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| Number | Title | Issue Date |
| 7172767 | Opioid agonist / antagonist combinations The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide ... | 02/06/2007 |
| 7105572 | Stable emulsion compositions An emulsion composition containing a compound represented by the formula: wherein R, R0, Ar and n are as defined in the specification or a salt thereof or a prodrug thereof, wherein the composition is ... | 09/12/2006 |
| 7105575 | Methods for the treatment of neuro- disorders using aminothiol compounds The present invention relates to new uses of S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by therapeutic agents, radiation treatment or diabetes. In particular, the inve... | 09/12/2006 |
| 6953806 | Substituted cyclohexane derivatives The present invention provides compounds of formula (I) wherein A1, A2, A3, A4, A5, A6, A7, A8, A9, A10, U, ... | 10/11/2005 |
| 6844320 | Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase i... | 01/18/2005 |
| 6777572 | Use of propargyl glycine amino propargyl diol compounds for treatment of renal failure Compounds characterized generally as propargyl glycine amino propargyl diol derivatives are useful for treatment of renal failure. Compounds of particular interest are those of Formula I wherein A is selected from CO and... | 08/17/2004 |
| 6762205 | Phenyl sulfamate derivatives Phenyl sulfamate derivatives represented by the following formula or salts thereof have a powerful inhibitory effect on steroid sulfatase and are hence useful for the prophylaxis or treatment of diseases associated with steroids such as estrogens, such as breast can... | 07/13/2004 |
| 6762202 | Infrared thermography and methods of use The present invention describes rapid noninvasive methods for measuring vasodilation or changes in blood flow in a patient following administration of at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-d... | 07/13/2004 |
| 6586476 | Methods for the treatment of nephro-disorders using aminothiol compounds The present invention relates to new uses of S-2-(3-aminopropylamino)ethyl dihydrogen phosphorothioate, (amifostine) and other aminothiol compounds to treat and reverse toxicities caused by therapeutic agents, radiation treatment or diabetes. In particula... | 07/01/2003 |
| 6583161 | Benzenesulfonamides and benzamides as therapeutic agents The invention provides compounds, compositions and methods relating to novel aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particul... | 06/24/2003 |
| 6528528 | Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis The present invention provides compounds of Formula I shown below. ##STR1## The present invention also provides methods of treating or preventing 3 inflammation or atherosclerosis, and a pharmaceutical composition that contains a compound of Formula I.... | 03/04/2003 |
| 6524624 | Two-part disinfecting systems and compositions and methods related thereto A two-part disinfecting systems, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition, whe... | 02/25/2003 |
| 6479551 | Treatment of migraine headache The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs that are non-acidic or segregating the metoclopramide and... | 11/12/2002 |
| 6479550 | -sulfenimino acid derivatives -Sulfenimino acid derivatives of formula I ##STR1## including the optical isomers thereof and mixtures of such isomers, wherein A is cycloalkyl, cycloalkenyl, aryl or heteroaryl, each optionally substituted, B is a direct bond or optionally substituted ... | 11/12/2002 |
| 6410591 | 3,7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma a therapeutically effective amount of a 3, 7 or 3 and 7 thia or oxa prostanoic acid deriv... | 06/25/2002 |
| 6403600 | Methoximinophenylacetic acid amides The invention relates to novel methoximinophenylacetamides, to a process for their preparation and to their use as fungicides.... | 06/11/2002 |
| 6387954 | Alkenyl sulphonamide derivatives The present invention provides certain alkenyl sulphonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.... | 05/14/2002 |
| 6380182 | Methods and compositions controlling biofouling using sulfamic acids The invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one sulfamic acid or salt thereof to inhibit bacterial adhesion to the submergib... | 04/30/2002 |
| 6194463 | N-sulphonyl and N-sulphinyl amino acid amides as microbicides -Amino acid amides of formula (I) wherein the substituents are defined as follows: n is a number zero or one; R1 to R7 are as defined herein; R8 is C1 -C6 alkyl, C3 -C6 al... | 02/27/2001 |
| 6191170 | Benzenesulfonamides and benzamides as therapeutic agents The invention provides compounds, compositions and methods relating to novel aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particul... | 02/20/2001 |
