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| Number | Title | Issue Date |
| 7666911 | Self assembled nanostructures and methods for preparing the same The present invention provides amphiphilic diacetylene compounds, and compositions and self-assembled nanotubes containing the same. Also provided are methods of producing the compounds, compositions, and nanotubes of the invention, and methods of destroying or inhi... | 02/23/2010 |
| 7482379 | Propenoyl hydrazides The present disclosure provides compositions for inhibiting proteases, methods for synthesizing the compositions, and methods of using the disclosed protease inhibitors. Aspects of the disclosure include a peptidyl propenoyl hydrazide compositions that inhibit prote... | 01/27/2009 |
| 7432286 | Pharmaceutically active sulfonyl hydrazide derivatives The present invention is related to sulfonyl hydrazide derivatives for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl hydrazide derivatives. Said sulfonyl hydrazide derivatives are efficient modulators of... | 10/07/2008 |
| 7419972 | 2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 The invention relates to new 2-substituted estra-1,3,5(10)-trien-17-ones of formula I as well as their pharmaceutically acceptable salts, their methods of manufacture and use as medicaments for prophylaxis and/or therapy of... | 09/02/2008 |
| 7414037 | Hydrazide-containing CFTR inhibitor compounds and uses thereof The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions a... | 08/19/2008 |
| 7368473 | Paclitaxel enhancer compounds One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with b... | 05/06/2008 |
| 7345094 | Paclitaxel enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken... | 03/18/2008 |
| 7332485 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 02/19/2008 |
| 7317125 | Diacylglycerol acyltransferase inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutica... | 01/08/2008 |
| 7236236 | Methods for detecting malaria parasites and reagent kits therefor Methods for detecting a malaria parasite are described that include: releasing the malaria parasite by allowing an erythrocyte in a specimen to undergo hemolysis; staining the released malaria parasite with a fluorescent dye to prepare a measurement sample; detectin... | 06/26/2007 |
| 7217717 | Phenalene derivatives Novel 1,3,4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives are disclosed. These compounds inhibit epidermal growth factor receptor (“EGFR”) tyrosine kinase. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative... | 05/15/2007 |
| 7189873 | Propargylether derivatives, a process for their preparation and their use for controlling phytopathogenic microorganisms The invention relates to 4-propargyloxy-benzyl dervatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl or optionally ... | 03/13/2007 |
| 7173063 | Topoisomerase poisons for the treatment of proliferative disorders Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X1 | 02/06/2007 |
| 7074952 | Synthesis of taxol enhancers Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): The thiohydrazide product compound... | 07/11/2006 |
| 7056945 | Selective inhibition of neuronal nitric oxide synthase Compositions, prodrugs and methods for inhibiting neural Nitric Oxide Synthase (nNOS). By inhibiting nNOS, the compounds, prodrugs and methods of the presnet invention are useable to treat or prevent disorders in human or veterinary patients that are caused, mediate... | 06/06/2006 |
| 7045315 | Methods for modulating expression of exogenous genes in mammalian systems In accordance with the present invention, there are provided various methods for modulating the expression of an exogenous gene in an isolated cell and in a mammalian subject employing modified ecdysone receptors. Also provided are modified ecdysone receptors, as we... | 05/16/2006 |
| 7037940 | Taxol enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, t... | 05/02/2006 |
| 7034182 | Compounds to treat Alzheimer's disease The present invention is substituted amines of formula (XV) useful in treating Alzheimer's disease and other similar diseases. ... | 04/25/2006 |
| 7001924 | Inhibitors of RNase P proteins as antibacterial compounds The present invention features compounds useful for inhibiting RNase P activity. These compounds can be used as therapeutics for treating or preventing a variety of bacterial infections. The compounds belong to several classes including mono- and bis-guanylhydrazone... | 02/21/2006 |
| 7001923 | Taxol enhancer compounds One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together wi... | 02/21/2006 |
| 6992188 | Substituted heterocyclic derivatives Corticotropin-releasing factor (CRF) antagonists having the formula wherein the dashed lines, A, B, D E, F, Z, G, R3, and R5 having the definitions set forth in the specification pharmaceutical com... | 01/31/2006 |
| 6924312 | Taxol enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, ... | 08/02/2005 |
| 6893659 | Pharmaceutical composition for oral administration of a N-piperidino-3- pyrazolecarboxamide derivative, its salts and their solvates The pharmaceutical compositions for oral administration according to the invention contain 0.5% to 20% of N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide in microcrystalline form, and pharmaceutical excipients; they are formulat... | 05/17/2005 |
