A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 7838555 | Macrocyclic diterpenes for the treatment and prophylaxis of acne vulgaris The present invention relates to the treatment of acne vulgaris in a subject by administering to the subject an ingenane of the formula wherein R24-R26 are herein defined. ... | 11/23/2010 |
| 7723383 | Therapeutic agents for treating acne The present invention relates to the treatment of acne vulgaris in a subject by administering to the subject an ingenane of the formula wherein R24-R26 are herein defined. ... | 05/25/2010 |
| 7534814 | Mutilin derivatives and their use as antibacterials A compound of formula wherein R2 is arylene or heterocyclene; or R and R2 together with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues have various... | 05/19/2009 |
| 7449492 | Therapeutic agents—I The present invention relates generally to chemical agents useful in the treatment and prophylaxis of infection by pathogenic or potentially pathogenic entities, or entities capable of opportunistic infection in mammals, including humans and primates, non-mammalian ... | 11/11/2008 |
| 7384977 | Water soluble paclitaxel prodrugs Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for ... | 06/10/2008 |
| 7326730 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and composi... | 02/05/2008 |
| 7179800 | Cannabinoids Compounds of the formula: wherein R, R1 and R4 are defined in the specification, and pharmaceutically acceptable salts, esters and tautomers thereof, having activity at peripheral cannabi... | 02/20/2007 |
| 7141606 | Gabapentin analogues for sleep disorders The invention provides a new use of compounds for formula 1 or 1A or a pharmaceutically acceptable salt thereof. The compounds are useful in the treatment of insomnia and related disorders. ... | 11/28/2006 |
| 7135496 | Water soluble paclitaxel derivatives Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for ... | 11/14/2006 |
| 7135581 | Antiangiogenic agents Compositions and methods for treating mammalian disease characterized by undesirable angiogenesis by administering derivatives of 2-methoxyestradiol of the general formula: wherein the variables are defined in th... | 11/14/2006 |
| 7081477 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosa... | 07/25/2006 |
| 7045524 | Pleuromutilin derivatives with antimicrobial activity Pleuromutilin compounds of the formula: are of use in anti-bacterial therapy. ... | 05/16/2006 |
| 6982282 | Emulsion vehicle for poorly soluble drugs An emulsion of α-tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans via various routes is disclosed. Also included in the emulsio... | 01/03/2006 |
| 6930128 | Estrogenic compounds as anti-mitotic agents The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosa... | 08/16/2005 |
| 6919376 | Therapeutic agents and corresponding treatments Compositions and methods of using an MT103 family member, wherein MT103 is the chemical N,N-dicyclohexyl-(1S)-isoborneol-10-sulfonamide. Uses of the compositions include cancer therapy, antibacterials, antifungals, induction of apoptosis, and hormonal antagonists. | 07/19/2005 |
| 6906046 | Pharmaceutical uses and synthesis of benzobicyclooctanes Benzobicyclooctane compounds, their use in inhibiting cellular events involving TNF-α and IL-8, and in the treatment of inflammation events in general; a combinatorial library of diverse bicyclooctanes and process for their synthesis as a library and as individual ... | 06/14/2005 |
| 6884817 | Water soluble paclitaxel derivatives Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for ... | 04/26/2005 |
| 6730699 | Water soluble paclitaxel derivatives Disclosed are water soluble compositions of paclitaxel and docetaxel formed by conjugating the paclitaxel or docetaxel to a water soluble polymer such as poly-glutamic acid, poly-aspartic acid or poly-lysine. Also disclosed are methods of using the compositions for ... | 05/04/2004 |
| 6727280 | Method for treating colorectal carcinoma using a taxane/tocopherol formulation The present invention provides methods for administering a taxane composition for the treatment of cancer. In one aspect, the compositions are not diluted prior to administration. Some embodiments provide methods for administering a taxane as a bolus injection or an... | 04/27/2004 |
| 6620845 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives ... | 09/16/2003 |
| 6472426 | Sterically hindered tetraamines and method for their production Polyamines having the formula: ##STR1## wherein R1 and R2 are alkyl, aralkyl or aryl having up to 10 carbon atoms; and a and b may be the same or different and are integers from 1 to 8; or a salt thereof with a pharmaceutically accep... | 10/29/2002 |
| 6458373 | Emulsion vehicle for poorly soluble drugs An emulsion of -tocopherol, stabilized by biocompatible surfactants, as a vehicle or carrier for therapeutic drugs, which is substantially ethanol free and which can be administered to animals or humans various routes is disclosed. Also included in... | 10/01/2002 |
| 6444702 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives ... | 09/03/2002 |
