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| Number | Title | Issue Date |
| 8088828 | Treating benign prostate hyperplasia with SARMS This invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of benign prostate hyperplasia in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) and/or its analog, derivative... | 01/03/2012 |
| 8053476 | Method for treating peripheral neuropathic pain The present invention concerns the use of compounds of the Formula (I) for treating different types of acute and chronic pain, especially non neuropathic inflammatory pain in mammals. The pain to be treated may be e.g. chro... | 11/08/2011 |
| 8008351 | Methods for prophylaxis or treatment of conditions associated with cortical spreading depression The present invention is directed to the use of a class of peptide compounds for the prophylaxis and treatment of chronic headache, particularly migraines. ... | 08/30/2011 |
| 7989498 | Inhibitors of IMPDH enzyme The present invention relates to compounds which inhibit IMPDH. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH e... | 08/02/2011 |
| 7981936 | Crystalline ACAT inhibitor The invention is directed to the Form A polymorph of N-benzyl-N′-(2,6-diisopropyl-phenyl)-N-isopropyl-malonamide and its use as a therapeutic/cosmetic agent. ... | 07/19/2011 |
| 7964645 | Di-aromatic substituted amides as inhibitors for GlyT-1 The present invention relates to compounds of formula I wherein R1, R2, R3, R4, R5... | 06/21/2011 |
| 7939565 | Active substance combinations having insecticidal and acaricidal properties The present invention relates to novel insecticidally and acaricidally active compound combinations of N2-[1,1-dimethyl-2-(methylsulphonyl)ethyl]-3-iodo-N1-{2-methyl-4-[1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl]phenyl}phthalamide of the form... | 05/10/2011 |
| 7919529 | δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amides Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and... | 04/05/2011 |
| 7919530 | Compounds, compositions, and methods for the treatment of synucleinopathies Bis- and tris-dihydroxyaryl compounds and their methylenedioxy analogs and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of synucleinopathies, such as Parkinson's disease, and the man... | 04/05/2011 |
| 7884134 | Synthesis scheme for lacosamide The present invention is concerned with an improved method of producing (R)-2-acetamido-N-benzyl-3-methoxypropionamide (lacosamide) comprising the O-methylation of a compound of formula I to produce a compound of formula II... | 02/08/2011 |
| 7875652 | Method and composition for treating pain or tinnitus aureum The present invention concerns the novel use of compounds of the Formula I: for treating allodynia as major and unique pain symptom independent of the nature of an underlying disease, but that is often related to neuropathic pain or other different types of chronic ... | 01/25/2011 |
| 7795315 | N-(2-amino-phenyl)-amide derivatives The present invention provides novel compounds of the general formula (I) and pharmaceutically acceptable salts thereof, processes for the manufacture of these novel compounds and medicaments containing such compounds. The ... | 09/14/2010 |
| 7776922 | Substituted [(phenylethanoyl)amino]benzamides The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of inflammatory disorders such as, for example,... | 08/17/2010 |
| 7776921 | Treating benign prostate hyperplasia with SARMS This invention provides a method of treating, preventing, suppressing, inhibiting or reducing the incidence of benign prostate hyperplasia in a male subject, by administering to the subject a selective androgen receptor modulator (SARM) and/or its analog, derivative... | 08/17/2010 |
| 7718703 | Norvaline derivative and method for preparation thereof Norvaline derivative of the formula [I] or pharmaceutically acceptable salt thereof, method for preparing the same, pharmaceutical composition containing the same, and use of the compound for inhibiting transporting activity of glycine transporter type 2 (GlyT2)... | 05/18/2010 |
| 7709532 | Methods for improving bioavailability of a renin inhibitor The present invention provides a method for improving the bioavailability of a renin inhibitor, preferably, of a δ-amino-γ-hydroxy-ω-aryl-alkanoic acid derivative, which method comprises co-administering to a mammal, especially a human, in need of such treatment,... | 05/04/2010 |
| 7696250 | Alpha ketoamide compounds as cysteine protease inhibitors The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compo... | 04/13/2010 |
| 7550509 | Carisoprodol articles and methods A method of using carisoprodol comprises informing a user that administration of carisoprodol in the presence of food decreases the Cmax for carisoprodol compared to administration in the absence of food. In one embodiment, informing comprises providing p... | 06/23/2009 |
| 7547731 | Formamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 06/16/2009 |
| 7528171 | Composition for external application The present invention relates to a composition for external application, a humectant and a skin barrier function reinforcing agent, each containing a diamide derivative represented by the following formula (1): (wherein, R | 05/05/2009 |
| 7449493 | Diamines as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis. | 11/11/2008 |
