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| Number | Title | Issue Date |
| 8445457 | Oral pharmaceutical solutions containing telbivudine A pharmaceutical solution suitable for oral administration comprising β-L-thymidine/2′-deoxy-L-thymidine (telbivudine), a pharmaceutically suitable solvent system, one or more taste-enhancing/masking agents, a preservative system, and a buffer system suitable to ... | 05/21/2013 |
| 8415321 | Nucleoside derivatives for treatment of infections, including Norovirus infections A method and composition for treating a host infected with a Caliciviridae virus, such as a Norovirus, comprising administering an effective treatment amount of a described modified nucleoside or a pharmaceutically acceptable salt thereof, is provided. ... | 04/09/2013 |
| 8415322 | Modified fluorinated nucleoside analogues The disclosed invention provides compositions and methods of treating a Flaviviridae infection, including hepatitis C virus, West Nile Virus, yellow fever virus, and a rhinovirus infection in a host, including animals, and especially humans, using a (2′R)-2′-deo... | 04/09/2013 |
| 8404660 | Method of obtaining of 4-N-furfurylcytosine and/or its derivatives, an anti-aging composition and use of 4-N-furfurylcytosine and/or its derivatives in the manufacture of anti-aging composition The subjects of the present invention are the method of preparation of 4-furfurylcytosine and/or its derivatives, its use in the manufacture of anti-aging compositions and an anti-aging composition. As 4-furfurylcytosine and/or its derivatives possesses a series of ... | 03/26/2013 |
| 8389497 | Use of alkylphosphocholines in combination with antitumor medications for the treatment of benign and malignant oncoses in humans and mammals The invention relates to the use of alkylphosphocholines in combination with antitumor medicaments for the treatment of benign and malignant oncoses in humans and animals. It is possible in this connection for the alkylphosphocholines to be employed in a combination... | 03/05/2013 |
| 8377905 | Stable crystal of 1-(2′-cyano-2′-deoxy-β-D-arabinofuranosyl)cytosine monohydrochloride Disclosed is a stable crystal of 1-(2′-cyano-2′-deoxy-β-D-arabinofuranosyl)cytosine monohydrochloride. There is provided a crystal of 1-(2′-cyano-2′-deoxy-β-D-arabinofuranosyl)cytosine monohydrochloride having characteristic peaks at 13.7°, 15.7°, 16.0°... | 02/19/2013 |
| 8314077 | Fatty acid-pharmaceutical agent conjugates The invention provides conjugates of fatty acids and pharmaceutical agents useful in treating noncentral nervous system conditions. Methods for selectively targeting pharmaceutical agents to desired tissues are provided. ... | 11/20/2012 |
| 8309534 | Compositions comprising a GPR109 ligand for treating disorders of the digestive tract and/or cancer Pharmaceutical compositions containing an effective amount of a ligand for GPR109 to decrease intracellular cAMP levels of a subject in combination with an effective amount of a DNA methyl transferase inhibito to reduce or inhibit downregulation of GPR109 in the int... | 11/13/2012 |
| 8283335 | Lipid composition for improving brain function The invention pertains to the use of a lipid fraction for the support of brain function. The lipid fraction comprises the medium-chain fatty acids at least 4 g hexanoic acid and/or at least 5 g octanoic acid, at least 1 g eicosapentaenoic acid, and in addition more ... | 10/09/2012 |
| 8283336 | Unit dosage for brain health The invention pertains to a composition comprising (i) uridine in nucleobase, nucleoside and/or nucleotide form; (ii) docosahexaenoic acid (DHA) and/or eicosapentaenoic acid (EPA); and (iii) a tocopherol and/or an equivalent thereof, wherein said composition has: a)... | 10/09/2012 |
| 8268800 | Certain compounds, compositions and methods The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds. ... | 09/18/2012 |
| 8258116 | Combination therapy for the treatment of HCV infection The present invention relates to therapeutic combinations comprising a protease inhibitor and a polymerase inhibitor for the treatment of HCV. The present invention also relates to therapeutic combinations comprising VX-950 and a polymerase inhibitor. Also within th... | 09/04/2012 |
