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| Number | Title | Issue Date |
| 7915315 | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity Benzocycloheptyl analogs that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs, which, after phosphorylation, can behave as agonists at S1P receptors. ... | 03/29/2011 |
| 7825161 | Higher fullerenes useful as radical scavengers Chemically functionalized fullerenes are useful in various applications as radical scavengers. These chemically functionalized fullerenes offer the advantages of preservation of the high innate radical scavenging efficiency of the fullerene cage and ease of synthesi... | 11/02/2010 |
| 7635719 | Use of adamatyl methoxydiphenyl propenoic acid for the treatment of acne The use of a substance belonging to the class of atypical retinoids for the topical treatment of acne is described. In particular the effects on an animal model for this skin disease of a pharmaceutical or cosmetic compound for topical use containing adamantyl metho... | 12/22/2009 |
| 7476693 | Suramin and derivatives thereof as topical microbicide and contraceptive The present invention is directed to methods of inhibiting STDs by topically administering suramin or a derivative thereof to actual or potential sites of infection, and methods of preventing pregnancy by topically applying suramin or a derivative thereof intravagin... | 01/13/2009 |
| 7323587 | Selective estrogen receptor modulators The present invention provides, inter alia, triphenylethylene derivatives, such as, 3-{4-[6-(3-Methoxy-phenyl)-8,9-dihydro-7H-benzocyclohepten-5-yl]-phenyl}-acrylic acid, as selective estrogen receptor modulators. Also provided are methods for treating estrogen stim... | 01/29/2008 |
| 7217706 | Propanolamine derivatives This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]: Wherein each symbol is as defined in the specification or salts thereof which have gut selective sympatho... | 05/15/2007 |
| 7115767 | Tetraline derivatives as ghrelin receptor modulators The present invention is related to compounds of formula (I), or a therapeutically suitable salt or prodrug thereof, the preparation of the compounds, compositions containing the compounds and the use of the comp... | 10/03/2006 |
| 7109164 | Aniline-derived ligands for the thyroid receptor New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH2—, —CO—, or —NH—; Y is —(... | 09/19/2006 |
| 7071231 | Naphthalene ureas as glucose uptake enhancers Compounds of formula I are useful for treating conditions associated with hyperglycemia, especially Type II diabetes. These compounds are useful in stimulating the kinase activity of the insulin receptor, activating the insulin receptor, and stimulating the uptake o... | 07/04/2006 |
| 7053071 | Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of... | 05/30/2006 |
| 6982284 | Compositions and methods for modification of skin lipid content The topical use of ursolic acid compounds to alter the lipid content of mammalian skin is disclosed. The compounds can be encapsulated in liposomes and administered in this form to the skin in, for example, a lotion or a gel. The compounds are effective in, among ot... | 01/03/2006 |
| 6982097 | Biocidal compositions and methods of using same This invention relates to biocidal compositions and methods of using same. Also provided is a process for the manufacturing of a biocidal composition in the form of a tablet and a method of using the biocidal compositions for the disinfection of water that may conta... | 01/03/2006 |
| 6949250 | Selective algaecides for control of cyanochloronta We have now discovered that certain 9,10-anthraquinone derivatives we developed possess potent activity against O. perornata while possessing a sufficiently high level of solubility in water to make their activity against O. perornata viable. These com... | 09/27/2005 |
| 6936273 | Liposomal analgesic formulation and use A liposome formulation containing about 1% diclofenac is an effective topical anti-inflammatory topical treatment for lameness in horses. More particularly it has been discovered that a formulation containing vitamin E, phospholipid and diclofenac salt such as the s... | 08/30/2005 |
| 6911473 | Detectable agent for wood treatment and method for its detection The present invention relates to a composition comprising an organic preservative acid and a UV-active indicator substance for preserving wood and for detection of the sufficient preservation of wood. ... | 06/28/2005 |
| 6902831 | Azulene-based compounds in organic light emitting device elements An organic light-emitting device (OLED) in which an azulene based compound is used as an emissive layer and/or one or more charge transport layers, or as a host material, or is doped into a functional layer of an OLED to improve device efficiency. ... | 06/07/2005 |
| 6881857 | Tricyclic diterpene derivatives Disclosed herein are novel tricyclic diterpene compounds. These compounds, including their prodrug esters and acid-addition salts, are useful as Interleukin-1 and Tumor Necrosis Factor-α modulators, and thus are useful in the treatment of various diseases. A... | 04/19/2005 |
| 6800605 | Aniline-derived ligands for the thyroid receptor New thyroid receptor ligands are provided which have the general formula in which: X is —O—, —S—, —CH2—, —CO—, or —NH—; Y is —(CH2)n— where n is an i... | 10/05/2004 |
| 6784208 | Method for preventing and treating visceral pain and gastrointestinal disorders The compounds of formula I-IV: wherein n is an integer of from 1 to 4, or pharmaceutically acceptable salts thereof are useful to prevent and treat visceral pain and gastrointestinal disorders. ... | 08/31/2004 |
| 6642277 | Food supplements containing polyphenols Disclosed is a plant-derived flavonol-containing dry composition suitable for human consumption, wherein at least 25% of the plant-derived material in the composition comprises polyphenols, together with uses thereof.... | 11/04/2003 |
