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| Number | Title | Issue Date |
| 8188147 | Therapeutic methods employing nitric oxide precursors Isolated polynucleotide molecules and peptides encoded by these molecules are used in the analysis of human carbamyl phosphate synthetase I phenotypes, as well as in diagnostic and therapeutic applications, relating to a human carbamyl phosphate synthetase I polymor... | 05/29/2012 |
| 8063104 | Guanidine derivatives as inhibitors of DDAH Compounds of formula (I) have been found to be useful as inhibitors of DDAH. The present invention thus provides the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in the treatment of a dis... | 11/22/2011 |
| 7829593 | Glutamine-containing compositions and a method for increasing blood flow using same The present invention provides a glutamine-containing composition which functions to increase blood flow. Glutamine is present in the composition in an amount of 25 mg/kg body weight to 150 mg/kg body weight. By administering the composition to a subject in need the... | 11/09/2010 |
| 7629384 | Topical delivery of L-arginine to cause beneficial effects The application of L-arginine and its derivatives to the skin causes beneficial effects of wound healing, increasing erectile function and increased growth of hair when applied in sufficient quantity to the skin. A hostile biophysical agent may be combined with the ... | 12/08/2009 |
| 7608641 | Creatine oral supplementation using creatine hydrochloride salt Creatine oral supplementation using creatine hydrochloride salt, that may be added to a liquid or other beverage, or may be also used as an additive to solid oral dosages, or as a supplement, and which may be consumed by the athlete, or other party looking for immed... | 10/27/2009 |
| 7576132 | Arginine silicate inositol complex and use thereof A method for preventing and treating a variety of disease states and disorders is provided, comprising the administration of an arginine silicate inositol complex to an individual in the presence of medical therapy or absence of medical therapy. Examples of said dis... | 08/18/2009 |
| 7507766 | Treatment of cancers Carnitine and other muscle protectors are useful to prevent side effects of aplidine and aplidine analogues. ... | 03/24/2009 |
| 7452916 | Enhancement of vascular function by modulation of endogenous nitric oxide production or activity Endothelial nitric oxide production is enhanced by administration of arginine or lysine as a dietary supplement. Enhanced nitric oxide production from arginine supplementation improves vascular function and structure. Additional compounds may be administered with ar... | 11/18/2008 |
| 7419981 | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor The instant invention relates to a combination of an alpha-2-delta ligand and a PDEV inhibitor for use in therapy, particularly in the treatment of pain, particularly neuropathic pain. Particularly preferred alpha-2-delta ligands are gabapentin and pregabalin. A par... | 09/02/2008 |
| 7393825 | Microdose therapy Methods for treating vascular conditions associated with localized imbalance in vascular tone, which are hypothesized to be largely due to elevated endothelin (ET) are provided. The methods involve administration of nitric oxide (NO), agents which are able to provid... | 07/01/2008 |
| 7338955 | Medicament for treatment of neuropathies Compounds of formula (I) in which R1=C1-6 alkyl, optionally halosubstituted; R2=H, C1-4 alkyl, optionally halosubstituted or replaced by halogen; R3=C2-4 alkyl, optionally halosubstituted; R4 | 03/04/2008 |
| 7323585 | Levodopa prodrugs, and compositions and uses thereof Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. ... | 01/29/2008 |
| 7323452 | Method for the accelerated in vivo removal of ethanol A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives... | 01/29/2008 |
| 7318930 | Control methods for boring bark beetles A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described. Additional tests have shown that beetles will not infest a tree which... | 01/15/2008 |
| 7285573 | Use of creatine or creatine analogs for the treatment of diseases of the nervous system The present invention relates to the use of creatine compounds including creatine, creatine phosphate or analogs of creatine, such as cyclocreatine, for treating diseases of the nervous system. Creatine compounds can be used as therapeutically effective agents again... | 10/23/2007 |
| 7276535 | Intratesticular injection of chemical sterilant A low effective dose of a biologically acceptable chemical sterilant is injected into the dorsal cranial portion of a scrotal testis of a male animal for the purpose effecting sterilization of the animal. The injection of the chemical sterilant into the dorsal crani... | 10/02/2007 |
| 7250031 | Method and apparatus for assessing vascular endothelial function Vascular endothelial function in terms of flow-mediated dilation (FMD) of peripheral arteries can be assessed reliably by measuring beat-to-beat pulse-wave conduction time (PCT) simultaneously for two symmetric segments of arteries locating on the right and left sid... | 07/31/2007 |
| 7241797 | Method of increasing milk production The invention relates generally to the use of pharmaceutical compositions to increase milk production alone or in combination with certain biological active ingredients. Specifically, the method relates to the use of pharmaceutical compositions that will act on the ... | 07/10/2007 |
| 7226947 | Use of creatine as a fat substitute The invention relates to the use of creatine or creatine salts as a fat substitute to be given to breeding animals and feeder animals. The creatine or creatine salts are used as a substitute for flesh meal, fish meal and/or antimicrobial performance enhancers, growt... | 06/05/2007 |
| 7214709 | Arginine/ascorbic acid mixed powder as an oral supplement A mixture obtained by mixing ascorbic acid powder with arginine powder in a weight ratio (ascorbic acid/arginine) of 1/5 to 20, especially 1/5 to 1/4; and a supplement such as a nutrient preparation and a health-care food containing the mixture. Mixing of arginine p... | 05/08/2007 |
| 7202278 | 4-fluoro-N-indan-2-yl benzamide and its use as a pharmaceutical A method of stimulating the expression of endothelial NO-synthase in a mammal, which method comprises administering a physiologically active amount of 4-fluoro-N-indan- 2-yl benzamide according to the formula (I) ... | 04/10/2007 |
