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| Number | Title | Issue Date |
| 8183230 | Antimicrobial preservatives to achieve multi-dose formulation using beta-cyclodextrins for liquid dosage forms The present invention is directed to pharmaceutical compositions containing a therapeutically effective amount of an Active Pharmaceutical Ingredient (“API”), a pharmaceutically acceptable cyclodextrin and a pharmaceutically acceptable preservative. The inventio... | 05/22/2012 |
| 8158610 | Dextrin-containing composition for preventing surgical adhesions A method of reducing the incidence of post-operative adhesions in or associated with a body cavity, which comprises introducing into the body cavity a composition containing an aqueous solution or suspension or gel formulation containing the polysaccharide dextrin. | 04/17/2012 |
| 8158609 | Use of cyclodextrins as an active ingredient for treating dry AMD and solubilizing drusen The present invention is directed to the treatment of disorders involving the accumulation of drusen, such as dry age-related macular degeneration and geographic atrophy via administration of therapeutically effective amounts of at least one monomeric or polymeric c... | 04/17/2012 |
| 8158580 | Pharmaceutical compositions containing a glycopeptide antibiotic and a cyclodextrin Disclosed are pharmaceutical compositions containing a cyclodextrin and a therapeutically effective amount of a glycopeptide antibiotic or a salt thereof. Also disclosed are methods of treating a bacterial disease in a mammal by administering such pharmaceutical com... | 04/17/2012 |
| 8153613 | Barrier film-forming germicidal composition for controlling mastitis A long-lasting persistent, uniform film-forming skin protecting germicidal composition provides a long-lasting persistent barrier film when applied to skin. The compositions have particular utility as barrier teat dips for protecting cows against mastitis. A barrier... | 04/10/2012 |
| 8119616 | Formulation of quinazoline based EGFR inhibitors containing a zinc binding moiety The present invention relates to a composition comprising an inclusion complex of a cyclodextrin and quinazoline containing zinc-binding moiety based derivatives. The cyclodextrin is preferable a β-cyclodextrin or a derivative thereof. The quinazolines have enhance... | 02/21/2012 |
| 8063027 | Surgical compositions for reducing the incidence of adhesions A method of preventing or reducing the incidence of post-operative adhesions in or associated with a body cavity, which comprises introducing into the body cavity a composition containing an aqueous solution or suspension or gel formulation containing the polysaccha... | 11/22/2011 |
| 8044035 | Pharmaceutical compositions of pyrimidine-2,4,6-triones A trioxopyrimidine-cyclodextrin complex formed of a trioxopyrimidine derivative or a salt thereof and a water-soluble cyclodextrin derivative has improved solubility. ... | 10/25/2011 |
| 7973022 | Fluoroquinolone carboxylic acid salt compositions The invention relates to pharmaceutical compositions that are a solution of a salt formed between a fluoroquinolone and a carboxylic acid, a cyclodextrin, and a pharmaceutically acceptable organic solvent and to methods of treating a condition in an animal by admini... | 07/05/2011 |
| 7935685 | Process for preparation of inclusion compounds between a non-steroidal anti-inflammatory drug and betacyclodextrin by microwave treatment A process for the preparation of inclusion complexes of a drug (piroxicam or ibuprofen) and a cyclodextrin, characterised in that: a) the drug and cyclodextrin, in the form of finely divided powders, are mixed in the presence of aqueous or hydroalcoholic solutions, ... | 05/03/2011 |
| 7932238 | Anti-inflammatory and/or analgesic composition for the intestine comprising branched maltodextrins The invention concerns a fiber-enriched anti-inflammatory and/or analgesic composition for the intestine, characterized in that it comprises branched maltodextrins having between 15 and 35% of glucoside bonds, 1 to 6, a reducing sugar content less than 20%, a polymo... | 04/26/2011 |
| 7902174 | Antiviral composition Chemical compounds, being the alkyl sulfate of sulfated saccharides, particularly, dextrin, dextran, and cyclodextrin, and pharmaceutical compositions containing these compounds. The compounds of the invention provide antiviral activity, particularly in the treatmen... | 03/08/2011 |
| 7897586 | Anaesthetic composition A stable anaesthetic composition is described which is particularly suitable for use in cats and dogs. The composition comprises an aqueous solution of an anaesthetically effective amount of a water soluble cyclodextrin or a cyclodextrin derivative complex of alfaxa... | 03/01/2011 |
