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| Number | Title | Issue Date |
| 7557140 | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: —S(═O)... | 07/07/2009 |
| 7498358 | Human ADAM-10 inhibitors The present invention provides compounds useful for inhibiting the ADAM-10 protein. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions ... | 03/03/2009 |
| 7420089 | Hydroxamates as therapeutic agents The present invention is directed to certain hydroxamate derivatives that are useful in the treatment of hepatitis C. These compounds are also inhibitors of histone deacetylase and are therefore useful in the treatment of diseases associated with histone deacetylase... | 09/02/2008 |
| 7411001 | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystalline forms of oxygenated esters of 4-iodophenylamino benzhyd... | 08/12/2008 |
| 7294639 | Biaromatic ligand activators of PPARγ receptors Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for reg... | 11/13/2007 |
| 7232929 | Amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid The invention relates to new 2,2,3,3-tetramethylcyclopropane carboxamide derivative compounds, pharmaceutical compositions thereof and uses thereof for treating psychotic disorders, neurodegenerative diseases, epilepsy and pain. ... | 06/19/2007 |
| 7169808 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity Formula (I) compounds are described, where the groups are defined in the description, as well as processes for their preparation and their use as medicaments, particularly as selective phosphodiesterase IV inhibitors. ... | 01/30/2007 |
| 7122564 | Biaromatic ligand activators of PPARγ receptors Novel pharmaceutical/cosmetic compositions contain at least one biaromatic ligand activator of a PPARγ receptor, such biaromatic ligand having the structural formula (I): and are well suited, inter alia, for reg... | 10/17/2006 |
| 7115768 | Multicyclic compounds which inhibit leukocyte adhesion mediated by VLA-4 Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, su... | 10/03/2006 |
| 7091231 | 12-Aryl prostaglandin analogs Compounds comprising are disclosed, wherein Y, A, X, R, D, and n are as described. A compound comprising a prostaglandin EP2 selective agonist wherein the ω-chain comprises a substituted pheny... | 08/15/2006 |
| 7078438 | N-(4 substituted phenyl)-anthranilic acid hydroxamate esters The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. ... | 07/18/2006 |
| 7078435 | Autoinducer compounds Autoinducer compounds which enhance gene expression in a wide variety of microorganisms, therapeutic compositions and therapeutic methods wherein gene expression within microorganisms is regulated are disclosed. ... | 07/18/2006 |
| 7019031 | Anticancer agents based on regulation of protein prenylation Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is effected by the prenylation reaction, whereby a hydrophobic group (e.g.... | 03/28/2006 |
| 6960614 | Oxygenated esters of 4-lodo phenylamino benzhydroxamic acids The present invention relates to oxygenated esters of 4-iodophenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof. The present invention also relates to crystaline forms of oxygenated esters of 4-iodophenylamino benzhydr... | 11/01/2005 |
| 6958161 | Modified release coated drug preparation A modified release preparation having one or more coated core elements, each core element including an active ingredient and having a modified release coating, wherein a stabilising coat is provided between each core element and its modified release coating so that,... | 10/25/2005 |
| 6933104 | Diagnosis and treatment of human kidney diseases Kidney disease is diagnosed by measuring urinary catalytic iron in humans. Progressive kidney disease is treated by administering an iron chelator to humans. In particular, the progression of kidney disease essentially can be halted and the severity of kidney diseas... | 08/23/2005 |
| 6911210 | Stable active ingredient combinations which are effective against blemished skin and against acne and contain interface-active glucose derivatives and hydroxycarbolic acids Use of cosmetic and/or dermatological preparations in the form of emulsions, comprising a) an effective amount of one or more α-hydroxycarboxylic acids and/or an effective amount of one or more β-hydroxycarboxylic acids b) one or more int... | 06/28/2005 |
| 6849626 | Aza-amino acid derivatives (factor Xa inhibitors 15) The invention relates to semicarbazides of the general formula I where R1, R2, R3, R4 and I have the meaning indicated in claim 1. The compounds of the formul... | 02/01/2005 |
| 6784153 | Methods of homing molecules to lung using membrane dipeptidase The present invention provides a method of identifying a membrane dipeptidase (MDP)-binding homing molecule that selectively homes to lung endothelium. The method includes the steps of contacting MDP with one or more molecules; and determining specific binding of a ... | 08/31/2004 |
| 6770778 | N-(4-substituted phenyl)-anthranilic acid hydroxamate esters The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof. ... | 08/03/2004 |
| 6756404 | Autoinducer compounds Autoinducer compounds which enhance gene expression in a wide variety of microorganisms, therapeutic compositions and therapeutic methods wherein gene expression within microorganisms is regulated are disclosed. ... | 06/29/2004 |
