Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 4694023 | Alpha-alkyl polyolefinic carboxylic acids and derivatives thereof useful in the treatment of psoriasis and allergic responses Polyolefinic compounds represented by the general formula ##STR1## in which R and R1 are each hydrogen or an alkyl group of from 1 to 5 carbon atoms; R2 is an alkyl group of from 1 to 5 carbon atoms; R3 is hydroxyl, a... | 09/15/1987 |
| 4689344 | Long-chain ,ω-dicarboxylic acids and derivatives thereof and pharmaceutical compositions containing them A novel class of compounds has been found to be effective in blocking cholesterol and neutral lipid synthesis in-vivo without adversely affecting energy metabolism, useful for the treatment of obesity, hyperlipidemia and maturity-onset diabetes. The activ... | 08/25/1987 |
| 4649040 | Therapy for retinoid pathogenesis The present invention discloses a pharmaceutical composition and a method of treating retinoid induced pathogenesis. The pathological effect of retinoid is ameliorated by a suitable dose of a rescuing agent selected from the group consisting of choline ch... | 03/10/1987 |
| 4648996 | Phenyl substituted-2,4,6,8-nonatetraenoic acid The compounds 9-phenyl-3,7-dimethyl-2,4,6,8 nonatetraenoic acids wherein the phenyl group is substituted with an alkyl, aminoalkyl, hydroxyalkyl, alkoxy, hydroxyalkylamino, and a hydroxy alkoxy group, and derivatives thereof which are used as disease modi... | 03/10/1987 |
| 4629736 | Fatty acid derivatives and process of producing them Fatty acid derivatives represented by the general formula ##STR1## and salts thereof. The compounds of this invention have excellent fibrinolytic action and a highly improved solubility.... | 12/16/1986 |
| 4628061 | Prostaglandins Novel compounds have a formula (I) ##STR1## wherein ##STR2## represents a bicyclo [2,2,1] hept-2Z-ene, bicyclo [2,2,1] heptane, 7-oxa-bicyclo [2,2,1] hept-2Z-ene, 7-oxa-bicyclo [2,2,1] heptane, bicyclo [2,2,2] oct-2Z-ene or bicyclo [2,2,2] ... | 12/09/1986 |
| 4626529 | Oily compositions comprising a dermatological active principle, intended for the treatment of the scalp or skin The present invention discloses a homogeneous oily composition essentially consisting of a dermatological active principle, an oily compound and an oil-soluble surface-active component, the oil-soluble surface-active component comprising an anionic surfac... | 12/02/1986 |
| 4622339 | Novel norbornane- and norbornene-carboxylic acid amides thromboxan antagonists Norbornane- and norbornene-carboxylic acid amides of the formula ##STR1## in which ##STR2## represents the part structure ##STR3## A represents a ##STR4## or --CH2 --CH2 -- group, R1 and R2 | 11/11/1986 |
| 4613618 | Method for treating disorders of lipid metabolism using benzene sulfonamides The invention relates to new medicaments having lipid regulating properties and processes for their preparation. The medicaments according to the invention contain as active principle at least one compound, (or its corresponding optical isomer) of the ary... | 09/23/1986 |
| 4608391 | Catecholamine derivatives, a process for their preparation and pharmaceutical compositions thereof New dopamine derivatives are disclosed, which are tertiary amines and which exhibit especially dopaminergic properties, and which have the formula ##STR1## wherein R1 signifies an alkyl group containing at least 4 carbon atoms, a cycloalky... | 08/26/1986 |
| 4603146 | Methods for retarding the effects of aging of the skin Various effects of aging of skin due to impairment of differentiation of epidermal epithelial cells and loss of collagen fibers, abnormal changes in elastic fibers and deterioration of small blood vessels in the dermis of the skin are retarded by applying... | 07/29/1986 |
| 4596823 | Prostaglandins Novel compounds have a formula (I) ##STR1## wherein ##STR2## represents a bicyclo[2,2,1]hept-2Z-ene, bicyclo[2,2,1]heptane, 7-oxabicyclo[2,2,1]hept-2Z-ene, 7-oxabicyclo[2,2,1]heptane, bicyclo[2,2,2]oct-2Z-ene or bicyclo[2,2,2]octane substit... | 06/24/1986 |
