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| Number | Title | Issue Date |
| 7799829 | Acyloxyalkyl carbamate prodrugs of α-amino acids, methods of synthesis and use Acyloxyalkyl carbamate prodrugs of α-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of α-amino acids and methods of using acyloxyalkyl carbamate prodrugs of α-amino acids, and pharmaceutical compositions thereo... | 09/21/2010 |
| 7560483 | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readil... | 07/14/2009 |
| 7329689 | Monohydrate hydrochloride of the 4-hydroxycarbamoyl-phenyl)-carbamic acid (6-diethylaminomethyl-naphtalen-2-yl) ester A compound having formula (I) and a process for the preparation thereof are described. ... | 02/12/2008 |
| 7326730 | Aminoadamantane derivatives as therapeutic agents The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and composi... | 02/05/2008 |
| 7288564 | Indole derivatives Compounds of formula (I) or salts or solvates thereof or physiologically functional derivatives thereof are potent binders at the EP4 receptor and are of use in the treatment or prevention of conditions such as a... | 10/30/2007 |
| 7235586 | Cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and 2-carbamoyloxy compounds as therapeutic agents The invention relates to the use of cyclopentane heptan(ene)oic acid, 2-thiocarbamoyloxy and carbamoyloxy as therapeutic agents e.g. as ocular hypotensives. The compounds used in accordance with the invention are represented by the following formula I: | 06/26/2007 |
| 7214714 | 20-hydroxyeicosatetraenoic acid production inhibitors A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof [wherein R1 represents a substituted morpholino group, a substituted piperidino group, a... | 05/08/2007 |
| 7176201 | Modulation of anxiety through blockade of anandamide hydrolysis Fatty acid amide hydrolase inhibitors of the Formula: are provided wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or ... | 02/13/2007 |
| 7087643 | Carbamate compounds for use in preventing or treating neuropathic pain and cluster and migraine headache-associated pain This invention is directed to a method for preventing or treating neuropathic pain and cluster and migraine headache-associated pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I): | 08/08/2006 |
| 7034057 | Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, TNF-α or combi... | 04/25/2006 |
| RE39055 | Hepatoselective pharmaceutical actives The invention provides an analogue of a pharmaceutical active whose molecular weight is less than 25,000 Daltons, the analogue comprising a pharmaceutical active whose molecular weight is less than 25,000 Daltons covalently linked to a pendant molecular group wherei... | 04/04/2006 |
| 6986898 | Synergistic and residual pesticidal compositions containing plant essential oils with enzyme inhibitors Synergistic and residual pesticidal compositions containing synergistic and residual mixtures of plant essential oils in admixture with enzyme inhibitors, with or without other compounds not previously used as active ingredients in pesticidal formulations. In additi... | 01/17/2006 |
| 6936638 | Ligands of adenine nucleotide translocase (ANT) and compositions and methods related thereto Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically accept... | 08/30/2005 |
| 6833387 | Chemical compounds The use of a 3-substituted indole compound of formula (I) or a pharmaceutically acceptable salt, amide or ester thereof; X is CH2 or SO2 and R1, R2, R3, R4, R5, R6 and R7 | 12/21/2004 |
| 6825224 | Prodrugs of carbamate inhibitors of IMPDH The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that convert to active inhibitors of the IMPDH enzyme in vivo. The compounds an... | 11/30/2004 |
| 6815464 | Carbamate compounds for use in the treatment of pain This invention is directed to a method for the treatment of pain comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (I) and Formula (II): | 11/09/2004 |
| 6777572 | Use of propargyl glycine amino propargyl diol compounds for treatment of renal failure Compounds characterized generally as propargyl glycine amino propargyl diol derivatives are useful for treatment of renal failure. Compounds of particular interest are those of Formula I wherein A is selected from CO and... | 08/17/2004 |
| 6756511 | Gamma-secretase inhibitors Gamma-secretase inhibitors, useful in the treatment or prevention of Alzheimer's disease, are disclosed. The preferred compounds have, as the central portion of the molecule, the structure (a) and are di-astereoisomers of known protease inhibitors. | 06/29/2004 |
| 6717012 | Antioxidant nitroxides and nitrones as therapeutic agents The invention provides novel adamantane compounds having one of the following formulas: wherein: R1 and R3 are H, OH, alkyl, cycloalkyl, amino or aryl, and can be the same or different; | 04/06/2004 |
| 6696497 | Fungicidal mixtures A fungicidal composition comprises an acceptable carrier and/or surface active agent and a synergistically effective amount of (a) at least one benzophenone of formula I ##STR1## wherein R1, R2, R3, R4, R5 | 02/24/2004 |