| 7202229 | Aspirin formulation for cardiovascular health The invention relates generally to an aspirin formulation which may comprise additional vitamins, minerals, herbs and supplements and methods for using the same for maintaining cardiovascular health. The aspirin formulation may comprise supplements such as vitamin B... | 04/10/2007 |
| 7201929 | Aspirin formulation for cardiovascular health The invention relates generally to an aspirin formulation which may comprise additional vitamins, minerals, herbs and supplements and methods for using the same for maintaining cardiovascular health. The aspirin formulation may comprise supplements such as vitamin B... | 04/10/2007 |
| 7196065 | Enteral formulation A formulation for enteral administration to a patient is disclosed. ... | 03/27/2007 |
| 7189761 | Nitric oxide donor composition and method for treatment of anal disorders A pharmaceutical composition contains a nitric oxide donor and advantageously an optional corticosteroid and/or topical anesthetic. The composition is useful in a method for treating anal disorders such as anal fissure, anal ulcer, hemorrhoidal disease, levator spas... | 03/13/2007 |
| 7186754 | Use of creatine or creatine compounds for skin preservation The present invention relates to the use of creatine compounds such as, for example, creatine, creatine phosphate or analogs of creatine, such as creatine-pyruvate, creatine-ascorbate, cyclocreatine, 3 guanidinopropionic acid, guanidinoacetate, homocyclocreatine, gu... | 03/06/2007 |
| 7169768 | Method of decreasing atherosclerosis and its complications A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke and peripheral vascular disease wherein the method involves administering to a human or an animal an amount of an inhibitor of the release of LHRH... | 01/30/2007 |
| 7169814 | Guanidinium transport reagents and conjugates Transport reagents and conjugates of therapeutic agents linked to transport reagents are described. In particular, the transport reagents have a plurality of guanidinium moieties that are either contiguous or spaced along a backbone, but are sufficiently removed fro... | 01/30/2007 |
| 7166300 | Agent for inducing hair growth containing extracts of saw palmetto and swertia The present invention consists in a composition comprising a mixture of extracts of saw palmetto and swertia, of derivatives thereof and of active components being part of said extracts. The composition may comprise additional agents and/or extracts, for exam... | 01/23/2007 |
| 7135498 | Nitric oxide donors for inducing neurogenesis There is provided a method of promoting neurogenesis by administering a therapeutic amount of a nitric oxide donor compound to a patient in need of neurogenesis promotion. Also provided is a compound for providing neurogenesis having an effective amount of a nitric ... | 11/14/2006 |
| 7122018 | Device and method for treatment of wounds with nitric oxide Topical exposure of nitric oxide gas to wounds such as chronic non-healing wounds may be beneficial in promoting healing and preparing the wound bed for further treatment and recovery. Nitric oxide gas may be used to reduce the microbial infection, manage exudates s... | 10/17/2006 |
| 7087786 | Process for preparing pesticidal intermediates A process for preparing pesticides or pesticidal intermediates, particularly 5-amino-1 aryl-3-cyanopyrazoles, having the formula said process comprising reacting a compound having the formula ... | 08/08/2006 |
| 7067156 | Dietary supplement for renal dialysis patients A dietary supplement which is formulated for medical patients, particularly renal dialysis patients undergoing a peritoneal renal dialysis treatment regimen. The supplement includes a powdered mixture of calcium caseinate, whey protein, L-carnitine and arginine. The... | 06/27/2006 |
| 7067698 | Bi-directional synthesis of oligoguanidine transport agents Synthesis routes that can be adapted to large scale synthesis of oligoguanidine compounds such as oligoarginine compounds are described which use a perguanidinylation step to convert a group of ω-amino groups to the corresponding guanidinyl groups. These compounds ... | 06/27/2006 |
| 7048918 | Insect bait Disclosed are insect baits for attracting insects such as ants, flies and cockroaches. The baits include amino acids and a sugar. The baits can be combined with an insect toxicant to effectively control and eliminate insect populations. Methods for controlling insec... | 05/23/2006 |
| 7045550 | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy Polyamine effectors are administered locally to provide protection against the adverse side-effects of chemotherapy or radiation therapy, such as alopecia, mucositis and dermatitis. Pharmaceutical preparations comprising one or more polyamine effectors formulated fo... | 05/16/2006 |
| 7022737 | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses Mammals are treated for infections or for conditions associated with pathologically proliferating mammalian cell growth by administration of a manipulator of nitrosative stress to selectively kill or reduce the growth of the microbes or helminths causing the infecti... | 04/04/2006 |
| 7001922 | Peptide deformylase activated prodrugs The invention provides compounds and methods for using them to inhibit the growth of microorganism that expresses Peptide Deformylase, the compounds having the general formula: ... | 02/21/2006 |
| 6995158 | Pharmaceutical preparation containing at least folic acid or a folate and tetrahydrobiopterin (BH4) or derivatives thereof used for the treating or preventing cardiovascular or neurological disorders by modulation of the activity of nitric oxide synthase (NOS) The invention relates to the uses of at least folic acid or a folate and tetrahydrobiopterin (BH4) or derivative thereof for treating or preventing cardiovascular of neurological disorders by modulation of the activity of nitric oxide synthase (NOS). ... | 02/07/2006 |
| 6967219 | Reversing or preventing premature vascular senescence Premature vascular senescence is reversed or prevented in tissue or cells by contacting the tissue or cells with a hydroxyguanidine. This finds application in treatment of patients with a disorder associated with elevated levels of advanced glycation end products in... | 11/22/2005 |
