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| Number | Title | Issue Date |
| 8058310 | Polyphenol proteasome inhibitors, synthesis, and methods of use The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in m... | 11/15/2011 |
| 8022105 | Prevention of neutrophil recruitment Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II. ... | 09/20/2011 |
| 7879907 | 3-phenylpropanoic compound activators of receptors of PPAR type and pharmaceutical/cosmetic compositions comprised thereof Novel 3-phenylpropanoic acid compounds have the general formula (I) below: and are formulated into pharmaceutical compositions for administration in human or veterinary medicine (in dermatology, and also in the field of car... | 02/01/2011 |
| 7767711 | Polyphenol proteasome inhibitors, synthesis, and methods of use The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present invention is also directed to pharmaceutical compositions useful in m... | 08/03/2010 |
| 7601756 | Method of treatment for irritable bowel syndrome A method for treating irritable bowel syndrome (IBS) is included. The method includes the step of administering a fibric acid derivative to a patient diagnosed with IBS in order to alleviate the symptoms associated with IBS. ... | 10/13/2009 |
| 7534815 | Preventive or remedy for hypertension Provided is a method of treating hypertension, which comprises administering an effective amount of a compound represented by the following formula (1) or (2): wherein, R1 and R2 are the same or differ... | 05/19/2009 |
| 7410983 | Combination of fenofibrate and coenzyme q10 for the treatment of endothelial dysfunction The present invention relates to a combination of a peroxisome proliferator activated receptor (PPAR) activator and a benzoquinone and their use in treating and/or preventing disorders characterized by endothelial dysfunction, such as cardiovascular disease, strokes... | 08/12/2008 |
| 7355063 | Shogaol compound and tyrosinase activity inhibitor comprising the compound The compound represented by the following formula (1): wherein A, B, R1, R2, R3 and Z are as defined in the specification is analogous to shogaol and gingerol useful in the fields of foods, medicines, quasi-drugs, cosmetics... | 04/08/2008 |
| 7345191 | Process for preparation of probucol derivatives A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5,... | 03/18/2008 |
| 7329771 | Intermediates in producing phenoxyacetic acid derivatives and method of using the same The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity... | 02/12/2008 |
| 7300646 | Skin lightening agents, compositions and methods Disclosed are coumarin derived compounds of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and/or... | 11/27/2007 |
| 7294737 | Process of preparing esters and ethers of probucol and derivatives thereof Provided are methods for manufacturing compounds of Formula I wherein all substituents are described herein. ... | 11/13/2007 |
| 7273948 | Process of preparing esters and ethers of probucol and derivatives thereof A probucol or a probucol derivative can be efficiently converted to a monoester or monoether of probucol by reacting the free hydroxyl-containing probucol or a derivative thereof (by which is meant a probucol compound with at least one substituent that is different ... | 09/25/2007 |
| 7230003 | Aromatic prodrugs of propofol, compositions and uses thereof Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pa... | 06/12/2007 |
| 7192981 | 3,4-dihydroxyhydrocinnamic acid derivative According to the invention, there is provided a novel 3,4-dihydroxyhydrocinnamic acid derivative, designated DHH105, having blood glucose lowering effects in vivo as a result of the enhancement of glucose transport mediated by the increase of insulin receptor signal... | 03/20/2007 |
| 7129268 | Peroxisome proliferator activated receptor-active arylene acetic acid derivatives Novel compounds of the general formula (I), wherein Ar, R1, R2, X1, X2, Y1, Y, and Z are as defined in the specification, the use of these compounds as pharm... | 10/31/2006 |
| 7122561 | Treatment of skin conditions The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also for treating skin cancer. The piperine and analogues or derivatives the... | 10/17/2006 |
| 7112608 | Hydroxyphenylundecane, a process for their production and their use The present invention relates to novel hydroxyphenylundecane derivatives of the formula (I), a method for the preparation of said compounds by cultivation of the fungus Cryphonectria parasitica, DSM 14453,... | 09/26/2006 |
| 7087645 | Compounds and methods for treating transplant rejection The use of compounds of the formula and pharmaceutically acceptable salts thereof, alone or in combination for the treatment of transplant rejection, wherein the substituents are further defined in the applicatio... | 08/08/2006 |
| 7078431 | 1,3-bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a disorder mediated by VCAM-1. Examples of inflammatory disorders that are ... | 07/18/2006 |
| 7053071 | Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals with leukemia or other forms of... | 05/30/2006 |
