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| Number | Title | Issue Date |
| 5731298 | Method for the treatment of scars and keloids A method and a pharmaceutical composition for non-topical wound, scar and keloid treatment is described which contains cross-linked glycosaminoglycans and conventional pharmaceutical auxiliary and/or carrier substances. The pharmaceutical composition is p... | 03/24/1998 |
| 5714477 | Pharmaceutical composition containing heparin, heparin fragments or their derivatives in combination with glycerol esters The present invention relates to pharmaceutical compositions containing heparin or heparin fragments or their derivatives in combination with one or more glycerol esters of at least one fatty acid as single absorption enhancer. The compositions are useful... | 02/03/1998 |
| 5709993 | Process for anticoagulation during extracorporeal blood circulation sequentially using citrate or nafamostat and heparin Process for preventing activation of enzyme systems such as coagulation and activation of complement system or bradykinin system in extracorporeal blood circulation in haemodialysis and similar procedures, by means of sequential anticoagulation, which com... | 01/20/1998 |
| 5707974 | Method of synthesis of 2-O-desulfated heparin and use thereof for inhibition of elastase and cathepsin G A method and medicament for the inhibition of neutrophil elastase and cathepsin G in mammals comprising administering a treatment effective amount of 2-O-desulfated heparin to a mammal in need thereof. The medicament preferably is administered by aerosoli... | 01/13/1998 |
| 5707973 | Sulfated polysaccharids for treatment or prevention of thromboses The invention relates to new mixtures of sulfated oligosaccharides having the general structure of heparin constitutive oligosaccharides, having an average molecular mass of 6&#b1;0.6 kD, a polydispersiveness close to 1 and the capacity of inhibiting the ... | 01/13/1998 |
| 5707604 | Vivo agents comprising metal-ion chelates with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and kinetic-spatial profiles This application concerns novel agents comprising cationic or chemically basic metal chelators in association with hydrophilic carriers of anionic or chemically acidic saccharides, sulfatoids and glycosaminoglycans. In certain embodiments, the agents comp... | 01/13/1998 |
| 5700787 | Capsular polysaccharide immunomodulator Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto als... | 12/23/1997 |
| 5696099 | Topical preparations for the treatment of acne and acneiform dermatitis Topical Preparations for the treatment of acne and acneiform dermatitis containing as active principle therapeutically active quantities of N,N'bis (2-hydroxyethyl) nonandiamide together with dermatansulfate lithium salt, having molecular weight ranging f... | 12/09/1997 |
| 5696100 | Method for controlling O-desulfation of heparin and compositions produced thereby Methods of making and using, as prophylactics or therapeutics for preventing or treating certain diseases including cancer, O-desulfated heparin compositions, preferably 2-O, 3-O desulfated heparin compositions, wherein the methods permit regulating the d... | 12/09/1997 |
| 5690910 | Method for treating asthma A method of treating a patient suffering from antigen-induced asthma who has been challenged with an antigen, or providing chronic treatment to an asthma patient to reduce airway hyperresponsiveness, comprising intrabronchial administration to the patient... | 11/25/1997 |
| 5686432 | Use of some glycosaminoglycans in the peritoneal dialysis The use of some glycosaminoglycans like sulodexide, low molecular weight heparin and low molecular weight dermatan sulfate and of the medicines by parenteral use that contain them in the treatment of patients suffering from chronic renal insufficiency sub... | 11/11/1997 |
| 5686431 | Methods of using low molecular weight heparins for treatment of pathological processes The present invention relates to methods for the prevention and/or treatment of pathological processes involving the induction of TNF- secretion comprising a pharmaceutically acceptable carrier and a low molecular Weight heparin (LMWH). In the phar... | 11/11/1997 |
| 5679659 | Method for making heparinized biomaterials An improved method of making a medical device having immobilized heparin on a blood-contacting surface in which heparin is admixed with sufficient periodate to react with not more than two sugar units per heparin molecule in a buffer solution having a pH ... | 10/21/1997 |
