% of (1R,3S,4R)-3-[(2'... | 09/23/2003 |
| 6602874 | Heterocyclic carboxamides A compound of the formula ##STR1## wherein X, Y, Z, R2 and R3 are as defined above, useful in treating or preventing migraine, depression and other disorders for which a 5-HT1, agonist or antagonist is indicated.... | 08/05/2003 |
| 6596741 | Biaryl ether derivatives useful as monoamine reuptake inhibitors The present invention relates to compounds of formula I: ##STR1## and to their pharmaceutically acceptable salts. Compounds of formula I exhibit activity as serotonin, norepinephrine, and dopamine reuptake inhibitors and can be used in the treatment of ce... | 07/22/2003 |
| 6562870 | Treatment of AIDS-associated non-Hodgkin's lymphoma by gallium nitrate The present invention comprises an improved method of treatment of AIDS-associated non-Hodgkin's lymphoma by administering gallium nitrate in a pharmaceutically acceptable vehicle.... | 05/13/2003 |
| 6538035 | Use of tolterodine to treat asthma The present invention is a method of treating an mammal selected from the group consisting of humans and horses who has asthma, COPD or allergic rhinitis and is in need of such treatment by inhaling an anti-asthma, anti-COPD anti-allergic rhinitis effecti... | 03/25/2003 |
