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| Number | Title | Issue Date |
| 5856323 | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase 2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 2,4-diaryl tetrahydrofurans, 2,4-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes, 2,4-diaryl pyrrolidines, and 2,5-diaryl pyrrolidines are disclosed that reduce the chemotaxis and respira... | 01/05/1999 |
| 5849727 | Compositions and methods for altering the biodistribution of biological agents This invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic or bioactive agents. The methods and composition of the invention can be used with several therapeutic or bioactive agents and can achieve site-... | 12/15/1998 |
| 5849747 | N, n-disubstituted amic acid derivatives The present invention relates to a compound of the formula (I): ##STR1## wherein Ar1, Ar2, Ar3 and Ar4 represent an aryl group or a heteroaromatic ring group; A represents a hydrocarbon group which may be s... | 12/15/1998 |
| 5843980 | Benzamidoxime prodrugs as antipneumocystic agents A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime of Formula II ##STR1## wherein: R1 and R2 are ... | 12/01/1998 |
| 5834498 | Cyclopentane heptan(ene)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents The invention relates to the use of derivatives of F-type prostaglandins as ocular hypotensives. The PGF derivatives used in accordance with the invention are represented by the following formula I: ##STR1## wherein wavy line attachments indicate eit... | 11/10/1998 |
| 5834468 | Substituted aryl and heteroaryl compounds as E-type prostaglandin antagonists This invention relates to substituted and unsubstituted (aryl- and heteroaryl-) alkyl-, alkyloxy-, alkylthio-, oxo-, thio-, and alkylamino!- heteroaryl and aryl!- alkylamino-, aminoalkyl-, alkyloxy-, and alkylthio!- aryl and heteroaryl compounds of ... | 11/10/1998 |
| 5834460 | Serine derivative A serine derivative represented by the general formula (I) ##STR1## (symbols in the formula represent the following meanings; X: a sulfur atom or an oxygen atom, Y: a nitrogen atom or CH, R1 and R2 : the same or different from each o... | 11/10/1998 |
| 5834508 | Ketone derivatives A novel ketone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell ... | 11/10/1998 |
| 5824704 | Anti-viral aromatic O-alkylated oximes, ethers and thioethers Compounds of the formula ##STR1## These compounds are useful for inhibiting the growth or replication of retroviruses such as HIV.... | 10/20/1998 |
| 5824691 | Guanidine derivatives as inhibitors of Na+ /H+ exchange in cells Guanidine derivatives of the formula: ##STR1## wherein Y is C--R1 (in which R1 is hydrogen, lower alkyl, hydroxy, protected hydroxy, etc.,) R2 is pyrrolyl, tetrazolyl, pyrazolyl, etc., R3 is hydrogen, lower alko... | 10/20/1998 |
| 5821267 | Amidino derivatives useful as nitric oxide synthase inhibitors The current invention discloses amidino derivatives useful as nitric oxide synthase inhibitors.... | 10/13/1998 |
| 5807886 | Bicyclic amidine dervatives as inhibitors of nitric oxide synthetase Compounds of the formula (I) ##STR1## wherein D represents a 5-membered heterocyclic aromatic ring containing 1 to 4 heteroatoms selected from O, N or S, optionally substituted at a carbon atom by halogen, trifluoromethyl, alkyl C1 to 6, nitro, cyano... | 09/15/1998 |
| 5792776 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders Disubstituted tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory... | 08/11/1998 |
| 5780503 | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders Disubstituted tetrahydrofurans, tetrahydrothiophenes, pyrrolidines and cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen radicals of polymorphonuclear leukocytes during an inflammatory... | 07/14/1998 |
| 5770620 | Aryl acrylic acid derivatives useful as protein tyrosine phosphatase inhibitors The present invention provides novel protein tyrosine phosphatase modulating compounds having an aryl acrylic acid structure, compositions comprising the compounds, and methods of making and using the same.... | 06/23/1998 |
| 5767147 | Inhibition of glutathione transferase by haloenol lactones This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: ##STR1## in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific mea... | 06/16/1998 |
| 5760069 | Method of treatment for decreasing mortality resulting from congestive heart failure A method of treatment using a compound of Formula I: ##STR1## wherein: R1 is hydrogen, lower alkanoyl of up to 6 carbon atoms or aroyl selected from benzoyl and naphthoyl; R2 is hydrogen, lower alkyl of up to 6 carbon atoms or arylal... | 06/02/1998 |
| 5750559 | Potentiation of the antireactive-antiasthmatic effect of inhaled loop diuretics by inhaled non-steroidal anti-inflammatory drugs The antireactive-antiasthmatic effect of inhaled loop diuretics is potentiated by the use of a combination of a loop diuretic and a non-steroidal anti-inflammatory drug as an inhalant for combating asthma. The use of a cyclooxygenase inhibitor as the non-... | 05/12/1998 |
| 5750561 | Compositions containing taxane derivatives The invention provides new compositions containing taxane derivatives, consisting of solutions of such derivatives in a solvent mixture composed of ethanol and polysorbate. These compositions are used to prepare perfusions.... | 05/12/1998 |
| 5747505 | Heterocyclic aryl-, alkyl- and cycloalkylacetamides The heterocyclic aryl-, alkyl- and cycloalklacetamides are prepared by reacting the appropriately substituted acetic acids with amines, if appropriate in complexed form. The heterocyclic aryl-, alkyl- and cycloalkylacetamides can be used as active compoun... | 05/05/1998 |
