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| Number | Title | Issue Date |
| 8097656 | Nitrogenated trans-stilbene analogs, method for the obtention and medical applications thereof This invention is related to new nitrogenated trans-stilbene compounds, more specifically, imine, pyrrole and indole derivatives, with procedures for the preparation and use thereof as pharmaceutical compositions for the treatment and/or chemoprevention of those mam... | 01/17/2012 |
| 7732492 | Nateglinide-containing preparation The present invention provides a small-sized preparation that is easy to take, containing 26% or more of nateglinide and 28% or more of at least one disintegrant selected from the group consisting of carmellose or salts thereof, sodium carboxymethyl starch, croscarm... | 06/08/2010 |
| 7709533 | Imines as ion channel modulators The present invention provides a class of chemical compounds useful in the treatment of sickle cell disease, diseases characterized by unwanted or abnormal cell proliferation and for the treatment of ocular disorders such as glaucoma. The active compounds are tri-(a... | 05/04/2010 |
| 7354954 | Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy According to the subject invention, there is disclosed a method for treating a patient/subject having a spastic disorder, a convulsive disorder, pain or epilepsy which includes administering to the subject having any one of these conditions a therapeutically effecti... | 04/08/2008 |
| 7151196 | Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a v... | 12/19/2006 |
| 7022339 | Antidiabetic preparation for oral administration There is provided a single preparation which directly decreases both of the post prandial blood glucose level and the fasting blood glucose level close to normal levels, by release-sustaining a drug capable of decreasing the post prandial blood glucose level of diab... | 04/04/2006 |
| 6914078 | Triarylmethane derivatives and their use as photochemotherapeutic agents Disclosed are compounds having one of the following structures: wherein R and R′ are hydrogen or substituted or unsubstituted C1 to C6 linear or branched alkyl, and at least one X is a halogen a... | 07/05/2005 |
| 6878749 | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes The invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, which comprises nateglinide (1) stet or repaglinide and at least one other antidiabetic compound selec... | 04/12/2005 |
| 6686345 | DNA-cleaving antitumor agents A chemical composition and method of use of the composition is described. The chemical composition includes an aza-enediyne, aza-enyne allene, or an aza-diallene. These compound are preferably non-hydrolyzable, cationic compounds that bind to nucleic acid... | 02/03/2004 |
| 6656967 | Fungicidal phenylimidate derivatives The invention provides fungicidal compounds of formula I and salts thereof: ##STR1## wherein the various radicals and substituents are as defined in the description, fungicidal compositions containing them and method for combating fungi which comprise... | 12/02/2003 |
| 6596708 | Composition for the treatment and prevention of endothelial dysfunction A composition for the treatment and prevention of endothelial dysfunction comprising a therapeutically effective amount of anti-inflammatory agents comprising; acetylsalicylic acid, an amino sugar and a zinc compound.... | 07/22/2003 |
| 6559188 | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes The invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, which comprises nateglinide (I) ##STR1## or repaglinide and at least one other antidiabetic compound selected from the group consisting of ... | 05/06/2003 |
| 6559185 | Nitromethyl ketone compounds having aldose reduction inhibiting properties and methods for their use The present invention relates to the compounds of formula: ##STR1## in which R1, R2, R3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.... | 05/06/2003 |
| 6541520 | Treatment of addiction and addiction-related behavior The present invention provides a highly efficient method for treating substance addiction and for changing addiction-related behavior of a mammal suffering from substance addiction. The method includes administering to a mammal an effective amount of gamm... | 04/01/2003 |
| 6534546 | Aniline derivatives possessing an inhibitory effect of nitric oxide synthase Compounds represented by the general formula (1): ##STR1## (where R1 is SR6 or NR7 R8, where R6 is typically an alkyl group having 1-6 carbon atoms, R7 is a hydrogen atom, an alkyl group having ... | 03/18/2003 |
| 6399542 | Alkoxyimino-substituted bicyclic compounds compositions containing the same and method of making such compounds Alkoxyimino-substituted bicyclic derivatives or salts thereof having an excellent effect of controlling diseases and insect pests are disclosed. These derivatives are represented by the following formula (I): ##STR1## wherein R1 represents, for... | 06/04/2002 |
| 6391869 | Compositions and methods for the treatment of anorectal disorders Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2-) scavengers, ଲ-adrenergic agonists, cAMP-dependent protein kinase activa... | 05/21/2002 |
| 6258852 | Aryl nitrone therapeutics for the treatment of inflammatory bowel disease Disclosed are methods for treating or preventing inflammatory bowel disease (IBD) using aryl nitrone compounds. Pharmaceutical compositions containing aryl nitrone compounds which are useful for the treatment or prophylaxis of IBD are also disclosed.... | 07/10/2001 |
| 6187808 | Hexahydro-naphthalenone oximes and hydrazones This invention provides 6-amino-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one oximes and hydrazones which are useful in treating Parkinson's disease.... | 02/13/2001 |
| 6166032 | Method for controlling tobacco use and alleviating withdrawal symptoms due to cessation of tobacco use A method for controlling tobacco use and alleviating withdrawal symptoms due to the cessation of tobacco use comprising administering to a human desiring to control tobacco use and/or suffering from withdrawal due to cessation of such use an effective amo... | 12/26/2000 |
