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| Number | Title | Issue Date |
| 8039511 | Use of isothiocyanates compounds in treating prostatic diseases and skin cancer A method for preventing and treating prostatic diseases and skin cancer using naturally or artificially synthesized isothiocyanates compounds or the derivatives or metabolites thereof. ... | 10/18/2011 |
| 7928140 | Benzothiazole PI3 kinase modulators for cancer treatment The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have ... | 04/19/2011 |
| 7459483 | Method and device for detecting fumigants in air samples The present invention relates to a method and a device for detecting fumigants in air samples. The device can be designed for example as a portable analyzer 10 equipped with a stab probe 11 for sampling soil air. There are provided detection means 1... | 12/02/2008 |
| 7432392 | Ester derivatives and medical use thereof A therapeutic agent for hyperlipidemia which has no side effects on the liver unlike conventional MTP inhibitors and has excellent MTP inhibitory activity. Also, provided is an ester compound represented by the general formula (1): | 10/07/2008 |
| 7407986 | Prevention and treatment of oxidative stress disorders by glutathione and phase II detoxification enzymes The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracellular levels of at least one Phase II detox... | 08/05/2008 |
| 7402569 | Treatment of with isothiocyanates The present invention relates to methods of preventing or inhibiting the growth of Helicobacter through the use of a composition that comprises a glucosinolate, an isothiocyanate or a derivative or metabolite thereof. The present invention also relates to met... | 07/22/2008 |
| 7363745 | Pest trapping device A pest trapping device including a cap, a spewing member, a fan, a rotatable shaft, a transformer, a tray, a blue light emitting element, an electric circuit board, and a net. The spewing member has symmetrical holes to which support rods are secured for supporting ... | 04/29/2008 |
| 7332525 | Method of treatment of prostate cancer and composition for treatment thereof A method and composition for the treatment of prostate cancer comprises an effective amount of a nonsteroidal antiandrogen and an effective amount of a selective estrogen receptor modulator. The composition has fewer side effects such as breast tenderness and gyneco... | 02/19/2008 |
| 7323203 | Process for producing pickles, and antimicrobial composition The process for producing pickles of the invention comprises using an oil-in-water antimicrobial composition that contains allyisothiocyanate as the active ingredient and further contains surfactant and water added thereto, in any stage of producing pickles. The inv... | 01/29/2008 |
| 7303770 | Cancer chemoprotective food products Vegetable sources of cancer chemoprotective agents have been identified which are extraordinarily rich in glucosinolates, metabolic precursors of isothiocyanates. The vegetable sources are used to provide a dietary means of reducing the level of carcinogens in mamma... | 12/04/2007 |
| 7230020 | 11β-hydroxysteroid dehydrogenase inhibitors A compound having Formula I R1—Z—R2Formula I wherein R1 is an optionally substituted phenyl ring; R2 is or comprises an optionally substituted aromatic ring; and Z is —X—Y—L— or —Y—X—L... | 06/12/2007 |
| 7208510 | Fungicidal combinations of active substances The present invention relates to fungicidally active compound combinations of a fluorobenzothiazole derivative of the formula (I) and at least one of the compounds listed in the disclosure. ... | 04/24/2007 |
| 7199122 | Methods for inhibiting angiogenesis Novel methods for inhibiting angiogenesis and treating diseases associated with angiogenesis are described. The methods may comprise administering to a patient an effective amount of a 1,2-dithiol-3-thione derivative or metabolite thereof. Preferred compounds for us... | 04/03/2007 |
| 7150878 | Extended duration insect repellent composition and method of application to the skin Disclosed is an insect repellent composition. The composition has an amount of an insect repellent active effective to repel insects when the composition is applied to the skin, and an amount of a urethane polymer sufficient to form a film on the surface of the skin... | 12/19/2006 |
| 7151118 | Biphenylcarboxylic amide derivatives as p38-kinase inhibitors Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors. ... | 12/19/2006 |
| 7148346 | Purification process This invention provides a process for purifying a cyclosporin, e.g. cyclosporin A, or a macrolide, to a high degree of purity on a large scale. In another aspect this invention provides a bulk quantity of cyclosporin A with an impurity level of less than about 0.7%,... | 12/12/2006 |
| 7115593 | Fungicidal combinations of active substances The present invention relates to active compound combinations of a fluorobenzo-thiazole of the formula (I) and at least one of the compounds listed herein. The active compound combinations of the present inventio... | 10/03/2006 |
| 7087553 | Soil fumigant, herbicide, larvacide, ovacide and fungicide A treatment for eliminating unwanted organisms in agriculture, the treatment comprising a first component comprising allyl isothiocyanate emulsified in water, and a second component comprising a solution of phosphorus and water. ... | 08/08/2006 |
| 7078054 | Soft gelatin capsule manufacture Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a migrateable solvent such as 1,2-propyleneglycol as a solvent in the capsule fi... | 07/18/2006 |
| 7067554 | Method for the synthesis of compounds of formula I and their uses thereof This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the rec... | 06/27/2006 |
| 6995142 | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compoun... | 02/07/2006 |