| 5679654 | Capsular polysaccharide immunomodulator Methods and products for protecting against abscess formation associated with surgery, trauma or diseases that predispose the host to abscess formation are provided. Methods for forming immunomodulators and pharmaceutical compositions relating thereto als... | 10/21/1997 |
| 5670135 | Ultrasonic contrast agent comprising carbohydrate particles A method of contrast enhanced ultrasonic diagnostic imaging comprising: administering to a subject a contrast enhancing amount of spheres or particles comprising a matrix enclosing a contrast agent which reflects sound waves, said matrix being a biocompat... | 09/23/1997 |
| 5668118 | Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G A method and medicament for the inhibition of neutrophil elastase and cathepsin G in mammals comprising administering a treatment effective amount of 2-O-desulfated heparin to a mammal in need thereof. The medicament preferably is administered by aerosoli... | 09/16/1997 |
| 5668119 | Topical pharmaceutical containing heparin and method of treatment A topical pharmaceutical for the treatment of thrombosis or hematoma, and a method for the topical treatment of thrombosis or hematoma, are described. The topical pharmaceutical contains effective thrombosis-inhibiting amounts of heparin, allantoin, thymo... | 09/16/1997 |
| 5668116 | Anti-inflammatory compounds and compositions A method for inactivating viruses which comprises the step of contacting the virus with an effective amount of a substantially pure divalent metal ion chelate of a polysulfate of xylan having glycosidically linked D-glucuronyl side chains with divalent me... | 09/16/1997 |
| 5650386 | Compositions for oral delivery of active agents Modified amino acid compounds useful for the delivery of active agents are provided. The amino acids, non-alpha-amino acids, have been modified by acylation on the amino group particularly with phenyl or cyclohexyl groups. These groups have a variety of s... | 07/22/1997 |
| 5648074 | Compositions and methods for disinfecting contact lenses and reducing proteinaceous deposit formation Compositions and methods for disinfecting contact lenses are disclosed. In one embodiment, the present compositions include a liquid medium containing chlorine dioxide precursor in an amount effective to form, when activated, a chlorine dioxide-containing... | 07/15/1997 |
| 5646178 | Cranberry extract and biologically active compounds derived therefrom Compounds isolated from plant materials of the genus Vaccinium, which have biological activity measurable as inhibition with adhesion of bacterial cells to surfaces, are described. The specific compounds include procyanidins, leucocyanin and leucodelphini... | 07/08/1997 |
| 5631243 | Collagen-based viscoelastic solution for visco-surgery The present invention relates to a method of treating a patient with visco-surgery, particularly ocular visco-surgery, utilizing a collagen-based viscoelastic solution having a reversibly high viscosity. The invention also relates to collagen-based viscoe... | 05/20/1997 |
| 5629284 | Method for treating retinal diseases A method for treating retinal diseases includes administering an effective amount of midkine to patients suffering from retinal diseases. The method of the invention is effective in ameliorating optical disorders of retinas and is quite safe.... | 05/13/1997 |
| 5624839 | Process for culturing hepatocytes for formation of spheroids Hepatocytes spheroids can be formed by culturing hepatocytes in a culture vessel using a lipid-bound glycosaminoglycan as a culture substrate. Floating spheroids of hepatocytes can be obtained efficiently, which are capable of maintaining liver-specific f... | 04/29/1997 |
| 5612321 | Antioxidant grafted polysaccharides Grafted polysaccharide compositions comprising polysaccharides grafted with antioxidants on at least one hydroxyl group of the polysaccharide. The use of antioxidant grafted polysaccharides or antioxidant grafted crosslinked polysaccharides as a treatment... | 03/18/1997 |
| 5607840 | Protein hydrolysate derived from mucosa tissue A protein hydrolyzate is produced from mucosa tissue of pigs, cattle or sheep by providing an aqueous mixture of the tissue, hydrolyzing the tissue with a proteolytic enzyme at a salt concentration of less than 0.1 molar to produce a digest solution conta... | 03/04/1997 |
