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| Number | Title | Issue Date |
| 7645792 | Prodrugs of propofol, compositions and uses thereof The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as m... | 01/12/2010 |
| 7625948 | Ester compound and medicinal use thereof A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1″) (wherein R1 and R2 are each hydrogen atom or optionally sub... | 12/01/2009 |
| 7576127 | Aromatic prodrugs of propofol, compositions and uses thereof Prodrugs of propofol, methods of making prodrugs of propofol, pharmaceutical compositions of prodrugs of propofol and methods of using prodrugs of propofol and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as migraine headache pa... | 08/18/2009 |
| 7538140 | Ester compound and medicinal use thereof A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1″) (wherein R1 and R2 are each hydrogen atom or optionally sub... | 05/26/2009 |
| 7432392 | Ester derivatives and medical use thereof A therapeutic agent for hyperlipidemia which has no side effects on the liver unlike conventional MTP inhibitors and has excellent MTP inhibitory activity. Also, provided is an ester compound represented by the general formula (1): | 10/07/2008 |
| 7427406 | Aerosols Cosmetic and/or pharmaceutical preparations comprising (a) a carbonate of the formula (I): wherein R1 is a linear alkyl and/or alkenyl group having from 6 to 22 carbon atoms, a 2-ethylhexyl, isotridecyl or isoste... | 09/23/2008 |
| 7317111 | Green and orange fluorescent labels and their uses The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative fluorescent detection of low levels of biomolecules. In a preferred embodiment, t... | 01/08/2008 |
| 7300674 | Sterile low bicarbonate dialysis concentrate solutions The present invention relates to a sterile calcium-free low bicarbonate dialysis concentrate composition for use in conjunction with regional citrate anti-coagulation in the context of either dialysis or hemofiltration. Methods of use of the sterile calcium free low... | 11/27/2007 |
| 7250396 | Juvenile hormone compositions and methods for making same The present invention relates to hormone coating layers having desirable hormone delivery characteristics and product lifetime. In one embodiment, the invention is a hormone composition including a substrate having an external surface, and a coating layer disposed o... | 07/31/2007 |
| 7241807 | Prodrugs of propofol, compositions and uses thereof The present invention provides propofol prodrugs, methods of making propofol prodrugs, pharmaceutical compositions of propofol prodrugs and methods of using propofol prodrugs and pharmaceutical compositions thereof to treat or prevent diseases or disorders such as m... | 07/10/2007 |
| 7204994 | Juvenile hormone compositions and methods for making same The present invention relates to hormone coating layers having desirable hormone delivery characteristics and product lifetime. In one embodiment, the invention is a hormone composition including a substrate having an external surface, and a coating layer disposed o... | 04/17/2007 |
| 7125895 | Cyclic amine derivatives and their uses This invention relates to novel arylalkyl cyclic amine derivatives. This invention also relates to chemokine receptor antagonists that are be effective as therapeutic agents and/or preventive agents for diseases such as atherosclerosis, rheumatoid arthritis, transpl... | 10/24/2006 |
| 7019031 | Anticancer agents based on regulation of protein prenylation Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g.... | 03/28/2006 |
| 6911460 | Antiviral agents and methods of treating viral infections The present invention relates to methods of treating viral or fungal infections using 3-aminopyridine-2-carboxyaldehyde thiosemicarbazone (3-AP) and 3-amino-4-methylpyridine-2-carboxaldehyde thiosemicarbazone (3-AMP) and its prodrug forms and to pharmaceutical compo... | 06/28/2005 |
| 6875764 | Urea and thiourea compounds useful for treatment of coccidiosis The present invention relates to novel compounds, pharmaceutical compositions containing the same as well as a method for treatment of parasitic disorders, wherein said compounds are administered. The present compounds are especially well suited for treatment of coc... | 04/05/2005 |
| 6864285 | Covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids functionally active on the CB2 cannabinoid receptor The present invention relates to novel covalent derivatives of alkanolamides of monocarboxylic and dicarboxylic acids with aminoalcohols of general formula (I) which can usefully be used as agonists of the CB2 cannabinoid receptor and hence as drugs active in pathol... | 03/08/2005 |
| 6861448 | NAD synthetase inhibitors and uses thereof Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar1—X—Ar2—Y—L—Z—Q, wherein Q is Q1Ar3 or Ar3Q1; Ar1... | 03/01/2005 |
| 6831196 | Urokinase inhibitors The invention relates to a highly active, highly specific urokinase inhibitor which is suitable for therapeutic applications and can be synthesized in an extremely simple manner. Surprisingly, it was found that amidino benzylamine derivatives, especially 4-amidino-b... | 12/14/2004 |
| 6797504 | Inhibitors of serine protease activity of matriptase or MTSP1 The present invention provides compounds which inhibit serine protease activity of matriptase or MTSP1. Also provided are pharmaceutical compositions comprising those compounds and methods of using the compounds and pharmaceutical compositions to treat conditions am... | 09/28/2004 |
| 6794384 | Hydroxylation activated drug release The present invention concerns prodrugs whose aromatic oxidation, particularly their enzymatic aromatic hydroxylation, results in their activation by the release of a drug moiety. It particularly concerns anti-tumor prodrugs and those which are specifically activate... | 09/21/2004 |
