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| Number | Title | Issue Date |
| 8071644 | Combinations of adapalene and benzoyl peroxide for treating acne lesions Adapalene or a pharmaceutically acceptable salt thereof formulated into a pharmaceutical composition is useful for reducing the number of acne lesions, via daily topical application, in combination or in association with benzoyl peroxide (BPO); such treatment may be... | 12/06/2011 |
| 8044098 | Use of hydroxybenzoic acids and their esters and analogues for preventing or treating virus infection This invention provides hydroxybenzoic acids, their esters and analogues thereof that are useful for the prevention and/or treatment of virus infection such as HBV, papillomavirus and/or herpes virus infection. ... | 10/25/2011 |
| 7589125 | 2,4-dihydroxybenzoic acid derivatives The present invention relates to novel compounds of formula (I) and to the salts, solvates and prodrugs thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful for the treatment or prevention of psoria... | 09/15/2009 |
| 7407985 | Compounds that abrogate DNA damage induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to... | 08/05/2008 |
| 7399766 | Soluble amide & ester pyrazinoylguanidine sodium channel blockers The present invention provides a pyrazinoylguanidine compound represented by formula (I): where the structural variables are as defined herein. The compounds are useful for promoting hydration of mucosal surfaces. ... | 07/15/2008 |
| 7368593 | Method of selective esterification A method of preparing a compound of formula I wherein R is a hydrocarbon and n is an integer from 1 to 5, including the steps of: contacting a compound of formula II with a compou... | 05/06/2008 |
| 7355081 | Curcumin analogues and uses thereof The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treat... | 04/08/2008 |
| 7314888 | Compounds and medicinal use thereof A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: | 01/01/2008 |
| 7307078 | Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardio... | 12/11/2007 |
| 7300646 | Skin lightening agents, compositions and methods Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or... | 11/27/2007 |
| 7241806 | Synergistic and residual pesticidal compositions containing plant essential oils with enzyme inhibitors Synergistic and residual pesticidal compositions containing synergistic and residual mixtures of plant essential oils in admixture with enzyme inhibitors, with or without other compounds not previously used as active ingredients in pesticidal formulations. In additi... | 07/10/2007 |
| 7230003 | Aromatic prodrugs of propofol, compositions and uses thereof Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pa... | 06/12/2007 |
| 7229949 | Safe delivery system for agriculturally active material A safe delivery system of agriculturally active material is formed using an encapsulation process. A microencapsulated suspension of agriculturally active material includes an encapsulating agent formed from a graft copolymer of starch and at least one vinyl monomer... | 06/12/2007 |
| 7157078 | Devices and methods for eliminating termite colonies This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to ... | 01/02/2007 |
| 7125869 | Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the field... | 10/24/2006 |
| 7122543 | Substituted benzoic acid derivatives having NF-κB inhibiting action A substituted benzoic acid derivative which is represented by the following formula (I) and has an NF-κB inhibiting action (in the formula, R3, R4 and R5 each independently represents a hydrogen atom, an alkyl group having 1 to 6 ca... | 10/17/2006 |
| 7115728 | Human peroxisome proliferator activated receptor γ The present invention relates to a novel human peroxisome proliferator activated receptor, hPPARγ. hPPARγ differs from the mouse peroxisome proliferator activated receptor γ in the nucleotide sequence and the amino acid sequence. The invention provides isolated, ... | 10/03/2006 |
| 7098025 | Human peroxisome proliferator activated receptor gamma (pparγ) gene regulatory sequences and uses therefor This invention relates to the isolation and cloning of the promoter and other control regions of human PPARγ gene. It provides a method for identifying and screening for agents useful for the treatment of diseases and pathological conditions affected by the level o... | 08/29/2006 |
| 7081458 | Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors i... | 07/25/2006 |
| 7074826 | R-NSAID esters and their use The present invention concerns esters of R-enantiomers of a non-steroidal anti-inflammatory drug, which is substantially free from the S-enantiomer. The compounds of the invention may be used in treating a disease or illness in a mammal. To this end, a composition c... | 07/11/2006 |
| 7072771 | Selective PARP-1 targeting for designing chemo/radio sensitizing agents Poly(ADP-ribose) polymerase-1 (PARP-1) is a central signaling enzyme in a cell nucleus. PARP-1 is a target for the development of radio and chemo sensitizing agents in cancer treatment as well as providing protection from stroke. An SH3 domain and an SH3 ligand doma... | 07/04/2006 |
| 7037535 | Method and composition for neutralizing house dust mite feces Methods for neutralizing dust mite feces are disclosed. In one embodiment, a botanical extract having a BAPNA-Trypsin Inhibition (IC50×10−3 (%, v/v or w/v) of from about 0.01 to about 500 and a sufficient solubility in water is introduced in... | 05/02/2006 |
