Class 514/542 - Z radical contains two or more nitrogen atoms at least one of which forms a C(=X)N group (X is chalcogen)

Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the Z radical contains two or more
No. of patents: 163
Last issue date: 06/10/2008

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Number	Title	Issue Date
7384979	Substituted amino acids as erythropoietin mimetics This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which ...	06/10/2008
7375120	Peptide deformylase inhibitors Novel PDF inhibitors and novel methods for their use are provided. ...	05/20/2008
7279562	Rapamycin conjugates Provided are rapamycin conjugates which are useful as immunogenic molecules for the generation of antibodies specific for rapamycin, for measuring levels of rapamycin or derivatives thereof; for isolating rapamycin binding proteins; and detecting antibodies specific...	10/09/2007
7199158	Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein R1–R6, R7, R7′, R8, R30–R34, X′, Y, Y′, t,...	04/03/2007
7084178	Antiamyloid phenylsulfonamides: N-cycloalkylcarboxamides derivatives A series of N-cycloalkylcarboxamide derivatives of N-benzyl benzenesulfonamides of Formula I are described. The compounds inhibit β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's...	08/01/2006
RE39088	Amide compounds and use of the same An amide compound of the formula (I): wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 ...	05/02/2006
6992105	Dipeptide derivatives Compounds of the formula wherein R, R1, COOR2, R3–R7, alk, and X have meaning as defined, such being useful as dual inhibitors of angiotensin converting enzyme and neutral e...	01/31/2006
6989384	Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis Compounds of the formula: where the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picomaviral 3C protease. These compounds, as well as pharmaceutical ...	01/24/2006
6951886	Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives of the formula: wherein the substituents are as defined in the specification, are effective as retroviral protease inhibitors and in particular as inhibitors o...	10/04/2005
6946474	Nitrogen-containing compounds and their use as glycine transport inhibitors The present invention provides trichloroethyl-sulfonylurea-containing compounds that inhibit glycing transporters, pharmaceutical compositions comprising such compounds, methods for using such compounds for inhibiting glycine transporters and methods for using such ...	09/20/2005
6919374	Viscosity modulating substance and use thereof It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) lowers whole blood viscosity in patient, including those suffering from sickle cell disease and plasma cell dyscrasias. Upon in vivo APM treatment patients experienced a significant l...	07/19/2005
6919343	N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives N-Biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. ...	07/19/2005
6888022	Methods and compounds for inhibiting β-amyloid peptide release and/or its synthesis Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or i...	05/03/2005
6803383	Inhibition of angiogenesis and tumor growth Compounds which inhibit tumor growth and angiogenesis, of general formula (II) are provided. These compounds include glycyl lysine derivatives bound to a central aromatic linking core. ...	10/12/2004
6777443	Dipeptide derivatives Compounds of the formula wherein R, R1, COOR2, R3-R7, alk, and X have meaning as defined, such being useful as dual inhibitors of angiotensin converting enzyme and neutral endo...	08/17/2004
6693137	Sulphonamide derivatives The present invention relates to the potentiation of glutamate receptor function using certain sulphonamide derivatives. It also relates to novel sulphonamide derivatives, to processes for their preparation and to pharmaceutical compositions containing th...	02/17/2004
6534501	Allosteric inhibitors of pyruvate kinase Chemical structures have been identified which allosterically modify pyrvate kinase and inhibit enzymatic activity. These compounds can be used as pharmaceuticals in the treatment of a wide variety of diseases and disorders where influencing metabolic pro...	03/18/2003
6528543	Urea derivatives Glucokinase activating compounds of the formula ##STR1## wherein R1 and R2 are independently hydrogen, halo, amino, nitro, cyano, sulfonamido, lower alkyl, perfluoro-lower alkyl, lower alkyl thio, perfluoro-lower alkyl thio, lower al...	03/04/2003
6515024	Succinoylamino hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors Succinoylamino hydroxyethylamino sulfonyl urea derivatives are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease....	02/04/2003
6492421	Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds aslo inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g....	12/10/2002
6486202	Inhibitors of isoprenyl transferase Provided are novel peptidomimetic isoprenyl transferase inhibitors, methods for synthesizing such inhibitors, and methods for the use of such inhibitors for the treatment of tumors....	11/26/2002
6472430	Amino thioxomethyl amino oxyacetic acid derivatives Antiatherosclerotic compounds are provided which have the following structure: ##STR1## wherein R is lower alkyl; R1 is hydroxy, amino, or lower alkoxy, R2 and R3 are each independently hydrogen, alkyl or aryl; Ar is phenyl, in...	10/29/2002
