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| Number | Title | Issue Date |
| 4959366 | Anti-arrhythmic agents A series of [N-alkyl-N-(nitro-, alkylsulphonamido, or amino-phenalkyl)amino]-alkyl, alkoxy or alkylthio phenyl derivatives having utility as anti-arrhythmic agents.... | 09/25/1990 |
| 4954512 | Anti-ulcer composition An anti-peptic ulcer composition containing, as an active ingredient, a therapeutically effective amount of a compound having the formula (I): ##STR1## wherein A represents H2 NCH2 --, ##STR2## B represents ##STR3## ... | 09/04/1990 |
| 4939163 | Anticonvulsant agents This invention provides certain 4-substituted benzamide derivatives, their pharmaceutical formulations, and their use as anticonvulsant agents.... | 07/03/1990 |
| 4933369 | Dimethyl tyrosyl amide sulfides, sulfoxides and sulfones The present invention relates to new compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof and the enantiomers thereof, wherein R1 is H, lower alkyl, alkenyl, aralkyl, or C(O)R2 wherein R2 | 06/12/1990 |
| 4931470 | Antiarrhythmic method This invention provides a method of treating or preventing cardiac arrhythmias employing certain 4-amino-N-2,6-(dimethylphenyl)benzamide derivatives.... | 06/05/1990 |
| 4927836 | Amide derivatives The invention concerns novel phenoxyacetic acid amide derivatives of the formula I (and pharmaceutically acceptable salts thereof) in which R1 is hydrogen or fluoro, R2 is phenyl, cycloalkyl, alkyl or alkenyl as defined herein, and R... | 05/22/1990 |
| 4885313 | 3,4-Dihydroxyphenylethylamine derivatives and their use Novel 3,4-dihydroxyphenylethylamine derivatives possess dopaminergic activity in animals and are therefore useful in the treatment of iner alia congestive heart failure, renal failure and reversible obstructive airways disease. The compounds are generally... | 12/05/1989 |
| 4880834 | Method for administering ethanolamine derivatives to livestock A method for treating livestock to decrease birth mortality rate and to increase post-natal survival rate by administering ethanolamine derivatives is disclosed.... | 11/14/1989 |
| 4851446 | Immunosuppressing method The present invention relates to an immunosuppressing method which comprises administering a spergualin-related compound represented by the following formula ##STR1## (wherein R1 is --(CH2)4 --, --(CH2) | 07/25/1989 |
| 4847295 | Cycloalkyl-substituted 4-aminophenyl halo derivatives and process for their preparation The invention relates to cycloalkyl substituted 4-aminophenyl halo derivatives of formula (I) ##STR1## wherein n is an integer of 1 to 5; A is >C.dbd.O or --CH2 -- and B is, independently, --O--, --NH-- or --CH2 --; and either R... | 07/11/1989 |
| 4847301 | Methods of use of -(aminoalkyl)-arylacetic acid derivatives Novel -aryl--(ω-aminoalkyl)--[hydroxy(aralkyl and cycloalkyl)]acetic acid derivatives and -aryl--(ω-aminoalkyl)-[alkanoyloxy(aralkyl and cycloalkyl)]acetic acid derivatives, such as N,N-dimethyl-2-(hydroxyp... | 07/11/1989 |
| 4845127 | Phenethanolamines, compositions containing the same and method for effecting weight control Optically active N-3-(4-substituted phenyl)propyl-ଲ-phenethanolamines are provided as well as pharmaceutical compositions containing such compounds. A method for effecting weight control in obese animals utilizing optically active phenethanolamine i... | 07/04/1989 |
| 4826876 | Chemical compounds having selective thyromimetic activity This invention relates to chemical compounds which have selective thyromimetic activity. A compound of this invention is 3,5-dibromo-3'-[6-oxo-3(1H)-pyridazinyl-methyl]-thyronine.... | 05/02/1989 |