| 7037914 | Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient A peroxisome proliferator activated receptor regulator containing a carboxylic acid derivative of formula (I) (wherein all symbols are as defined in the specification), a non-toxic acid thereof or a hydrate thereof as ... | 05/02/2006 |
| 6998397 | Method for decreasing cholesterol level in blood A method for improving blood cholesterol and its conjugates levels in a mammal, which is based on the administration of steroidal plant hormone 24-epibrassinolide. ... | 02/14/2006 |
| 6982281 | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly fenofibrate, are provided. The compositions comprise a therapeutically effective amount of an active agent and a solubilizer. The solubilizer is selected to effectivel... | 01/03/2006 |
| 6869967 | Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in th... | 03/22/2005 |
| 6855341 | Anti-viral compositions and methods of making and using the anti-viral compositions Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involvi... | 02/15/2005 |
| 6825226 | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, the present i... | 11/30/2004 |
| 6683111 | Compounds, their preparation and use The present invention relates to compounds of the general formula (I) ##STR1## The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).... | 01/27/2004 |
| 6670398 | Compounds and methods for treating transplant rejection The use of compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, alone or in combination for the treatment of transplant rejection, wherein the substituents are further defined in the application.... | 12/30/2003 |
| 6670395 | Prophylactic and therapeutic treatment of skin sensitization and irritation Methods, compositions and systems for preventing an adverse reaction of the skin to the presence of a skin-sensitizing and/or skin-irritating agent by administering an effective amount of phenoxyacetic acid and/or a lower alkyl ester thereof to a warm blo... | 12/30/2003 |
| 6660770 | Pesticidal activity of functionalized alkenes The present invention provides non-peptide organic compounds that have a structure analogous to or reminiscent of the TMOF structure and have pesticidal activity. Thus the present invention concerns pesticidal compounds that inhibit digestion in pests by ... | 12/09/2003 |
| 6638977 | Plasminogen activator inhibitor antagonists Compounds and pharmaceutical compositions useful as plasminogen activator inhibitor (PAI) antagonists are provided. In particular, methods of antagonizing PAI with substituted and unsubstituted aryl and heteroaryl ethers and thioethers are provided.... | 10/28/2003 |
| 6635663 | Pesticidal emulsifiable concentrate The present invention provides a low-irritant pesticidal emulsifiable concentrate comprising (a) 1 to 60% by weight of at least one pesticidal active ingredient compound selected from the group consisting of pyriproxyfen and a pyrethroid compound, (b) 2 t... | 10/21/2003 |
| 6627658 | Lipoxin analogs as novel inhibitors of angiogenesis The present invention is directed to methods for the prevention or inhibition of angiogenesis. The method is accomplished by the administration of an effective amount of 15-epi-16-(para-fluoro)-phenoxy-lipoxin A4, LXA4, 15-epi-L... | 09/30/2003 |
| 6617352 | Compounds and methods for the inhibition of the expression of VCAM-1 This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.... | 09/09/2003 |
| 6610682 | Pharmaceutical compositions and methods for the treatment of arteriosclerosis A pharmaceutical composition comprising as its active ingredients one or more drugs selected from the group consisting of angiotensin II receptor antagonists and angiotensin converting enzyme inhibitors, and one or more insulin resistance improving agents... | 08/26/2003 |
| 6605639 | Ligands of nuclear receptor It has been newly found out that ascochlorin, which is a publicly known fat-soluble antibiotic, and its homologues serve as a ligand of retinoid X receptor and react in vivo with the amino group of serum protein to form Schiff bases without showing any si... | 08/12/2003 |
| 6593365 | Diflunisal esters and related compounds O-medium alkyl esters of diflunisal and related compounds are disclosed having anti-platelet activity, hydroxy radical scavenging properties, enhanced hepatic clearance and low ulcerogenic potential. These compounds have general formula (I) wherein n equa... | 07/15/2003 |
| 6534088 | Fibrate-statin combinations with reduced fed-fasted effects This invention discloses an orally administered pharmaceutical composition for the treatment of elevated levels of cholesterol and related conditions comprising a statin and fenofibrate in the form of microparticles of solid fenofibrate that are stabilize... | 03/18/2003 |
| 6534546 | Aniline derivatives possessing an inhibitory effect of nitric oxide synthase Compounds represented by the general formula (1): ##STR1## (where R1 is SR6 or NR7 R8, where R6 is typically an alkyl group having 1-6 carbon atoms, R7 is a hydrogen atom, an alkyl group having ... | 03/18/2003 |
