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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 8084499 | Modified clay mineral Modified clay minerals obtained by treating a clay mineral with a particular acylarginine derivative are useful for stabilizing emulsion compositions, inter alia, W/O emulsion composition, while hardly causing skin irritation, and providing moisture retention proper... | 12/27/2011 |
| 7943666 | Esters of capsaicin for treating pain The present invention relates to the formulations of ester derivatives of capsaicin and ester derivatives of myristoleic acid. These derivatives are capable of reverting to the active parent compound following enzymatic or chemical hydrolysis. These derivatives have... | 05/17/2011 |
| 7781485 | Hsp90 family protein inhibitors The present invention provides Hsp90 family protein inhibitors comprising, as an active ingredient, a benzoic acid derivative represented by General Formula (I): [wherein n represents an integer of 0 to 10; R1 re... | 08/24/2010 |
| 7671089 | Levodopa prodrugs, and compositions and uses thereof Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed. ... | 03/02/2010 |
| 7446128 | Agent for treating interstitial cystitis A compound which can be used as an agent for treating interstitial cystitis. An agent for treating interstitial cystitis, which comprises a phenoxyacetic acid derivative represented by a general formula (I) wherein R1 ... | 11/04/2008 |
| 7439393 | Phenethanolamine derivatives for treatment of respiratory diseases The invention relates to 4-{(1R)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol; and salts and solvates thereof, including those which are pharmaceutically acceptable, along with formulations thereof, combinations there... | 10/21/2008 |
| 7425577 | Lipase-colipase inhibitor The present invention relates to novel colipase-lipase inhibitors of the general formulae to be used in the treatment of prophylaxis of obesity, as well as pharmaceutical compositions containing the same, and method for treating obesity using said compounds. ... | 09/16/2008 |
| 7417059 | Substituted aromatic-ring compounds, process for producing the same and use The present invention is directed to a class of cyclohexene derivatives bearing sulfamoyl and ester groups which have an inhibitory activity on nitric oxide (NO) production and cytokine production, and are useful as an agent for the prophylaxis and/or treatment of d... | 08/26/2008 |
| 7407985 | Compounds that abrogate DNA damage induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to... | 08/05/2008 |
| 7384979 | Substituted amino acids as erythropoietin mimetics This invention relates to a series of substitituted amino acids of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention are small molecules which ... | 06/10/2008 |
| 7368608 | 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivatives and a process for preparing 2-amidomethyl-1,4-benzodioxane derivatives An 1-amido-3-(2-hydroxyphenoxy)-2-propanol derivative represented by the following formula (1), wherein cycle A may have further 1 to 4 substituents, and said substituent means a substituent selected from the group consisti... | 05/06/2008 |
| 7365085 | Compounds and methods Disclosed is a compound having the formula: pharmaceutically acceptable salts or solvates thereof and pharmaceutical compositions containing the same, wherein the structural variables are as defined... | 04/29/2008 |
| 7361787 | Phenethanolamine derivatives for treatment of respiratory diseases The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseases ... | 04/22/2008 |
| 7361686 | Compounds for the treatment of metabolic disorders Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyper-lipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed. Formula (I) wherein n is 1 or 2; m is 2 or 3; ... | 04/22/2008 |
| 7358052 | Catalytic amplification of multiplexed assay signals Methods, compositions, kits, and a system are disclosed for detecting one or more analytes in a sample. A mixture comprising the (i) sample, (ii) a first binding reagent comprising a cleavage-inducing moiety and a first binding agent specific for an analyte, and (ii... | 04/15/2008 |
| 7329777 | Methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis This invention relates to methods for treating heart failure, thromboembolic disorders, and pulmonary fibrosis, comprising administering an effective amount of a compound of formula (I) in which the several varia... | 02/12/2008 |
| 7323188 | Composition for controlling harmful bio-organisms and method for controlling harmful bio-organisms using the same A composition for controlling harmful bio-organisms comprising (a) at least one imidazole compound represented by formula (I): wherein R represents a lower alkyl group or a lower alkoxy group; and n represents an... | 01/29/2008 |
| 7314888 | Compounds and medicinal use thereof A compound or a salt thereof having the atom corresponding to N3 and the two or more atoms selected from N1, N2, N4 and N5, said atoms constitute the pharmacophore represented by the following formula: | 01/01/2008 |
| 7279585 | Lipophilic electrophoretic probes Compounds, compositions, and methods for labeling membranes are disclosed. Compounds of formula G-L-E are described wherein G is a lipophilic group, L is a cleavable linkage and E is an electrophoretic group. The compounds become associated with membranes, and can b... | 10/09/2007 |
| 7256191 | Materials and methods for the treatment of depression The subject invention provides compounds which are easily metabolized by the metabolic drug detoxification systems. Particularly, fluvoxamine analogs which have been designed to include esters within the structure of the compounds are taught. Also provided are metho... | 08/14/2007 |