| 8252768 | Designer therapy of pancreatic tumors Chemotherapeutic and Radiation sensitizing agents which target tumor cells, specifically, based on the elevation of enzyme pathways, provide highly selective drug therapy. These agents are combined with modulating doses of cytidine deaminase inhibitors to increase s... | 08/28/2012 |
| 8222230 | Pharmaceutical compositions with superior product performance and patient compliance The present invention provides novel formulations of isobutyric acid (2R,3R,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-4-fluoro-2-isobutyryloxymethyl-4-methyl-tetrahydro-furan-3-yl ester) and hydroxypropylcellulose that provide high bulk density, low particle size b... | 07/17/2012 |
| 8207142 | Inhibitor of DNA methylation Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vitro. Methods are provided for treating methylation-linked conditions through the application of 2-pyrimidinone derivatives, such as Zebularin... | 06/26/2012 |
| 8193165 | Anti-viral nucleoside analogs and methods for treating viral infections, especially HIV infections The present invention relates to novel compounds according to the general formulas I, II, III, IV or V: wherein B is nucleoside base according to the structure: and the remaining ... | 06/05/2012 |
| 8178510 | Preparation of thioarabinofuranosyl compounds and use thereof Patients suffering from cancer are treated by being administered a compound represented by the following formula: wherein each R individually is H or an aliphatic or aromatic acyl group; ... | 05/15/2012 |
| 8158606 | β-L-2′-deoxynucleosides for the treatment of resistant HBV strains and combination therapies It has been discovered that β-L-2′-deoxynucleosides are active against drug-resistant hepatitis B virus with mutations. A method for treating lamivudine resistant HBV (M552V) in a host is provided that includes administering a β-L-2′-deoxynucleoside or its pha... | 04/17/2012 |
| 8158605 | Azacytidine analogues and uses thereof The present invention is directed toward compounds of Formula (I) as follows: wherein, R is H, R5C(O); R1 is | 04/17/2012 |
| 8143234 | Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function The present invention provides methods of improving a cognitive function or a neurological function, treating or ameliorating a decline in a cognitive function or a neurological function, increasing cytidine levels, or treating a neurological disorder in a subject, ... | 03/27/2012 |
| 8129358 | Substituted pyrazole and triazole compounds as KSP inhibitors Disclosed are new substituted pyrazole and triazole compounds of Formula (I) and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses thereof: ... | 03/06/2012 |
| 8124593 | Methods of treatment using sapacitabine A first aspect of the invention relates to a method of treating leukaemia or myelodysplastic syndromes (MDS), said method comprising administering a therapeutically effective amount of sapacitabine, or a metabolite thereof, to a subject in accordance with a dosing r... | 02/28/2012 |
| 8114854 | Crystalline forms of gemcitabine amide prodrug, compositions and use thereof The present invention relates to novel crystal forms of an amide prodrug of gemcitabine, compositions thereof and methods for using. ... | 02/14/2012 |
| 8071567 | 4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication The present invention relates to the use of nucleoside derivatives of formula Ia wherein the symbols are as defined in the specification, and of pharmaceutically acceptable salts thereof and to pharmaceutical compositions c... | 12/06/2011 |
| 8067392 | Compositions and methods for treatment of mitochondrial diseases Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidien nucleotide precursors in amounts sufficient to treat symptoms result... | 11/29/2011 |
| 8067391 | ODCase inhibitors for the treatment of malaria The present invention includes methods of treating or preventing malaria by administering an anti-malarial effective amount of 6-substituted uridine derivatives to a subject need thereof. The invention also includes new 6-substituted uridine derivatives for use as t... | 11/29/2011 |