| 6720306 | Tetrapartate prodrugs A compound of Formula I, providing tetrapartate prodrugs is provided wherein: L1 is a bifunctional linking moiety; D is a moiety that is a leaving group, or a residue of a compound to be delivere... | 04/13/2004 |
| 6683112 | Gabapentin prodrugs and formulations The present invention relates to novel prodrugs of gabapentin and to pharmaceutical formulations and sustained release formulations containing the prodrugs.... | 01/27/2004 |
| 6667340 | Inhibitors of phosphatidyl myo-inositol cycle The present invention relates to the preparation and biological activity of 3-deoxy-Dmyo-inositol ether lipid analogs as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth. The compounds of the present invention are useful as ant... | 12/23/2003 |
| 6645978 | Lipoxin A4 and its analogs for the treatment of dry eye Ophthalmic compositions containing Lipoxin A4 and its analogs and methods of their use for treating dry eve are disclosed.... | 11/11/2003 |
| 6583175 | Alkylxanthates and use of alkylxanthates in the integrated pest management This invention relates to novel alkylxanthates of formulae 1 to 3 and use of alkylxanthates of formulae 1 to 6 in the integrated pest management, more specifically alkyl xanthates are used as insect growth regulators for pest management in agricultural fi... | 06/24/2003 |
| 6541473 | Resorcinol derivatives The present invention relates to certain resorcinol derivatives and their use as skin lightening agents.... | 04/01/2003 |
| 6495152 | Sulfur containing polyhydroxyalkanoate compositions and method of production A class of biopolymer including sulfur in the form of a thioester in the polymer backbone or a thioether in the polymer side chains has been developed. These are preferably produced by fermentation of bacteria with appropriate sulfur containing substrates... | 12/17/2002 |
| 6426365 | CETP activity inhibitors The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): ##STR1## wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lo... | 07/30/2002 |
| 6369103 | Method for preventing or reducing risk of onset of cardiovascular events employing an HMG CoA reductase inhibitor A method is provided for preventing or reducing the risk of onset of a cardiovascular event by administering an HMG CoA reductase inhibitor such as pravastatin, to a patient which has one or more risk factors for a coronary and/or cerebrovascular event su... | 04/09/2002 |
| 6350724 | Lice removing composition The present invention provides a composition, and a method of use thereof, that is pesticide-free and yet is capable of cleansing an individual of a pest infestation. The composition of the present invention consists essentially of an acid, an alcohol, an... | 02/26/2002 |
| 6335022 | Nanoemulsion based on oxyethylenated or non-oxyethylenated sorbitan fatty esters, and its uses in the cosmetics, dermatological and/or ophthalmological fields The present invention relates to a nanoemulsion, the oil globules of which have an average size of less than 100 nm, comprising (1) a surfactant which is solid at a temperature of less than or equal to 45° C., which surfactant is chosen from sorbitan fat... | 01/01/2002 |
| 6331535 | Retinyl carbonate derivatives, preparation process and uses The present invention relates to novel retinol derivatives having the formula (I): ##STR1## and to processes for preparing them. The invention also relates to the use of these compounds in or for the preparation of compositions intended for treating ... | 12/18/2001 |
| 6262084 | Compounds that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of 댔ଲ.sub.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions the... | 07/17/2001 |
| 6251833 | 2-arylcyclopentan-1,3-diones The present invention relates to novel 2-aryl-3-hydroxy-Ɗ2 -cyclopentene-1-one derivatives of the formula (I) ##STR1## in which A, B, D1, D2, G, W, X, Y and Z are each as defined in the description, to processes for their... | 06/26/2001 |
| 6248782 | Method of treating viral diseases A therapeutic process for treating disease in mammals caused by retroviruses in which the infected mammal is treated with a ribonucleotide reductase inhibitor such as a polyhydroxy benzoic, mandelic or phenylacetic acid derivative, such as N,3,4-trihydrox... | 06/19/2001 |
| 6201017 | Ectoparasite controlling agent for animals An ectoparasite-controlling agent for animals comprising 0.1 to 20% by weight of the neonocotinoid compounds defined in the specification and 10 to 95% by weight of a glycol or glycol monoalkyl ether has an excellent effectiveness by the application metho... | 03/13/2001 |
| 6180095 | Polymeric prodrugs of amino- and hydroxyl-containing bioactive agents The present invention is directed to double prodrugs containing polymeric-based transport forms. These polymeric prodrugs are preferably of the formula: ##STR1## wherein: L1 is a bifunctional linking moiety; G is H or ##STR2## where B is H... | 01/30/2001 |
| 6159988 | Arylcycloalkyl derivatives, their production and their use Compounds of formula I, ##STR1## and the physiologically tolerable salts thereof, wherein the substituents R1 -R4 have the meanings given in the specifications and show an activity against inflammatory conditions.... | 12/12/2000 |
| 6124352 | Antifungal agents A method of treating fungal diseases as well as pharmaceutical, veterinary and agricultural compositions useful in such treatment. The method includes administering an effective antifungal amount of a compound of the formula (I): ##STR1## wherei... | 09/26/2000 |
| 6096773 | Compounds that inhibit the binding of integrins to their receptors A method for the inhibition of the binding of 댔 댡 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositi... | 08/01/2000 |
