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Walt Disney was no Mickey Mouse inventor. He devised a serious animation camera which he patented. With the device, his company created "Snow White".
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| Number | Title | Issue Date |
| 8101658 | Nitric oxide donating prostamides Nitroderivatives of prostaglandins having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension. ... | 01/24/2012 |
| 8067464 | Compositions and methods using apocynin compounds and nitric oxide donors The invention describes novel compositions comprising at least one apocynin compound or a pharmaceutically acceptable salt thereof, and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The invention also provides novel kits comprisin... | 11/29/2011 |
| 7759392 | Pharmaceutical compounds Compounds or their salts of general formula (I): A-B—N(O)s wherein: s is an integer equal to 1 or 2; A=R-T1-, wherein R is the drug radical and T1=(CO)t or (X)t′, wherein X═O, S, NR1c, R1c ... | 07/20/2010 |
| 7723382 | Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer from 0 to 6, an... | 05/25/2010 |
| 7622502 | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses cert... | 11/24/2009 |
| 7622501 | Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H)-furanones useful in the treatment of cyclooxygenase-2 mediated diseases, Formula (I). The invention also encompasses certain pharmaceutical composition... | 11/24/2009 |
| 7378437 | Drugs for diabetes Use for the diabetes treatment of compounds or salts thereof, having the following general formula (I): A-(B)b0—(C)c0—NO2 wherein A contains the radical of a drug having an antiinflammatory or analgesic activity, B is a bivalent ... | 05/27/2008 |
| 7358393 | Method for preparing β-alaninamides The invention relates to β-alanine amides of general formula (I), wherein: R1 represents hydrogen or C1-6 alkyl that is optionally substituted by hydroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, optionally substituted aryl or het... | 04/15/2008 |
| 7297808 | Statin derivatives Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing chol... | 11/20/2007 |
| 7235237 | Methods of treating vascular diseases characterized by nitric oxide insufficiency The present invention provides methods of treating or preventing vascular diseases caused by nitric oxide (NO) insufficiency. The methods encompass administering a composition comprising an antioxidant, a compound to treat cardiovascular diseases, a nitrosated compo... | 06/26/2007 |
| 7199154 | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods... | 04/03/2007 |
| 7199258 | Process for preparing nitrooxyderivatives of naproxen The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of naproxen or bromonaproxen and R1–R12 are hydrogen or alkyl groups, m, n, o, q, r and s are ea... | 04/03/2007 |
| 7186753 | Pharmaceutical compounds Compounds or their salts of general formula (I): A—B—N(O)s wherein: s is an integer equal to 1 or 2; A=R—T1—, wherein R is the drug radical and T1=(CO)t or (X)t′, wherein X=O, S, NR1c, R | 03/06/2007 |
| 7169809 | Nitric oxide releasing prodrugs of diaryl-2-(5H)-furanones as cyclooxygenase-2 inhibitors The invention encompasses novel compounds of Formula I, which are nitric oxide-releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encom... | 01/30/2007 |
| 7166638 | Statin derivatives Statin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for treating and/or preventing several diseases, in particular coronary syndromes, neurodegenerative disorders as well as for reducing chol... | 01/23/2007 |
| 7166605 | Probucol nitro-derivatives Probucol derivatives and pharmaceutical compositions containing the same to be employed in treatment or prophylaxis of diseases. ... | 01/23/2007 |
| 7166618 | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that don... | 01/23/2007 |
| 7163958 | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use The invention describes novel nitrosated nonsteroidal antiinflammatory drugs (NSAIDs) and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated NSAID, and, optionally, at least one compound that donates, transfers or re... | 01/16/2007 |
| 7160920 | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders Disclosed are (i) compounds of a steroid, a β-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production of NO or EDRF i... | 01/09/2007 |
| 7115661 | Methods and compositions for mitigating pain Methods and therapeutic compounds for treating pain, mitigating inflammation, effecting analgesia and/or effecting sedation in a subject are described. A subject is administered an effective amount of a therapeutic compound which is a nitrate ester. Novel pharmaceut... | 10/03/2006 |
| 7087240 | Device and method for the treatment of erectile dysfunction Devices and methods for treatment of erectile dysfunction and methods of manufacture and of use are provided. The devices include filmogenic material, a therapeutic agent, a permeation enhancer, and other ingredients. An embodiment of the device includes a backing a... | 08/08/2006 |
| 7034058 | Anti-tumor pharmaceutical composition comprising N-vanillyl fatty acid amide The present invention provides an anti-tumor pharmaceutical composition having a high anti-tumor effect with low side-effects. The anti-tumor pharmaceutical composition comprises a N-vanillyl fatty acid amide of formula (1): ... | 04/25/2006 |
