...that when IBM conducted a market study of Chester Carlson's invention in 1959, the company concluded that it would take only 5000 units of his new product to saturate the market? IBM therefore declined to be part of the new product introduction. Too bad for IBM. Carlson's invention was the xerography process, and his new product was the beginning of the Xerox Corporation. It is estimated that every day, worldwide, 3,000,000,000 copies are made!!
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| Number | Title | Issue Date |
| 7034054 | Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions. ... | 04/25/2006 |
| 6964905 | Semiconductor device and method of manufacturing therefor An active region on a semiconductor substrate is electrically isolated by trench isolation. A structure of the trench isolation is constituted of: a trench; a silicon oxide film formed on the inner wall of trench; an oxidation preventive film formed between silicon ... | 11/15/2005 |
| 6833478 | N,N-dinitramide salts as solubilizing agents for biologically active agents A method is provided for enhancing the solubility of an ionizable compound in a lipophilic medium by admixing the compound with an effective solubility-enhancing amount of an N,N-dinitramide salt. The ionizable compound, upon ionization, gives rise to a biologically... | 12/21/2004 |
| 6806292 | Substituted imide derivatives The present invention relates to novel substituted imide derivatives of the general formula (I) in which R1 represents optionally substituted cycloalkyl, R... | 10/19/2004 |
| 6638979 | Imidamide derivatives The present invention relates to novel imidamide derivatives of the formula (I) ##STR1## in which R, R1, R2 and R3 are each as defined in the description, to a process for their preparation and to their use for control... | 10/28/2003 |
| 6583125 | Formulation of nitrogen mustard Compositions of matter comprising a substituted cyclodextrin and cytotoxic compound, especially cytotoxic drugs such as antibiotic, anti-fungal and anti-neoplastic, drugs are claimed. The compositions cause significantly less ulceration compared to the sa... | 06/24/2003 |
| 6472400 | Advanced gylcation end-product intermediaries and post-Amadori inhibition The instant invention provides compositions and methods for modeling post-Amadori AGE formation and the identification and characterization of effective inhibitors of post-Amadori AGE formation, and such identified inhibitor compositions.... | 10/29/2002 |
| 6291442 | Pharmacological modulators of voltage-gated potassium ion channels Disclosed herein is the discovery that an allosteric receptor site exists on the intracellular surface of Shaker class voltage-gated potassium ion channels that is distinct from the pore and is involved in regulating gating of the pore. A class of compoun... | 09/18/2001 |
| 6287601 | Topical nitric oxide donor compositions Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID mixed in a lipid-based carrier are described. The applicati... | 09/11/2001 |
| 6281252 | Method for reducing oxalate A method for reducing oxalate levels in a patient that includes administering to the patient a therapeutically effective amount of non-absorbable amine polymers such as a polymer characterized by a repeat unit having the formula: ##STR1## and salts a... | 08/28/2001 |
| 6231894 | Treatments based on discovery that nitric oxide synthase is a paraquat diaphorase Paraquat has been found to accept electrons from nitric oxide synthase (NOS) whereupon the reduced paraquat generates toxic O2- and prevents NOS from giving electrons to arginine and thereby inhibits NO production. This is generalize... | 05/15/2001 |
| 6045827 | Treatment of equine laminitis Compositions and methods of the topical treatment of equine laminitis are disclosed. In particular, combinations of a fast acting nitric oxide (NO) donor, a sustained acting NO donor and an NSAID mixed in a lipid-based carrier are described. The applicati... | 04/04/2000 |
| 5905086 | Remedy for anxiety neurosis N-(2-Hydroxyethyl)nicotinamide nitrate or its salt prevents or ameliorates anxiety neurosis or panic disorder, or the following anxiety. This compound or its salt has few side effects and exhibits immediate action.... | 05/18/1999 |
| 5840759 | Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric ox... | 11/24/1998 |
| 5837736 | Nitric oxide-releasing compounds to sensitive cancerous cells to chemotherapeutic agents The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric ox... | 11/17/1998 |
| 5814667 | Use of nitric oxide-releasing compounds as hypoxic cell radiation sensitizers The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric ox... | 09/29/1998 |
| 5714511 | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs A method for the treatment of mammalian tissue injured or at risk of injury during sepsis or shock including the administration to a mammal a diazeniumdiolate which releases a therapeutically effective amount of nitric oxide sufficient to protect the tiss... | 02/03/1998 |
| 5650442 | Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers The present invention provides a method for sensitizing hypoxic cells in a tumor to radiation, wherein nitric oxide is delivered to target hypoxic cells through the administration of a nitric oxide-containing compound that spontaneously releases nitric ox... | 07/22/1997 |
| 5382595 | Butenoic or propenoic acid derivative A butenoic or propenoic acid derivative having the following formula in which G is an aryl or a heterocyclic ring, R11 and R12 are hydroben or an alkyl, X is sulfur or oxygen, R2 and R3 are hydrogen, an substituent such as an alkyl and J is pyridyl or phe... | 01/17/1995 |
| 5354771 | Methods for treatment of sepsis using branch chain amino acids Methods for treatment of free-radical-mediated tissue injury, particularly sepsis, are provided wherein compositions containing at least one keto analog of a branched-chain amino acid are administered. The composition is administered orally or parenterall... | 10/11/1994 |
| 5340837 | Benzophenonehydrazones Compounds of the formula ##STR1## wherein each of o and p, independently of the other, is 0, 1, 2, 3, 4 or 5, the radicals R1 being the same or different when o is greater than 1 and the radicals R2 being the same or different w... | 08/23/1994 |
| 5039705 | Anti-hypertensive compositions of secondary amine-nitric oxide adducts and use thereof This invention concerns anti-hypertensive compositions and a method of lowering blood pressure in mammals. The active component of the compositions is a compound of the formula: ##STR1## wherein R1 and R2 are independently chose... | 08/13/1991 |
| 5021429 | Pharmacologically active aminoalkylphenyl compounds and their use Compounds of the general formula: ##STR1## and physiologically acceptable salts, and hydrates, N-oxides and bioprecursors of such compounds and such salts in which R1 and R2, which may be the same or different, represent hydrogen ... | 06/04/1991 |
| 4954526 | Stabilized nitric oxide - primary amine complexes useful as cardiovascular agents A method of treating cardiovascular disorders in a mammal, by administering to said mammal an effective amount of a compound of the formula: [R--N(H)N(NO)O--]y X wherein R is loweralkyl, aryl, arylalkyl, or cycloalkyl, any of which R groups may be o... | 09/04/1990 |
| 4568694 | Growth-enhancing cystamine derivatives Cystamine derivatives of the formula: ##STR1## [wherein n represents 2 or 3, R1 and R2 each represents a hydrogen atom, or an alkyl group optionally substituted by a hydroxy, amino, alkylamino or dialkylamino group, or represent... | 02/04/1986 |
| 4366164 | Amine derivatives The invention provides compounds of general formula ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in which Y and Z, which may be the same or different, each represent oxygen, sulphur, .dbd.CHNO2 or .dbd... | 12/28/1982 |
| 4130645 | Fungicidal phenylnitramines and new phenylnitramines The present invention relates to novel methods for the protection of agricultural crops against plant pathogenic fungi comprising applying to the foliage of said crops a fungicidally effective amount of a compound selected from certain substituted phenyln... | 12/19/1978 |