| 4562006 | Cycloheptadiene derivatives Cycloheptadiene analogues of arachidonic acid as well as their cyclopropyl intermediates are described as inhibiting human leukocyte lipoxygenase and antagonizing SRS-A. Methods of manufacture and pharmaceutical compositions are described. The compounds a... | 12/31/1985 |
| 4545977 | Compositions and methods for treating severe acne with isotretinoin A therapeutically effective amount of isotretinoin is co-administered to patients suffering from severe cystic acne with a protective amount of taurine which reduces the side effects of isotretinoin.... | 10/08/1985 |
| 4542160 | Method of use of bicycloheptane substituted prostaglandin analogs as cardiovascular agents Bicycloheptane substituted prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.... | 09/17/1985 |
| 4434178 | Antiperspirants Aluminum compounds containing organic groups of the formula ##STR1## when R1 and R2 are as hereinafter set forth are disclosed as having activity as antiperspirants. Antiperspirant compositions containing one or more of these co... | 02/28/1984 |
| 4430345 | Prostaglandins Novel bicyclo [2,2,1] heptanes and hept-2Z-enes are substituted at the 5-position by a 6-carboxyhex-2-enyl group or a modification thereof, and at the 6-position by an aldoxime or ketoxime group which is O-substituted by an aliphatic hydrocarbon residue, ... | 02/07/1984 |
| 4424202 | Azelaaldehydates as psychotropic agents A method for producing a psychotropic response, especially for alleviating the symptoms of alcohol withdrawal, comprises administering to a human or animal subject in need thereof a psychotropically effective non-toxic amount of an azelaaldehydate. A comp... | 01/03/1984 |
| 4393075 | Quinone compounds and their use in suppressing the production of SRS-A in mammals New quinone compounds of the formula: ##STR1## wherein R1 is methyl or methoxy, or the two R1 groups jointly represent --CH.dbd.CH--CH.dbd.CH--; X is --CH.dbd.CH-- or --C.dbd.C--; Y1 is hydrogen, hydroxyl, carboxyl, c... | 07/12/1983 |
| 4386103 | Dichloroamino acid derivatives useful as potent germicidal and fungicidal agents Dichloroamino acid derivatives other than -dichloroamino acids are prepared from chlorination of corresponding amino acids, and are found to be potent germicidal and fungicidal agents.... | 05/31/1983 |
| 4386086 | Method for controlling ectoparasitic Acarina A method of controlling ectoparasitic Acarina that bore into and through the dermal integument of warm blooded animals by orally administering an 2-aryl-1,3-indandione and derivatives to said animals in an amount sufficient to kill said ectoparasites.... | 05/31/1983 |
| 4378373 | Derivatives of benzoylphenoxyalkanoic acids having normolipemizing activity Derivatives of benzoylphenoxyalkanoic acids corresponding to the formula: ##STR1## wherein: X represents for example a halogen, R1 and R2 represent for example alkyl groups, R represents for example an aminoacid; and the salts t... | 03/29/1983 |
| 4340603 | Novel inotropic prodrugs Novel, transient inotropic prodrug forms of the N-(2-phenylethyl)-ω-phenylalkylamines, notably of dobutamine, have (i) the structural formula (I): ##STR1## with the proviso that at least one R1, R2 or OR1, when ... | 07/20/1982 |
| 4338333 | Ethanamine derivatives their preparation and use in pharmaceutical compositions The compounds of formula (II): ##STR1## in which R1 is a hydrogen, fluorine, chlorine or bromine atom or a hydroxyl, hydroxymethyl, methyl, methoxyl, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethy... | 07/06/1982 |
| 4312631 | Surface-active compounds based on natural rosin acids Compounds of the invention are obtained by oxyalkylating natural rosin acids, disproportionated rosin acids or rosin acids modified with aromatic hydroxy compounds or with cycloalkyl and especially aralkyl and aryl compounds capable of splitting off halog... | 01/26/1982 |
