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| Number | Title | Issue Date |
| 8119691 | Method for treating airway hyper-responsiveness with lipoxin analogs The use of lipoxin analogs for the treatment or prevention of asthma and asthma related diseases is described. In particular, acetylenic lipoxin analogs are effective for the treatment and prevention of eosinophil recruitment involved with the inflammation processes... | 02/21/2012 |
| 8003696 | Composition and method for treating bacterial, viral, fungal diseases, inflammation and pain The present invention is directed to compositions and methods of treating bacterial, viral, fungal diseases; inflammation or inflammatory-related disorders; pain; and skin conditions. The composition comprises an organic solvent extract, which is prepared by the met... | 08/23/2011 |
| 7943667 | Potentiating the effect of compound comprising nitric oxide Treatment of or prophylaxis against the occurrence of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction or infection in the lungs comprises administration into the lung(s) as a gas composition comprising nitric oxide, e.g. ethyl nitrite... | 05/17/2011 |
| 7855232 | Organoselenium compound for cancer chemoprevention A compound containing an alkylene selenocyanate or an alkylene isoselenocyanate moiety effective to prevent the occurrence or progression of cancer or a precancerous condition. The compound can be provided and administered in the form of a pharmaceutical composition... | 12/21/2010 |
| 7767714 | Method of preventing infectious diseases Effective preventive method for infectious diseases, an enhancing method of an infectious disease-preventive action of cystine and composition, food and feed effective for infectious diseases are provided. A method of preventing infectious diseases wherein cy... | 08/03/2010 |
| 7723389 | N-acetylcysteine compositions and methods for the treatment and prevention of drug toxicity The invention provides pharmaceutical compositions for the treatment or prevention of the toxic effects of therapeutic agents and methods of treating or preventing such toxicity using a toxicity reducing amount of N-acetylcysteine either alone or in combination with... | 05/25/2010 |
| 7662857 | Diagnostic agents for pancreatic exocrine function A diagnostic agent for pancreatic exocrine function comprising a dipeptide represented by the following formula (I): X1—R1—Y1 (I) or a pharmaceutically acceptable salt thereof, wherein X... | 02/16/2010 |
| 7598293 | Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorp... | 10/06/2009 |
| 7592372 | Liquid drug preparations Liquid drug preparations characterized by containing fudostein and an acid together with a sweetener such as sugar alcohol, trehalose or a sweetener having a high degree of sweetness. These liquid drug preparations are fudostein-containing liquid drug preparations w... | 09/22/2009 |
| 7589126 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation The present invention relates to a 5-amidino-2-hydroxybenzenesulfonamide derivative represented by the general formula: wherein R1 is a hydrogen atom or an optionally substituted lower alkyl group; | 09/15/2009 |
| 7563822 | Agents for the prevention or treatment of renal diseases The present invention relates to an agent for the prevention or treatment of a renal disease comprising as an active ingredient a 5-amidino-2- hydroxybenzenesulfonamide derivative represented by the general formula: ... | 07/21/2009 |
| 7560487 | Use of (R)—ibuprofen methanesulfonamide and salts thereof in the treatment and prevention of rejection reactions of transplanted organs The use of (R)-ibuprofen methanesulfonamide is described for the preparation of medicaments for the treatment and prevention of functional injury resulting from rejection reactions of transplanted organs. In particular, the use of non-toxic salts of (R)-ibupr... | 07/14/2009 |
| 7557142 | Therapeutic use of methionine to reduce the toxicity of platinum-containing anti-tumor compounds Methods of preventing or reducing ototoxicity in patients undergoing treatment with therapeutically effective amounts of platinum-containing chemotherapeutic agents such as cisplatin or aminoglycoside antibiotics are provided. The methods comprise administering an e... | 07/07/2009 |
| 7501452 | Treatment of xerostomia Xerostomia is treated with a sulfur-containing antioxidant, such as N-acetylcysteine. Delivery compositions including polyoxyalkylene block copolymers may be used, which may be formulated to exhibit reverse-thermal viscosity behavior. ... | 03/10/2009 |
| 7427619 | Formulation of amino acids and riboflavin useful to reduce toxic effects of cytotoxic chemotherapy Pharmaceutical compositions effective in alleviating or reducing the effects of fatigue and weakness associated with cancer and cancer chemotherapy are disclosed. The pharmaceutical compositions of the present invention comprise riboflavin, effectors of the urea cyc... | 09/23/2008 |
| 7423065 | Therapeutic use of methionine-derivitives to reduce the toxicity of noise Methods of preventing or reducing hearing or balance loss and damage to ear cells in patients who have been exposed to toxic levels of noise are provided. These methods comprise administering an effective amount of a methionine protective agent, such as D-methionine... | 09/09/2008 |
| 7423064 | Composition for treating bacterial, viral, fungal diseases, inflammation and pain The present invention is directed to compositions and methods of treating bacterial, viral, fungal diseases; inflammation or inflammatory-related disorders; pain; and skin conditions. The composition comprises an organic solvent extract, which is prepared by the met... | 09/09/2008 |
| 7399755 | Formulations comprising multiple dietary and endogenously made antioxidants and B-vitamins and use of same The invention is directed to formulations comprised of multiple dietary and endogenously made antioxidants and B-vitamins and the use of these formulations in preventing and treating coronary artery disease. ... | 07/15/2008 |