| 5605891 | Use of polysaccharides in acute peripheral neuropathies Polysaccharides and more in particular glycosaminoglycans, their mixtures, fractions and derivatives thereof are effective agents in the therapy of acute peripheral neuropathies of traumatic and ischemic origin and in the therapy of acute peripheral neuro... | 02/25/1997 |
| 5599801 | Purified heparin fractions, method for obtaining them and pharmaceutical compositions containing them Heparin fractions obtained by nitrous depolymerization, containing at most 150 ppb of total N-nitroso compounds, prepared by subjecting heparins of natural origin which have been depolymerized with a nitrite to the action of UV radiation.... | 02/04/1997 |
| 5583027 | Enzyme intended for the fragmentation of N-acetylheparosan, production of preparations containing this enzyme and fragmentation process using this enzyme The invention relates to an enzyme capable of fragmenting a high molecular mass N-acetylheparosan. This enzyme was obtained with the strain Escherichia coli (K5), strain SEBR 3282.... | 12/10/1996 |
| 5583121 | Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes A method of treating hypovolemic shock and related shock syndromes by the administration of substantially non-anticoagulant heparinoids without the hemorrhaging problems generally associated with heparin; such syndromes include degradation of the microvas... | 12/10/1996 |
| 5580789 | Method for collecting blood A process is disclosed for the production of an anticoagulant composition which allows for the accurate analysis of blood electrolyte concentrations. Also disclosed is the anticoagulant composition produced in accordance with the disclosed method and an a... | 12/03/1996 |
| 5578584 | Feed containing galacto-oligosaccharides for domestic fowls A feed for domestic fowls which comprises a galacto-oligosaccharide composition which is prepared by heat-treating lactose in the presence of a mineral acid; or by adding an inorganic acid to lactose and then heat-treating the resulting mixture using an e... | 11/26/1996 |
| 5576304 | Antithrombotic composition A pharmaceutical composition comprising dermatan sulphate, together with a low molecular weight heparin, free or fixed combination, is useful as a antithrombolytic agent with a low risk of bleeding complications.... | 11/19/1996 |
| 5565432 | Smooth muscle cell proliferation inhibitors This invention comprises polyanionic benzylglycosides of benzene triacid amides of the general formula I ##STR1## wherein each of R1, R2, R3, and R4 are, independently, H, SO3 M, or ##STR2##... | 10/15/1996 |
| 5552323 | Method of blending an anticoagulant A blended heparin salt for use as an anticoagulant in a blood sample, which substantially eliminates a skew in a determined amount of ionized calcium imparted by the heparin in the blood sample. The blended heparin salt comprises a proportional blend of a... | 09/03/1996 |
| 5550116 | N,O-sulphated heparosans and pharmaceutical compositions containing them The invention relates to N,O-sulphated heparosans consisting of chains or of a mixture of chains of molecular mass between 1500 and 15,000 Da, characterized by a repeated disaccharide structure of formula I: ##STR1## in which: E represents an acetyl ... | 08/27/1996 |
| 5543403 | Sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type The invention relates to sulfated glycosaminoglycanoid derivatives of the heparin and heparan sulfate type, of which N-sulfate, N-acetate, and hydroxy groups, are replaced by alkoxy, aryloxy, aralkoxy, or O-sulfate groups. The compounds have antithromboti... | 08/06/1996 |
| 5541166 | Sulphated polysaccharides having anti-metastatic and/or anti-inflammatory activity A method of anti-metastatic and/or anti-inflammatory treatment of an animal or human patient comprises administration to the patient of an effective amount of at least one sulphated polysaccharide which blocks or inhibits endoglycosidase, particularly hep... | 07/30/1996 |
| 5540928 | Extraluminal regulation of the growth and repair of tubular structures in vivo A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissu... | 07/30/1996 |
| 5541155 | Acids and acid salts and their use in delivery systems The present invention relates to a delivery system, and in particular to carboxylic acids for use as a delivery system of sensitive agents such as bioactive peptides. The carboxylic acids and salts can form non-covalent mixtures with biologically-active a... | 07/30/1996 |
