Class 514/589 - Nitro or nitroso bonded directly to amino nitrogen (e.g., nitramine, nitrosamine, nitro-urea, etc.)

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter containing a nitro or nitroso group bonded
No. of patents: 39
Last issue date: 10/19/2010

Number	Title	Issue Date
7816407	Agmatine and agmatine analogs in the treatment of epilepsy, seizure, and electroconvulsive disorders Pharmaceutical preparations containing of agmatine, congeners, analogs or derivatives thereof for use in preventing or treating epilepsy, seizures and other electroconvulsive disorders are provided. Embodiments include administering an effective amount of agmatine, ...	10/19/2010
7387790	Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells Nanoparticles made from a select group of lipids and optionally containing a therapeutically active agent are employed in pharmaceutical compositions for delivery to targeted tissues and/or cells for the treatment or diagnosis of such diseases as cancer. ...	06/17/2008
7220428	Pharmaceutical and diagnostic compositions containing nanoparticles useful for treating targeted tissues and cells Nanoparticles made from a select group of lipids and optionally containing a therapeutically active agent are employed in pharmaceutical compositions for delivery to targeted tissues and/or cells for the treatment or diagnosis of such diseases as cancer. ...	05/22/2007
7052716	Cosmetic and dermatological preparations comprising an effective content of bile acids, their salts and/or their derivatives Cosmetic and dermatological preparations having an effective content of bile acids, their salts and/or their derivatives, it being possible for said active ingredients to be present either individually or as a mixture. ...	05/30/2006
7034054	Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions. ...	04/25/2006
6753005	Method for tissue perfusion Disclosed are compositions and methods for the facile perfusion of a tissue with active agents following direct intra-tissue injection. Targets may consist of cells, cellular components, and/or extracellular components. The high perfusion efficiency permits high con...	06/22/2004
6635677	Methoxyamine combinations in the treatment of cancer This invention generally relates to novel compositions and methods for the treatment of certain cancers. Additionally, this invention relates to novel compositions and methods to screen drugs for the treatment of certain cancers. Specifically, the inventi...	10/21/2003
6593362	Non-peptidic cyclophilin binding compounds and their use This invention relates to pharmaceutical compositions and methods of using non-peptidic cyclophilin-binding compounds in medical conditions involving breakdown of mitochondrial energy metabolism induced by calcium overload, in treating alopecia and promot...	07/15/2003
6566304	Biogenic control and limitation of the reproduction of parasitic earth nematodes in stock culture The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling pla...	05/20/2003
6503948	Method for prevention or treatment of acute allograft rejection and a pharmaceutical composition therefor A method for treating an organ donor prior to harvesting organ to reduce graft rejection in a recipient. An amount effective to reduce graft rejection of at least one compound selected from the group consisting of compounds having formulas I, II, III, IV,...	01/07/2003
6297281	Association of no syntase inhibitors with trappers of oxygen reactive forms The invention concerns a pharmaceutical composition containing, as active principle, at least one NO syntase inhibiting substance and at least one oxygen reactive form trapping substance, optionally with a pharmaceutically acceptable support. The inventio...	10/02/2001
6284747	Pharmaceutical formulation Compositions of matter comprising a substituted cyclodextrin and cytotoxic compound, especially cytotoxic drugs such as antibiotic, anti-fungal and anti-neoplastic, drugs are claimed. The compositions cause significantly less ulceration compared to the sa...	09/04/2001
6277835	Method of tumor treatment The present invention provides methods for treating mammalian cancer tumors, preferably solid tumors, comprising administering to a mammal in need of such treatment an effective amount of a 1,2,4-benzotriazine oxide as defined in Formula I or pharmacologi...	08/21/2001
6147060	Treatment of carcinomas using squalamine in combination with other anti-cancer agents A method for treating a tumor includes a first treatment procedure using a conventional cancer treatment technique, and a second treatment procedure which includes administering an effective amount of squalamine. The first treatment procedure may be a tre...	11/14/2000
6046234	Formulations and methods of reducing toxicity of antineoplastic agents This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineopl...	04/04/2000
5776925	Methods for cancer chemosensitization Methods for cancer chemosensitization are provided. Texaphyrins are new chemosensitizers for enhancing the cytotoxicity of chemotherapeutic agents. The enhancement appears to be P-glycoprotein-independent since texaphyrins are effective in both a P-glycop...	07/07/1998
5731325	Treatment of melanomas with thalidomide alone or in combination with other anti-melanoma agents A method for treatment of malignant melanoma by administering an effective amount of thalidomide alone or in combination with other anti-melanoma drugs....	03/24/1998
5691307	O⁶ -substituted guanine compositions and methods for depleting O⁶ Novel O6 -substituted guanine compounds and pharmaceutical compositions thereof are useful for effectively reducing O6 -alkylguanine-DNA alkyltransferase (AGT). The novel compounds are useful for treating tumors and when used with an...	11/25/1997
5614550	Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses Compounds of formula (I) are provided: ##STR1## wherein: R1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R2, R3, R4 and R5 are h...	03/25/1997
5578583	Microemulsions used as vehicles for carrying chemotherapeutic agents to neoplastic cells Microemulsions, similar in chemical composition to the lipid portion of low density lipoprotein (LDL), but not containing the protein portion, can be used as vehicles for the delivery of chemotherapeutic or diagnostic agents to neoplastic cells, while avo...	11/26/1996
