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| Number | Title | Issue Date |
| 8183289 | 4-substituted phenoxyphenylacetic acid derivatives Compounds of Formula (I): in which R1, R2, R7, R8, R9, R10 and A have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases. | 05/22/2012 |
| 8168677 | Method for treatment of inflammatory bowel disease Method for therapeutic treatment of inflammatory bowel disease, including Crohn's disease, comprising administering to a patient in need thereof a therapeutically effective amount of a composition comprising a retinoid as an active ingredient to treat the inflammato... | 05/01/2012 |
| 8148425 | Pharmaceutical composition containing phloroglucinol and paracetamol The invention relates to a pharmaceutical composition for oral or rectal administration, that contains phloroglucinol and paracetamol in a pharmaceutically acceptable carrier. The inventors have evidenced a synergy developed by these two active ingredients in antisp... | 04/03/2012 |
| 8124655 | Use of LR-90 and LR-102 to overcome insulin resistance The present invention provides methods for ameliorating, overcoming, or inhibiting insulin resistance in a subject, comprising administering to the subject an effective amount of a compound selected from the group consisting of LR-90 and LR-102, or a pharmaceuticall... | 02/28/2012 |
| 8076374 | Glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula (I), or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention d... | 12/13/2011 |
| 8071647 | Method for treatment of adhesion of the intestines Method for suppressing adhesion of the intestines or therapeutic treatment of adhesion of the intestines comprising administering to a patient in need thereof a therapeutically effective amount of 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]b... | 12/06/2011 |
| 8053474 | Compound with carboxyl acid group and amide group and application thereof The present invention discloses compounds with a carboxyl acid group and an amide group which also containing the tertiary amino groups. The carboxyl acid group having a partial negative charge can attract the tertiary amino group with each other to form a quaternar... | 11/08/2011 |
| 8003697 | Disodium salts, monohydrates, and ethanol solvates for delivering active agents The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these deliver... | 08/23/2011 |
| 7915314 | Disodium salts, monohydrates, and ethanol solvates for delivering active agents The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these deliver... | 03/29/2011 |
| 7863329 | Glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention dis... | 01/04/2011 |
| 7838557 | Concentrated X-ray contrast media can act as universal antigens and can inhibit or prevent allergic reactions The present application is directed to the use of X-ray contrast media that act as universal antigens that are labeled herein as “pseudoantigens.” X-ray contrast media have the potential to exist in an aggregated state that is greater in increased concentrations... | 11/23/2010 |
| 7776918 | Remedy for viral disease The object of the present invention is to provide a pharmaceutical composition for preventing or treating viral infectious diseases. The compounds of the present invention have extremely potent anti-HCV activity and HCV growth inhibitory effects, and since they also... | 08/17/2010 |
| 7718700 | Growth factor-binding compounds and methods of use Growth factor binding compounds having a plurality of acyclic isophthalic acid groups attached to a non-peptide organic scaffold and pharmaceutical compositions of the same are disclosed. Methods of administering and using the growth factor binding compounds or the ... | 05/18/2010 |
| 7696248 | Glucagon receptor antagonists, preparation and therapeutic uses The present invention discloses novel compounds of Formula I, or pharmaceutically acceptable salts thereof, which have glucagon receptor antagonist or inverse agonist activity, as well as methods for preparing such compounds. In another embodiment, the invention dis... | 04/13/2010 |
| 7671090 | Inhibitors of αmediated cell adhesion The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a pharmaceutically acceptable salt thereof.... | 03/02/2010 |
| 7659311 | Disodium salts, monohydrates, and ethanol solvates for delivering active agents The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these deliver... | 02/09/2010 |
| 7605180 | Nateglinide-containing preparation The present invention discloses, as a immediate-release preparation useful as an antidiabetic, a nateglinide-containing preparation comprising nateglinide as an active ingredient wherein the nateglinide is amorphous. ... | 10/20/2009 |
| 7579376 | Geranyl compounds This invention provides compounds having excellent antitumor activity, which are represented by the following formulae in which R1, R2, R3, m, n and R4 ha... | 08/25/2009 |
| 7553872 | Compounds and compositions for delivering active agents Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well. ... | 06/30/2009 |
| 7553873 | Glutamate aggrecanase inhibitors The present invention relates to modulators of metalloproteinase activity. ... | 06/30/2009 |
| 7531575 | Method of modulating cellular activity and agents useful for same Described is a rational design of therapeutic and/or prophylactic methods of treating conditions characterized by aberrant or otherwise unwanted microglial cell functioning and rational design methods for treating a range of neurological disorders which are characte... | 05/12/2009 |
