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| Number | Title | Issue Date |
| 6143730 | Preparation and use of sulfated oligosaccharides Sulfated oligosaccharides, wherein the oligosaccharide has the general formula I: R1 --(Rx)n --R2 (I) wherein R1 and R2 and each Rx represents a monosaccharide ... | 11/07/2000 |
| 6132723 | Immunogenic oligosaccharide compositions The invention provides immunogenic oligosaccharide compositions and methods of making and using them. In particular, the compositions comprise oligosaccharides covalently coupled to carrier protein, wherein the resultant conjugate has been shown to contai... | 10/17/2000 |
| 6127334 | Methods for producing biphasic insulin formulations Insulin preparations of superior physical stability, comprising dissolved and/or precipitated human insulin or an analogue or derivative thereof, and a water-soluble reduced or non-reducing carbohydrate containing at least 4 carbon atoms in the main carbo... | 10/03/2000 |
| 6121233 | Methods for the inhibition of cancer metastasis mediated by endothelial adhesion molecules Methods and compositions are disclosed for the inhibition of cancer metastases mediated by endothelial adhesion molecules. The present invention discloses that sialyl Lea and di-sialyl Lea, which are expressed at the surface of cance... | 09/19/2000 |
| 6121242 | Treatment of bacterial dysentery Disclosed are methods for the neutralization of shiga-like toxins (SLT) associated with enteric E. coli infection which methods inhibit progression of this infection into hemolytic uremic syndrome (HUS).... | 09/19/2000 |
| 6114313 | Pharmaceutical compositions for freeze drying A pharmaceutical composition comprising a nucleotide analogue, mannitol and a modifying additive which is sodium chloride or a polyol which is suitable for freeze drying.... | 09/05/2000 |
| 6114309 | Combinatorial library of moenomycin analogs and methods of producing same A combinatorial chemical library of compounds structurally related to the moenomycin class of antibiotics has the formula ##STR1## wherein D is a donor mono- or disaccharide, A is an acceptor monosaccharide, and P-R is a lipophosphoglycerate mimetic ... | 09/05/2000 |
| 6096725 | Methods of using Gal oligosaccharides as immune system targeting agents The invention relates to methods for attenuating xenograft rejection in humans and old world monkeys, using oligosaccharides containing a Gal댑-3Gal motif, to neutralize or remove anti-Gal antibodies. The invention additionally relates to met... | 08/01/2000 |
| 6096726 | Multicomponent complex for use with substrate Compositions and methods for use with substrates which are useful in the sustained delivery of bioeffecting agents are described. The compositions of the invention include a multicomponent complex which attaches a bioeffecting agent to a substrate with an... | 08/01/2000 |
| 6093697 | Synthetic insulin mimetic substances Compounds are disclosed which have the formula (I) ##STR1## wherein R1 -R2 are each independently selected from the group consisting of: (a) a hydrogen atom; and (b) a lower alkyl group, straight or branched chain, having 1 to 8... | 07/25/2000 |
| 6090792 | Maltose-trehalose converting enzyme, and preparation and uses thereof An enzyme, which has a molecular weight of about 57,000-120,000 daltons on SDS-PAGE and a pI of about 3.8-5.1 on isoelectrophoresis using ampholyte, converts maltose into trehalose and vice versa. The enzyme was isolated from microorganisms of the genera ... | 07/18/2000 |
| 6087342 | Substrates having bound polysaccharides and bacterial nucleic acids The cytokine stimulating effects of immune- stimulating polysaccharides and bacterial nucleic acids, and of lower molecular weight fragments thereof, is potentiated by coupling the immune-stimulating bioactive substance to the surface of a substrate, whic... | 07/11/2000 |
| 6083932 | Pharmaceutical compositions derived from ginseng and methods of treatment using same Disclosed is a ginseng extract, HT1001, comprising a saponin fraction which is about 20-50% by weight of the ginseng extract. The extract is also described in terms of ultraviolet absorbance peak display and total ion count peaks display. Pharmaceutical c... | 07/04/2000 |
