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| Number | Title | Issue Date |
| 8188149 | Use of R(+)-N-propargy1-1-aminoindan to treat or prevent hearing loss The subject invention provides a method of treating or inhibiting hearing loss in a mammalian subject. The method includes administering to a mammalian subject an amount of R(+)-N-propargyl-1-aminoindan or pharmaceutically acceptable salt thereof effective to treat ... | 05/29/2012 |
| 8133916 | Control of milk production and mammary involution The present invention is a method for increasing serotonin activity in mammary glands such that involution of milk secretion of the same mammary glands occurs. The present invention further is a composition that can be implanted, or infused into the mammary glands t... | 03/13/2012 |
| 8080584 | Delayed release rasagiline citrate formulation Disclosed are formulations which are designed to delay release of rasagiline while maintaining specific pharmacokinetic properties. ... | 12/20/2011 |
| 7855233 | Citrate salt of Rasagiline The subject invention provides rasagiline citrate, its compositions and processes for the manufacture thereof. ... | 12/21/2010 |
| 7790772 | Treatment of CNS disorders with 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-n... | 09/07/2010 |
| 7759397 | 6-amino(aza)indane compounds suitable for treating disorders that respond to modulation of the dopamine Dreceptor The present invention relates to 6-amino(aza)indane compound of the formula (I) Wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical Ra and wherein Ar may also carry I or 2 radicals Rb | 07/20/2010 |
| 7750051 | Crystalline solid rasagiline base The subject invention provides crystalline R(+)-N-propargyl-1-aminoindan, pharmaceutical compositions and methods of manufacture thereof. ... | 07/06/2010 |
| 7612114 | Selective estrogen receptor modulator The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents ... | 11/03/2009 |
| 7572834 | Rasagiline formulations and processes for their preparation The subject invention provides a pharmaceutical composition comprising N-propargyl-1(R)-aminoindan mesylate; a pharmaceutically acceptable carrier; and greater than 0.7 ppm but less than 30 ppm in total of a compound having the structure: | 08/11/2009 |
| 7432247 | Methods of cardioprotection using dichloroacetate in combination with an inotrope The present invention provides compositions and methods for maintaining cardiac function by administering dichloroacetate (DCA) in combination with an inotrope. ... | 10/07/2008 |
| 7411093 | Aminocycloalkanes as DPP-IV inhibitors The present invention relates to compounds of formula (I) wherein R1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or p... | 08/12/2008 |
| 7396860 | Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis The subject invention provides a method for treating amyotrophic lateral sclerosis (ALS) in a subject in need of such treatment comprising administering to the subject R(+)-N-propargyl-1-aminoindan or a pharmaceutically acceptable salt thereof alone or in combinatio... | 07/08/2008 |
| 7326733 | Methods for increasing bone density Methods and compounds for remodeling bone and treating osteopenic conditions are described. Methods and compounds for increasing bone mineral density by decreasing serotonin levels in osteoblasts are also described. ... | 02/05/2008 |
| 7306811 | Fungicide composition based on halosulphone in particular for packaging A packaging sheet comprising a mixture of compound A where R1 may be an alkyl, alkoxy or alkylene radical having 1 to... | 12/11/2007 |
| 7307071 | RAF-MEK-ERK pathway inhibitors to treat cancer Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia, and which cancer is preferably resistant to the inhibition of the Bc... | 12/11/2007 |
| 7276518 | Substituted cyclohexane-1,4-diamine compounds Substituted cyclohexane-1,4-diamine compounds, methods for production thereof, pharmaceutical compositions comprising these compounds and methods of treatment using these compounds. ... | 10/02/2007 |
| 7232830 | Method for treatment of neurodegenerative diseases and effects of aging A method for treatment of neurodegenerative disease conditions stemming from multiple sclerosis, aging, autoimmune diseases and fibromyalgia. A compound effective to increase neuronal metabolism of histamine to a histamine H2 agonist is administered in an... | 06/19/2007 |
| 7211694 | Substituted 4-aminocyclohexanols Substituted 4-aminocyclohexanols, processes for their preparation, pharmaceutical compositions comprising these compounds and to the use of substituted 4-aminocyclohexanols in the preparation of pharmaceutical compositions for the treatment of various indications, e... | 05/01/2007 |
| 7201854 | Active compound combinations for protecting animal hides and leather The present application relates to the use of active compound combinations containing phenolic active compounds and fungicidal active compounds for preserving animal hides and leather. ... | 04/10/2007 |
| 7183436 | Substituted 4-aminocyclohexanols Substituted 4-aminocyclohexanols, methods of producing the same, pharmaceuticals containing these compounds, the use of substituted 4-aminocyclohexanols for producing pharmaceutical compositions for the treatment of various indications, in particular pain, and for r... | 02/27/2007 |
