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| Number | Title | Issue Date |
| 8178582 | Pharmaceutical compositions having desirable bioavailability The present invention is directed to the provision of pharmaceutical compositions. The compositions include a therapeutic agent and a relatively low amount of surfactant for providing higher bioavailability of the therapeutic agent. The compositions are particularly... | 05/15/2012 |
| 8106095 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 01/31/2012 |
| 8071649 | Method for treatment of nocturia A method for treatment of nocturia by administering to a mammal, such as a human, in need of such treatment, a therapeutically effective amount of loxoprofen or a pharmacologically acceptable salt thereof. ... | 12/06/2011 |
| 8030354 | Substituted biphenyl GPR40 modulators The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present... | 10/04/2011 |
| 7951843 | Amide linked modulators of γ-secretase The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, R1 R2, R3, R4, R5, R6, R7, and R8 are provided in the specification. Compoun... | 05/31/2011 |
| 7932290 | Method for the treatment of metabolic disorders Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. wher... | 04/26/2011 |
| 7928144 | Antiinflammatory and analgesic preparation for external use It is intended to provide an antiinflammatory and analgesic preparation for external use whereby side effects of a nonsteroidal antiinflammatory and analgesic drug on the skin can be regulated, the nonsteroidal antiinflammatory and analgesic drug can be prevented fr... | 04/19/2011 |
| 7897643 | Biphenyl carboxylic acids and derivatives thereof The present disclosure relates to compounds having the general Formula (I) with the definitions of R1, R2, R3, and R4 as provided herein, and/or salts thereof. The disclosure also relates to the use of such compounds for t... | 03/01/2011 |
| 7825160 | (Biphenyl) carboxylic acids and derivatives thereof The present invention relates to compounds having the general formula (I) with the definitions of A, X, R1-R6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzhe... | 11/02/2010 |
| 7763656 | Use of Acetylamino benzoic acid compounds for nonsense suppression and the treatment of disease Novel acetylamino benzoic acid compounds, methods of using and pharmaceutical compositions comprising an acetylamino benzoic acid derivative are disclosed. The methods include methods of treating or preventing a disease ameliorated by modulation of premature transla... | 07/27/2010 |
| 7750048 | GPR40 agonists The invention is directed to compounds of Formula (I) useful as GPR40 agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, insulin resistance, hyperglycemia, obesity, diabetes such as NIDDM, and other di... | 07/06/2010 |
| 7635718 | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia. ... | 12/22/2009 |
| 7605181 | Method for the treatment of metabolic disorders Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. ... | 10/20/2009 |
| 7582679 | Compositions containing solid ibuprofen concentrates and methods of making solid ibuprofen concentrates The present invention is directed to a solid ibuprofen concentrate composition and method of producing the composition. The solid ibuprofen concentrate contains (a) a solid ibuprofen free acid and (b) a solid ibuprofen alkali salt, and is characterized in that at le... | 09/01/2009 |
| 7557144 | Modulation of protein expression using carbocyclic aryl alkenoic acid derivatives The present invention generally relates to diseases or conditions modulated by undesired protein expression. In one aspect, the methods provide for administration to a mammal, particularly a human, of a therapeutically effective amount of a carbocyclic aryl compound... | 07/07/2009 |
| 7517911 | 3,4,5-trimethoxy phenyl-based ester compound and preparation method thereof and whitening cosmetic composition containing the same The present invention relates to ester compounds derived from 3,4,5-trimethoxy phenyl acetate, 3,4,5-trimethoxy cinnamate or 3,4,5-trimethoxy hydrocinnamate that are represented by Formula (I), wherein R1 is CH2—, —CH═CH— or CH2 | 04/14/2009 |
| 7442833 | Triphenylethylene compounds as selective estrogen receptor modulators Compounds of formula (I): with a variety of therapeutic uses, more particularly novel prodrugs that are particularly useful for delivering a parent compound for selective estrogen receptor modulation. ... | 10/28/2008 |
| 7420083 | Substituted aryloximes The present invention relates to substituted aryl oximes and methods of using them. ... | 09/02/2008 |
| 7365225 | Aryl dicarboxamides The present invention is related to aryl dicarboxamides of formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and/or II, inadequate glucose... | 04/29/2008 |
| 7358245 | Treatment of gastroesophageal reflux disease The administration of cannabinoid receptor agonists for inhibition of transient lower esophageal sphincter relaxations, gastroesophageal reflux disease and regurgitation is disclosed. ... | 04/15/2008 |
