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| Number | Title | Issue Date |
| 8163797 | Method of treating with stable pravastatin formulation The present invention provides oral pravastatin formulations comprising a physical mixture of pravastatin and at least one pharmaceutically-acceptable excipient, wherein the composition for at least 6 months after its preparation is stable and has a pH of greater th... | 04/24/2012 |
| 8084496 | Resveratrol ferulate compounds and compositions Resveratrol ferulate compounds and compositions. ... | 12/27/2011 |
| 8080583 | Emulsion cosmetic compositions containing resveratrol derivatives and linear or branched silicone An emulsion cosmetic composition comprising at least one resveratrol derivative, a water phase, and an oil phase containing at least one linear or branched volatile or near volatile silicone and a method for delivering active resveratrol to the skin. ... | 12/20/2011 |
| 8076372 | Acythiols and component thiol compositions as anti-HIV and anti-retroviral agents Certain thiol and acylthiol compounds inhibit retrovirus growth by attacking the highly conserved zinc finger regions of essential viral proteins. These compounds, compositions containing them, and methods of using them to treat retroviral infections such as HIV are... | 12/13/2011 |
| 8008347 | Methoxypolyethylene glycol thioester chelate and uses thereof The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the p... | 08/30/2011 |
| 7985772 | Derivatives of 3,3-diphenylpropylamines The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodr... | 07/26/2011 |
| 7781484 | Thiol ester compositions and processes for making and using same Thiol ester compositions, methods of making the thiol ester compositions, and methods of using the thiol ester compositions are provided. In some embodiments, the thiol ester compositions include thiol esters, hydroxy thiol esters and cross-linked thiol esters. The ... | 08/24/2010 |
| 7560484 | Vaccine preparation containing fatty acid as a constituent The present invention provides an adjuvant that is a hydroxy unsaturated fatty acid or a derivative thereof, as well as a vaccine preparation containing the adjuvant as a constituent. For example, a vaccine shows sufficient activity to enhance the immunity when a hy... | 07/14/2009 |
| 7407985 | Compounds that abrogate DNA damage induced cell cycle G2 checkpoint and/or augment anti-cancer activity of DNA-damaging treatments The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to... | 08/05/2008 |
| 7405238 | Pharmacological inducement of the fed mode for enhanced drug administration to the stomach Drugs intended for absorption in the stomach or upper intestinal tract are administered in oral drug delivery systems in conjunction with any of various substances that have been discovered to function as potent agents for inducing the fed mode. By inducing the onse... | 07/29/2008 |
| 7388028 | Methoxypolyethylene glycol thioester chelate and uses thereof The present invention is directed generally to protecting cells, tissues and organs against the damaging effects of ionizing or other damaging agents associated with radiation or chemotherapy, or degenerative diseases or processes of various organs that elicit the p... | 06/17/2008 |
| 7381749 | Sulfonamides as inhibitors of histone deacetylase for the treatment of disease Disclosed herein are carbonyl compounds of having the structural formula: or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and ... | 06/03/2008 |
| 7378442 | Chemical entities with multiple modes of anti-inflammatory action The invention relates to methods of treatment and pharmaceutical compositions of new chemical compounds that inhibit the various enzymes in the arachidonic acid pathway implicated in inflammatory disease conditions. ... | 05/27/2008 |
| 7368593 | Method of selective esterification A method of preparing a compound of formula I wherein R is a hydrocarbon and n is an integer from 1 to 5, including the steps of: contacting a compound of formula II with a compou... | 05/06/2008 |
| 7365096 | Methods for selectively inhibiting Janus tyrosine kinase 3 (Jak3) Methods are disclosed for inhibiting or disrupting Janus tyrosine kinase 3 (Jak3) dependent function in cells of lymphoid or myeloid origin, especially for blocking proliferation and function of lymphocytes (e.g., T-cells, B-cells). A Mannich base compound, or a der... | 04/29/2008 |
| 7358277 | Use of a lactate salt for the treatment and prophylaxis of atherosclerosis The use of a lactate metal salt, in particular an L-lactate, for the treatment of atheroscloerosis and/or for the prophylaxis or treatment of diseases caused by atherosclerosis is disclosed. ... | 04/15/2008 |
| 7354906 | Composition of anti-HIV drugs and anti-cortisol compounds and method for decreasing the side effects of anti-HIV drugs in a human The present invention is based, in part, upon the discovery that the use of an anti-HIV drug in combination with at least one cortisol blocker such as procaine, reduces the side effects associated with anti-HIV drugs. The invention also relates to a method of treati... | 04/08/2008 |
| 7335683 | Compositions and methods for cystic fibrosis therapy Compositions and methods for therapy of cystic fibrosis and other conditions are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones capable of stimulating chloride transport in epithelial tissues. Therapeutic methods involv... | 02/26/2008 |
