Famous Patents
3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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| Number | Title | Issue Date |
| 8148427 | Benzylamine derivative or pharmaceutically acceptable acid addition salt thereof, and use thereof for medical purposes The benzylamine derivative represented by the formula below and a pharmaceutically acceptable acid addition salt thereof, and a pharmaceutical containing the derivative or the pharmaceutically acceptable acid addition salt thereof, and a therapeutic or prophylactic ... | 04/03/2012 |
| 8013019 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 09/06/2011 |
| 7767715 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 08/03/2010 |
| 7745490 | Substituted N-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies Substituted n-aryl benzamides, related compounds and their pharmaceutically acceptable derivatives, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzhe... | 06/29/2010 |
| 7566739 | Substituted N-sulfonylaminophenylethyl-2-phenoxyacetamide compounds as VR1 receptor antagonists This invention provides compounds of the formula (I) useful for the treatment of disease conditions caused by over activation of Vr1 receptors such as pain or the like in mammals as well as compositions comprising them. ... | 07/28/2009 |
| 7528170 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 05/05/2009 |
| 7479508 | Nimesulide containing topical pharmaceutical compositions This invention relates to compositions of nimesulide for topical application. ... | 01/20/2009 |
| 7417169 | Amino alcohol derivatives, medicinal composition containing the same, and use of these The present invention provides compounds represented by general formula (I): a prodrug thereof, or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; each of R2 and R3 is independentl... | 08/26/2008 |
| 7388031 | Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z... | 06/17/2008 |
| 7375120 | Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ... | 05/20/2008 |
| 7375136 | pH-dependent NMDA receptor antagonists NMDA receptor blockers, including pH-sensitive NMDA receptor blockers, are provided as neuroprotective drugs that are useful in stroke, traumatic brain injury, epilepsy, and other neurologic events that involve acidification of brain or spinal cord tissue. Compositi... | 05/20/2008 |
| 7361787 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases ... | 04/22/2008 |
| 7351742 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the ... | 04/01/2008 |
| 7326772 | Peptide for assaying hERG channel binding The present invention provides compositions and methods useful for assaying binding of compounds to the hERG K+ channel. According to a method of the present invention, a compound of interest is added to the hERG K+ channel in the presence of a... | 02/05/2008 |
| 7321001 | Asthma and allergic inflammation modulators Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins inv... | 01/22/2008 |
| 7291620 | N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to compounds which are inhibitors of the beta-secretase enzyme and which are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also direct... | 11/06/2007 |
| 7247748 | Amide compounds and methods of using the same Disclosed is a compound having the formula (I) pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined herein. The compounds, salts and solvates of this invention are ... | 07/24/2007 |
| 7244766 | Sulfonamide derivatives for the treatment of diseases The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds accord... | 07/17/2007 |
| 7226948 | Treatment of neurodegenerative conditions with nimesulide The present invention relates to the use of nimesulide and structurally related compounds in the prevention and/or treatment of neurodegenerative conditions. It is based, at least in part, on the discovery that nimesulide exhibits a neuroprotective effect against β... | 06/05/2007 |
| 7205003 | Method and topical formulation for treating skin conditions associated with aging A composition and method are provided for alleviating the dermatological signs of intrinsic and extrinsic aging. A topical formulation containing a cosmeceutically active base, wherein the formulation provides a pH in the range of about 8.0 to 13.0 at the skin surfa... | 04/17/2007 |
| 7196119 | Development of new selective estrogen receptor modulators The present disclosure concerns a new class of selective estrogen receptor modulators (SERMs). The disclosure also includes the identification of a previously unknown membrane associated estrogen receptor. Methods for making and using the disclosed SERMs are disclos... | 03/27/2007 |