| 7173153 | Sertraline hydrochloride form II and methods for the preparation thereof This invention relates to a method for the preparation of sertraline hydrochloride, (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphtalenamine hydrochloride, in its crystalline form II. ... | 02/06/2007 |
| 7157604 | Selective estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 01/02/2007 |
| 7148257 | Methods of treating mesothelioma with suberoylanilide hydroxamic acid Methods for treating mesothelioma comprising administering the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) are disclosed. ... | 12/12/2006 |
| 7147864 | Methods for preventing photodamaged skin by administering selegiline or desmethylselegiline The present invention is directed to methods that can be used in the treatment of wounds, burns, and photodamaged skin. Methods can be used for both humans and animals and involve the administration of compositions containing selegiline and/or desmethylselegiline. | 12/12/2006 |
| 7144584 | S(+) desmethylselegiline and its use to treat narcolepsy The present invention provides novel compositions and methods for using the S(+) enantiomer of desmethylselegiline (N-methyl-N-(prop-2-ynyl)-2-aminophenylpropane), for the treatment of selegiline-responsive diseases and conditions. Diseases and conditions responsive... | 12/05/2006 |
| 7115258 | Vesicular monoamine transporter gene therapy in parkinson's disease The present invention provides methods and compositions for the therapeutic intervention of Parkinson's disease. More particularly, methods of making and sequestering dopamine are disclosed. Additionally, methods of genetically modifying donor cells by gene transfer... | 10/03/2006 |
| 7115780 | Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a —S(O)z(C1–C4)Alk wherein z is 0, 1 or 2, a —NHSO2(C1–C | 10/03/2006 |
| 7105699 | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-n... | 09/12/2006 |
| 7105502 | Nitric oxide-releasing imidate and thioimidate diazeniumdiolates The invention provides NO- or NO−-releasing imidate; and thioimidate, diazeniumdiolates, in which the N2O2− functional group is bonded to a carbon atom. The imidate and thioimidate diazeniumdiolates are bound to a poly... | 09/12/2006 |
| 7094930 | Pharmaceutically acceptable salts of sertraline and pharmaceutical compositions thereof The present invention is directed to certain pharmaceutically acceptable salts of the therapeutically potent selective serotonin reuptake inhibitor, sertraline: and pharmaceutical compositions thereof, wherein sa... | 08/22/2006 |
| 7087785 | Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-n... | 08/08/2006 |
| 7071194 | Method for improving respiratory function and inhibiting muscular degeneration The present invention provides a method for improving respiratory function and inhibiting muscular degeneration (e.g., dystrophy and atrophy). Alternative embodiments of the invention provide a method of inhibiting motor neuron apoptosis and the subsequent muscular ... | 07/04/2006 |
| 7067555 | Sertraline oral concentrate The present invention provides an essentially nonaqueous, liquid pharmaceutical concentrate composition for oral administration containing sertraline or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients. The present in... | 06/27/2006 |
| 7022881 | Sertraline hydrochloride polymorphs The present invention is directed to forms II, III, V, VI, VII, VIII, IX and X of sertraline hydrochloride and novel methods for their preparation. According to the present invention, sertraline hydrochloride polymorph II may be produced by slurrying sertraline hydr... | 04/04/2006 |
| 6992106 | Anti-tumor composition The present invention provides composition having as active ingredients a stilbene derivative and a platinum coordination compound which is highly efficacious and highly safe for treating tumors, particularly for the treatment of solid or malignant tumors and thus m... | 01/31/2006 |
| 6974839 | Method of delaying ejaculation The invention provides a method of delaying ejaculation. The method comprises administering an effective amount of a tramadol material to a human male prior to sexual intercourse. The method is particularly useful for treating premature ejaculation. ... | 12/13/2005 |
| 6956060 | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof The subject invention provides R(+)-N-propargyl-1-aminoindan and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing same. The subject invention also provides methods of treating a subject afflicted with Parkinson's disease, ... | 10/18/2005 |
| 6949530 | Nitric oxide-releasing amidine diazeniumdiolates, compositions and uses thereof and method of making same The present invention relates to nitric oxide-releasing amidine diazeniumdiolates, compositions comprising same, methods of using same, and a method for preparing same from imidate diazeniumdiolates and primary or secondary amines. ... | 09/27/2005 |
| 6943195 | Cycloalkenone derivative (−)-3-[3-[(1R,2R,4S)-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyanilino]-2-methyl-2-cyclopenten-1-one, or its hydrate or solvate, or a pharmaceutical composition containing the same. ... | 09/13/2005 |
| 6939992 | Polymorphic forms of sertraline hydrochloride A crystalline form of sertraline hydrochloride was found, referred to hereinafter as polymorphic form CSC2 having a dissolution rate which surprisingly will increase rate of absorption of a drug. Furthermore, different crystalline forms of sertraline hydrochl... | 09/06/2005 |