| 7255999 | Methods and compositions for analyzing proteins Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture comprising the sample and a first reagent comprising a cleavage-inducin... | 08/14/2007 |
| 7253194 | Compounds and inhibitors of phospholipases The present invention relates generally to amino acid derivatives and to methods of making the same. In particular, the invention relates to compounds bearing a stereochemical identity, that is, the same stereochemistry, with the chiral α-carbon of D-α-amino acids... | 08/07/2007 |
| 7247434 | Methods and compositions for determining the sequence of nucleic acid molecules Methods and compounds, including compositions therefrom, are provided for determining the sequence of nucleic acid molecules. The methods permit the determination of multiple nucleic acid sequences simultaneously. The compounds are used as tags to generate tagged nu... | 07/24/2007 |
| 7235583 | Fatty acid-anticancer conjugates and uses thereof The invention provides conjugates of fatty acids and anticancer agents useful in treating cancer, and compositions and formulations thereof. Methods for using the conjugates also are provided. ... | 06/26/2007 |
| 7223796 | Acyl-4-carboxyphenylurea derivatives, processes for preparing them and their use The invention relates to acyl-4-carboxyphenylurea derivatives and to their physiologically tolerated salts and physiologically functional derivatives. The invention particularly relates to compounds of formula I, | 05/29/2007 |
| 7220781 | Meta-benzamidine derivatives as serine protease inhibitors Compounds of formula I in which R1, R2, R3, each X, L, Y, Cy, Lp, D and n have the meanings as set out in the specification, and corresponding compounds in which the unsubstituted... | 05/22/2007 |
| 7220778 | Methods and devices for epithelial protection during photodynamic therapy Methods for preventing damage to epithelial tissue during PDT induced using a photosensitizing agent or pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control photoactivation of the photoactive species to... | 05/22/2007 |
| 7217531 | Multiplex analysis using membrane-bound sensitizers The present invention is directed to methods and compositions for determining the presence, absence, and/or amounts of one or more membrane-associated analytes in a sample. In accordance with the invention, binding compounds derivatized with releasable molecular tag... | 05/15/2007 |
| 7199081 | Aqueous compositions for seed treatment An aqueous composition suitable for applying fungicides to plant propagation materials is provided, comprising water and a blend of the following components, by weight: a) 2–10% of a surface-active agent comprising a1) at least one anionic surfactant;... | 04/03/2007 |
| 7163827 | Aromatic esters for marking or tagging organic products A compound represented by formula I is used as a marker for organic products. wherein Ar1 and Ar2 each independently represent a substituted or unsubstituted phenylene group or a substituted... | 01/16/2007 |
| 7163942 | Sulfonamide compounds for the treatment of neurodegenerative disorders The present invention relates to compounds of the Formula I wherein R1, R2, R3, m, and n are as defined. Compounds of the Formula I have activity inhibiting production of Aβ-pept... | 01/16/2007 |
| 7160735 | Tagged microparticle compositions and methods Compositions and methods are disclosed for detecting multiple target analytes in a sample using microparticles having molecular tags attached by cleavable linkages. Generally, an assay mixture is formed comprising a sample and a reagent comprising multiple such micr... | 01/09/2007 |
| 7150878 | Extended duration insect repellent composition and method of application to the skin Disclosed is an insect repellent composition. The composition has an amount of an insect repellent active effective to repel insects when the composition is applied to the skin, and an amount of a urethane polymer sufficient to form a film on the surface of the skin... | 12/19/2006 |
| 7148257 | Methods of treating mesothelioma with suberoylanilide hydroxamic acid Methods for treating mesothelioma comprising administering the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) are disclosed. ... | 12/12/2006 |
| 7138140 | Suplatast tosilate crystals Provided are a suplatast tosilate crystal showing characteristic peaks in powder X-ray diffraction diffraction angles (20±0.1°) of 5.6°, 9.0°, 11.0°, 15.3°, 16.5°, 17.2°, 17.9°, 19.2°, 19.9°, and 21.5°; and a preparation process of the crystal. Owing to ... | 11/21/2006 |
| 7135300 | Profiling frequencies of receptor heterodimers Methods are provided for detecting formation of oligomeric complexes of molecules on the surface of cell membranes. These methods employ pairs of tagged probes and cleaving probes, each of which binds specificly to a cell surface molecule. The tagged probe includes ... | 11/14/2006 |
| 7135162 | Agent for diagnosing and treating malignant tumors A composition of a compound or derivative thereof in which at least one carbon atom of 5-aminolevulinic acid is a carbon isotope and/or a nitrogen atom in its amino group is a nitrogen isotope, and where said derivative is an ester, amide, salt, hydrate or solvate o... | 11/14/2006 |
| 7132559 | Non-racemic hexafluoroleucine, and methods of making and using it One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides compris... | 11/07/2006 |
| 7132519 | Releasable nonvolatile mass-label molecules Releasable tag reagents for use in the detection and analysis of target molecules, particular in mass spectrometric analyses are provided. Also provided are methods of detection that employ releasable tag reagents. ... | 11/07/2006 |
| 7132403 | Antihelminthic anthraquinones and method of use thereof Anthraquinones are described which are antihelminthic and in particular, are useful in compositions for inhibiting Schistosoma sp. in vitro or in vivo. The preferred anthraquinones have the formula: wherei... | 11/07/2006 |
