|7354914||Lactams substituted by cyclic succinates as inhibitors of Aβ protein production|
This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifica...
|7354724||Drosophila G protein coupled receptors, nucleic acids, and methods related to the same|
The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention a...
|7348353||Acetylene derivatives having mGluR 5 antagonistic activity|
The invention provides compounds of formula (I) wherein m, n, A, R, R′, R″, R0, X and Y are as defined in the description, and their preparation. The compounds of formula (I) are useful as pharmaceuticals in the treatment of e.g. nervous system disord...
|7332497||Pyrazolopyrimidines as therapeutic agents|
The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, and R3 are defined as described herein...
|7332485||Peptide deformylase inhibitors|
Novel PDF inhibitors and novel methods for their use are provided. ...
The present invention relates to compounds of Formula I: Formula I which are agonists of the M-1 muscarinic receptor. ...
|7326732||EP2 receptor agonists|
A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20
|7316815||Polyamino acid derivatives and use thereof in compositions for treating keratin fibers|
The invention concerns the use in a cosmetic composition of at least a poly-aminoacid of general formula (I) in which X is —O—, —S— or —NR3; R1 represents in particular a hydrogen atom or a C1-C40 alkyl radical; ...
|7312359||Tetralin and indane derivatives and uses thereof|
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods f...
|7309497||Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients|
The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i...
|7304049||Succinoylaminobenzodiazepines as inhibitors of Aβ protein production|
This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, mor...
|7294643||UK-1 analogues: methods of preparation and use|
The present invention includes a number of structural analogues of UK-1. A comparision of the anticancer activity of the UK-1 analogues with their ability to inhibit the growth of methicillin-sensitive and methicillin-resistant Staphylococcus aureus demonstra...
|7288262||Composition comprising a cyclohexane-based compound, compound and use of said compound to structure a composition|
Compositions, in particular cosmetic compositions, comprising a cyclohexane-based compound defined by formula (I): wherein: R, which may be identical or different, are each chosen from hydrogen atoms an...
|7271196||CETP activity inhibitors|
The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight cha...
|7255853||Photoprotective cosmetic compositions containing aromatic amide, sulphonamide or carbamate derivatives of acrylonitrile and novel aromatic amide, sulphonamide or carbamate derivatives of acrylonitrile|
Cosmetic compositions for topical use for protecting the skin and the hair, containing, in a cosmetically acceptable support, at least one compound of formula (1) or (2) in which X1 represents R3
|7253210||Methylene-bridged selective androgen receptor modulators and methods of use thereof|
This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and a...
|7247741||Acetylamino benzoic acid compounds and their use for nonsense suppression and the treatment of disease|
Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature transla...
|7244751||Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity|
The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI), their preparations and the methods of using these compounds or their p...
|7241802||Substituted cyclohexylcarboxylic acid amide compounds|
Substituted cyclohexylcarboxylic acid amide compounds, processes for their production, pharmaceutical compositions containing these compounds and the use of substituted cyclohexylcarboxylic acid compounds for producing pharmaceutical compositions for treating condit...
|7223746||Omega cycloalkyl 17-heteroaryl prostaglandin E2 analogs as EP2-receptor agonists|
The invention relates to the use of derivatives of E-type prostaglandins as EP2 agonists, in general, and, in particular as ocular hypotensives. The PGE derivatives used in accordance with the invention are represented by the following formula I:
|7208510||Fungicidal combinations of active substances|
The present invention relates to fungicidally active compound combinations of a fluorobenzothiazole derivative of the formula (I) and at least one of the compounds listed in the disclosure. ...
|7208527||Potassium channel modulators|
This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SKCa and/or IKCa channels. ...
|7193108||Phenylpropionic acid derivatives|
Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α 4 integrin, such as inflammatory diseases in which α 4 integ...
|7192983||N-protected/N-substituted-beta-amino hydroxy sulfonates|
N-protected/N-substituted alpha-amino aldehydes, which are useful as pharmaceuticals and pharmaceutical intermediates, can be stored and shipped in a more stable form as N-protected/N-substituted-beta-amino hydroxy sulfonates which can be readily converted back into...