| 7288262 | Composition comprising a cyclohexane-based compound, compound and use of said compound to structure a composition Compositions, in particular cosmetic compositions, comprising a cyclohexane-based compound defined by formula (I): wherein: R, which may be identical or different, are each chosen from hydrogen atoms an... | 10/30/2007 |
| 7276536 | Method for increasing the bioavailability of the active form of S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino) phenyl] 2-methylpropanethioate The invention is directed to a method of increasing the bioavailability of the active form of S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino)phenyl]2-methylpropanethioate by administration of a therapeutically effective amount of the drug with food. The invention... | 10/02/2007 |
| 7262291 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 08/28/2007 |
| 7253296 | Acylated aminopropanediols and analogues and therapeutic uses thereof The invention relates to novel acylated aminopropanediols and the nitrogen and sulfur analogues thereof, pharmaceutical compositions comprising same, therapeutic uses thereof, in particular for the treatment of cerebral ischemia. The invention also provides a method... | 08/07/2007 |
| 7244436 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 07/17/2007 |
| 7244437 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 07/17/2007 |
| 7223793 | Phenolic acid derivatives and composition for preventing or treating blood lipid level-related diseases comprising the same The present invention relates to phenolic acid derivatives of the formula I and compositions for the preventing and the treating blood lipid level-related diseases comprising the phenolic acid derivatives. The compounds have excellent effects of reducing blood lipid... | 05/29/2007 |
| 7223798 | Lipoxin Aanalogs This invention is directed to lipoxin A4 analogs of the following formula (II): wherein R1, R2, R3, R4 and R5 are described herein. These analogs are ... | 05/29/2007 |
| 7205435 | Type B botulism toxin inhibitors Novel compounds of general formula (I), are provided with inhibitory properties for the type B botulism toxin activity, along with methods for preparation thereof and corresponding pharmaceutical compositions. ... | 04/17/2007 |
| 7192963 | Pyrrolo[2,3-d]pyrimidine compounds A compound of the formula wherein R1, R2 and R3 are as defined above, useful as inhibitors of protein kinases, such as the enzyme Janus Kinase 3. ... | 03/20/2007 |
| 7189708 | Topical composition for skin A topical skin composition containing a dipeptide compound represented by formula (1) or a salt of the dipeptide: wherein R1 represents a hydrogen atom, an alkyl group, an alkanoyl group, or —CH(R | 03/13/2007 |
| 7166744 | Retinoid derivatives and methods for producing said compounds and anti-cancer pharmaceutical composition comprising said compounds The present invention relates to a novel retinoid derivative compound represented by the formula I: wherein X, R1, R2 and R3 are as defined herein or pharmaceutically acceptalbe s... | 01/23/2007 |
| 7166726 | Aryl substituted 3,4-dihydroanthracene derivatives having retinoid antagonist or retinoid inverse agonist type biological activity Disclosed herein are compounds of the formula wherein R1 is independently H or alkyl of 1 to 6 carbons; R2 is optional and is defined as lower alkyl of 1 to 6 carbons, F, Cl, Br... | 01/23/2007 |
| 7157421 | Piracetam and piracetam analog conjugate and a pharmaceutical composition for treatment of neuronal disorders A compound of the formula where R1 is H, C1–C4 alkyl and OH; R2 in is H, C1–C4 alkyl and OH; R3 is H and C1–C4 | 01/02/2007 |
| 7141609 | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. ... | 11/28/2006 |
| 7138127 | Clostridial toxin derivatives and methods for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 11/21/2006 |
| 7112612 | N-alkylated GABA compounds, processes for their preparation and their use as medicaments The present invention relates to N-alkylated GABA (Gamma-aminobutyric acid) compounds, to processes for their preparation, to their use in therapy and to pharmaceutical compositions containing them. More particularly these compounds are useful for treatment of disor... | 09/26/2006 |
| 7091336 | Lyophilized powder of lentinan and the process of preparation thereof The present invention discloses an antineoplastic sterile lyophilized powder of lentinan and the process of preparation thereof. The lyophilized powder of lentinan is essentially consisted of 0.50–1.40 parts of lentinan and 50–140 parts of excipient for lyophili... | 08/15/2006 |
| 7091231 | 12-Aryl prostaglandin analogs Compounds comprising are disclosed, wherein Y, A, X, R, D, and n are as described. A compound comprising a prostaglandin EP2 selective agonist wherein the ω-chain comprises a substituted pheny... | 08/15/2006 |
| 7078435 | Autoinducer compounds Autoinducer compounds which enhance gene expression in a wide variety of microorganisms, therapeutic compositions and therapeutic methods wherein gene expression within microorganisms is regulated are disclosed. ... | 07/18/2006 |
| 7078402 | Aminothiol ester compounds, pharmaceutical and cosmetics compositions containing same and uses thereof The invention relates to novel aminothiol ester compounds having the general formula (I): and to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary... | 07/18/2006 |
| 7056729 | Botulinum neurotoxin-substance P conjugate or fusion protein for treating pain Agents for treating pain, methods for producing the agents and methods for treating pain by administration to a patient of a therapeutically effective amount of the agent. The agent can include a clostridial neurotoxin, or a component or fragment or derivative there... | 06/06/2006 |
