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| Number | Title | Issue Date |
| 7696249 | Diphenyl urea derivatives The invention relates to novel specifically trifluoromethyl and halogen substituted 1,3-diphenyl ureas and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects like the preparation of the comp... | 04/13/2010 |
| 7329670 | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas The compounds are aryl and heteroaryl substituted heterocyclic ureas of the formula A—NH—C(O)—NH—B where A is the aryl or hetaryl substituted heterocyclic group and B is an aryl or heteroaryl moiety. The compounds inhibit raf kinase and are useful in the tre... | 02/12/2008 |
| 7323496 | Compounds for treatment of inflammation, diabetes and related disorders Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction in an animal model of arthritis and in lowering b... | 01/29/2008 |
| 7265136 | Substituted stilbene compounds with vascular damaging activity A compound for use in inducing necrosis in vascular tissue of a tumor in an animal. The compound contains a first moiety which is a cis-stilbene moiety and a second moiety which is an inhibitor of the formation or action of nitric acid. Also, a method for inducing n... | 09/04/2007 |
| 7262220 | Urea- and urethane-substituted acylureas, process for their preparation and their use The invention relates to urea- and urethane-substituted acylureas and to their physiologically tolerated salts and physiologically functional derivatives. In particular, the invention relates to the compounds of the formula I | 08/28/2007 |
| 7232897 | Compositions and methods for modulating NH2-terminal Jun Kinase activity Disclosed herein are compositions and methods used to modulate a NH2-terminal Jun Kinase activity. These compositions and methods can be employed to regulate metabolic disorders associated with, for example, insulin such as diabetes. The reduction in NH | 06/19/2007 |
| 7202277 | Benzamidine derivatives having anti-inflammatory and immunosuppressive activity Compounds which can be represented by the general formula (I) indicated below: and in which: A is selected independently from the carboxamide group, the thiocarboxamide group, a... | 04/10/2007 |
| 7186736 | NNI for treatment of multi-drug resistant HIV The present invention is directed to compounds and methods suitable for the treatment of HIV infection. ... | 03/06/2007 |
| 7169815 | 3-methoxybenzyl thiourea derivatives and improved lipid compositions containing same 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods... | 01/30/2007 |
| 7105567 | 3-substituted urea derivatives and medicinal use thereof The present invention relates to a urea derivative of the formula (1) wherein each symbol is as described in the specification, a pharmaceutically acceptable salt thereof and pharmaceutical use thereof. The compo... | 09/12/2006 |
| 7094807 | Substituted aryl thioureas and related compounds; inhibitors of viral replication The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compou... | 08/22/2006 |
| 7053243 | 3-Methoxybenzyl thiourea derivatives and improved lipid compositions containing same 1-(3-methoxybenzyl)-3-substituted thiourea antioxidant compounds and improved lipids compositions which are supplemented with amounts of such antioxidant compounds effective for augmenting oxidative stability of the base lipid are provided. Also provided are methods... | 05/30/2006 |
| 6984647 | Aminotetralin-derived urea modulators of vanilloid VR1 receptor This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain ... | 01/10/2006 |
| 6962945 | N-aryloxypropanolyl-N′-phenethyl-urea The present invention provides N-aryloxypropanolyl-N′-phenethyl-urea derivatives of formula 3, method for their preparation and use thereof as potent appetite suppressants for treatment of obesity wherein R is select... | 11/08/2005 |
| 6924311 | Methods for affecting various diseases utilizing LXR compounds The present invention relates to methods for elevating high density lipoprotein (HDL) plasma levels, decreasing the absorption of dietary cholesterol in the intestine, decreasing the plasma level of low density lipoprotein (LDL), and increasing the conversion of cho... | 08/02/2005 |
| 6838472 | Substituted urea retinoid agonists The current invention provide novel compounds, methods of treating or preventing emphysema, cancer and dermatological disorders, pharmaceutical compositions suitable for the treatment or prevention of emphysema, cancer and dermatological disorders and methods for de... | 01/04/2005 |
| 6713650 | ABCA-1 elevating compounds The present invention provides compounds that elevate cellular expression of the ABCA-1 gene, promoting cholesterol efflux from cells and increasing HDL levels in the plasma of a mammal, in particular humans. The compounds are useful for treating coronary artery dis... | 03/30/2004 |
| 6620806 | Methods and kits for improving vascular health The present invention provides methods and kits for improving or maintaining vascular health, including preventing myocardial infarction or stroke; maintaining or improving vascular reactivity; treating acute or chronic renal failure, peripheral arterial ... | 09/16/2003 |
| 6608052 | Compounds useful as anti-inflammatory agents Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceut... | 08/19/2003 |