| 6670400 | Phenoxyethylamine derivatives having high affinity for the 5-HT1A receptor, preparation thereof, use thereof as drugs, and pharmaceutical compositions containing said derivatives Phenoxyethylamine derivatives of general formula (I) having high affinity for the 5-HT1A receptor, methods for preparing same, pharmaceutical compositions containing said derivatives, and their use, in particular as gastric acid secretion inhib... | 12/30/2003 |
| 6620813 | Hydroxamate derivatives of non-steroidal anti-inflammatory drugs In accordance with the present invention, there are provided novel chemical entities which have multiple utilities, e.g., as prodrugs of NSAIDs; as dual inhibitors of cyclooxygenase (COX) and 5-lipoxygenase (5-LO); as anticancer agents (through promoting ... | 09/16/2003 |
| 6451851 | Pharmaceutical composition with antiviral activity containing an hydroxymic acid derivative and an antiviral agent The invention refers to pharmaceutical compositions having an enhanced antiviral activity and/or decreased side effects. The composition comprises a hydroximic acid derivative of formula (I), or a therapeutically useful acid addition salt thereof and a kn... | 09/17/2002 |
| 6403647 | Pulsed administration of compositions for the treatment of blood disorders The invention relates to novel compositions and to methods for the pulsed administration of compositions to a patient or to cells in vitro for the treatment of human blood disorders. Compositions contain chemical compounds that stimulate the expression of... | 06/11/2002 |
| 6399093 | Method and composition to treat musculoskeletal disorders A method and composition for the treatment of musculoskeletal disorders in mammals by the application of a topical composition comprising a permeation enhancing amount of one or more penetration enhancers, and one or more bio-affecting agents to provide a... | 06/04/2002 |
| 6395260 | Topical cosmetic compositions comprising benzaldoximes Benzaldoximes having at least one aromatic hydroxyl or alkoxy group are effective constituents in topical cosmetic compositions, in particular, skin lightening compositions.... | 05/28/2002 |
| 6391909 | Anandamide inhibitors as analgesic agents Disclosed is a method of inhibiting anandamide amidase in an individual or animal and novel inhibitors of anandamide amidase. The disclosed method can be used to reduce pain in an individual or animal suffering from pain, reducing nausea in an individual ... | 05/21/2002 |
| 6365619 | Treatment of arteriosclerosis A method is disclosed of treating transplant-associated arteriosclerosis in a mammal which comprises administering to a mammal, preferably man, in need of such treatment an effective amount of a VLA-4 antagonist of formula I and a VCAM-1 inhibitor of form... | 04/02/2002 |
| 6344485 | Method for treating glaucoma Methods of using prostaglandin agonists for the reduction of intraocular pressure, and accordingly glaucoma.... | 02/05/2002 |
| 6337347 | Autoinducer compounds Autoinducer compounds which enhance gene expression in a wide variety of microorganisms, therapeutic compositions and therapeutic methods wherein gene expression within microorganisms is regulated are disclosed.... | 01/08/2002 |
| 6251940 | Inflammatory cell inhibitors Compounds of general formula (I) ##STR1## wherein R4 is an ester or thioester group and R, R1, R2, and R3 are as specified in the description, inhibit monocyte and/or macrophage and/or lymphocyte activation and ... | 06/26/2001 |
| 6191150 | Formamide compounds as therapeutic agents A family of compounds having the general structural formula ##STR1## where W is a reverse hydroxamic acid group, and R1, R2, R3, R4, R5 and R6 are as described in the specification, or a ph... | 02/20/2001 |
| 6124332 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6124329 | Metalloproteinase inhibitors Compounds of general formula (II) ##STR1## wherein R1, R2 and Z are defined in the claims, are matrix metalloproteinase inhibitors.... | 09/26/2000 |
| 6124333 | Metalloproteinase inhibitors Therapeutically active hydroxamic acid derivatives, processes for their preparation, pharmaceutical compositions containing them, and the use of such compounds in medicine. The compounds are inhibitors of metalloproteinases involved in tissue degradation.... | 09/26/2000 |
| 6121322 | Azulene derivatives The invention provides novel azulene derivatives of general formula I ##STR1## wherein R1 to R6 have the significance given in the description, as well as their tautomers, enantiomers, diastereomers, racemates and physiologicall... | 09/19/2000 |
| 6100277 | Retroviral protease inhibitor combinations The present invention is directed to a method for the treatment of mammalian retrovirus infections, such as HIV, using combinations of retroviral protease inhibitors which are effective in preventing the replication of the retroviruses in vitro or in vivo... | 08/08/2000 |
| 6042877 | Method for the manufacture of anti-microbial articles A method for making an anti-microbial article is described, the method comprising: providing a substrate; forming a solution comprising a chelating polymer and a metal ion; depositing the solution on the substrate; drying the substrate to form a coated su... | 03/28/2000 |
| 6022893 | Hydroxamic acid derivatives The present invention relates to: (i) hydroxamic acid derivative of the formula (I): ##STR1## wherein R1 is hydrogen, or C1-4 alkyl; R2 is hydrogen, C1-8 alkyl, phenyl, C1-4 alkyl substituted by phenyl; E is --CONR3 --, i... | 02/08/2000 |