| 6083931 | Method of inhibiting cancer metastasis The present invention is aimed at providing an anticancer agent which can inhibit the metastasis of cancer cells when used alone. In addition, the present invention is also aimed at providing an anticancer agent which can inhibit the metastasis of cancer ... | 07/04/2000 |
| 6083929 | Extended type 1 chain glycosphingolipids as tumor-associated antigens A variety of compounds are provided which are usefdl as immunogens and as tumor markers. The present invention discloses methods relating to the detection of cancer. Extended forms of the lacto-series type 1 chain are shown to be present in various cancer... | 07/04/2000 |
| 6083927 | Hepatic disturbance improver A hepatic disturbance improver which reduces fat in hepatocytes which includes an oligosaccharide of formula (1), (2) or (3), obtainable by hydrolyzing porphyran contained in seaweed of the genus Porphyra. The hepatic disturbance improver is advantageous,... | 07/04/2000 |
| 6077830 | Bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts The present invention relates to bismuth salts of antibiotics of the moenomycin group, processes for their preparation, their use and pharmaceuticals comprising such salts. The salts according to the invention contain antibiotics of the moenomycin group w... | 06/20/2000 |
| 6077822 | Drug salts It has been found that sugar acid salts represent beneficial controlled release forms for basic organic drug compounds. Examples of appropriate salts include mono, di, oligo and polysaccharide poly-O-sulphonic acid salts of antibiotics such as tetracyclin... | 06/20/2000 |
| 6071532 | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof The present invention provides glycophospholipid and peptide-phospholipid conjugates comprising a phospholipid moiety and a saccharide or peptide moiety joined by an ether linkage comprising a secondary or tertiary amine. The conjugate structure of the in... | 06/06/2000 |
| 6066341 | Composition for the treatment of scours in calves A composition for use in the rehydration and treatment of scours in calves. The composition includes fiber, electrolytes and three energy sources. The energy sources are sugar, medium chain triglycerides and glycine, present in a combined amount of about ... | 05/23/2000 |
| 6057302 | Sophorolipids as stimulating agent of dermal fibroblast metabolism The use of at least one sophorolipid in cosmetics as an agent for stimulating the metabolism of fibroblasts of the dermis of the skin, particularly as an agent that restructures the skin, agent that repairs the skin, and/or an agent that tones up the skin... | 05/02/2000 |
| 6037330 | Composition for site specific detection of gastrointestinal damage and method using the same Disclosed is a composition for the site-specific detection of gastrointestinal damage containing (a) a first disaccharide that does not degrade in the colon, small intestine or stomach; (b) a second disaccharide that degrades in the colon but does not deg... | 03/14/2000 |
| 6037327 | Specific saccharide compositions and methods for treating Alzheimer's disease and other amyloidoses A pharmaceutical agent for treating an amyloid disease in a patient, wherein the pharmaceutical agent comprises a saccharide containing at least one substituted anionic group, or a pharmaceutically acceptable salt of the saccharide containing at least one... | 03/14/2000 |
| 6030628 | Cosmetic or dermatological preparations containing glycoglycerolipids and their use as surfactants Cosmetic or pharmaceutical preparations, characterized by an effective content of pharmaceutically and/or cosmetically acceptable glycoglycerolipids.... | 02/29/2000 |
| 6028061 | Angiogenesis inhibitors and use thereof The present invention is based on the unexpected discovery that a molecule having as its major repeating units N-acetylglucosamine alternating in sequence with 2-O-sulfated uronic acid, inhibits FGF mitogenicity, and thus is useful in inhibiting angiogene... | 02/22/2000 |
| 6022865 | Stable aqueous solution having high concentrations of calcium and phosphate ions and solid complex A stable aqueous solution having high concentrations of both biologically available calcium and biologically available phosphate is provided by combining phosphate and calcium ions in the aqueous solution wherein the phosphate is in the form of a sacchari... | 02/08/2000 |
