Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 8163803 | Compounds derived from lidocaine, pharmaceutical compositions, use and method of treatment, prevention or inhibition of disease The present invention relates to lidocaine derived compounds, which present less anesthetic activity than lidocaine itself, but with more anti-inflammatory and spasmolytic activity than said lidocaine as well as pharmaceutical compositions with at least one of these... | 04/24/2012 |
| 8143313 | Compositions and methods for preventing or treating an inflammatory response The present invention relates to methods for modulating the inflammatory response of respiratory tract cells using an agent that increases ceramide levels in the cells of the respiratory tract. ... | 03/27/2012 |
| 7964644 | Use of neurotoxic substances for the production of a means for the treatment of joint paint and method for application of said means The invention relates to using neurotoxic substances which in particular are toxic to the axons and to the nociceptive nerve endings in the preparations of agents treating joint pains. ... | 06/21/2011 |
| 7919528 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 04/05/2011 |
| 7893110 | Carboxylic acid amides provoking a cooling sensation The present invention refers to cooling compounds of formula I wherein R1, R2, R3, X, Y, Z, and m have the same meaning as given in the specification. The present invention refers furthermore to a process for their producti... | 02/22/2011 |
| 7863333 | N-alkylated diaminopropane derivatives as modulators of chemokine receptor activity The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis. | 01/04/2011 |
| 7846972 | Multimeric oleamide derivative having connexin-26 inhibiting potency and use thereof in cancer therapy, etc The present invention relates to multimeric oleamide derivatives having connexin 26 inhibitory activities and embraces the dimer oleamide derivatives represented by the following formula (1) or a pharmacologically acceptable salt thereof: | 12/07/2010 |
| 7838561 | Method for preventing or treating cardiac hypertrophy A method for treating or preventing cardiac hypertrophy in a mammal, comprising manipulating levels of RBP, retinoids, or an affiliated signaling and regulatory pathway in the mammal. Preferably, the method comprises reducing or inhibiting the level of RBP or retino... | 11/23/2010 |
| 7776919 | Carboxamide derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 08/17/2010 |
| 7754769 | Compositions and methods for preventing or treating an inflammatory response The present invention relates to methods for modulating the inflammatory response of respiratory tract cells using an agent that increases ceramide levels in the cells of the respiratory tract. ... | 07/13/2010 |
| 7645799 | Substituted biaryl compounds as factor XIa inhibitors The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R3, and ring B are as defined herein.... | 01/12/2010 |
| 7632866 | Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators Compounds, compositions and methods are provided which are useful in the treatment of conditions such as central or peripheral nervous system disorders through the modulation of potassium ion flux through voltage-dependent potassium channels and/or depressing cortic... | 12/15/2009 |
| 7592373 | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds Compounds of formula (I) wherein A, B, b, W, X, Y, Z, R1, R2, and R3 have the meanings given in claim 1, pharmaceutical compositions these compounds, and methods of preventing or trea... | 09/22/2009 |
| 7579379 | CETP activity inhibitors The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branc... | 08/25/2009 |
| 7538141 | Compounds for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 05/26/2009 |
| 7517913 | Polyamine conjugates with acidic retinoids and preparation thereof Invented are novel polyamine conjugates which have been readily obtained using as key-step the condensation of linear, conformationally restricted, cyclic and branched polyamines or suitably protected derivatives with vitamin A derivatives. These compounds inhibit t... | 04/14/2009 |
| 7482378 | Physiological cooling compositions The present invention provides, in one aspect, a physiological cooling composition comprising at least one cyclohexane carboxamide, at least one acyclic carboxamide, and at least one stereoisomer of menthyl lactate. In another aspect, disclosed is a method for produ... | 01/27/2009 |
| 7439394 | Cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I, processes for the production thereof, pharmaceutical compositions containing these compounds, methods of producing pharmaceutical compositions including the... | 10/21/2008 |