| 6403571 | Combination therapy for reducing the risks associated with cardiovascular disease The instant invention involves a combination therapy and pharmaceutical compositions comprised of a therapeutically effective amount of a cholesterol reducing agent such as an HMG-CoA reductase inhibitor in combination with a platelet aggregation inhibito... | 06/11/2002 |
| 6235706 | Combination therapy for reducing the risks associated with cardiovascular disease The present invention involves a combination therapy of administering a cholesterol reducing agent, such as a 3-hydroxy-3-methylglutaryl coenzyme a (HMG-CoA) reductase inhibitor and a platelet aggregation inhibitor for treating, preventing or reducing the... | 05/22/2001 |
| 6063797 | γ-RAR antagonist ligand or -RAR agonist ligand as an apoptosis inhibitor The use of a combination of an alpha RAR receptor-specific agonist ligand and a gamma RAR receptor-specific antagonist ligand to reduce the rate of apoptosis is disclosed.... | 05/16/2000 |
| 6057364 | Fluoro-substituted adamantane derivatives The invention relates to fluoro-substituted adamantane derivatives of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are as defined herein. The invention a... | 05/02/2000 |
| 6020370 | Bridged cyclic amino acids as pharmaceutical agents Bridged cyclic amino acids of formula ##STR1## are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain and neuropathological... | 02/01/2000 |
| 5935943 | Insecticidal composition The presence of isobornyl thiocyanoethyl ether exerts a synergistic effect on the insecticidal activity against harmful wood eating insects of certain known insecticides selected from the group consisting of imidacloprid, phenyl pyrazole insecticides, pyr... | 08/10/1999 |
| 5854284 | Candle for dispersion of insect repellent based on DEET An insect repellent candle including a liquid containing DEET and a fragrance oil which acts as a carrier for dispersing DEET vapor into the atmosphere upon evaporation of the fragrance oil. The liquid system is contained within the wax of a candle which ... | 12/29/1998 |
| 5738862 | Solid and liquid compositions for dispersion of insect repellent based on deet An insect repellent including a liquid system containing DEET and a fragrance oil which acts as a carrier for dispersing DEET vapor into the atmosphere upon evaporation of the fragrance oil. In one embodiment of the invention, the liquid system is contain... | 04/14/1998 |
| 5681846 | Extended stability formulations for paclitaxel The present invention is directed to improved pharmaceutical compositions employing paclitaxel that are formulated to increase stability and solubility. These improved formulations are useful in long-term, multi-day continuous infusion protocols, and have... | 10/28/1997 |
| 5674893 | Method for preventing reducing or risk of onset of cerebrovascular events employing an HMG CoA reductase inhibitor A method is provided for preventing or reducing the risk of onset of a cardiovascular event by administering an HMG CoA reductase inhibitor such as pravastatin, to a patient which has one or more risk factors for a coronary and/or cerebrovascular event su... | 10/07/1997 |
| 5629045 | Biodegradable nosiogenic agents for control of non-vertebrate pests Fouling of marine structures such as boats by shell bearing sea animals which attach themselves to such structures, such as barnacles, is inhibited by coatings containing lipid soluble, non-toxic, biodegradable substances which prevent the animals from si... | 05/13/1997 |
| 5616615 | Enaminone esters The present invention concerns enaminones having the formula: ##STR1## wherein R is COOCH3 ; R1 is CH3 ; R2 is H; and R3 is selected from the group consisting of C6 H4 (p-Cl) and... | 04/01/1997 |
| 5616330 | Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same This invention is directed to a composition of a taxine in a stable oil-in-water emulsion for intravenous administration. The invention also relates to a method for incorporating a taxine into an oil and making a stable oil-in-water emulsion. The composit... | 04/01/1997 |
| 5369109 | Optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids The present invention provides optically active esters of 7-substituted 3,5-difunctionalized 6-heptenoic acids represented by the following formula: ##STR1## wherein R is a substituted or unsubstituted aromatic group, a substituted or unsubstitu... | 11/29/1994 |
| 5356931 | Use of -arylacrylic derivatives for controlling pests Alpha-Arylacrylic acid derivatives of the general formula I ##STR1## where X is ethylene or ethenylene; n is 0 or 1; m is 0, 1, 2, 3 or 4; R1 is cyano, cyanato, thiocyanato, nitro, hydroxyl, carboxyl, haloalkyl, haloalkoxy, unsubstituted or sub... | 10/18/1994 |
| 5318989 | Cytotoxic bicyclo [7.3.1.]tridec-4-ene-2,6-diyne compounds and process for the preparation thereof The present invention relates to a novel and efficient process for the preparation of 8-hydroxybicyclo[7.3.1]tridec-4-ene-2,6-diyne ring system which is part of the aglycone of esperemicin and to novel cytotoxic antitumor agents having said bicyclic ring ... | 06/07/1994 |
| 5166212 | Certain n-substituted butyramide derivatives Disclosed are compound of the formula ##STR1## wherein X and Y independently represent hydroxymethyl; cyano; carboxy; functionally modified carboxy selected from esterified carboxy, carbamoyl, and N-substituted carbamoyl; 5-tetrazolyl; 2-oxazolyl, ... | 11/24/1992 |