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An aircraft having vertical takeoff and landing capability provided with at least first and second laterally extending paddle wheels rotatable on a central axis perpendicular to the longitudinal axis of the aircraft fuselage and between its nose and tail.
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| Number | Title | Issue Date |
| 8101664 | Urea foam Provided, among other things, is a delivery module for a non-greasy, water-based urea composition comprising: an aerosol delivery device; within the aerosol delivery device, the urea composition comprising 20% or more urea by weight, non-greasy lipophilic component(... | 01/24/2012 |
| 7999008 | Urea compounds that promote desquamation The invention relates to the use of at least one urea derivative of the following formula (I) in a composition containing a physiologically acceptable medium, as agent intended for stimulating desquamation of the skin and/o... | 08/16/2011 |
| 7977385 | Agents for corneal or intrastromal administration to treat or prevent disorders of the eye Methods and preparations for treating disorders of the eye and/or causing dissolution of corneal proteoglycans and organized healing of corneal stroma, softening of the cornea for non-surgical refractive correction of eyesight, removing corneal haze and opacificatio... | 07/12/2011 |
| 7687544 | Method of using catalpic acid to treat type 2 diabetes and associated disorders A method of treating and preventing type 2 diabetes and obesity an animal, including mammals and humans, in which a therapeutically effective amount of catalpic acid to the animal is administered orally or parentally. ... | 03/30/2010 |
| 7456220 | Immunodulatory compositions and methods of use thereof The invention relates to immunomodulatory compositions and related methods. The immunomodulatory compositions of a formula disclosed herein are useful for the prevention of sepsis and the treatment and prevention of diseases associated with inflammation and/or NOS. | 11/25/2008 |
| 7405194 | Therapeutic agents and methods of use thereof for the treatment of melanoma The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 07/29/2008 |
| 7371372 | Compositions comprising IMPDH inhibitors and uses thereof for treating HCV infection The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or pegylated alpha-interferon and an IMPDH inhibitor selected from VX-148 or VX-944, wherein the IMPDH inhibitor is presen... | 05/13/2008 |
| 7348307 | Methionine aminopeptidase-2 inhibitors and methods of use thereof The present invention provides methods of treating a lymphoma (e.g., a T-cell lymphoma or a B-cell lymphoma) in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention, for example, compounds of f... | 03/25/2008 |
| 7312359 | Tetralin and indane derivatives and uses thereof Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, p, q, Ar, R1 and R2 are as defined herein. Also provided are methods f... | 12/25/2007 |
| 7307071 | RAF-MEK-ERK pathway inhibitors to treat cancer Materials and methods for treating certain cancers are described, preferably cancers that result from the up-regulation of the RAF-MEK-ERK pathway, and more preferably chronic myelogenous leukemia, and which cancer is preferably resistant to the inhibition of the Bc... | 12/11/2007 |
| 7268111 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 09/11/2007 |
| 7262208 | Hydroxypropyl amides for the treatment of Alzheimer's disease The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the... | 08/28/2007 |
| 7252846 | Topical composition and method for the treatment and prophylaxis of dermal irritations A composition and method for the prevention and therapeutic treatment of skin conditions and disorders are disclosed. The composition and method of the invention are particularly directed to the treatment and prevention of dermal irritations. These irritations inclu... | 08/07/2007 |
| 7220768 | Isoxazole-containing thiourea inhibitors useful for treatment of varicella zoster virus This Invention provides a compound of the Formula: wherein X is R1, R2,... | 05/22/2007 |
| 7211602 | Treatment of neurodegenerative disorders through the modulation of the polyamine pathway The present invention provides methods and compositions for modulating polyamine pathway activity as a means for ameliorating neurodegenarative disorders. In particular, for ameliorating the symptoms or onset of amyotrophic lateral sclerosis (ALS) by modulating the ... | 05/01/2007 |
| 7205001 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 04/17/2007 |
| 7182952 | Urea and nitrogen based compounds as feeding stimulants/aggregants and masking agents of unpalatable chemicals for subterranean termites Nitrogen containing compounds are effective as subterranean termite feeding stimulants/aggregants and as masking agents for concealing the presence of other compounds which are repellents to termites, when they are used in low concentrations, less than or equal to a... | 02/27/2007 |
| 7163703 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 01/16/2007 |
| 7157420 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides methods of treating an autoimmune disorder (e.g., lupus erythematosus, multiple sclerosis, myasthenia gravis, vasculitis and diabetes mellitus) in a subject by administering to the subject a therapeutically effective amount of one or m... | 01/02/2007 |
| 7105482 | Methionine aminopeptidase-2 inhibitors and methods of use thereof The present invention provides methods of treating, parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention. ... | 09/12/2006 |
| 7084108 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 08/01/2006 |
