Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 5741821 | Use of natural products and related synthetic compounds for the treatment of cardiovascular disease Use of a compound of formula (I), wherein Ar is an aromatic ring system comprising one or more optionally substituted phenyl rings optionally linked to or fused with one or more other optionally substituted phenyl rings or one or more 5 or 6-membered, opt... | 04/21/1998 |
| 5719189 | Medicinal feed for the systemic treatment of ectoparasitic and ectobacterial diseases of fish The present invention provides a medicinal feed for fish, which comprises a triphenylmethane derivative or a combination of triphenylmethane derivatives alone or in combination with at least one compound selected from the group consisting of thionine, nit... | 02/17/1998 |
| 5714511 | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically effective amount of nitric oxide sufficient to protect the tiss... | 02/03/1998 |
| 5712271 | Method of treating urinary bladder dysfunctions The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions.... | 01/27/1998 |
| 5712287 | Method of treating urinary bladder dysfunctions The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions.... | 01/27/1998 |
| 5710151 | Method of treating urinary bladder dysfunctions The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions.... | 01/20/1998 |
| 5708036 | Method of treating premature uterine contractions using the optically active R(-)-isomer of albuterol The optically pure R-isomer of the adrenergic beta-2 agonist albuterol, substantially free of its corresponding S-isomer, has been found to potently inhibit premature uterine contractions in female subjects, suffering from said condition, while avoiding s... | 01/13/1998 |
| 5708035 | Methods of use and compositions of R(-) fluoxetine A method and composition are disclosed utilizing the pure R(-) isomer of fluoxetine which is a potent antidepressant and appetite suppressant substantially free of adverse effects. In addition, a method and composition are disclosed utilizing the pure R(-... | 01/13/1998 |
| 5696168 | Treatment of attention-deficit/hyperactivity disorder A group of propanamines, norepinephrine uptake inhibitors, are used to treat attention-deficit/hyperactivity disorder.... | 12/09/1997 |
| 5684049 | HIV-inhibiting benzeneacetamide derivatives A compound for use as a medicine having the formula ##STR1## a pharmaceutically acceptable acid addition salt form or a stereochemically isomeric form thereof, wherein R1 and R2 each independently are hydrogen, C1-6 a... | 11/04/1997 |
| 5681863 | Non-metabolizable clomiphene analogs for treatment of tamoxifen-resistant tumors Compounds of the formula: ##STR1## wherein R1 and R2 are each selected from the group consisting of C1 -C2 lower alkyl; X is NH or S; and n is a whole number within the range of 1-4 inclusive; and when n=0,... | 10/28/1997 |
| 5674909 | Derivatives of 2-amino-1,2,3,4-tetrahydronaphthalene active on the cardiovascular system Compounds of formula ##STR1## wherein R, R', R", R1, R2, R3, R4, R5, R6, X, Y, m, n and p have the meanings reported in the description; and their pharmaceutically acceptable salts are desc... | 10/07/1997 |
| 5670513 | Medicinal feed for the systemic treatment of ectoparasitic and ectobacterial diseases of fish The present invention provides a medicinal feed for fish, which comprises a triphenylmethane derivative or a combination of triphenylmethane derivatives alone or in combination with at least one compound selected from the group consisting of thionine, nit... | 09/23/1997 |
| 5668156 | Di (aromatic) compounds and their use in human and veterinary medicine and in cosmetics Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a divalent radical, and R1, R2 | 09/16/1997 |
| 5650442 | Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric ox... | 07/22/1997 |
| 5635213 | Pharmaceutical formulation A pharmaceutical formulation for intraduodenal administration comprising at least one phamacologically active agent, with limited solubility in water and is dispersed in an aqueous carrier. According to the invention, the active agent has a particle size ... | 06/03/1997 |
| 5631280 | Inhibitors of farnesyl-protein transferase The present invention comprises peptidomimetic compounds which comprise a suitably aniline and aminoalkylbenzene moieties. The instant compounds inhibit the farnesyl-protein transferase enzyme and the farnesylation of certain proteins. The invention is fu... | 05/20/1997 |
| 5618847 | Medicinal feed for the systemic treatment of ectoparasitic and ectobacterial diseases of fish The present invention provides a medicinal feed for fish, which comprises a triphenylmethane derivative or a combination of triphenylmethane derivatives alone or in combination with at least one compound selected from the group consisting of thionine, nit... | 04/08/1997 |
| 5612351 | Method of treating urinary bladder dysfunctions The present invention relates to a novel method for treating a mammal suffering from urinary bladder dysfunctions.... | 03/18/1997 |
| 5589512 | Method for treating borderline personality disorder with serotonin re-uptake blockers There is disclosed a method for treating borderline personality disorder in a patient by administering a nontoxic dose of a serotonin re-uptake blocker. Preferably, the serotonin re-uptake blocker is fluoxetine or norfluoxetine.... | 12/31/1996 |
| 5589511 | Method for treating migraine headaches using optically pure S(+) fluoxetine Methods and compositions are disclosed utilizing the pure S(+) isomer of fluoxetine which is a potent antidepressant and appetite suppressant substantially free of unwanted, adverse toxic or psychological effects. In addition, methods and compositions are... | 12/31/1996 |