| 7893040 | Cyclodextrin nanotechnology for ophthalmic drug delivery The invention provides an ophthalmic composition which is an aqueous suspension comprising drug, cyclodextrin and water, the composition having an aqueous phase of from about 0.1% (w/v) to about 90% (w/v) of the drug in solution, as dissolved free drug and as dissol... | 02/22/2011 |
| 7888335 | Mitoquinone derivatives used as mitochondrially targeted antioxidants This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds. The exemplified compounds are all mitoquinone derivatives, being methoxy... | 02/15/2011 |
| 7888334 | Mitoquinone derivatives used as mitochondrially targeted antioxidants This invention relates to methods to screen for, identify, select and synthesise amphiphilic mitochondrially targeted antioxidant compounds, and compositions, dosage forms and methods reliant on said compounds. The exemplified compounds are all mitoquinone derivativ... | 02/15/2011 |
| 7879822 | Stabilized sulforaphane A method of stabilizing sulforaphane is provided. The method includes contacting sulforaphane, or an analog thereof, and a cyclodextrin to form a complex between the sulforaphane, or analog thereof, and the cyclodextrin. ... | 02/01/2011 |
| 7879821 | Method for modulating inflammatory responses by altering plasma lipid levels A method for treating an immune-related disorder in a patient comprising administering an agent to the patient for altering the patient's plasma concentration of free cholesterol, wherein said agent is a non-statin agent and is administered in an amount sufficient t... | 02/01/2011 |
| 7879820 | Use of a cyclodextrin as pearlescent agent and pearlescent compositions Use of at least one agent chosen from cyclodextrins and the derivatives thereof as a pearlescent agent, in a composition, for example, a pearlescent cosmetic composition, comprising a physiologically acceptable aqueous medium. Use of at least one agent chosen from c... | 02/01/2011 |
| 7858597 | Preparation of formulations of angiotensin II AT1 receptors antagonists for the treatment of arterial hypertension, other cardiovascular illnesses and its complications Preparation of AT1 receptors antagonists formulations using the cyclodextrins, their derivatives and/or biodegradable polymers for the treatment of arterial hypertension, other cardiovascular disease and their complications. Until now, no applications using the AT1 | 12/28/2010 |
| 7851457 | β-Cyclodextrin derivatives The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of β-cyclodextrin. Per-substituted alkylamino derivates displayed inhibitory activit... | 12/14/2010 |
| 7829550 | Use of cyclodextrin for treatment and prevention of bronchial inflammatory diseases The invention provides the use of a cyclodextrin compound for the manufacturing of a medicament for the treatment or prevention of bronchial inflammatory diseases, particularly for asthma. ... | 11/09/2010 |
| 7820640 | Methods for treating hearing loss In one aspect, the present invention provides otoprotectant compositions useful for ameliorating hearing loss. In some embodiments, the otoprotective compositions comprise at least one glutathione peroxidase mimic. In some embodiments, the otoprotective compositions... | 10/26/2010 |
| 7786095 | Amphiphilic macrocyclic derivatives and their analogues Soluble amphiphilic macrocycle analogues having lipophilic groups attached to one side of the units making up the macrocycle and hydrophilic groups attached to the other side. These amphiphilic macrocyclic derivatives have the ability to self-assemble in aqueous sol... | 08/31/2010 |
| 7781417 | Cyclodextrin dimers and derivatives thereof, methods for preparing them and their use, in particular, for the solubilizing pharmacologically active substances The invention relates to a compound according to the following general formula (I), in which: m represents an integer equal to 5, 6 or 7; n and n1 represent an integer from 1 to 5; the A groups represent, in particular, a hydrogenated atom; X represents O... | 08/24/2010 |
| 7749982 | Complex containing mequitazine, a cyclodextrin and an interaction agent The present invention relates to a complex that includes mequitazine, a cyclodextrin, and an interaction agent wherein the rate of solubilization in water of complexed mequitazine, measured for a 2 g/l mixture of mequitazine in water at 35° C. after 15 minutes of s... | 07/06/2010 |
| 7737132 | β-cyclodextrin derivatives as antibacterial agents The invention provides a new class of antibiotics to which pathogenic bacteria have not been exposed, and thus should not have developed resistance. This new class of antibiotics are derivatives of β-cyclodextrin (β-CD), which is a cyclic molecule comprising seven... | 06/15/2010 |