| 6020323 | Compositions and methods for regulation of active TNF- Substances comprising disaccharides and substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, and methods of using same, are disclosed for the regulation of cytokine activity in a host. For instance, the secre... | 02/01/2000 |
| 6017899 | Non-reducing saccharide-forming enzyme, its preparation and uses Disclosed are novel non-reducing saccharide-forming enzyme, and its preparation and uses. The enzyme is obtainable from the culture of microorganisms such as Rhizobium sp. M-11 (FERM BP 4130) and Arthrobacter sp. Q36 (FERM BP-4316), and capable of forming... | 01/25/2000 |
| 6013640 | Phosphoglycolipid and methods for its use The invention concerns a novel phosphoglycolipid compound. The compound of the subject invention is 2-Deoxy-6-O-[2-deoxy-4-O-phosphono-3-O-[(R)-3-tetradecanoyloxytetradecanoy l]-2-[(R)-3-octadecanoyloxytetradecanoylamino]-ଲ-D-glucopyranosyl]-2-[ ... | 01/11/2000 |
| 6013635 | Treatment of C. difficile toxin B associated conditions This invention relates to prevention and/or treatment of antibiotic associated diarrhea, including Clostridium difficile associated diarrhea (CDAD), pseudomembranous colitis (PMC) and other conditions associated with C. difficile infection, using oligosac... | 01/11/2000 |
| 6004938 | Inositolglycans having insulin-like action The invention relates to inositolglycans having insulin-like action. Specific compounds are provided having the formula I A--Z--R (I) where A is the radical H--P(O)(OH)--, H--P(S)(OH)--, HO--P(S)(OH)--, HS--P(... | 12/21/1999 |
| 6001819 | Bacterial inhibition with an oligosaccharide compound The present invention is directed to compositions for the treatment of respiratory infections caused by a bacteria selected from the group consisting of S. pneumoniae, H. influenzae, H. parainfluenza, Burkholderia (Pseudomonas) cepacia, and a mixture ther... | 12/14/1999 |
| 5994324 | Water-soluble vitamin composition having excellent tablet properties and process for production thereof There is disclosed a water-soluble vitamin composition which containing about 90 to 99.8% by weight of a water-soluble vitamin, a polymer binder and at least one additive selected from the group consisting of monosaccharides, disaccharides, sugar alcohols... | 11/30/1999 |
| 5989542 | Capsular polysaccharides from enterococci The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In addition, the invention is directed to the antigens produced... | 11/23/1999 |
| 5989592 | Inhibition of complement pathway by sea cucumber fractions The present invention relates to methods for inhibiting the complement pathway in a mammal comprising administering an effective dose of a composition comprising an active ingredient selected from the group consisting of isolated sea cucumber (Phylum Echi... | 11/23/1999 |
| 5989352 | Lactitol composition and process for the preparation thereof The invention relates to a new anhydrous lactitol crystalline composition exhibiting essentially a porous and cellular structure and possessing a very high lactitol crystalline purity. This composition has remarkable functional properties, making its use ... | 11/23/1999 |
| 5985852 | Inhibition of selectin binding This invention provides compositions for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently crosslinked lipid composition is prepared having saccharides ... | 11/16/1999 |
| 5985330 | Inhibition of angiogenesis by sea cucumber fractions The present invention provides inhibition of angiogenesis in a warm-blooded animal by the administration of preparations isolated from the echinoderm sea cucumber (Class Holothuroidea). This preparation is useful as a therapeutic agent against malignant t... | 11/16/1999 |
| 5981497 | Utilization of sophorolipids as therapeutically active substances or cosmetic products, in particular for the treatment of the skin This invention relates to a new use of a sophorolipidic compound, of pharmaceutically acceptable salts of the acidic form of the sophorolipid, and of the ester of the deacetylated sophorolipidic acid form as therapeutically active substances in a method f... | 11/09/1999 |
| 5981509 | Preparation for prophylaxis or treatment of renal diseases containing sulfated polysaccharide The specification relates to a preparation for the prophylaxis or treatment of renal diseases, and a method for the prophylaxis or treatment of renal diseases, and specifically, it relates to the above preparation and method using a sulfated polysaccharid... | 11/09/1999 |