| 7342044 | Preservative blends containing quaternary ammonium compounds The present invention provides a biocidal composition comprising a synergistic mixture of certain quaternary ammonium biocides and one or more ketone acids, aromatic carboxylic acids, salts thereof, or mixtures thereof. ... | 03/11/2008 |
| 7335379 | Transdermal pharmaceutical formulation for minimizing skin residues This invention relates to novel transdermal or transmucosal pharmaceutical formulation which reduces the occurrences of contamination of other individuals and the transference to clothing of the user. The novel formulation includes at least one pharmacologically act... | 02/26/2008 |
| 7332516 | Geminally di-substituted NSAID derivatives as Aβ42 lowering agents The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is ... | 02/19/2008 |
| 7326690 | Modulation of cell fates and activities by phthalazinediones Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survi... | 02/05/2008 |
| 7323452 | Method for the accelerated in vivo removal of ethanol A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives... | 01/29/2008 |
| 7318930 | Control methods for boring bark beetles A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described. Additional tests have shown that beetles will not infest a tree which... | 01/15/2008 |
| 7314888 | Compounds and medicinal use thereof A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: | 01/01/2008 |
| 7309719 | Stabilized pharmaceutical preparation of gamma-aminobutyric acid derivatives and process for preparing the same The present invention provides a stabilized pharmaceutical preparation of a 4-amino-3-substituted-butanoic acid derivative which can be obtained by incorporating an amino acid as a stabilizer. ... | 12/18/2007 |
| 7309720 | 2-ethoxy-3-phenylpropionic acid derivatives for the treatment of lipid disorders A compound of formula (I) wherein T represents O, S or NR and wherein R represents a H, a C1-6alkyl group or a phenyl C1-6alkyl group and pharmaceutically acceptable salts thereof, processes for preparing such compounds, their the utility in tr... | 12/18/2007 |
| 7300670 | Oral suspension formulation An aqueous pharmaceutical suspension for oral administration of a drug, which suspension maintains its content uniformity for prolonged period. ... | 11/27/2007 |
| 7300955 | Method and materials for treatment of Alzheimer's disease The invention provides the combined use of an inhibitor of formation or release of β-amyloid and a nitric oxide releaser for the treatment or prevention of Alzheimer's disease. ... | 11/27/2007 |
| 7282224 | Pain relief composition Disclosed is a pain relief composition comprising an effective amount of a nerve inhibiting component, including capsaicin, a capsaicinoid or a capsaicin analogue, which numbs or inhibits the nerve endings that signal pain, in combination with at least one of the fo... | 10/16/2007 |
| 7279597 | Phenyl amine carboxylic acid compounds and compositions for delivering active agents Phenyl amine carboxylic acid compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 10/09/2007 |
| 7276077 | Body fluid flow control device A device to provide body fluid flow control in the form of a valve to be located within a duct or passageway. The device is controlled through pressure above a preselected threshold. Bulk resilience about a passageway in a valve body provides the mechanism for contr... | 10/02/2007 |
| 7238835 | Process for the preparation of substituted 2-(phenoxymethyl) benzoic acids The invention relates to a process for the preparation of a compound of the general formula (I) in which a) a compound (II) is reacted in the presence of a base B1 with a compound (III) and | 07/03/2007 |
| 7235584 | Non-psychotropic cannabinoids Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) ... | 06/26/2007 |
| 7223582 | Esterase, its DNA, its overexpression and production of optically active aryl propionic acids using the same The present invention relates to an esterase, its DNA, its overexpression and a method for preparing an optically active aryl propionic acid of formula (1) using the same in high yield, wherein R1 repr... | 05/29/2007 |
| 7217705 | Combination of a CB1 receptor antagonist and of a product which activates dopaminergic neurotransmission in the brain, the pharmaceutical compositions comprising them and their use in the treatment of parkinson's disease The present invention relates to the combination of one or more CB1 antagonist azetidine derivatives and of one or more products which activate dopaminergic neurotransmission in the brain, to the pharmaceutical compositions comprising them and to their use in the tr... | 05/15/2007 |
| 7214713 | Antraquinone compositions as anticancer compositions and nutrition supplements and methods of making and using them A food supplement having prophylactic and-cancer effects, wherein the supplement comprises 20 to 99.99% by weight of a product of biosynthesis by the productive microorganism Penicillium oxalicum var. Armeniaca CCM 8242, obtained by fermentation of a nutrient broth ... | 05/08/2007 |
| 7196081 | Compounds with hydroxycarbonyl-halogenoalkyl side chains The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the following general f... | 03/27/2007 |