| 7432302 | Composition containing polyamine transport inhibitor and use thereof Proliferative cutaneous disease states or conditions are treated by administering a polyamine transport inhibitor R-X-L-polyamine wherein R is a straight or branched C10-50 saturated or unsaturated aliphatic, carboxyalkyl... | 10/07/2008 |
| 7417023 | Targeted delivery of bioaffecting compounds for the treatment of cancer A homogeneous conjugate for targeting and treating diseased cells wherein the conjugate comprises an anti-cancer drug and a targeting protein, wherein said anti-cancer drug is selected from the group consisting of heat sensitizers, photosensitizers and apoptosis ind... | 08/26/2008 |
| 7390923 | Propionamide derivatives useful as androgen receptor modulators Compounds of formula (I) wherein R1 to R4, X and A are as defined in the claims and pharmaceutically acceptable salts and esters thereof, are disclosed. The compounds of formula (I) possess utility as tissue-selective andro... | 06/24/2008 |
| 7390925 | Oxime-containing acyl guanidines as beta-secretase inhibitors There is provided a series of substituted oxime-containing acyl guanidines of Formula (I) or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R | 06/24/2008 |
| 7381745 | Ligands for metabotropic glutamate receptors and inhibitors of NAALADase The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the... | 06/03/2008 |
| 7378551 | Amide compound A gelling agent having a high ability of gelling an oily base which is capable of giving a gel composition having a strong gel strength and a good transparency, a gel composition having a strong gel strength and a good transparency, an external composition having a ... | 05/27/2008 |
| 7375137 | Methods of treating cancer with HDAC inhibitors The present invention provides methods of treating cancers, chemoprevention, selectively inducing terminal differentiation, cell growth arrest and/or apoptosis of neoplastic cells, and/or inhibiting histone deacetylase (HDAC) by administration of pharmaceutical comp... | 05/20/2008 |
| 7368573 | Triamide-substituted heterobicyclic compounds This invention relates to MTP/Apo-B secretion inhibitors of Formula (I) wherein R1-R7, X1, m and n are as defined in the specification, as well as pharmaceutical compositions comprising the ... | 05/06/2008 |
| 7364752 | Solid dispersion pharamaceutical formulations A pharmaceutical composition is disclosed which comprises a solid dispersion of an HIV protease inhibitor in a water soluble carrier, such as PEG, having enhanced bioavailability and improved dissolution properties. The solid dispersion may optionally be encapsulate... | 04/29/2008 |
| 7355074 | Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same A compound containing at least two aromatic rings covalently bonded together, with each aromatic ring containing at least one oxyacetamide-based side chain, the compound being capable of forming a chloride ion channel across a lipid bilayer, and transporting chlorid... | 04/08/2008 |
| 7351719 | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds The present invention relates to amide compounds of general formula I wherein the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. Moreover t... | 04/01/2008 |
| 7348355 | Triamide-substituted heterobicyclic compounds The invention relates to triamide MTP/ApoB inhibitors of the formula 1 wherein R1-R8 are as defined in the specification, as well as pharmaceutical compositions and uses thereof, and processes for prep... | 03/25/2008 |
| 7338978 | Insecticidal anthranilamides This invention provides compounds of Formula 1, their N-oxides and agriculturally suitable salts wherein A, B, J, R1, R2, R3 and R4 and n are as... | 03/04/2008 |
| 7335673 | 2,3-Diphenylpropionic acid derivatives or their salts, medicines or cell adhesion inhibitors containing the same, and their usage A 2,3-diphenylpropionic acid derivatives or the salts represented by general formula (1) below; and pharmaceutical compositions and cell adhesion inhibitors comprising the derivatives or the salts as the active ingredient. In the formula, A, B and C independently re... | 02/26/2008 |
| 7332164 | Heterobifunctional polymeric bioconjugates Heterobifunctional polymeric prodrug platforms for delivering biologically active compounds, including proteins, monoclonal antibodies and the like are disclosed. One preferred compound is Methods of making and u... | 02/19/2008 |
| 7317125 | Diacylglycerol acyltransferase inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutica... | 01/08/2008 |
| 7314956 | Multifunctional carrier for the delivery of a pharmacological agent or genetic material into a cell The present invention provides a drug delivery vehicle that can improve the pharmacokinetics of pharmacological agents. The invention relates to a multifunctional carrier capable of delivering a carried material such as a pharmacological agent or genetic material to... | 01/01/2008 |
| 7312360 | Substituted hydroxyethylamines Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, RN, and Rc are defined herein. These compounds i... | 12/25/2007 |
| 7309792 | Dimeric small molecule potentiators of apoptosis Caspase activity and apoptosis are promoted using active, dimeric Smac peptide mimetics of the general formula M1-L-M2, wherein moieties M1 and M2 are monomeric Smac mimetics and L is a covalent linker. Target cancerous or inflammatory cells are contacted with an ef... | 12/18/2007 |
