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Pneumatic Shoe Lacing Apparatus
This invention provides a pneumatic shoe lacing apparatus for the pneumatic lacing of shoe.
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| Number | Title | Issue Date |
| 8148430 | Process for the hydrogenation of aromatic compounds The present invention focuses on a process for the hydrogenation of aromatic or heteroaromatic compounds and in particular on the ring hydrogenation of compounds having the formula (I). Aromatic amino acids and amino alcoho... | 04/03/2012 |
| 8101666 | Methods and compounds for detection of medical disorders The invention provides methods for detection of medical disorders, associated with cellular oxidative stress, cell degeneration and/or cell death. The invention further relates to compounds comprising a thiol (—SH) group, for detecting cells undergoing oxidative s... | 01/24/2012 |
| 8003701 | Method of inhibiting inflammatory pain A method of treating or inhibiting, in particular, pain caused by inflammation in a mammal by administering to the mammal an effective inflammatory pain alleviating amount of a (1RS,3RS,6RS)-6-dimethyl-aminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol compound, p... | 08/23/2011 |
| 8003702 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds... | 08/23/2011 |
| 7989501 | Treating renal cancer using a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde The present invention features methods of treating a mammalian subject having renal cancer by administration of certain dimethylsulfonate compounds, such as a 4-[bis[2-[(methylsulfonyl)oxy]ethyl]amino]-benzaldehyde. The present invention further features administrat... | 08/02/2011 |
| 7989500 | Synthesis, methods of using, and compositions of cycloalkylmethylamines The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The phar... | 08/02/2011 |
| 7910626 | Use of S1P receptor agonists in heart diseases The invention relates to the use of a sphingosine-1-phosphate receptor agonist in the treatment of heart diseases. ... | 03/22/2011 |
| 7888394 | Synthesis, polymorphs, and pharmaceutical formulation of FAAH inhibitors Pharmacological inhibition of fatty acid amide hydrolase (FAAH) activity leads to increased levels of fatty acid amides. The alkylcarbamic acid aryl ester of Formula (I), KDS-4103, is a FAAH inhibitor. Described herein is a process for the preparation of the compoun... | 02/15/2011 |
| 7863336 | Continuous administration of dopa decarboxylase inhibitors and compositions for same Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parki... | 01/04/2011 |
| 7838562 | Methods of inhibiting vascular permeability and apoptosis Agonist of vascular endothelial sphingosine-1-phosphate receptors are described. Compounds such as FTY720 can be phosphorylated by sphingosine kinase-2 into the phosphorylated forms which serve as sphingosine-1-phosphate receptor agonists. The vascular endothelial s... | 11/23/2010 |
| 7790771 | Use of tosylchloramide(s) for treating disease of the skin, mucous membrane, organs and tissues The invention concerns the use of tosylchloramide(s), tosylchloramide salt(s), their derivatives and/or the decomposition products for treating diseases of the skin, mucous membranes, organs and tissues, excluding treatment of retroviral diseases (HIV) and disinfect... | 09/07/2010 |
| 7781487 | Di-fluoro containing compounds as cysteine protease inhibitors The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical comp... | 08/24/2010 |
| 7776924 | Nitroaniline-based alkylating agents and their use as prodrugs Nitroaniline-based unsymmetrical mustards of the general formula (I) are provided, together with methods of preparation and methods for their use as prodrugs for gene-dependent enzyme prodrug therapy (GDEPT) and cell ablation therapy in conjunction with nitroreducta... | 08/17/2010 |
| 7645801 | Reduced irritant enema for treatment of inflammatory bowel disease (IBD) The present invention comprises packaged enemas for the treatment of Inflammatory Bowel Disease (IBD), having substantially pure 5-ASA as the active ingredient, with a liquid carrier medium having a material avoidance of bowel irritant substances, such as anti-oxida... | 01/12/2010 |
| 7625950 | Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and n are as defined in the specification, processes for their production, their... | 12/01/2009 |
| 7524886 | L-(−)-moprolol L-(+)-tartrate L-(−)-moprolol L-(+)-tartrate salt (2:1), method for preparing it and pharmaceutical composition comprising it. ... | 04/28/2009 |
| 7521480 | Aryl ureido benzoic acid derivatives and their use This invention relates to novel aryl ureido benzoic acid derivatives useful as selective and non-competitive antagonists of the ionotropic GluR5 receptor. Due to their biological activity, the aryl ureido derivatives of the invention are considered useful for treati... | 04/21/2009 |
| 7488758 | Levalbuterol hydrochloride polymorph B The invention is directed to levalbuterol HCl Form B and methods of making the same. ... | 02/10/2009 |
| 7427639 | β2-adrenergic receptor agonists Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.... | 09/23/2008 |
| 7425578 | Immunoregulatory compounds and derivatives and methods of treating diseases therewith Compounds are disclosed having the structure of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: ... | 09/16/2008 |