5534529	Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses Compounds of formula (I) are provided: ##STR1## wherein: R1 represents an alkyl group; or a group of formula (II), (III), (IV) or (V): ##STR2## and wherein the groups R2, R3, R4 and R5 are h...	07/09/1996
5358952	O⁶ -substituted guanine compounds and methods for depleting O⁶ -alkylguanine-DNA alkyltransferase levels O6 -substituted guanine compounds of the formula ##STR1## wherein R is a benzyl group or a substituted benzyl group, cause a depletion of O6 -alkylguanine-DNA alkyltransferase (AGT) activity in mammalian cells. These compounds m...	10/25/1994
5264425	Glycosaminoglycan salts and pharmaceutical compositions containing them Salts of glycosaminoglycans (heparin, its fractions or fragments which are supersulfated, dermatan sulfate, heparan sulfate, and modified heparins) with bases of formula (I), ##STR1## wherein R1, R2, R3, and R4	11/23/1993
5057304	Active compounds for use in the treatment of tumors Antitumor compositions and methods in which a cancerostatic agent and an effective amount of (+)-verapamil, (+)-gallopamil, (+)-devapamil and/or (+)-emopamil which reinforce the antitumor action of the cancerostatic agent are administered to a patient eit...	10/15/1991
5034221	Topical agent and method for the treatment of Pseudofolliculitis barbae A topical agent and method for the treatment and prevention of pseudofolliculitis barbae, commonly known as "razor bumps", is effected by the topical application to beard areas of the face of a combination of acetylsalicylic acid, corn starch, isopropyl a...	07/23/1991
5023271	Pharmaceutical microemulsions A method for parenteral administration of fat-soluble pharmaceuticals and vitamins using microemulsions is disclosed. The microemulsions are comprised of a naturally occurring amphipatic substance and a hydrophobic lipid along with the active ingredient, ...	06/11/1991
5001158	Nitrosoureas compounds preparation thereof and utilization thereof in anticancerous Compounds having the general formula (I), ##STR1## wherein X and Y represent individually H or --NO, at least one of them being a group-NO, n is 0, 1 or 2, R represents hydrogen, an aliphatic, cycloaliphatic, cycloaliphatic-alkyl, aryl or aralkyl rad...	03/19/1991
4952607	Copper complex for treating cancer The present invention relates to copper complexes exhibiting superoxide dismutase-like activity in mammalian cells. The copper complexes, which act as superoxide radical (O2-) scavengers, are used in treating cancer by replacing the ...	08/28/1990
4900548	Use of diethylcarbamazine to enhance antigen-antibody and antigen-host immune cell interactions This invention relates to the use of diethylcarbamazine (DEC), its analogs, homologs, and pharmaceutically acceptable salts thereof as an antiviral agent. This invention further relates to the use of DEC in in vivo diagnosis to increase antibodies to a pa...	02/13/1990
4623662	Antiatherosclerotic ureas and thioureas This invention is concerned with ureas and thioureas which may be represented by the formula: ##STR1## wherein X represents at least one substituent selected from the group consisting of (C1 -C4)alkyl, (C1 -C4	11/18/1986
4452814	Nitrosourea derivatives Nitrosourea derivatives are provided which possess a high level of inhibitory activity against leukemia and tumors and which are therefore useful for pharmaceutical purposes. The compounds have the structure represented by formulae (I), (II) and (III): ...	06/05/1984
4430347	Cystamine derivatives suitable for use as medicaments The invention relates to new chemical compounds. The compounds according to the invention are compounds of the following formula ##STR1## in which one of the substituents A and B is hydrogen and the other is the radical -N.dbd.O. These compounds are ...	02/07/1984
4423076	1-Branched-alkyl-3-(2-haloethyl)-3-nitrosoureas as novel antitumor agents 1-Branched-alkyl-3-(2-haloethyl)-3-nitrosoureas which exhibit antitumor activity. Pharamaceutical compositions containing these novel compounds and methods of using them are also disclosed....	12/27/1983
4390532	Topical combinations of an ଱-estradiol with a methyl xanthine Topical compositions comprising an active ingredient selected from at least two of the following three classes of compounds: (a) N-methyl-substituted xanthines containing at least two methyl substituents; (b) ଱-estradiol and certain derivatives thereof; ...	06/28/1983
4367239	Nitrosourea derivatives, pharmaceutical compositions thereof and method of preparation The present invention relates to novel aminoalkyl substituted nitrosourea derivatives as well as their acid addition salts with pharmaceutically acceptable acids showing pronounced antineoplastic effectiveness in animal experiments. The novel compounds of...	01/04/1983
4357351	Lepidoptericidal isothiourea compounds Lepidoptericidal and herbicidal active compounds having the generic formula ##STR1## wherein R, R1, R2 and R3 are as disclosed herein. In general, these compounds show enhanced lepidoptericidal activity and show reduc...	11/02/1982
4182757	Novel nitrosourea compounds and process for preparing the same A nitrosourea compound of the formula: ##STR1## wherein R1 is alkyl of one to six carbon atoms, hydroxyalkyl of one to six carbon atoms, alkenyl of three to five carbon atoms or alkynyl of three to five carbon atoms, R2 is aldop...	01/08/1980
4150146	Process for the preparation of unsymmetrically 1,3-disubstituted nitroso ureas The invention relates to the preparation of unsymmetrically 1,3-disubstituted nitroso ureas from the corresponding N-substituted alkyl-N-nitrosocarbamoyl azide which is reacted with an amine, a diamine, an aminoalcohol, an aminoacid or an aminoacid deriva...	04/17/1979
4148921	Antitumor agents Novel inosadiamine derivatives of the formula ##STR1## exhibit high effectiveness against various mammalian tumor systems....	04/10/1979

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Class 514/589 - Nitro or nitroso bonded directly to amino nitrogen (e.g., nitramine, nitrosamine, nitro-urea, etc.)