6472393	Serine protease inhibitors Compounds having the structure shown below wherein A, B, N1, N2, X, Y, Q, R2, R5 and R6 are as defined herein are useful to inhibit serine protease enzymes, such as TF/factor VIIa factor Xa, thrombin ...	10/29/2002
6403644	Method of treating disease with sulfonylamino acid derivatives The present invention is related to: (i) matrix metalloproteinase inhibitors containing sulfonylamino acid derivatives of the formula (Ia); ##STR1## wherein R1 is hydrogen, C1-4 alkyl; R2 is hydrogen, C1-8 alkyl etc.; E is --CONR	06/11/2002
6391918	N-sulphonyl and N-sulphinyl phenylglycinamide Novel ଱-amino acid amides of formula (I) as well as possible isomers and mixtures of isomers thereof, wherein the substituents are defined as follows: n is the number zero or one; R1 is optionally substituted alkyl, alkenyl, alkynyl, cycl...	05/21/2002
6391917	Dialkyl ureas as calcitonin mimetics Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the de...	05/21/2002
6384076	Inhibition or erythrocyte sickling by N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester It has now been found that N-L-alpha-aspartyl-L-phenylalanine 1-methyl ester (APM) exhibits antisickling properties. In vitro testing verified that APM significantly lowered the frequency of sickling of red blood cells from each of twelve pediatric aged p...	05/07/2002
6313119	Sulfonamide derivatives as inhibitors of bone resorption and as inhibitors of cell adhesion Sulfonamide derivatives, their physiologically tolerable salts and their prodrugs according to the present invention are vitronectin receptor antagonists and inhibitors of cell adhesion, as well as inhibit bone resorption by osteoclasts. These derivatives...	11/06/2001
6306881	Anti-inflammatory agents Compounds of general formula (I) ##STR1## wherein R4 is an ester or thioester group and R, R1, R2, and R3 are as specified in the description, inhibit intracellular Leukotriene A4 hydrolase activity a...	10/23/2001
6221913	Dialkyl ureas as calcitonin mimetics Dialkyl urea compounds are described which act as calcitonin mimetics. These compounds are useful in the treatment of diseases which are associated with bone resorption. The calcitonin mimetics of the present invention are also useful in assays for the de...	04/24/2001
6211176	଱- and ଲ-amino acid hydroxyethylamino sulfonyl urea derivatives useful as retroviral protease inhibitors ଱- and ଲ-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease....	04/03/2001
6194463	N-sulphonyl and N-sulphinyl amino acid amides as microbicides ଱-Amino acid amides of formula (I) wherein the substituents are defined as follows: n is a number zero or one; R1 to R7 are as defined herein; R8 is C1 -C6 alkyl, C3 -C6 al...	02/27/2001
6187812	Phenylacetic acid derivatives, preparation thereof and intermediates therefor, and compositions containing them Phenylacetic acid derivatives of the formula I ##STR1## where the substituents and the index have the following meanings: X is oxygen or sulfur; R is hydrogen or alkyl; R1 is hydrogen or alkyl; R2 is cyano, nitro, trifluoromethyl, halogen, alk...	02/13/2001
6177466	Sulfonylamino acid derivatives The present invention is related to: (i) matrix metalloproteinase inhibitors containing sulfonylamino acid derivatives of the formula (Ia): ##STR1## wherein R1 is hydrogen, C1-4 alkyl; R is hydrogen, C1-8 alkyl etc.; E is --CONR3 --,...	01/23/2001
6174887	Amide compounds and use of the same An amide compound of the formula (I): ##STR1## wherein R is amino and the like, A is alkylene and the like, X is O, S and the like, M is arylene and the like, R1, R2, R3 and R4 are H, hydroxy and the like, R	01/16/2001
6160015	Compounds useful in the treatment of neurofibromatosis The present invention relates to compositions useful in the treatment of benign proliferative disorder neurofibromatosis comprising a farnesyl protein transferase inhibitor. Further contained in this invention are methods of treating benign proliferative ...	12/12/2000
6159989	Antagonists of gonadotropin releasing hormone There are disclosed compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both m...	12/12/2000
6153609	Arylsulfonylamino hydroxamic acid derivatives A compound of the formula ##STR1## wherein n, X, R3, R4 and Q are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, macular degeneration, resteno...	11/28/2000
6143776	Tosylproline analogs as thymidylate synthase inhibitors Tosylproline analogs of formula I, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are thymidylate synthase inhibitors; and are useful as anti-tumor agents and as anti-parasitics, anti-bacteria...	11/07/2000
6136834	Tetrazole compounds and pharmaceutical agents containing such derivative A tetrazole derivative of formula (I) ##STR1## wherein R is H, alkyl, alkoxy, carbocyclic ring, alkyl or alkoxy substituted by carbocyclic ring; AA1 and AA2 is a bond or ##STR2## and ##STR3## respectively, or AA...	10/24/2000

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Class 514/542 - Z radical contains two or more nitrogen atoms at least one of which forms a C(=X)N group (X is chalcogen)