| 4816486 | Amide derivatives and 5-lypoxygenase inhibitors containing the same Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned N-cyclohexyl-N-methyl-(2-(3-(3-methoxy-4-hydroxyphenyl)-2-(propenoylamino) -3, 5-dibromobenzyl)amine and N-cyclohexyl-N-methyl-(2-(5-(3-methoxy-4-hydroxyphenyl)... | 03/28/1989 |
| 4803225 | Dihydroxy-phenethylamino compounds useful as pharmaceuticals There are provided compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. There are also described the use of the compounds of formula I as pharmaceuticals, methods for making the compounds and pharmaceutical, e.g. card... | 02/07/1989 |
| 4794111 | Dihydropyridine preparations containing ଲ-blockers An antihypertensive and antianginal combination comprising (A) 0.1 to 10 parts by weight of an asymmetrical dihydropyridine of the formula ##STR1## in which R1 and R5 each independently is methyl, hydroxymethyl or cyano, R2... | 12/27/1988 |
| 4767781 | Derivatives of beta-amino-gamma-trimethylammonio-butyrate and their production and use A compound of the formula: ##STR1## wherein R1 is hydrogen, alkyl or acyl, R2 is hydroxy, alkoxy or amino, is useful as an antidiabetic agent.... | 08/30/1988 |
| 4735959 | Carboxylic acid amides and pharmaceutical compositions containing them There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary metabolism. Furthermore, the compounds of Formula I... | 04/05/1988 |
| 4732916 | Novel guanidinomethylbenzoic acid derivatives A guanidinomethylbenzoic acid derivative represented by the formula ##STR1## or a salt thereof. An antiulcer agent comprising the compounds of the afore-said formula as an effective ingredient is also disclosed.... | 03/22/1988 |
| 4692465 | 2-phenylethylamine derivatives Compounds of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, wherein: Ar is benzofuran-2-yl, or phenyl optionally substituted by groups R1 and/or R2 wherein R1 is halogen, trifluor... | 09/08/1987 |
| 4681898 | N-N-disubstituted alkenamides and phenylalkenamides Compounds of the formula ##STR1## where n is 0 or 1, R is alkyl, phenyl or R4 -substituted phenyl, R2 and R3 are, independently, alkyl or R2 and R3 together with N is ##STR2## m is 1, 2 or 3, R | 07/21/1987 |
| 4668703 | γ-allenyl-γ-aminobutyric acids This invention is for γ-allenyl-γ-aminobutyric acid derivatives which are γ-aminobutyric acid transaminase inhibitors.... | 05/26/1987 |
| 4661515 | Compounds having angiotensin converting enzyme inhibitory activity and diuretic activity Novel compounds possessing both angiotensin enzyme inhibitory activity and diuretic activity are disclosed. The compounds are represented by the general formula ##STR1## in which X is ##STR2## in which R1, R2, R3 | 04/28/1987 |
| 4652584 | Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension Phenoxypropanol derivatives having a 2-acetylenic moiety on the phenyl group thereof of the following formula (I): ##STR1## and their use as anti-hypertensives, e.g. in man. Also part of the invention are pharmaceutical compositions and intermediates... | 03/24/1987 |
| 4639468 | Derivatives of glycinamide, their preparation and their use A glycinamide derivative of the general formula I: ##STR1## wherein: R is a linear or ramified alkyl group C5 -C18, a linear or ramified alkenyl group C5, C6, C7, C8, C9, C | 01/27/1987 |
| 4629737 | Secondary amines and use in pharmaceutical compositions A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, in which: W is an optionally substituted phenyl group of the formula ##STR2## wherein R1 is hydrogen or fluorine, R2 is hyd... | 12/16/1986 |
| 4629740 | Anticonvulsant agents This invention provides for certain benzamide derivatives and their pharmaceutical formulations and their use as anticonvulsant agents.... | 12/16/1986 |