| 6887863 | Hydrazide and alkoxyamide angiogenesis inhibitors Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis... | 05/03/2005 |
| 6831196 | Urokinase inhibitors The invention relates to a highly active, highly specific urokinase inhibitor which is suitable for therapeutic applications and can be synthesized in an extremely simple manner. Surprisingly, it was found that amidino benzylamine derivatives, especially 4-amidino-b... | 12/14/2004 |
| 6800660 | Taxol enhancer compounds Disclosed is a compound represented by the Structural Formula (I): Y is a covalent bond, a phenylene group or a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C... | 10/05/2004 |
| 6774116 | Prodrugs via acylation with cinnamate A prodrug composition containing a cinnamate moiety and a biologically active molecule moiety which can be released by hydrolysis or activated by light is disclosed. The cinnamate moiety can have substituents of various electronically donating or electronically with... | 08/10/2004 |
| 6703426 | Treatment of breast cancer Compounds of the class of 4-oxo-butenoic acid derivatives are disclosed along with the surprising use property of these compounds as a anti-tumor agents in humans against breast carcinoma, which include: 2-(N'-Fluoren-9-ylidene-hydrazino)5,5-dimethyl-4-ox... | 03/09/2004 |
| 6703424 | Dispersible compositions containing L-DOPA ethyl ester The present invention relates to a dispersible pharmaceutical composition comprising a therapeutically effective amount of L-DOPA ethyl ester, a therapeutically effective amount of a decarboxylase inhibitor, a filler, a disintegrant, and a lubricant. The ... | 03/09/2004 |
| 6673777 | Guanylhydrazones useful for treating diseases associated with T cell activation There is disclosed a method for treating diseases and disorders involving T cell activation and HIV-infection, using the p38 mitogen activated protein kinase (MAPK) signaling pathway as a target for intervention. There is further disclosed a use for guany... | 01/06/2004 |
| 6610715 | Cathecol hydrazone derivatives, process for preparing the same and pharmaceutical composition containing the same The present invention provides novel cathecol hydrazone derivatives of formula (I) or pharmaceutically acceptable salts thereof, wherein R1 is C1-7 alkyl or C3-7 cycloalkyl; R2 is hydrogen, hydroxy, C1-5 | 08/26/2003 |
| 6521663 | Aminoguanidinyl- and Alkoxyguanidinyl-substituted phenyl acetamides as protease inhibitors Phenyl acetamide compounds are described, including compounds of Formula I: ##STR1## or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R3 -R6, R11, B, Y and W are set forth in the specification. Th... | 02/18/2003 |
| 6518310 | Aminoguanidines and alkoxyguanidines as protease inhibitors Aminoguanidine and alkoxyguanidine compounds, including compounds of the formula: ##STR1## wherein X is O or NR9 and R1 -R4, R6 -R9, R11, R12, Ra, Rb, R | 02/11/2003 |
| 6433017 | Amphiphilic polyamine compounds In accordance with the present invention, there are provided amphiphilic polyamine compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.... | 08/13/2002 |
| 6410574 | Fungicidal composition and method for using the same The present invention relates to a fungicidal composition obtained by mixing a 1,2,3-thiadiazole derivative of general formula (I) useful as a plant disease controller with at least one fungicide selected from the compounds having a fungicidal activity ag... | 06/25/2002 |
| 6399659 | Hydrazine oxoacetamide derivative and insecticide The present invention relates to a hydrazine oxoacetamide derivative or its salt which exhibits an excellent insecticidal effect even at a low concentration. The hydrazine oxoacetamide derivative has the following Formula (I): ##STR1## wherein R... | 06/04/2002 |
| 6376545 | Dispersible compositions containing L-DOPA ethyl ester The present invention relates to a dispersible pharmaceutical composition comprising a therapeutically effective amount of L-DOPA ethyl ester, a therapeutically effective amount of a decarboxylase inhibitor, a filler, a disintegrant, and a lubricant. The ... | 04/23/2002 |
| 6348499 | Amphiphilic polyamide compounds Amphiphilic polyamide compounds and derivatives thereof having the property of promoting transfection of polynucleotides and polypeptides into cells, and formulations comprising said compounds.... | 02/19/2002 |
| 6346547 | N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith Low-toxicity, highly-bioavailable, pharmaceutical antioxidant compositions for preferred oral administration to mammals are provided which have at least one amino acid-based compound of the general formula (I): A--N(Z)--CH(R1)C(O)--Q (I) wherein A ... | 02/12/2002 |
| 6297275 | Method for controlling fungi using phenylhydrazine derivatives A method for controlling fungi using a phenylhydrazine derivative compound of the formula: ##STR1## wherein: X is phenyl, phenylalkoxy, phenoxy, or benzyl, alone or in combination with one or more halogen, alkyl, or alkylthio; Y is hydrogen, alkanoyl, hal... | 10/02/2001 |