| 5580542 | Method of testing for nephritis Disclosed is an acetyltransferase activity measuring agent which contains an arylamine derivative. As the arylamine derivative, sodium p-aminohippurate can be used preferably. Use of the acetyltransferase activity measuring agent of this invention permits... | 12/03/1996 |
| 5565466 | Methods for modulating the human sexual response The invention is directed to improved methods for modulating the human sexual response by administering a vasodilator to the circulation by a route of administration that avoids the "first-pass" effect.... | 10/15/1996 |
| 5561135 | N,N,N',N'-tetrasubstituted-1,2-ethanediamine derivative compounds The invention relates to new N,N,N'N'-tetra-substituted-1,2-ethanediamine compounds of the general formula (I): ##STR1## wherein X is a carbonyl (CO), hydroxymethylen (CHOH) or p-fluorophenyl-methylen (p--F--C6 H4 --CH) group an... | 10/01/1996 |
| 5556886 | HIV-inhibiting benzeneacetamide derivatives A compound for use as a medicine having the formula ##STR1## a pharmaceutically acceptable acid addition salt form or a stereochemically isomeric form thereof, wherein R1 and R2 each independently are hydrogen, C1-6 a... | 09/17/1996 |
| 5556857 | Disturbance-of-consciousness improving agent The present invention provides a disturbance-of-consciousness improving agent which is a highly effective and quick remedy and which can be administered orally. The disturbance-of-consciousness improving agent of the invention contains a sigma receptor ag... | 09/17/1996 |
| 5554656 | Disinfectant concentrates and disinfectants on amine and alcohol base and their use The invention relates to a disinfectant concentrate which contains amine and alcohol wherein the alcohol component includes at least one glycol ether of limited miscibility with water and the amine component includes at least one secondary and/or tertiary... | 09/10/1996 |
| 5552162 | Method for improvement of scar size and appearance A method for improving the size and appearance of a scar associated with a fibromatosis, a keloid, or a hypertrophic wound healing disorder comprises stimulating collagenase activity in the scar. Preferably, stimulating collagenase activity is accomplishe... | 09/03/1996 |
| 5550107 | Combination therapy for the treatment of estrogen-sensitive disease A method of treatment of breast and endometrial cancer in susceptible warm-blooded animals may include inhibition of ovarian hormonal secretion by surgical (ovariectomy) or chemical (use of an LHRH agonist, e.g. [D-Trp6, des-Gly-NH2 | 08/27/1996 |
| 5541231 | Stabilized Pharmaceutical This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one... | 07/30/1996 |
| 5534531 | Compounds New compounds having the general formula I ##STR1## wherein L may be H or D; Y may be CN or ##STR2## wherein A may be H, D, alkyl with 1-4 carbon atoms, OR wherein R is H or alkyl with 1-4 carbon atoms, or CR1 R2 R3 | 07/09/1996 |
| 5530028 | Insecticidal N'-substituted-N,N'-diacylhydrazines Insecticidal compounds having the formula N-(2-Ra -3-Rb -4-Rh -benzoyl)-N'-(2-Rc -3-Rd -4-Re -5-Rf -benzoyl)-N'-Rg -hydrazine wherein Ra is a halo or lower alkyl... | 06/25/1996 |
| 5525633 | Triaryl-ethylene derivatives The present invention relates to novel triaryl-ethylene derivatives that are useful as anti-neoplastic agents, antiatherosclerotic agents, and hypocholesterolemic agents.... | 06/11/1996 |
| 5525631 | Compositions of the ethyl ester of L-DOPA A composition which comprises a pharmaceutically acceptable carrier and an active ingredient, such active ingredient comprising L-DOPA ethyl ester derived from its crystaline form in an amount which is at least 97%, by weight, of the active ingredient, an... | 06/11/1996 |
| 5521220 | Acyclic ethylenediamine derivatives The present invention relates to novel acyclic ethylenediamine derivatives of nitrogen containing heterocyclic compounds, and specifically, to compounds of the formula ##STR1## wherein R1, R2, R3, R4, R | 05/28/1996 |
| 5504115 | Inhibitors of farnesyl protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 04/02/1996 |
| 5480912 | Method of treating HIV-1 with -substituted benzenemethanamine derivatives The present invention is concerned with antiretroviral (e.g. anti HIV-1) compounds having the formula ##STR1## Pharmaceutical compositions containing said compounds of formula (I-a) or (I-b), and processes of preparing said compounds and compositions... | 01/02/1996 |
| 5462965 | Use of heterocyclic amino-alcohol compounds for treatment of CNS diseases A class of heterocyclic amino-alcohol compounds is described for treatment of CNS-related diseases, namely, for use as a neuroprotective agent, to reduce neurotoxic injury associated with conditions of hypoxia, anoxia or ischemia which typically follows s... | 10/31/1995 |
| 5459140 | Combination preparation based on dipivalylepinephrine (DPE) for reducing intraocular pressure A preparation for reducing intraocular pressure consisting essentially of a therapeutically effective amount of the fixed combination of dipivalylepinephrine and carbachol (preparation 1) or dipivalylepinephrine and beta-blocker (preparation 2). The prepa... | 10/17/1995 |
| 5455276 | Method for treating depression Pharmaceutical compositions for treating psychiatric disorders are provided. The compositions include 2-phenylethylamine ("PEA") and at least one inhibitor of monoamine oxidase B. Methods for the treatment of psychiatric disorders, including depression, u... | 10/03/1995 |