| 7425580 | (Diaryl-methyl)-malononitriles and their use as estrogen receptor ligands The present invention concerns compounds of formula: where R1, R2, R3 and R4 are defined in the specification. ... | 09/16/2008 |
| 7425579 | Methods for inhibiting activity of polyamine transporters A method for inhibiting the activity of a natural polyamine transporter comprising the step of contacting the transporter with an inhibitorily effective amount of a compound of formula (I) or (II): ... | 09/16/2008 |
| 7423185 | Amino alcohol derivatives, pharmaceutical compositions containing the same, and use thereof The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 and R2 are each hydrogen or lower alkyl; R3, R4... | 09/09/2008 |
| 7384983 | Inhibitor of monoamine uptake The present invention provides compounds and methods for the inhibition of monoamine uptake in mammals. ... | 06/10/2008 |
| 7371773 | Breast cancer resistance protein () inhibitor The invention provides a drug which inhibits BCRP. A breast cancer resistance protein inhibitor containing, as an active ingredient, a diphenylacrylonitrile derivative represented by the following formula (1): [where... | 05/13/2008 |
| 7368440 | Methods for the administration of amifostine and related compounds The present invention provides methods of administering amifostine, WR-1065, or a combination thereof, to patients receiving radiation therapy or chemotherapy in a manner that significantly reduces or decreases the adverse or undesirable side-effects of the compound... | 05/06/2008 |
| 7361690 | Compositions and methods for the treatment of urinary incontinence A method for treating increased uninary urgency or urinary incontinence, comprising administering an effective amount of a compound corresponding to formula I It has been surprisingly discovered that the methods of the pres... | 04/22/2008 |
| 7354942 | Benzylether and benzylamino beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to benzylether and benzylamino derivative compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secre... | 04/08/2008 |
| 7351743 | Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines. ... | 04/01/2008 |
| 7342038 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment or prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 3,3-diphenyl indole compounds, as well as analogues thereof, which are specific potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell proliferation in situ as a ther... | 03/11/2008 |
| 7338953 | Method of treating chronic fatigue syndrome Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of racemic reboxetine, or a pharmaceutically acceptable salt thereof, to the individual. ... | 03/04/2008 |
| 7326735 | Formulations for anaesthetic use A formulation for anaesthetic use is described. The formulation contains propofol, and may be used to induce and/or maintain anaesthesia or sedation in a vertebrae. The formulation additionally contains a solvent or a combination of solvents and is suitable for mixi... | 02/05/2008 |
| 7323496 | Compounds for treatment of inflammation, diabetes and related disorders Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering b... | 01/29/2008 |
| 7317011 | Method of treating peripheral neuropathy Disclosed herein are methods of treating an individual suffering from peripheral neuropathy. The methods generally include administration of a therapeutic amount of optically pure (S,S) reboxetine, or a pharmaceutically acceptable salt thereof. Embodiments of these ... | 01/08/2008 |
| 7314890 | Sulfonamides The present invention provides wherein R1 is selected from the group consisting of C1-C10 alkoxy, OH and NR4R5; R2 | 01/01/2008 |
| 7297820 | Stilbene derivatives and their use for binding and imaging amyloid plaques This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregat... | 11/20/2007 |
| 7287650 | Structures that inhibit microbial growth Structures treated with a microbiological interception enhancing agent comprising of a water-soluble cationic material having a counter ion associated therewith at specific sites on the cationic material, in combination with a biologically active metal salt, wherein... | 10/30/2007 |
| 7276503 | Method of treating chronic fatigue syndrome Disclosed herein are methods of treating an individual suffering from, chronic fatigue syndrome. The methods generally include administration of a therapeutic amount of optically pure (S,S) reboxetine, or a pharmaceutically acceptable salt thereof, to the individual... | 10/02/2007 |
| 7276166 | Fiber-fiber composites A fiber-fiber composite is disclosed herein comprising majority fibers and minority fibers, the minority fibers having a softening point lower than said majority fibers such that when the admixture of majority fibers and minority fibers are wet laid to form a paper-... | 10/02/2007 |
| 7273889 | NMDA receptor antagonist formulation with reduced neurotoxicity The present invention is directed to pharmaceutical compositions of effective amounts of NMDA receptor antagonists and preservative for the administration to a patient in need of effective analgesia and anesthesia. The compositions of the invention advantageously do... | 09/25/2007 |