| 7435851 | Puleganic amides The present invention provides substituted puleganic amides and compositions thereof, which are both useful as a topical treatment for skin, such as a repellant for insects and arthropods. ... | 10/14/2008 |
| 7432307 | Modulators of retinol-retinol binding protein (RBP)-transthyretin (TTR) complex formation Described herein are methods and compositions for the detection of transthyretin (TTR), retinol binding protein (RBP) and retinol complex formation. The methods and compositions described herein also provide for the screening of modulators of retinol-RBP-TTR complex... | 10/07/2008 |
| 7429618 | Potassium channel modulators This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SKCa and/or IKCa channels. ... | 09/30/2008 |
| 7425578 | Immunoregulatory compounds and derivatives and methods of treating diseases therewith Compounds are disclosed having the structure of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: ... | 09/16/2008 |
| 7423177 | Carboxamide derivatives as therapeutic agents This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the... | 09/09/2008 |
| 7414152 | N-substituted p-menthane carboxamides Cooling compounds are provided having the formula: wherein, m is 0 or 1, Y and Z are selected independently from the group consisting of H, OH, C1-C4 straight or branched alkyl, and a C1-C4 straight or branched alkoxy, X is... | 08/19/2008 |
| 7407987 | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. ... | 08/05/2008 |
| 7388029 | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth. ... | 06/17/2008 |
| 7368478 | Methods for inhibiting angiogenesis and tumor growth Angiogenesis, tumor growth, and metalloproteinase 2 (MMP2) interaction with integrin-αvβ3 are inhibited by an inhibitor compound of formula: wherein G1 and G2 are each independe... | 05/06/2008 |
| 7364866 | G protein coupled receptors, nucleic acids, and methods related to the same The present invention provides Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells, and methods for its production. The invention al... | 04/29/2008 |
| 7361688 | Substituted aminoalcohols useful in treatment of Alzheimer's disease The invention provides compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characteriz... | 04/22/2008 |
| 7354914 | Lactams substituted by cyclic succinates as inhibitors of Aβ protein production This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifica... | 04/08/2008 |
| 7354724 | Drosophila G protein coupled receptors, nucleic acids, and methods related to the same The present invention provides a Drosophila melanogaster GPCR (DmGPCR) polypeptides and polynucleotides which identify and encode such a DmGPCR. In addition, the invention provides expression vectors, host cells and methods for its production. The invention a... | 04/08/2008 |
| 7348353 | Acetylene derivatives having mGluR 5 antagonistic activity The invention provides compounds of formula (I) wherein m, n, A, R, R′, R″, R0, X and Y are as defined in the description, and their preparation. The compounds of formula (I) are useful as pharmaceuticals in the treatment of e.g. nervous system disord... | 03/25/2008 |
| 7332485 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 02/19/2008 |
| 7332497 | Pyrazolopyrimidines as therapeutic agents The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, and R3 are defined as described herein... | 02/19/2008 |
| 7326731 | Muscarinic agonists The present invention relates to compounds of Formula I: Formula I which are agonists of the M-1 muscarinic receptor. ... | 02/05/2008 |
| 7326732 | EP2 receptor agonists A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20 | 02/05/2008 |
| 7316815 | Polyamino acid derivatives and use thereof in compositions for treating keratin fibers The invention concerns the use in a cosmetic composition of at least a poly-aminoacid of general formula (I) in which X is —O—, —S— or —NR3; R1 represents in particular a hydrogen atom or a C1-C40 alkyl radical; ... | 01/08/2008 |
| 7312359 | Tetralin and indane derivatives and uses thereof Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods f... | 12/25/2007 |
| 7309497 | Injectable pharmaceutical composition for systematic administration of pharmacologically active ingredients The invention relates to novel pharmaceutical compositions for the systemic administration of pharmacologically active ingredients. The invention relates in particular to an injectable pharmaceutical composition comprising (a) a pharmacologically active ingredient i... | 12/18/2007 |
| 7304049 | Succinoylaminobenzodiazepines as inhibitors of Aβ protein production This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, mor... | 12/04/2007 |