| 6174923 | Use of ethynyl alanine amino diol compounds for treatment of renin-mediated disorders Compounds characterized generally as ethynyl alanine amino diol derivatives are useful to treat disorders mediated by plasma renin activity. Compounds of particular interest are renin inhibitors of Formula I ##STR1## wherein A is selected from CO and SO | 01/16/2001 |
| 6143776 | Tosylproline analogs as thymidylate synthase inhibitors Tosylproline analogs of formula I, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are thymidylate synthase inhibitors; and are useful as anti-tumor agents and as anti-parasitics, anti-bacteria... | 11/07/2000 |
| 6040340 | Implantation rates after in vitro fertilization, treatment of infertility and early pregnancy loss with a nitric oxide donor alone or in combination with progesterone, and a method for contraception with nitric oxide inhibitors A method is provided for the improvement of implantation rates and/or pregnancy rates in a female mammal, comprising administering to a female mammal in whom pregnancy is desired an effective amount of (a) a nitric oxide synthase substrate, a nitric oxide dono... | 03/21/2000 |
| 5965529 | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclo... | 10/12/1999 |
| 5962413 | Treatment of uterine contractility disorders with a nitric oxide synthase substrate and/or donor, or a nitric oxide inhibitor Dysmenorrhea, disfunctional uterine bleeding, preterm labor and postpartum labor in female mammals are treated by inhibiting uterine contractility by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in comb... | 10/05/1999 |
| 5952386 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen... | 09/14/1999 |
| 5942548 | Use of ethynyl alanine amino diol compounds for treatment of hypertension Compounds characterized generally as ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of cardiovascular disorders. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO a... | 08/24/1999 |
| 5895783 | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclo... | 04/20/1999 |
| 5750524 | Remedy for hyperlipidemia The invention relates to a remedy for hyperlipidemia, which comprises, as an active ingredient, an indane derivative represented by the general formula (1): ##STR1## wherein R1 means an alkyl group having 1-12 carbon atoms, a benzyl g... | 05/12/1998 |
| 5744165 | Nimesulide salt cyclodextrin inclusion complexes Inclusion complexes of nimesulide alkali and alkaline earth salts with cyclodextrins and cyclodextrin derivatives are disclosed. Compositions containing the inclusion complexes, processes for the preparation of the complexes as well as methods to use the ... | 04/28/1998 |
| 5708034 | Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them Sulfonimidamides of the formula I ##STR1## in which at least one of the three substituents R(1), R(2) and R(3) is a ... | 01/13/1998 |
| 5672608 | Acenaphthyl substituted guanidines and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o... | 09/30/1997 |
| 5670519 | Acenaphthyl-substituted guanidines and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o... | 09/23/1997 |
| 5668143 | Heterocyclic benzenesulfonylimine derivatives as inhibitors of IL-1 action The present invention relates to heterocyclic benzenesulfonylimine derivatives and their use as inhibitors of Interleukin-1 (IL-1) action. Such inhibitors are useful in the treatment of various disease states as disclosed herein including rheumatoid arthr... | 09/16/1997 |
| 5622968 | Acenaphthyl substituted guanidines and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, and N"-aminoguanidines, and N,N'N", N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the ... | 04/22/1997 |
| 5597809 | Treatment of optic neuritis Methods of treating optic neuritis comprising administering a protective agent which inhibits glutamate-mediated retinal cell damage to a mammal at risk of developing optic neuritis.... | 01/28/1997 |
| 5508045 | Method and agents for control and management of labor during pregnancy A method for control, management and inhibition of a preterm labor by providing to a pregnant woman a donor of nitric oxide. Management and inhibition of preterm labor is achieved by administering to a pregnant woman a nitric oxide or donor source in a sa... | 04/16/1996 |
| 5484812 | Propargyl glycine amino use of propargyl diol compounds for treatment of ophthalmic disorders Compounds characterized generally as propargyl glycine amino propargyl diol derivatives are useful as renin inhibitors for the treatment of ophthalmic disorders. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected f... | 01/16/1996 |
| 5484811 | Use of ethynyl alanine amino diol compounds for treatment of ophthalmic disorders Compounds characterized generally as ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of ophthalmic disorders. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and S... | 01/16/1996 |
| 5459149 | Penta-2,4-dienamides and use as pesticides The present Application discloses pesticidally active compounds of formula (I): Q(CH2)a (O)b Q1 CR2 =CR3 CR4 =CR5 CXNR1 Rx or a salt or propesticide t... | 10/17/1995 |