| 4294852 | Skin treating compositions The invention relates to a composition for treatment and control of excessively thickened, inflexible and scaly stratum corneum which often fissures into the dermis resulting in foci of bleeding and inflammation which are symptomatic of numerous altered s... | 10/13/1981 |
| 4281018 | Novel 4-[(carboxyl- and sulfamyl-substituted alkyl)-amino]benzoic acids and analogs This disclosure describes novel 4-[(carboxyl- and sulfamyl-substituted alkyl)amino]benzoic acids and analogs which are useful as hypolipidemic and antiatherosclerotic agents.... | 07/28/1981 |
| 4235988 | Delivery means for biologically active agents A sustained release delivery means comprising a biologically active agent and a hydrophilic linear block poly oxyalkylene- polyurethane copolymer.... | 11/25/1980 |
| 4200647 | Vitamin A compositions to treat rheumatic disease Compositions and methods for treating rheumatic diseases with vitamin A compounds are disclosed.... | 04/29/1980 |
| 4193931 | Polyene compounds Novel 7-(substituted indanyl or naphthyl)-3-methyl-octa-2,4,6-triene derivatives useful as anti-tumor agents are disclosed.... | 03/18/1980 |
| 4169145 | ω-Nor-cycloalkyl-13,14-dehydro-prostaglandins ω-NOR-CYCLOALKYL-13,14-DEHYDRO-PROSTAGLANDIN COMPOUNDS, SPECIFICALLY 13,14-DEHYDRO-17-CYCLOHEXYL-20,19,18-TRINOR-PGF2 having antiulcer and luteolytic activity, are disclosed.... | 09/25/1979 |
| 4154851 | Benzylamino alkanoic acid derivatives, using compositions containing the same, and methods for utilizing said derivatives and compositions This invention relates to novel ω-benzylamino alkanoic acids, to their salts with an organic or mineral base or with an organic or mineral acid. These alkanoic acids may be in a racemic form or resolved into their optically-active enantiomers. They are p... | 05/15/1979 |
| 4115586 | Antihyperthermic use for prostaglandins The present invention provides a method whereby pyrogen-induced, prostaglandin-induced and idiopathic fever is alleviated by systemic administration of a hypothermic prostaglandin. The hypothermic prostaglandins of the present invention are ω-aryl-PGF-ty... | 09/19/1978 |
| 4103029 | Amino substituted arylthio-alkanoic acids having hypolipidemic activity This invention relates to novel compounds and compositions of amino substituted arylthio-alkanoic acid, the corresponding pharmaceutically-acceptable salts and the esters thereof. The invention also relates to methods for reducing plasma lipid levels in a... | 07/25/1978 |
| 4087550 | Hydroxylated amine thioethers for improving the greasy and unaesthetic appearance of the hair and skin A method and composition for combatting the greasy and unaesthetic appearance of the hair and to improve the appearance of the skin comprises in a carrier at least one active component of the formula ##STR1## wherein R1 and R2 a... | 05/02/1978 |
| 4087544 | Treatment of cranial dysfunctions using novel cyclic amino acids The present invention is concerned with new cyclic amino acids and with the preparation thereof.... | 05/02/1978 |
| 4075318 | Skin protective compositions Compositions effective for protecting the skin from dermatologic irritation are formed by incorporating a protective agent which is an organic compound containing two or more polar groups, e.g. carboxyl groups, which are separated by at least 15 atoms the... | 02/21/1978 |
| 4058623 | Prostaglandin-containing lyophilized powders Lyophilized prostaglandin-containing powders are stabilized with tris(hydroxymethyl)-aminomethane hydrochloride.... | 11/15/1977 |
| 3959492 | Method for reducing serum blood cholesterol A method of lowering blood cholesterol using 3,4,5-trimethoxybenzoyl-5-amino caproate sodium and related compounds is disclosed.... | 05/25/1976 |
| 3937801 | Reducing the incidence of gastrointestinal side effects during the treatment of inflammatory conditions with antiinflammatory drugs A method is disclosed for inhibiting and alleviating gastrointestinal side effects often encountered during therapy with antiinflammatory agents such as indomethacin, phenylbutazone, oxyphenylbutazone and the like. The method comprises the administration ... | 02/10/1976 |