| 8058261 | 3′-ethynylcytidine derivative To provide a compound which exhibits excellent anti-tumor activity and excellent oral absorption and which is a useful anti-tumor drug. The invention provides a 3′-ethynylcytidine derivative represented by formula (1): | 11/15/2011 |
| 8058260 | 2′-C-methyl-ribofuranosyl cytidine prodrugs, pharmaceutical compositions and uses thereof The present disclosure provides 2′-C-methyl-ribofuranosyl cytidine prodrugs, methods of making 2′-C-methyl-ribofuranosyl cytidine prodrugs, pharmaceutical compositions of 2′-C-methyl-ribofuranosyl cytidine prodrugs, and methods of using 2′-C-methyl-ribofuran... | 11/15/2011 |
| 8044033 | Fluorocytidine derivatives and COX-2 inhibitors for the treatment of cancer The present invention provides, in certain embodiments, methods for the treatment of colorectal cancer comprising administering a COX-2 inhibitor and fluorocytidine derivative to a human patient. In certain embodiments, a radiation therapy is also administered to th... | 10/25/2011 |
| 8044034 | Nanoparticle derivatives of gemcitabine The use of squalenic acid or a derivative thereof in formulating at least one polar active principle with a molecular weight of 100 Da or more, in the form of nanoparticles, and pharmaceutical compositions thereof. ... | 10/25/2011 |
| 8022047 | Combination anticancer agents A cancer therapeutic agent comprising a combination of compound A described below, or a pharmaceutically acceptable salt thereof, and compound B described below, or a pharmaceutically acceptable salt thereof: Compound A represented by the formula of cla... | 09/20/2011 |
| 7951788 | Method of treating cancer and other conditions or disease states using L-cytosine nucleoside analogs The present invention relates to the use of the compound according to formula (I) Where S is (A) or (B); X is H or F; R1 is H, an acyl group, a C1-C20 alkyl or ether group, a phosphate, diphosphate, triphosphate or a phosphodiester g... | 05/31/2011 |
| 7951787 | Phosphoramidate compounds and methods of use Phosphoramidate derivatives of nucleotides and their use in the treatment of cancer are described. The base moieties of, for example, each of deoxyuridine, cytarabine, gemcitabine and citidine may be substituted at the 5-position. The phosphoramidate moiety has atta... | 05/31/2011 |
| 7947661 | Compounds for the treatment of marihuana dependence, withdrawal, and usage The invention provides methods for treating or suppressing marihuana usage, withdrawal, or dependence involving administration of a therapeutically-effective amount of a cytosine-containing or cytidine-containing compound, uridine-containing compound, creatine-conta... | 05/24/2011 |
| 7932235 | Triazolyl tropane derivatives This invention relates to novel triazolyl tropane derivatives, their acceptable acid addition salts, solvates, hydrates and polymorphs thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in metho... | 04/26/2011 |
| 7928086 | β-L-2′-deoxynucleosides for the treatment of resistant HBV strains and combination therapies It has been discovered that β-L-2′-deoxynucleosides are active against drug-resistant hepatitis B virus with mutations. A method for treating lamivudine resistant HBV (M552V) in a host is provided that includes administering a β-L-2′-deoxynucleoside or its pha... | 04/19/2011 |
| 7915233 | Compositions and methods for treatment of mitochondrial diseases Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidien nucleotide precursors in amounts sufficient to treat symptoms result... | 03/29/2011 |
| 7893037 | Pharmaceutical composition and process The present invention relates to a method of forming granules of (2R,3S,4R,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate; hydrochloride salt (I), comprising mixing I, with a granulating amount of a gra... | 02/22/2011 |
| 7879815 | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for... | 02/01/2011 |
| 7863254 | Compounds for the treatment of psychiatric or substance abuse disorders The invention provides methods for treating or preventing psychiatric and substance abuse disorders, involving administration of a therapeutically-effective amount of a cytosine-containing or cytidine-containing compound, creatine-containing compound, adenosine-cont... | 01/04/2011 |