| 6576674 | Method of controlling zoological and aquatic plant growth A method of controlling target aquatic microorganism pest populations by exposing the target population to a toxic amount of an aquacidal compound comprising an anthraquinone. The method is particularly effective for treating ballast water of ships or oth... | 06/10/2003 |
| 6495546 | Propanolamine derivatives Propanolamine derivatives represented by the following formula (I): ##STR1## These derivatives may be 댣 agonists and exert sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-urinary incontinence and anti-pollakiuria ac... | 12/17/2002 |
| 6492424 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders Novel glucocorticoid and thyroid receptor ligands as provided which have the general formula (I): ##STR1## in which R1 is an aliphatic hydrocarbon, an aromatic hydrocarbon, carboxylic acid or ester thereof, alkenyl carboxylic acid or ester ... | 12/10/2002 |
| 6479551 | Treatment of migraine headache The invention is directed to pharmaceutical compositions useful in the treatment of migraine. The compositions contain metoclopramide and one or more NSAIDs in unit dosage form. By selecting NSAIDs that are non-acidic or segregating the metoclopramide and... | 11/12/2002 |
| 6455578 | Aromatic derivatives and iron complexes thereof for the use as normalizing agents of the iron level The present invention is directed to aromatic derivatives of formula (I), wherein: R1 is (a), wherein R3 and R4 are selected from between H and OH, provided that R3 and R4 are not simultaneously H, an... | 09/24/2002 |
| 6420394 | Topically applied pharmaceutical formulation The present invention relates to a novel pharmaceutical formulation for the topical application of drugs, particularly non-steroidal anti-inflammatory drugs (NSAID's), comprising a therapeutically effective amount of a drug, sodium phosphate buffer, and, ... | 07/16/2002 |
| 6384079 | Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging Uses of topical compositions comprising a 2-hydroxycarboxylic acid or related compound to alleviate or improve signs of skin, nail and hair changes associated with intrinsic or extrinsic aging are disclosed. 2-Hydroxycarboxylic acids and their related com... | 05/07/2002 |
| 6383527 | Compositions comprising valerian extracts, isovaleric acid or derivatives thereof with a NSAID Preparations and extracts of valerian, as well as isovaleramide, isovaleric acid, and its pharmaceutically acceptable salts, esters, and substituted amides, and other valerian-related compounds, in combination with NSAIDs exhibit clinically significant ph... | 05/07/2002 |
| 6365625 | Compound for inhibiting HIV infectivity This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalenesulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrat... | 04/02/2002 |
| 6248749 | Use of inhibitors of the activity of retinoic acid for treating sensit ive skin and/or acute damage induced by UV radiation The invention concerns tye use of a inhibitor of retinoic acid as sole ingredient in a pharmaceutical or cosmetic composition comprising administering effective amount of the composition to treat sensitive skin or skin damage induced by UV radiation.... | 06/19/2001 |
| 6210686 | Dietary supplement and method for lowering risk of heart disease Yeast-derived fiber has been demonstrated, as described herein, to effectively improve the serum lipid profile in humans, when provided as a dietary supplement, without some of the disadvantages known to accompany dietary supplementation with oat fiber or... | 04/03/2001 |
| 6197336 | Fast dissolving compositions having analgesic activity An analgesic composition useful in the preparation of fast dissolving tablets is provided, where the composition is the result of combining ibuprofen, arginine, linear PVP and an alkaline bicarbonate to which usual excipients for the preparation of tablet... | 03/06/2001 |
| 6121322 | Azulene derivatives The invention provides novel azulene derivatives of general formula I ##STR1## wherein R1 to R6 have the significance given in the description, as well as their tautomers, enantiomers, diastereomers, racemates and physiologicall... | 09/19/2000 |
| 6121320 | Combination anti-leukemic therapy by utilizing suramin and biologic response modifiers A method of treating leukemia which includes administering an effective amount of composition comprising suramin and a biological response modifier, wherein the suramin and the biological response modifier show synergistic or additive anti-leukemic activi... | 09/19/2000 |
| 6075050 | Compound for inhibiting HIV infectivity This invention pertains to the discovery that condensation polymers of an aldehyde and aromatic sulfonic acids and fractions thereof, such as formaldehyde naphthalenesulfonic acid condensation polymers, can abrogate HIV gp120 binding to CD4, as demonstrat... | 06/13/2000 |
| 6063797 | γ-RAR antagonist ligand or -RAR agonist ligand as an apoptosis inhibitor The use of a combination of an alpha RAR receptor-specific agonist ligand and a gamma RAR receptor-specific antagonist ligand to reduce the rate of apoptosis is disclosed.... | 05/16/2000 |
| 5958972 | Tricyclic inhibitors of matrix metalloproteinases Tricyclic compounds are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A (72 kD gelatinase) and stromelysin-1 and for the treat... | 09/28/1999 |
| 5891905 | Methods of treatment using procyanidin antioxidants Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions contai... | 04/06/1999 |
| 5861385 | Substituted triols Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.... | 01/19/1999 |
| 5849727 | Compositions and methods for altering the biodistribution of biological agents This invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic or bioactive agents. The methods and composition of the invention can be used with several therapeutic or bioactive agents and can achieve site-... | 12/15/1998 |