| 7074832 | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide or metronidazole, are described. Sulfacetamide compositions further including sulfur are also described. Methods for treating dermatological disorders using the compositio... | 07/11/2006 |
| 7074780 | Substituted phenylcyclohexanecarboxamides and their use The present invention relates to substituted phenylcyclohexanecarboxamides of the formula (I) to processes for their preparation and to their use in medicaments, in particular for the prevention and/or treatment of car... | 07/11/2006 |
| 7067556 | Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide, are described. Sulfacetamide compositions further including sulfur are also described. Methods for treating dermatological disorders using the compositions are also descr... | 06/27/2006 |
| 7052683 | Composition to detoxify formaldehyde in gaseous state, in aqueous solutions, and to protect human cell lines against formaldehyde A chemical compound is disclosed herein for performing a complex enzymatic neutralization and fixation of formaldehyde, providing a method for instantaneous neutralization of formaldehyde vapors and offering a complete and rapid control of incidental releases, and a... | 05/30/2006 |
| 7037890 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 05/02/2006 |
| 7033838 | Method for the diagnosis of infection, and a diagnostic kit for performing the method The method for the diagnosis of Helicobacter pylori infection by the oral administration of defined amounts of 13C-labeled urea and examination for 13C content of blood samples removed at a defined time is effected by a) rem... | 04/25/2006 |
| 7030133 | Inhibitors of formation of advanced glycation endproducts (AGEs) The nonenzymatic glycation and crosslinking of proteins is a part of the aging process with the glycation endproducts and crosslinking of long-lived proteins increasing with age. This process is increased at elevated concentrations of reducing sugars in the blood an... | 04/18/2006 |
| 7022737 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infecti... | 04/04/2006 |
| 7008960 | Agents for intravitreal administration to treat or prevent disorders of the eye Methods and preparatons for treating disorders of the eye and/or causing posterior vitreous disconnection or disinsertion. Preparations containing a) urea, b) urea derivatives (e.g., hydroxyurea, thiourea), c) a non-steroidal anti-inflamatory agents, d) antmetabolit... | 03/07/2006 |
| 6995285 | ABCA-1 elevating compounds The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis... | 02/07/2006 |
| 6986896 | Method of treating fungal conditions of the skin Methods of treating fungal conditions and onychomycosis are described which include administration of a safe and effective amount of urea in a topical formulation to an affected area on the skin or around a nail of a patient in need of treatment. ... | 01/17/2006 |
| 6979412 | Method of preparing a compound concentrate and processing such a concentrate The invention relates to a method of preparing a compound for the prevention of a contamination of raw materials, products, water and/or production means, which compound comprises at least hydrogen peroxide, glycerol and glycol acid, and wherein a mixture of glycero... | 12/27/2005 |
| 6962945 | N-aryloxypropanolyl-N′-phenethyl-urea The present invention provides N-aryloxypropanolyl-N′-phenethyl-urea derivatives of formula 3, method for their preparation and use thereof as potent appetite suppressants for treatment of obesity wherein R is select... | 11/08/2005 |
| 6960615 | Carbamide peroxide compositions for the treatment of dermatological disorders and methods for their use Topical compositions which include urea and carbamide peroxide are described. Compositions having a pH in the acidic range, particularly in the range of about 2.5 to about 9 are also described. Methods for treating dermatological disorders using the composition are ... | 11/01/2005 |
| 6943001 | Epoxide hydrolases, nucleic acids encoding them and methods for making and using them The invention is directed to polypeptides having epoxide hydrolase activity, polynucleotides encoding the polypeptides, antibodies that bind to these polypeptides, and methods for making and using these polynucleotides and polypeptides. The epoxide hydrolases are us... | 09/13/2005 |
| 6919307 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides methods of treating a parasitic infection, a lymphoid malignancy or an autoimmune disorder in a subject by administering to the subject a therapeutically effective amount of an angiogenesis inhibitor compound comprising a MetAP-2 inhib... | 07/19/2005 |
| 6875451 | Compositions and methods for the treatment of primary and metastatic neoplastic diseases using arsenic compounds The invention relates to the use of arsenic compounds to treat a variety of neoplastic diseases. The present invention encompasses the administration to a mammal of arsenic in the form of a salt, complex, organic compound or ionic solution to treat tumors of epithel... | 04/05/2005 |
| 6846837 | Topical administration of basic antifungal compositions to treat fungal infections of the nails Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a pharmaceutically acceptable base in a formulation having a pH of 7.5 to about 13... | 01/25/2005 |
| 6841701 | Inhibitors for the blood-clotting factor Xa The invention relates to derivatives of amidino-benzylamine, especially derivatives of 4-amidino-benzylamine, with two bonded amino acids. These derivatives represent a novel group of highly active and very selective F Xa-inhibitors for treating cardiovascular disea... | 01/11/2005 |