| 6589986 | Methods of treating anxiety disorders This invention provides methods for treating, preventing or inhibiting anxiety, anxiety-related conditions and phobias in a mammal using compounds of the formula: ##STR1## wherein: R1 is H, alkyl, alkanoyl or the radical Ar; R2 is H ... | 07/08/2003 |
| 6486194 | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases The present invention provides a method of treating a neurodegenerative disease and in particular Alzheimers disease which comprises administering to a human in need thereof a therapeutically effective amount of a non-steroid COX-II inhibitor. Although a ... | 11/26/2002 |
| 6465457 | Carbonate, carbamate, thiocarbonate dithiocarbonate and thiocarbomate derivatives useful as fungicides Fungicidal compounds of formula (I): ##STR1## wherein W is CH3 O.CH.dbd.CCO2 CH3, CH3 ON.dbd.CCONR3 R4 or CH3 ON.dbd.CCO2 CH3 and stereoisomers thereof; n i... | 10/15/2002 |
| 6416789 | Synergistic combination of fungicides to protect wood and wood-based products from fungal decay, mold and mildew damage A wood treatment material having a synergistic combination of fungicides including boron-containing compounds, organo-iodine compounds and amine-oxides is provided. This combination is shown to be especially effective in providing resistance to decay, mol... | 07/09/2002 |
| 6395763 | Prodrugs of carbamate inhibitors of IMPDH The present invention relates to novel compounds, methods of preparing these compounds, and pharmaceutical compositions comprising these compounds. These compounds are carbamate prodrugs that convert to active inhibitors of the IMPDH enzyme in vivo. The c... | 05/28/2002 |
| 6346545 | Urethanes, thio and dithio analogues and their use as inhibitors of cholesterol biosynthesis The present invention relates to urethanes and the thio and dithio analogues thereof of general formula ##STR1## wherein m, n, A, X, Y and R1 to R8 are defined as in claim 1, the enantiomers, diastereomers and the salts thereof, part... | 02/12/2002 |
| 6251938 | Phenylethylamine derivatives This invention is directed to compounds of the following formula: ##STR1## wherein m is from 0-4; X is O or S; Y is halogeno; R1 is hydrogen or C1-4 alkyl; R2 is hydrogen, C1-4 alkyl or optionally substituted pr... | 06/26/2001 |
| 6197805 | Broad spectrum antimicrobial mixtures This invention is directed to a broad spectrum antimicrobial composition which comprises a mixture of an iodopropynyl compound in combination with 2-(methoxycarbonylamino)benzimidazole and, where desirable, an algicide said mixture provided in an amount s... | 03/06/2001 |
| 6063761 | Hepatoselective pharmaceutical actives The invention provides an analogue of a pharmaceutical active whose molecular weight is less than 25,000 Daltons, the analogue comprising a pharmaceutical active whose molecular weight is less than 25,000 Daltons covalently linked to a pendant molecular g... | 05/16/2000 |
| 5973000 | Hair revitalization tonic composition containing a lipid derivative and use thereof The invention relates to a hair revitalizing tonic composition containing, as an active ingredient, at least one lipid derivative of the general formula ##STR1## wherein R1, R2, R3, R4 and Y are as defined ... | 10/26/1999 |
| 5942548 | Use of ethynyl alanine amino diol compounds for treatment of hypertension Compounds characterized generally as ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of cardiovascular disorders. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO a... | 08/24/1999 |
| 5922761 | Methods for in vivo reduction of iron levels and compositions useful therefor In accordance with the present invention, there are provided methods for the in vivo reduction of free iron ion levels in a mammalian subject. The present invention employs a scavenging approach whereby free iron ions are bound in vivo to a suitable physi... | 07/13/1999 |
| 5874465 | Hydrazinecarboxylate miticides and insecticides Compounds having the structural formula: ##STR1## wherein: R is C1 -C6 hydroxyalkyl, C1 -C6 haloalkyl, C1 -C6 alkyl, C7 -C9 aralkyl, or nitroso; R' is C1 | 02/23/1999 |
| 5840746 | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases The present invention provides a method of treating a neurodegenerative disease and in particular Alzheimers disease which comprises administering to a human in need thereof a therapeutically effective amount of a non-steroid COX-II inhibitor. Although a ... | 11/24/1998 |
| 5821260 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty... | 10/13/1998 |
| 5811449 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 09/22/1998 |
| 5792787 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty... | 08/11/1998 |
| 5783596 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty... | 07/21/1998 |
| 5773209 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 06/30/1998 |
| 5750351 | Treatment for atherosclerosis and other cardiovascular and inflammatory diseases A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturat... | 05/12/1998 |