| 7396859 | Perturbed membrane-binding compounds The present invention provides uses of compounds that bind selectively to cells undergoing perturbations and alterations of their normal membrane organization, while binding to a lesser degree to cell having membranes of normal organization. These compounds are term... | 07/08/2008 |
| 7390833 | Method for treating ADAMTS-5-associated disease The present invention relates to methods of treating ADAMTS-5-associated diseases and particularly osteoarthritis comprising administering an agent capable of modulating ADMATS-5 activity to a subject afflicted with the disease. The agent is preferably a biaryl sulf... | 06/24/2008 |
| 7388030 | Suppressors of anemia and appetite suppressors and methods for suppressing anemia and suppressing appetite The present invention provides a method for suppressing hemolytic anemia by selectively ameliorating reticulocyte increase and iron deposition on spleen caused as the side effects of methionine. The present invention also provides an appetite suppressor with reduced... | 06/17/2008 |
| 7384979 | Substituted amino acids as erythropoietin mimetics This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which ... | 06/10/2008 |
| 7378387 | Method of suppressing immune response by reducing intracellular content of glutathione in macrophages and monocytes A method of suppressing immune responses, comprising administering to a patient in need thereof an effective amount of a composition comprising a substance capable of reducing the content of reductive glutathione in macrophages. ... | 05/27/2008 |
| 7375248 | Inhibitors of matrix metalloproteinase Compounds of formula (I): wherein R1 represents optionally substituted C4-12 alkyl, optionally substituted C2-6alkylaryl, or optionally substituted 5- or 6-membered aryl or hete... | 05/20/2008 |
| 7371897 | Preparation method for (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid Provided is a novel preparation method of (Z)-7-chloro-((S)-2,2-dimethylcyclopropanecarboxamido)-2-heptenoic acid represented by the following formula (1), a key intermediate of cilastatin used as a supplement to imipenem. The novel preparation method of the inventi... | 05/13/2008 |
| 7365196 | Sulphonamido-substituted bridged bicycloalkyl derivatives A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures. The compounds are inhibitors of gamma-secretase, and hence are useful in the treatment of and/or prevention of Alzheimer's disease. ... | 04/29/2008 |
| 7361783 | (2S)-2-ethylphenylpropionic acid derivative The invention provides novel (2S)-2-ethylphenylpropanoic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor (PPAR) α to activate and exhibit lipid-lowering effect, inhibitory effect on the arteriosclerosis, ant... | 04/22/2008 |
| 7355069 | Ortho-substituted benzoic acid derivatives for the treatment of insulin resistance The present invention provides a compound of formula (I), wherein n is 0, 1 or 2 and R1 represents halo, a C1-4alkyl group which is optionally substituted by one or more fluoro, a C1-4alkoxy group which is optionally substituted by o... | 04/08/2008 |
| 7351857 | Methods of using substituted tetralins and indanes The invention features tetralin and indane compounds, compositions containing them, and methods of using them as PPAR alpha modulators to treat or inhibit the progression of, for example, diabetes. ... | 04/01/2008 |
| 7351703 | Sulfonylamino carboxylic acid N-arylamides as guanylate cyclase activators The present invention relates to compounds of the formula I in which A1, A2, R2 and R3 have the meanings indicated in the claims, which are valuable pharmaceutical active compound... | 04/01/2008 |
| 7335384 | Nutrient compositions for the treatment and prevention of inflammation and disorders associated therewith The present disclosure describes a novel composition for the treatment and/or prevention of neurogenic inflammation. Such composition is also useful in the treatment and/or prevention of disease states and conditions associated with neurogenic inflammation. Such dis... | 02/26/2008 |
| 7335776 | Remedies for depression containing EP1 antagonist as the active ingredient A pharmaceutical composition for the treatment and/or prevention of depression comprising a compound having an antagonistic activity for EP1 receptor which a prostaglandin E2 receptor subtype. EP1 antagonist is useful for the ... | 02/26/2008 |
| 7335686 | Method and composition for treating osteoporosis This invention relates to a novel class of acidic amino acid/dicarboxylic acid derivatives (sulfonic acid/sulfate derivatives of naturally occurring amino acids and their amides) useful as inhibitors of osteoclastogenesis. The invention also provides methods of usin... | 02/26/2008 |
| 7326690 | Modulation of cell fates and activities by phthalazinediones Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survi... | 02/05/2008 |
| 7323452 | Method for the accelerated in vivo removal of ethanol A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives... | 01/29/2008 |
| 7321001 | Asthma and allergic inflammation modulators Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins inv... | 01/22/2008 |
| 7318930 | Control methods for boring bark beetles A composition which causes adult boring bark beetles to discontinue boring, discontinue laying eggs and become disoriented and bore out of the tree or cease boring altogether and die is described. Additional tests have shown that beetles will not infest a tree which... | 01/15/2008 |
| 7318428 | Paint ball gun having paint ball dispenser with threaded connector A paint ball gun is disclosed including a dispenser having a locking connector designed to lockingly engage a locking connector on a gun feed tube or one end of a hollow connecting member. ... | 01/15/2008 |
| 7317040 | Nitric oxide synthase inhibitor phosphate salt A compound of formula (I): namely (2S)-2-amino-4-{[2-(ethanimidoylamino)ethyl]thio}butanoic acid, compound with phosphoric acid, or a solvate or physiologically functional derivative thereof, is useful as a relat... | 01/08/2008 |
| 7314889 | Compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, the... | 01/01/2008 |