| 6987129 | Compounds and methods for the treatment of urogenital disorders The present invention provides methods for treating a variety of urogenital disorders, such as, for example, vaginismus, dyspareunia, vulvodynia (including vulvar vestibulitis), interstitial cystitis, nonspecific urethriris (i.e., nonspecific pain and/or burning of ... | 01/17/2006 |
| 6946484 | Formulations and methods of using nitric oxide mimetics against a malignant cell phenotype Methods and formulations for inhibiting and preventing a malignant cell phenotype by administering to cells a low dose of a nitric oxide mimetic are provided. ... | 09/20/2005 |
| 6930113 | Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer... | 08/16/2005 |
| 6916835 | Nitrate esters and their use for neurological conditions Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effective amount of a therapeutic c... | 07/12/2005 |
| 6872751 | Composition and method for augmenting or restoring the production of fetal protein in patient in need thereof The present invention relates to methods for prevention and/or treatment of diseases or conditions caused by deficiency in the adult isoform of a given protein wherein said method comprises administering to a patient in need thereof a composition containing NO or at... | 03/29/2005 |
| 6844320 | Treatment of preeclampsia, toxemia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor Preeclampsia and preterm labor in a pregnant female mammal are treated by administering thereto a combination of a progestin and a nitric oxide synthase substrate, a nitric oxide donor or both, optionally in further combination with one or more of a cyclooxygenase i... | 01/18/2005 |
| 6800770 | Anti-spasticity of an eicosanoid analog The invention compounds and methods for the treatment of motor disorders. In particular, the invention provides eicosanoid analogs which are effective in ameliorating motor disorders such as spasticity caused by multiple sclerosis (MS). ... | 10/05/2004 |
| 6677374 | Nitrate esters and methods of making same Compounds and methods for mitigating neurodegeneration, effecting neuroprotection and/or effecting cognition enhancement in a subject are described. Neurological or cognitive conditions are treated by administering to a subject an effective amount of a th... | 01/13/2004 |
| 6627632 | Compositions and methods for the treatment of anorectal disorders Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2-) scavengers, ଲ-adrenergic agonists, cAMP-dependent protein kinase activa... | 09/30/2003 |
| 6559180 | Nitroglycerin-menthol potentiation for treatment of angina The strength of a nitroglycerin dosage to be administered to patients suffering from angina can be reduced when a portion of the dosage is replaced with menthol containing substances (MCS). MCS and specifically 1% Menthol has been found to potentate the e... | 05/06/2003 |
| 6534546 | Aniline derivatives possessing an inhibitory effect of nitric oxide synthase Compounds represented by the general formula (1): ##STR1## (where R1 is SR6 or NR7 R8, where R6 is typically an alkyl group having 1-6 carbon atoms, R7 is a hydrogen atom, an alkyl group having ... | 03/18/2003 |
| 6528068 | Cosmetic composition containing N-acyl neutral amino acid esters of lower alcohols An N-long-chain acyl neutral amino acid ester containing a straight-chain or branched-chain, saturated or unsaturated acyl group having from 6 to 22 carbon atoms, where the hydrocarbon group of the alcohol constituting the ester is a straight-chain or bra... | 03/04/2003 |
| 6514934 | Imidazoline -adrenergic receptor antagonist compounds in combination with nitric oxide donors, compositions and methods of use The present invention is directed to nitrosated or nitrosylated -adrenergic receptor antagonists, compositions comprising -adrenergic receptor antagonists that are optionally substituted with at least one NO or NO2 moiety and comp... | 02/04/2003 |
| 6492332 | Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation This invention relates to a method of inhibiting tumor cell adhesion, pain, and inflammation at a wound during a surgical procedure by delivering an irrigation solution containing a tumor cell anti-adhesion agent and a plurality of additional agents to an... | 12/10/2002 |
| 6472425 | Methods for treating female sexual dysfunctions The present invention provides methods for treating female sexual dysfunctions by administering to a female individual a therapeutically effective amount of at least one compound that donates, transfers or releases nitrogen monoxide, that induces the prod... | 10/29/2002 |
| 6472390 | Use of therapeutic dosages for nitric oxide donors which do not significantly lower blood pressure or pulmonary artery pressure Patients with pathologic conditions involving constriction or proliferation of smooth muscle or disease associated with cysteine containing proteins, or who are at risk for such, are administered a therapeutically effective amount of a nitric oxide (NO) d... | 10/29/2002 |
| 6413496 | Pharmaceutical compositions and devices for their administration A device for providing pharmaceutical doses comprising a container, filled with a pharmaceutical composition including a pharmaceutically active agent in a solution of liquified 1,1,1,2-tetrafluoroethane (HFC-134a), or 1,1,1,2,3,3,3 heptafluoropropane (HF... | 07/02/2002 |
| 6380244 | Nutritional and therapeutic uses of 3-hydroxyalkanoate oligomers Nutritional or therapeutic compositions are provided for increasing ketone body levels in the blood of mammals by providing a source of ketone bodies in the form of linear or cyclic oligomers and/or derivatives of 3-hydroxyacids. The 3-hydroxyacid can be ... | 04/30/2002 |