| 4585796 | Novel phenethanolamines The tertiary amines of the formula ##STR1## wherein n represents a whole number of 1 to 5; X1 represents phenyl or phenyl mono-, di- or tri-substituted by R1, R2 and R3 ; X2 represents hydrogen, lower... | 04/29/1986 |
| 4564636 | Diphenylazomethines and pharmaceutical compositions containing them Diphenylazomethines of the formula (I) ##STR1## in which R represents --(CH2)4 OH, --(CH2)2 --CHOH--CH3, --CH2 --CHOH--C2 H5, --CH2 --CHOH--CH2 | 01/14/1986 |
| 4562201 | Aminomethyl benzanilides The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S-- where R1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y)... | 12/31/1985 |
| 4562206 | Orally effective inotropic compounds A method for increasing cardiac contractility in a warm-blooded animal suffering from acutely depressed cardiac contractility which comprises administering to said animal an effective amount of a compound of the formula ##STR1## wherein R is hyd... | 12/31/1985 |
| 4559361 | Naphthalenecarboxamides, their production and use Novel compounds of the formula: ##STR1## wherein R is phenyl-C1-6 alkyl, and salts thereof, have intraocular pressure depressant action.... | 12/17/1985 |
| 4545995 | Substituted phenylalkenyl ammonium salts as antiarrhythimc agents The novel unsaturated arylalkyl ammonium salts described herein are useful as antiarrhythmic agents. A method of treating arrhythmia by increasing the refractoriness of cardiac tissue is provided, as well as pharmaceutical formulations containing such amm... | 10/08/1985 |
| 4460580 | N-Alkylated aminoalcohols and their pharmaceutical compositions useful for the treatment of cardiac insufficiency The invention relates to novel N-alkylated aminoalcohols of the formula ##STR1## in which Ar is a radical of aromatic character which is unsubstituted or substituted by hydroxyl, n has the values nought or 1 and Alk is an alkylene radical having 2 to... | 07/17/1984 |
| 4435425 | Fluorinated diaminobutane derivatives Fluorinated diaminobutane compounds in vivo are inhibitors of gamma-aminobutyric acid transaminase and have the following formula: ##STR1## wherein: R1 represents hydrogen, C1 -C6 alkyl, or phenyl-(C1 -C | 03/06/1984 |
| 4428883 | Novel method of administering ଲ-blockers and novel dosage forms containing same The invention provides a novel method of administering selected known adrenergic ଲ-receptor blocking agents, such as dichloroisoproterenol, pronethalol, sotalol and alprenolol, which are of use in the treatment of angina pectoris, arrhythmias, hyper... | 01/31/1984 |
| 4425360 | Pharmacologically active novel O-substituted pyruvic acid oximes The present invention provides pyruvic acid oximes of the general formula: ##STR1## wherein R is a hydrogen atom, a C3 -C8 cycloalkyl, C1 -C6 alkoxy, cinnamyloxy, phenylamino, phenyl-N-alkylamino or phenylt... | 01/10/1984 |
| 4407816 | 3-Substituted-2-propenimidamides and method of manufacturing the same New derivatives of 3-furyl-, 3-thienyl- and 3-phenyl-2-propenimidamides are disclosed, which are useful as anti-ulcer agents. These new compounds are synthesized by reacting an imino ether derived from a corresponding 3-substituted-2-propenenitrile with a... | 10/04/1983 |
| 4402975 | Aminocarboxylic acids, amino alcohols, or the derivatives thereof, processes for production thereof, and pharmaceutical uses thereof A compound represented by the following formula ##STR1## wherein R1 represents a hydrogen atom, an acyl group or an alkoxycarbonyl group; X1 represents an alkylene group having 3 to 6 carbon atoms, a 1,4-cyclohexylene group, or ... | 09/06/1983 |
| 4400394 | Benzylidene derivatives Compounds of the formula: ##STR1## in which X1, X2 and X3, which are identical or different, each represent hydrogen, halogen, methyl, or methoxy, n represents an integer from 1 to 10, and R represents hydroxyl, OM, N... | 08/23/1983 |