| 5744168 | Methods and compositions for the prevention and treatment of gastrointestinal disorders The subject invention encompasses methods for prevention and treatment of a human or lower animal subject having a gastrointestinal disorder caused or mediated by algae and/or cyanobacteria comprising administering to the subject bismuth and one or more a... | 04/28/1998 |
| 5744474 | Treatment of incontinence Urinary incontinence in humans is treated by administration of venlafaxine or a compound chosen from a series of aryloxy propanamines.... | 04/28/1998 |
| 5736566 | Heteroaromatic compounds and crop protection agents containing them Heteroaromatic compounds of the formulae IA and IB ##STR1## where the dashed line is a double bond between the carbon atom and a Z atom, and the index and the substituents have the following meanings: R1 alkyl, alkoxy, alkylamino R2 ... | 04/07/1998 |
| 5733931 | Cyclohexanediurea derivative and process for its production The present invention provides a cyclohexanediurea derivative, inclusive of its salt, represented by the following formula (I): ##STR1## wherein R1 and R2 are the same or different and they each represent a straight-chain or bra... | 03/31/1998 |
| 5733935 | Hydroxylamine derivatives and fungicides containing the same A hydroxylamine derivatives of formula (I): ##STR1## wherein R represents ##STR2## in which R1 and R2 represents alkyl group, alkenyl group, alkynyl group, cycloalkyl group, haloalkyl group, haloalkynyl group, alkoxy -... | 03/31/1998 |
| 5733924 | DC 107 derivatives and treatment methods DC107 derivatives represented by the formula (I): ##STR1## or pharmacologically acceptable slats thereof, wherein R1 is hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrah... | 03/31/1998 |
| 5725878 | Pharmaceutical composition comprising HIV protease inhibiting compounds A pharmaceutical composition is disclosed which comprises a solution of an HIV protease inhibiting compound in a pharmaceutically acceptable organic solvent comprising a pharmaceutically acceptable alcohol. The composition can optionally comprise a pharma... | 03/10/1998 |
| 5726201 | Gemfibrozil containing pharmaceutical compositions The invention relates to oral solid pharmaceutical composition containing as active ingredient gemfibrozil and conventional pharmaceutical auxiliary agents comprising as surfactant bis-(2-ethyl-hexyl)-sodium-sulfosuccinate in an amount of 0.05-0.5% by wei... | 03/10/1998 |
| 5723495 | Benzamidoxime prodrugs as antipneumocystic agents A method of treating Pneumocystis carinii pneumonia in a subject in need of such treatment is disclosed. The method comprises orally administering to the subject a bis-benzamidoxime of formula I: ##STR1## wherein R1 and R2 are e... | 03/03/1998 |
| 5719176 | 2-amino-1,3-propanediol compound and immunosuppressant A 2-amino-1,3-propanediol compound represented by general formula (I) or a pharmaceutically acceptable salt thereof, and an immunosuppressant containing the same as the active ingredient. In said formula R represents optionally substituted linear or branc... | 02/17/1998 |
| 5714484 | -(1,3-dicarbonylenol ether) methyl ketones as cysteine protease inhibitors Cysteine protease inhibitors which deactivate the protease by covalently bonding to the cysteine protease and releasing the enolate of a 1,3-dicarbonyl (or its enolic form). The cysteine protease inhibitors of the present invention accordingly comprise a ... | 02/03/1998 |
| 5714142 | Method and compositions for increasing the serum half-life of pharmacologically active agents by binding to transthyretin-selective ligands Compositions and methods are provided for increasing the serum half-life of a pharmacologically active agent. The novel compositions are covalent conjugates of the selected pharmacologically active agent and a transthyretin-binding ligand such as tetraiio... | 02/03/1998 |
| 5714512 | Compositions containing taxane derivatives This invention relates to compositions containing taxane derivatives, consisting of a solution of such derivatives in a surfactant. These compositions can be used to prepare perfusion solutions.... | 02/03/1998 |
| 5708021 | Debittered ranitidine preparation Ranitidine salts with polycarboxylic acids, such as copolymers of acrylic and/or methacrylic acid with their lower alkyl esters, are water-soluble salts with a very reduced bitter taste. The salts are suitable as liquid gastritis preparations.... | 01/13/1998 |
| 5698582 | Compositions containing taxane derivatives This invention relates to compositions containing taxane derivatives, consisting of a solution of such derivatives in a surfactant. These compositions can be used to prepare perfusion solutions.... | 12/16/1997 |
| 5698584 | 3,4-diaryl-2-hydroxy-2,5-dihydrofurans as prodrugs to COX-2 inhibitors The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases c... | 12/16/1997 |
| 5696151 | Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants Compounds of the formula ##STR1## wherein X is O or S, useful for the inhibition of the replication of HIV-1 and reverse transcriptase mutants thereof, in vitro and in vivo.... | 12/09/1997 |
| 5693666 | 6,7-modified paclitaxels The present invention provides paclitaxel derivatives of formula I ##STR1## and pharmaceutical compositions.... | 12/02/1997 |
| 5693667 | Fungicides for the control of take-all disease of plants A compound, composition, and method for controlling Take-all disease of plants by applying a fungicide of the formula: ##STR1## wherein Z1 and Z2 are carbons of a furan ring; A is selected from the group consisting of --C(X)-ami... | 12/02/1997 |
| 5688819 | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents The present invention provides cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compounds, which may be substituted in the 1-position with amino, amido, ether or ester groups, e.g., a 1-OH cyclopentane heptanoic acid, 2-(cycloalkyl or arylalkyl) com... | 11/18/1997 |