| 7034046 | NR1H4 nuclear receptor binding compounds The present invention relates to compounds according to the general formula (I) which bind to the nuclear receptor, NR1H4, and act as agonists and antagonists of the NR1H4 receptor. The invention further relates to the treatment of diseases and/or conditions through... | 04/25/2006 |
| 6974584 | Pesticidal compositions containing plant essential oils against human body louse Pesticidal compositions for the control of human body louse containing one or more plant essential oils. In addition, the present invention is directed to a method for controlling human body louse by applying a pesticidally-effective amount of the above pesticidal c... | 12/13/2005 |
| 6949585 | Cyclooctanone derivatives and cyclodecanone derivative, and use thereof The present invention provides a compound which has cytokine production inhibitory activity and is useful for the treatment of diseases which is associated with cytokine. The compound is represented by the following general formula (I) [wherein A represents a cyclic... | 09/27/2005 |
| 6943196 | NF-κB inhibitor comprising phenylmethyl benzoquinone as the active ingredient An NF-κB inhibitor having as an active ingredient a benzoquinone derivative represented by the general formula (1) wherein R1, R2, and R3 are each independently H, alkyl having 1 to 5 carbons, or alkoxy having 1 to 5 carbons; R... | 09/13/2005 |
| 6941614 | Carpet grooming attachment A carpet grooming attachment for a motorized brush device, the attachment having a generally triangular shaped housing; the attachment attaching to the wheel axle of a motorized brush device; a brush; means for delivering fluid attached to a external surface of the ... | 09/13/2005 |
| 6936637 | Prevention of apoptosis in non-cancerous cells Treatment of normal, non-cancerous, animal cells with an agent that depletes polyamines within the cells results in an inhibition of apoptosis when the cells are exposed to an inducer of apoptosis. This inhibition of apoptosis is not observed, or is observed to a le... | 08/30/2005 |
| 6894076 | Esters derived from (RR,SS)-2-hydroxybenzoate of 3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl New esters derived from (RR, SS)-3-(2-dimethylaminomethyl-1-hydroxycyclohexyl)phenyl 2-hydroxybenzoate, analog to Tramadol, a process for obtaining them and the use of these compounds for the production of a medicament with analgesic properties. These new pro... | 05/17/2005 |
| 6881756 | Method for treating skin disorders The present invention relates to a method for reducing inflammation in the skin and/or treating inflammatory skin disorders, pain, or pruritis by topically applying a composition comprising totarol or a pharmaceutically-acceptable ester thereof. ... | 04/19/2005 |
| 6858653 | Pesticidal compositions containing plant essentials oils against termites Pesticidal compositions for the control of mites in stored food products containing one or more plant essential oils. In addition, the present invention is directed to a method for controlling mites from accessing stored food products by applying a pesticidally-effe... | 02/22/2005 |
| 6855341 | Anti-viral compositions and methods of making and using the anti-viral compositions Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involvi... | 02/15/2005 |
| 6825233 | Compounds having retinoid-like activity There are provided compounds represented by the formula I or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, wherein the various substituents are as defined. Also inc... | 11/30/2004 |
| 6811772 | Composition, method, and apparatus to attract bees Applicant's invention includes an improved bee attracting composition. Applicant's invention further includes a bee attracting device formed from his improved bee attracting composition. Applicant's bee attracting device can be further coated with a second bee attra... | 11/02/2004 |
| 6800658 | Substituted diphenyl indanone, indane and indole compounds and analogues thereof useful for the treatment of prevention of diseases characterized by abnormal cell proliferation The present invention provides substituted 3,3-diphenyl indanone, indane and indole compounds, as well as analogues thereof, which are specific, potent and safe inhibitors of mammalian cell proliferation. The compounds can be used to inhibit mammalian cell prolifera... | 10/05/2004 |
| 6797694 | Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca2+ activated potassium channel (IKCa), and the use of such compounds for the treatment or alleviation of diseases or conditions rela... | 09/28/2004 |
| 6790864 | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly don... | 09/14/2004 |
| 6787573 | Antiviral therapy The invention relates to the field of antiviral agents, and more specifically to antiviral therapy. The invention provides use of at least one compound or mixture of compounds of the general formula or a functional equiv... | 09/07/2004 |
| 6773700 | Composition, method, and apparatus to attract bees Applicant's invention includes an improved bee attracting composition. Applicant's invention further includes a bee attracting device formed from his improved bee attracting composition. Applicant's bee attracting device can be further coated with a second bee attra... | 08/10/2004 |
| 6716421 | Devices and methods for eliminating termite colonies This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such that the termiticide causes death to about 50 to about 100% of te... | 04/06/2004 |