| 7507765 | Geranyl compounds This invention provides compounds having excellent antitumor activity, which are represented by the following formulae in which R1, R2, R3, m, n and R4 have the significations as ... | 03/24/2009 |
| 7491748 | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient A carboxylic acid derivative of formula (I): wherein R1 is —COOH, —COOR6, etc.; A is a single bond, alkylene, etc.; R2 is alkyl, alkoxy, etc.; B is a carbocyclic ring or a heterocyclic r... | 02/17/2009 |
| 7456217 | Inhibitors of alpha4 mediated cell adhesion The present invention relates to a phenylalanine derivative of Formula (I) wherein X1 is a halogen atom, X2 is a halogen atom, Q is a CH2R— is a carboxyl group which may be esterified; or a pharmaceutically acceptable salt thereof.... | 11/25/2008 |
| 7429673 | TRPV1 agonists, formulations containing them and uses thereof The compounds of the general formula (I) in which X is represents two hydrogen atoms, a π-bond, oxygen or methylene: R2 is a C6-C12 aryl, or arylalkyl residue: R3 is hydrogen, 2-hydroxyethyl or 2-aminoethyl are useful for the treatment of path... | 09/30/2008 |
| 7427600 | Active agent delivery systems and methods for protecting and administering active agents The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions... | 09/23/2008 |
| 7423066 | Methods, compounds, and compositions for reducing body fat and modulating fatty acid metabolism Methods, pharmaceutical compositions, and compounds for reducing body weight, modulating body lipid metabolism, and reducing food intake in mammals are provided. The compounds of the invention include fatty acid ethanolamide compounds, homologues and analogs of whic... | 09/09/2008 |
| 7419970 | Cosmetic compositions comprising N-acylamino amides The invention concerns novel compounds of the N-acylamino-amide family, compositions, in particular cosmetic or pharmaceutical, containing them, and their use for treating body or face skin ageing, whether chronobiologic or light-induced, and in particular skin agei... | 09/02/2008 |
| 7414037 | Hydrazide-containing CFTR inhibitor compounds and uses thereof The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and treatment of CFTR-mediated diseases and conditions. The compositions a... | 08/19/2008 |
| 7414077 | Therapeutic intervention to mimic the effect of caloric restriction Methods are provided for promoting longevity and decreasing the incidence of ageing associated pathologies (e.g. cancer) by the administration of one or more of the following LFFA: linoleic, oleic, and palmitic acid. Secondary LFFA derived from this set, as well as ... | 08/19/2008 |
| 7405239 | Acylhydrazone derivatives and the use thereof in the inhibition, regulation and/or modulation of kinase signal transduction The invention relates to acylhydrazone derivatives of formula (I), which are SGK inhibitors and can be used for the treatment of diseases and afflictions associated with SGK, such as diabetes, obesity, metabolic syndrome (dyslipidaemia), systematic and pulmonary hyp... | 07/29/2008 |
| 7384982 | Disodium salts, monohydrates, and ethanol solvates for delivering active agents The inventors have discovered that the disodium salt of certain delivery agents has surprisingly greater efficacy for delivering active agents than the corresponding monosodium salt. Furthermore, the inventors have discovered that the disodium salts of these deliver... | 06/10/2008 |
| 7384979 | Substituted amino acids as erythropoietin mimetics This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which ... | 06/10/2008 |
| 7381731 | Pharmaceutical composition comprising citrulline Embodiments of the present invention include compositions and pharmaceutical compositions comprising citrulline and Hmg-CoA reductase inhibitors. Further embodiments relate to the use of such composition treat subjects and stimulating nitric oxide synthase. ... | 06/03/2008 |
| 7371777 | Cyclic compound and PPAR agonist The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. ... | 05/13/2008 |
| 7358390 | Polymorphic forms of nateglinide Provides are crystalline forms of nateglinide, labeled Forms A, C, D, F, G, I, J, K, L, M, N, O, P, Q, T, U, V, Y, α, β, γ, δ, ε, σ, θ and Ω, processes for their preparation and processes for preparation of other crystalline forms of nateglinide. Also provid... | 04/15/2008 |
| 7355069 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance The present invention provides a compound of formula (I), wherein n is 0, 1 or 2 and R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by o... | 04/08/2008 |
| 7354954 | Use of GABA agonists for treatment of spastic disorders, convulsions, and epilepsy According to the subject invention, there is disclosed a method for treating a patient/subject having a spastic disorder, a convulsive disorder, pain or epilepsy which includes administering to the subject having any one of these conditions a therapeutically effecti... | 04/08/2008 |
| 7351857 | Methods of using substituted tetralins and indanes The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes. ... | 04/01/2008 |
| 7351858 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance The present invention provides a compound of formula (I), wherein n is 0, 1 or 2; R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by one ... | 04/01/2008 |