| 7186755 | Nimesulide gel systems for topical use The present invention relates to nimesulide topical formulations comprising a carboxyvinylpolymer neutralized as a gel-forming agent or a polyacrylamide-isoparaffin and a solvent selected from the group consisting of ethanol, isopropanol and diethylene glycol monoet... | 03/06/2007 |
| 7172767 | Opioid agonist / antagonist combinations The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide ... | 02/06/2007 |
| 7141609 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 11/28/2006 |
| 7115780 | Propanolaminomethyltetralines, their preparation and pharmaceutical composition comprising same The invention concerns compounds of formula (I), wherein A is a group of formula (a) or (b), wherein: R represents a hydrogen or halogen atom, a —S(O)z(C1–C4)Alk wherein z is 0, 1 or 2, a —NHSO2(C1–C | 10/03/2006 |
| 7105569 | Fungicidal active compound combinations New active compound combinations of valinamide derivatives of the formula (I) in which R1 and R2 has the meaning given in the description, with k... | 09/12/2006 |
| 7081436 | Paste formulation for seed treatment of plants Disclosed herein is a composition comprising a seed treatment formulation and an organosilicone additive of the formula: wherein: X is a number from 0 to 30; Y ... | 07/25/2006 |
| 7070803 | Controlled release pharmaceutical composition for oral use containing midodrine and/or active metabolite, desglymidodrine Novel controlled release pharmaceutical compositions for oral use containing midodrine and/or its active metabolite desglymidodrine. The novel compositions are designed to release midodrine and/or desglymidodrine after oral intake in a manner which enables absorptio... | 07/04/2006 |
| 7067698 | Bi-directional synthesis of oligoguanidine transport agents Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds ... | 06/27/2006 |
| 7041694 | Cyclooxygenase-2 inhibition Selective inhibitors of cyclooxygenase-2 are used to treat liver disease and in combination with anti-viral drugs to treat virus-caused liver disorders. Selective inhibitors of cyclooxygenase-2 which also inhibit the synthesis of cyclooxygenase-2 improve over the ef... | 05/09/2006 |
| 7037941 | Alpha-and Beta-amino acid hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors Certain Alpha- and Beta-amino acid hydroxyethylamino sulfamic acid derivatives represented by the following formula are useful as retroviral protease inhibitors: ... | 05/02/2006 |
| 7034045 | Monofluoroalkyl derivatives The present invention provides certain monofluoroalkyl derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders. ... | 04/25/2006 |
| 7030160 | Propanolaminotetralines, preparation thereof and compositions containing same The invention relates to phenoxypropanolamines, to pharmaceutical compositions containing them, to processes for preparing them, and to the method of use thereof in the treatment of diseases that are improved by beta-3 agonist action. ... | 04/18/2006 |
| 7011854 | Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke... | 03/14/2006 |
| 7005549 | Peracid precursors for antimicrobial use This disclosure describes unique chemical structures for use as solid or concentrated chemical precursors to the production of peroxy acids when combined with hydrogen peroxide or a hydrogen peroxide precursor such as percarbonates or perborates. Peroxy acids (perac... | 02/28/2006 |
| 6998423 | Prevention of loss and restoration of bone mass by certain prostaglandin agonists Prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such prostaglandin agonists. The prostaglandin agonists are useful for the treatment of bone disorders includ... | 02/14/2006 |
| 6982097 | Biocidal compositions and methods of using same This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using the biocidal compositions for the disinfection of water that may conta... | 01/03/2006 |
| 6963010 | Hydrophobic polyamine analogs and methods for their use The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use. ... | 11/08/2005 |
| 6958416 | Valproyltaurinamide derivatives as anticonvulsant amd CNS active agents The invention relates to derivatives of valproyltaurinamide of formula (I) in which R1 and R2 are independently hydrogen, a C1-C6-alkyl group, an arylalkyl group or an aryl group. The derivatives are especially useful for ... | 10/25/2005 |
| 6953578 | Materials and methods for detection and treatment of immune system dysfunctions The subject invention concerns novel materials and methods for the treatment and/or prevention of autoimmune disease. In a specific embodiment, elevated production of prostaglandin synthase-2 (PGS-2) is correlated with autoimmune dysfunction. ... | 10/11/2005 |