| 6946579 | Arylpiperazines having activity at the serotonin 1A receptor A series of aryl piperazine compounds are effective pharmaceuticals for the treatment of conditions related to or affected by the serotonin 1A receptor; the compounds are particularly effective antagonists at that receptor, and are particularly useful for... | 09/20/2005 |
| 6906051 | Lactone integrin antagonists The present invention relates to a class of compounds represented by the Formula I: or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selec... | 06/14/2005 |
| 6867232 | Gel-like resin molded article contained in volatilization control container A gel-like resin molded article contained in a volatilization control container is provided. A gelled drug containing allyl isothiocyanate and a resin base is contained in a container, and the container is provided with an opening portion which occupies a contact ar... | 03/15/2005 |
| 6866869 | Liquid antimicrobial compositions A liquid antimicrobial composition comprises: (1) a mixture of iodide anions and thiocyanate anions; (2) periodic acid or an alkali metal salt thereof; and (3) optionally, a peroxidase. | 03/15/2005 |
| 6861442 | PYK2 and inflammation The present invention relates generally to the fields of immunology and medicine, and more specifically to the field of cellular signal transduction. The present invention relates, inter alia, to methods for diagnosis, treatment, and identification of therapeutics f... | 03/01/2005 |
| 6812248 | Prevention and treatment of degenerative diseases by glutathione and phase II detoxification enzymes The present invention generally relates to the field of treating degenerative disease by administering a pharmaceutically effective amount of a compound that elevates glutathione or at least one Phase II detoxification enzyme in diseased tissue. The present inventio... | 11/02/2004 |
| 6737441 | Treatment of helicobacter with isothiocyanates The present invention relates to methods of preventing or inhibiting the growth of Helicobacter through the use of a composition that comprises a glucosinolate, an isothiocyanate or a derivative or metabolite thereof. The present invention also relates to methods of... | 05/18/2004 |
| 6719959 | Extended duration insect repellent composition and method of application to the skin Disclosed is an insect repellent composition. The composition has an amount of an insect repellent active effective to repel insects when the composition is applied to the skin, and an amount of a urethane polymer sufficient to form a film on the surface of the skin... | 04/13/2004 |
| 6716987 | Derivatives of benzofuran or benzodioxazole compounds An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R1 and R2 independently represent hydrogen, lower alkyl, cyano, —(CH2)n—E1 | 04/06/2004 |
| 6710086 | Protected forms of pharmacologically active agents and uses therefor In accordance with the present invention, there are provided conjugates of dithiocarbamates “DC”) and pharmacologically active agents (e.g., NSAIDs). Invention conjugates provide a new class of pharmacologically active agents (e.g., anti-inflammatory agents) whi... | 03/23/2004 |
| 6613801 | Method for the synthesis of compounds of formula I and their uses thereof This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction betw... | 09/02/2003 |
| 6586407 | Injectable pharmaceutical formulations for partricin derivatives New injectable pharmaceutical formulations are described, containing a partricin derivative in the form of a free base as the active ingredient, or a pharmaceutically acceptable water-soluble salt thereof in a solubilizing/dispersing medium made up of a l... | 07/01/2003 |
| 6576226 | Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease The present invention relates to compositions and methods of treating periodontal disease and related disorders utilizing a sustained, controlled release targeted delivery method to effectively disrupt and inhibit bacterial biofilms at periodontal treatme... | 06/10/2003 |
| 6566403 | N-acetonylbenzamide fungicides This invention relates to new compositions comprising predominantly one enantiomer of an N-acetonylbenzamide fungicide, methods of preparing N-acetonylbenzamides, and their use as fungicides.... | 05/20/2003 |
| 6545043 | Compounds related to natural sources and their use as biopesticides A method for suppressing target pests, comprising exposing the pests to an effective biopesticidal amount of a composition, the composition comprising a carrier and a purified glucosinolate breakdown product having a hydroxyl group attached, wherein a sta... | 04/08/2003 |
| 6465512 | Leukemic cell growth inhibiting method Disclosed is a method for growth inhibition of human leukemic cells or therapeutic treatment method of a leukemic patient by using a medicament of which the effective ingredient is a methylsulfinylalkyl isothiocyanate such as 4-(methylsulfinyl)butyl isoth... | 10/15/2002 |
| 6455518 | Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-O-(2-hydroxyethyl)-rapamycin A synergistic combination of an IL-2 transcription inhibitor (e.g., cyclosporin A or FK506) and 40-O-(2-hydroxyethyl)-rapamycin is provided, which is useful in the treatment and prevention of transplant rejection and also certain autoimmune and inflammato... | 09/24/2002 |
| 6447811 | Pesticide against plant-pathogenic microorganisms A formulation comprising lactoperoxidase, thiocyanate and/or iodide and a hydrogen peroxide donor system, in particular glucose oxidase and glucose, is useful for controlling plant-pathogenic microorganisms such as fungi and bacteria. Preferably the formu... | 09/10/2002 |
| 6433011 | Method for inhibiting formation of aberrant crypt foci in the colon of a mammal A method is provided for inhibiting the development of colon tumorigenesis in a mammal by administering to the mammal a pharmacologically effective amount of an isothiocyanate selected from the group consisting of sulforaphane and phenethyl isothiocyanate... | 08/13/2002 |