| 6075044 | Heterocyclic derivatives as inhibitors of purine salvage phosphoribosyltransferases The use of certain heterocyclic derivatives for treating parasitic protozoa infections in mammals, in particular bovine trichomoniasis and giardiasis, is disclosed.... | 06/13/2000 |
| 6043286 | Pesticidal compounds Pesticidal as a pesticide against whitefly, Lepidoptera and certain fungi is provided of compound of general formula (I) ##STR1## or a salt thereof is provided, in which n represents an integer from 0 to 4; m represents an integer 0 or 1; each R inde... | 03/28/2000 |
| 6043281 | Nitromethyl ketones, process for preparing them and compositions containing them The present invention relates to the compounds of formula: ##STR1## in which R1, R2, R3, E, A, X, Z, p and n are as defined herein. These compounds are aldose reductase inhibitors.... | 03/28/2000 |
| 6020369 | Method compositions and apparatus for treating and preventing respiratory viral infections Respiratory viral infections may be effectively prevented or treated by administering an aerosol spray comprising a polyoxometalate to the lungs.... | 02/01/2000 |
| 6020374 | Biologically active synthetic dye compounds A pharmaceutical composition comprising, in admixture with a pharmaceutically acceptable carrier, a therapeutically effective amount of a polyaromatic ring-containing compound, capable of mimicking the physiological activity of insulin or insulin-like gro... | 02/01/2000 |
| 5990151 | Optically active substituted phenylalkylamine derivatives The present invention relates to an optically active, substituted phenylalkylamine derivative represented by Formula [1]: ##STR1## wherein A is a substituted or non-substituted phenyl or thienyl; X1 is hydrogen, halogen, hydroxyl or a subs... | 11/23/1999 |
| 5962463 | Methods of stimulating non-amyloidogenic processing of the amyloid precursor protein Stimulating non-amyloidogenic processing by the activation of cell surface serotonin receptors linked to phospholipase and protein kinase C is described. Activation of the cell surface serotonin receptors is accomplished by contacting the cell with an age... | 10/05/1999 |
| 5939458 | Reduction of hair growth Mammalian hair growth is reduced by applying an inhibitor of aminoacyl-tRNA synthetase to the skin.... | 08/17/1999 |
| 5883106 | 5-lipoxygenase inhibitors Novel compounds having the ability to inhibit 5-lipoxygenase enzyme and having the following formula I: ##STR1## and the pharmaceutically acceptable salts thereof, wherein Ar1 is a heterocyclic moiety which is selected from imidazolyl, pyr... | 03/16/1999 |
| 5869067 | Bi-aromatic compounds and pharmaceutical and cosmetic compositions The present invention relates to new aromatic compounds, to their preparation and to their use in human and veterinary medicine and in cosmetic compositions.... | 02/09/1999 |
| 5861435 | Method for preventing settlement of aquatic fouling organisms A method for preventing settlement of aquatic fouling organisms on surface of an aquatic structure without environmental hazard is provided. The method is based upon absolutely novel concept to prevent the settlement by means of thick slime layer, i.e. bi... | 01/19/1999 |
| 5824684 | Method for treating drug and alcohol addiction A method for treating treating drug and alcohol addiction comprising administering to a human suffering from such addiction an effective amount of an acetylcholine esterase reactivator.... | 10/20/1998 |
| 5763479 | Naphthoquinone derivatives for the treatment of chronic inflammation A redox, hydrogen-acceptor compound, having utility in treating inflammation, is a 1,4-dioxonaphthalene or 1,4-dilminon aphthalene having either a 2,3-double bond, in which cast there are 2 and 3-substituents, or a 2,3-single bond. Examples of such compou... | 06/09/1998 |
| 5760052 | Composition for use as a fungistat and for the treatment of fungal infections A composition for use as a fungistat for the treatment and prevention of infections such as sporotrichosis, onychomycosis infections, white line disease, hoof rot, jungle rot, pseudallecheria boydii, scopulariopsis, athletes foot, canker sole and fungal i... | 06/02/1998 |
| 5705531 | 1,5-disubstituted 7A-methylperhydroinden-3A-ol derivatives, useful in treating cardiovascular disorders, processes for their preparation and pharmaceutical compositions containing the same 1,5-Disubstituted 5a-methylperhydroinden-3a-ol derivatives of formula (I): ##STR1## where either the symbol - - - - represents a single bond, the group A is in cis configuration with respect to the 3a-hydroxy, 7a-methyl and 1-L groups, and A is (CH.dbd.CH... | 01/06/1998 |
| 5686429 | Method for providing nutrition to elderly patients The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes a... | 11/11/1997 |
| 5620983 | Compounds and methods of use to derivatize neighboring lysine residues in proteins under physiological conditions The present invention concerns compounds that block the movement of viral particles through the nuclear membrane and thereby prevent the productive infection of terminally differentiated cells by virus the life cycle of which includes such an importation ... | 04/15/1997 |
| 5618846 | Treatment method for cancer The in vivo chemotherapeutic treatment of cancer cells in a living animal is improved by first administering to the animal, a compound which inhibits normal cell proliferation while promoting malignant cell proliferation, specifically a potent antagonist ... | 04/08/1997 |
| 5589468 | Method for providing nutrition to elderly patients The present invention provides a method for providing nutrition to elderly patients. Pursuant to the present invention, the enteral composition includes a protein source, a lipid source, and a carbohydrate source. Preferably, the protein source includes a... | 12/31/1996 |
| 5519018 | Substituted phenols and their use for the treatment of disorders caused by cell proliferation Substituted phenols of the formula I ##STR1## processes for their preparation and compositions containing substituted phenols of the formulae I and II ##STR2## for the treatment of disorders caused by cell proliferation, such as psoriasis, ... | 05/21/1996 |