|7189721||Bicyclic protein kinase inhibitors|
The present invention relates to novel 3-hetero-arylidene-2-indolinone compounds and physiologically acceptable salts thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase rel...
|7179943||Bicyclic derivatives that modulate voltage-gated potassium channels and methods of use thereof|
Bicyclic amide derivatives of formula (I) or tautomers or pharmaceutically acceptable salts thereof or both are provided: Also provided are processes for preparing the bicyclic amide derivatives as well as pharma...
|7179455||Pesticide in gel form|
The invention relates to a bait matrix which includes a gelling agent and a pesticide. The bait matrix is useful for controlling pests by attracting and poisoning them. The gel matrix is substantially weatherproof and hence can be used when exposed to the weather.
|7173063||Topoisomerase poisons for the treatment of proliferative disorders|
Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X1
|7169819||Pharmaceutical compositions of fenretinide having increased bioavailability and methods of using the same|
A pharmaceutical composition for parenteral delivery, comprising a retinide such as fenretinide in combination with a solvent capable of dispersing or solubilizing the retinide. The solvent comprises an alcohol, such as ethanol, in combination with an alkoxylated ca...
|7160922||Hemihydrate of a selective functional M1 muscarine receptor agonist|
The present invention provides crystalline biphenyl-4-carboxylic acid (R)-(6-(1-((4-fluorobenzyl)methylamino)ethylideneamino)-2(R)-hydroxyindan-1-yl)amide hemihydrate, compositions thereof, methods of using the same, processes for making the same, and processes for ...
|7151095||Immunoregulatory compounds and derivatives and methods of treating diseases therewith|
Compounds are disclosed having the structure of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is:
|7148260||Water-based emulsifier wax gels including free sphingoid bases and oil in-water emulsion including the same|
Water-based emulsifier wax gels are provided that include skin-identical sphingolipids The present invention also provides a process for the preparation of such gels, the use of such gels for the preparation of oil-in-water emulsions, and the resulting emulsions tha...
|7132454||HEXIM1 as a suppressor of HIV replication and cardiac hypertrophy|
Cellular transcription is modulated by increasing or decreasing the amount of active HEXIM1 in the cell. The methods are applied to the treatment of HIV infection and cardiac hypertrophy. Assays using reconstituted 7SK:P-TEFb snRNP screen for agents that modulate HE...
|7129377||Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer|
The present invention relates to an androgen receptor alkylating compound, wherein the compound may include, inter alia, an active functional group, which permits the alkylation of the androgen receptor. ...
|7128924||Safe, eco-friendly, health protective herbal colors and aroma useful for cosmaceutical applications|
The invention relates to a novel safe and eco-friendly health protective and beauty enhancing herbal compositions having various cosmetic applications such as lipsticks, eye shadows, glow-glitters and rouges, said compositions containing colorants from plants of the...
|7129374||Catalytic antioxidants and methods of use|
The invention provides small molecules that act as catalytic antioxidants and methods of use thereof. The compounds can repeatedly bind and destroy reactive oxygen species by serving as substates for enzymes of the methionine sulfoxide reductase (Msr) class. Some em...
|7119090||Pyrrole substituted 2-indolinone protein kinase inhibitors|
The present invention relates to novel pyrrole substituted 2-indolinone compounds and physiologically acceptable salts and prodrugs thereof which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of prot...
|7119120||Phosphate transport inhibitors|
Disclosed are compounds which have been identified as inhibitors of phosphate transport. Many of the compounds are represented by Structural Formula (I): Ar1—W—X—Y—Ar2; or a pharmaceutically acceptable salt thereof. ...
|7115660||Methods for inhibiting angiogenesis and tumor growth|
Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-αvβ3 are inhibited by an inhibitor compound of formula (I): wherein G1 and G2 are each independently NH—C(O)—O—R1, —...
|7115710||Diagnosis and treatment of PTP related disorders|
The present invention relates to PTP05 polypeptides and PTP10 polypeptides, nucleic acids encoding such polypeptides, cells, tissues and animals containing such nucleic acids, antibodies to such polypeptides, assays utilizing such polypeptides, and methods relating ...