| 7732428 | Surgical compositions and methods of using the same A method of preventing or reducing the incidence of post-operative adhesions in or associated with a body cavity, which comprises introducing into the body cavity a composition containing an aqueous solution or suspension or gel formulation containing the polysaccha... | 06/08/2010 |
| 7704975 | Modafinil compound and cyclodextrin mixtures Mixtures of a modafinil compound with a cyclodextrin, methods for their use, and compositions thereof are disclosed, along with complexes comprising a modafinil compound and a cyclodextrin which are taste-masked and suitable for oral consumption in an aqueous soluti... | 04/27/2010 |
| 7700579 | Process for the preparation of piroxicam: b-cyclodextrin inclusion compounds The present invention relates to a process for the preparation of inclusion compounds of piroxicam with β-cyclodextrin. More particularly, according to the process of the invention, the aqueous solution of two components is subjected, before drying, to a freezing p... | 04/20/2010 |
| 7683040 | Intranasal formulation of rotigotine This invention pertains to a liquid intranasal pharmaceutical formulation comprising a pharmaceutically acceptable acid addition salt of rotigotine and α-cyclodextrin, preferably in the form of a buffered aqueous solution having a viscosity of 0.5-1.5 mm2 | 03/23/2010 |
| 7678776 | Inclusion complexes of butylphthalide with cyclodextrin or its derivatives, a process for their preparation and the use thereof The present invention relates to the inclusion complexes of butylphthalide, which is D, L-mixed or levorotatory, with cyclodextrin or cyclodextrin derivatives, to a process for their preparation and the use thereof. In the invention, the butylphthalide is complexed ... | 03/16/2010 |
| 7671042 | Pharmaceutical compositions containing cyclodextrins and taxoids The present invention relates to water-soluble solid pharmaceutical compositions and their solutions in aqueous solvents, said compositions containing a) as an active ingredient a finely dispersed large surface area amorphous preferably lyophilized taxoid such as pa... | 03/02/2010 |
| 7645746 | Composition for reducing malodor impression on inanimate surfaces The present invention relates to an aqueous composition for reducing malodor impression. The composition comprises from about 0.01% to about 1%, by weight of the composition, of perfume. Optionally, but preferably, the composition comprises from about 0.1% to about ... | 01/12/2010 |
| 7625878 | Sulfoalkyl ether-alkyl ether cyclodextrin derivatives A sulfoalkyl ether-alkyl ether cyclodextrin (SAE-AE-CD) derivative is provided. The SAE-AE-CD possesses advantages over known SAE-CD and AE-CD derivatives as well as over the parent cyclodextrin by being more water soluble and less membrane disturbing. The SAE-AE-CD... | 12/01/2009 |
| 7592328 | Natural cyclodextrin complexes The present invention is directed to the novel use of complexes of cyclodextrin. In particular the invention is directed to a complex of a cyclodextrin selected from the group consisting of α-CD, β-CD and γ-CD and a cannabinoid selected from the classical cannabi... | 09/22/2009 |
| 7589080 | β-cyclodextrin compositions, and use to prevent transmission of sexually transmitted diseases Methods of reducing the risk of transmission of a sexually transmitted pathogen by contacting the pathogen or cells susceptible to infection by the pathogen with a β-cyclodextrin are provided. Methods for reducing the risk of transmission of a sexually transmitted ... | 09/15/2009 |
| 7569557 | Compositions of estrogen-cyclodextrin complexes Pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and a cyclodextrin are provided with improved stability. In specific embodiments the composition comprises a complex between ethinyl estradiol and β-cyclodextrin in a granul... | 08/04/2009 |
| 7550445 | Aripiprazole complex formulation and method An aripiprazole formulation is provided which includes the antipsychotic agent aripiprazole in the form of an inclusion complex in a β-cyclodextrin, preferably, sulfobutyl ether β-cyclodextrin (SBECD), which in the form of an injectable produces reversible general... | 06/23/2009 |
| 7498318 | Food for diabetics Provided is a carbohydrate mixture comprising at least one modified carbohydrate from a base body and a carbohydrate residue coupled therewith. The base body concerned is either a digestible glucose-containing carbohydrate in the form of a digestible glucan or a non... | 03/03/2009 |