| 6573284 | Method of treating melanoma Novel pro-drugs and assay reagents are provided which are useful as therapeutic agents especially for delivery and targetting therapeutically active agents to melanoma cells. The pro-drugs and assay reagents are substrates for tyrosinase and may be repres... | 06/03/2003 |
| 6545052 | Methods and compositions for inhibiting free radical polymerization in skin and hair A method is provided for inhibiting free radical degradation in the skin of a human or nonhuman animal comprising contacting the skin with a skin treatment composition having a concentration of a 1-(3-methoxybenzyl)-3-substituted thiourea compound effecti... | 04/08/2003 |
| 6479458 | Targeting the reverse mode of the Na+/Ca2+ exchanger for the treatment of optic neuropathy associated with glaucoma and ischemic optic neuropathy A method for preventing retinal ganglion cell depth, associated with glaucoma, in an animal of the mammalian species, including humans, comprising the step of administering to ganglion cells and their axons (optic nerve) of said mammal a pharmaceutical co... | 11/12/2002 |
| 6414030 | Use of benzenesulfonyl(thio)ureas for the treatment and prophylaxis of dysfunctions of the autonomous nervous system and use of benzenesulfonyl(thio)ureas in combination with beta-receptors blockers Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## in which R1, R2, E, X, Y and Z have the meanings described herein, show effects on the autonomous nervous system. The invention relates to the use of the compo... | 07/02/2002 |
| 6362228 | Phenethyl-thiourea compounds and use Novel phenylethyl-thiourea (PHET) compounds as inhibitors of reverse transcriptase and effective agents for the treatment of HIV infection, including mutant, drug-sensitive, drug-resistant, and multi-drug resistant strains of HIV.... | 03/26/2002 |
| 6316478 | IL-8 receptor antagonists This invention relates to novel spiro compound derivatives of benzoisothiazolyl-urea and -thiourea and compositions thereof. These compounds are useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 11/13/2001 |
| 6316503 | LXR modulators The invention provides compounds, compositions and methods for modulating the effects of LXR in a cell. The compounds and compositions are useful both as diagnostic indicators of LXR function and as pharmacologically active agents. The compounds and compo... | 11/13/2001 |
| 6313172 | Methods and compositions for modulating alpha adrenergic receptor activity Methods and compositions for the treatment of pain using this area derivatives. Particularly disclosed are new compositions for the treatment of chronic pain, and methods for their use.... | 11/06/2001 |
| 6271261 | IL-8 receptor antagonists Novel IL-8 receptor antagonists and methods of using them are provided.... | 08/07/2001 |
| 6255349 | Alph-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a phenylenediamine group Compounds having the formula: ##STR1## wherein R1 -R5 are independently selected from hydrogen, alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkynyl of 2 to 6 carbon atoms, perhaloalkyl of 1 to 6 carbon atoms, cycl... | 07/03/2001 |
| 6207715 | Alpha-methylbenzyl-containing thiourea inhibitors of herpes viruses containing a substituted phenylene-diamine group Compounds of the formula: ##STR1## are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi he... | 03/27/2001 |
| 6187799 | Inhibition of raf kinase activity using aryl ureas Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.... | 02/13/2001 |
| 6093742 | Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provi... | 07/25/2000 |
| 6034102 | Atherosclerosis treatment A method of treating atherosclerosis, independent of lipid lowering, in mammals, including humans, in need of treatment by inhibiting progression of an atherogenic lesion or by stabilizing plaque. Such lesion progression inhibition or plaque stabilization... | 03/07/2000 |
| 5977177 | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them. Substituted benzenesulfonylureas and -thioureas of the ... | 11/02/1999 |
| 5958983 | Polyaromatic antiviral compositions The present invention relates to polyaromatic compounds having useful antiviral activity against viruses of the herpes family, to a composition containing them, and to a method of using them for the treatment of herpes viruses infections.... | 09/28/1999 |
| 5952386 | Dihalopropene compounds, insecticides containing them as active ingredients, and intermediates for their production The present invention provides dihalopropene compounds of the general formula: ##STR1## wherein R1 is C1 -C10 alkyl or the like; L is C(.dbd.O)NH or the like; R2, R3 and R4 are indepen... | 09/14/1999 |
| 5929117 | Immunotherapeutic agents Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor , nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory con... | 07/27/1999 |
| 5928633 | Material for elimination or detoxification of super antigens A material with excellent selective absorption of super antigens. Said material contains urea bonds or thiourea bonds and remains active even in a high protein concentration solution in the neutral region, Activity remains after sterilization. Also provid... | 07/27/1999 |
| 5886044 | IL-8 receptor antagonists This invention relates to the novel use of phenyl ureas in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 03/23/1999 |
| 5880155 | Substituted benzenesulfonylureas and-thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them. Substituted benzenesulfonylureas and -thioureas of the ... | 03/09/1999 |