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Class 514/468 - Polycyclo ring system having the hetero ring as one of the cyclos


Subclass of Class 514 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the five-membered hetero ring is
No. of patents: 424
Last issue date: 05/22/2012


                9      
NumberTitleIssue Date
5134140Psychotropic benzofuran derivatives
The antipsychotic, antidepressant, anxiolytic compounds of the formula: ##STR1## wherein Z is phenyl or phenyl substituted with alkyl, alkoxy, hydroxy, halogen or methylenedioxy or Z is one of the structures ##STR2## in which m is one of the int...
07/28/1992
5132322Etoposide analogues
Compounds that are analogs of etoposide and exhibit antitumor activity are disclosed. The compounds of the present invention have the following formula: ##STR1## where: R1 is ଲ-OCH2 CH2 NH2 ...
07/21/1992
5093360Retinal, derivatives and their therapeutic use
Therapeutic as well as preventive measures to improve cosmetic conditions and to alleviate the symptoms of dermatologic disorders with retinal and its derivatives is disclosed. Cosmetic conditions and dermatologic disorders in humans and domestic animals ...
03/03/1992
50860712,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivatives
Pharmaceutically useful compounds are 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivatives which are excellently stable and potent in vivo....
02/04/1992
5075331Benzofuran compounds, compositions containing them and processes for using the compositions
A benzofuran compound of the formula ##STR1## wherein A represents ##STR2## wherein R1, R2, R3, B and D have various meanings. The benzofuran compound is usefully employed in pharmaceutical and cosmetic comp...
12/24/1991
5071853Polycyclic amines useful as cerebrovascular agents
A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed....
12/10/1991
5066669Benzofuran derivatives
A novel biphenyl derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted sulfur-containing or oxygen-containing heteromonocyclic ring; Ring B is a ring of the formula: ##STR2## each of R1 and R3...
11/19/1991
5055452Medicinal and cosmetic compositions
A benzofuran derivative which is a compound of formula (I): ##STR1## wherein a to d each are 0 or 1, with a+b+c+dࣙ2; R1 to R6 are each H or C1 -C6 alkyl; R7 is --CH2 OR8 (...
10/08/1991
5051132Lyophilized preparation of 6-(3-dimethylaminopropionyl)forskolin
A lyophilized preparation comprising 6-(3-dimethylaminopropionyl)forskolin, a buffer agent having a pH value of about 3 to about 6 when dissolved, and, as an optional ingredient, a sugar. The lyophilized preparation is excellent in resolubility and stable...
09/24/1991
5049581Dibenzofurans having anti-tumor activity
The present invention relates to compounds of formula (I) ArCh2 R or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid additio...
09/17/1991
5026726Gossylic iminolactones and gossylic lactones and their anti-viral activities
A compound of the chemical formula ##STR1## wherein n is 1 or 2, X is NH and O, and R1 and R2 are H, (C1 -C12) alkyl, (C2 -C12)alkenyl, (C2 -C12)alkynyl, (C2...
06/25/1991
5021448Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist
A method of reducing serum uric acid and/or increasing renal clearance of uric acid in a mammal in need thereof comprising administering to such mammal a uricosuric effective amount of a thromboxane synthetase inhibitor, a thromboxane receptor antagonist,...
06/04/1991
5019573Substituted dibenzofurans and methods of using same
Novel substituted dibenzofuran compounds are disclosed. The compounds exhibit activity in antagonizing the effects of leukotriene B4 (LTB4). Pharmaceutical compositions containing the novel compounds and methods of treatment employin...
05/28/1991
5017603Xanthomegnin, a known compound, is an antiparasitic agent
The controlled aerobic fermentation of the fungal organism Fusarium lateritium var. longum produces xanthomegnin. Xanthomegnin has been discovered to have potent parasiticidal, anthelminthic, and insecticidal activity....
05/21/1991
5008286Certain substituted naphthofurans with anti-tumor properties
The present invention relates to compounds of formula (I) ArCH2 R1 (I) or a monomethyl or monethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon ato...
04/16/1991
5002965Use of ginkgolides to prevent reperfusion injury in organ transplantation
A living tissue or living cell preservation solution comprising an effective amount of a ginkgolide to reduce reperfusion injury in living tissue which has been stored therein and a substance or mixture or substances present in an amount sufficient to pro...
03/26/1991
5001149Azadirachtin derivative insecticides
Derivatives of azadirachtin are described which should facilitate their synthesis and provide greater stability than their naturally-occurring counterpart. The derivative 2',3',22,-23-tetraydroanzadirachtin is also described, that derivative retaining ful...
03/19/1991
4999376Pharmaceutical composition for treating and preventing cardiovasular disease
The new pharamaceutical composition (PTC) and process are provided for treating and preventing cardiovascular disease. The fine-PTC is composed of following ingredients: Puerarin or derivate of Puerarin; Danshensu or Danshenketone; Tetramethyl pyrazine; P...
03/12/1991
4999343Production of polysaccharides and saponin of dangshen
The new pharmaceutical composition (PTC) and process are provided for treating and preventing cardiovascular disease. The fine-PTC is composed of following ingredients: Puerarin or derivative of Puerarin; Danshensu or Danshenketone; Tetramethyl pyrazine; ...
03/12/1991
4983587Dihydrodibenzofuran derivatives and fungicides containing these compounds
Substituted benzofuran derivatives of the formula ##STR1## where R1, R2 and R3 are hydrogen, an alkali or alkaline earth metal, alkyl, aralkyl, alkanoyl, halogen-substituted alkanoyl, benzoyl or a radical R4
01/08/1991
49786796- and/or 7-substituted-1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis
Positions 7- and/or 6-substituted 1,2,3,4,4a,9b-Hexahydro-8-hydroxydibenzofuran-3-ols and analogs of that general structure are described. These compounds are found to be potent inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukot...
12/18/1990
4970199Steroidal glycolipids as host resistance stimulators against viral infection
Disclosed are steroidal derivatives of glycolipids, in which steroids are bridged, via a medium length hydrocarbon chain, to 1-thio-D-mannopyranoses or 1-thio-L-fucopyranoses in combination with an anti-AIDS drug, that protect an immunocomprimised hot, pa...
11/13/1990
4970212Method of treating human illnesses which compromise the ability to mount an effective immunological response
A method is disclosed for treating human patients suffering from illnesses, including AIDS, which compromise their ability to mount an effective immunological response. This method comprises administering to the patient a pharmaceutically acceptable cytos...
11/13/1990
4963526Oral insulin and a method of making the same
The present invention provides for a composition of matter useful as an oral dosage form of insulin based upon a two phase liquid aqueous system in which insulin component or components are incorporated. The invention also provides for a method of prepari...
10/16/1990
4960791Salannin derivative insect control agents
Derivatives of salannin, including 2',3',20,21,22,23-hexahydro salannin and 20,21,22,23-tetrahydro salannin derivatives, having up to 40-fold greater insect antifeedant activity than native salannin....
10/02/1990
4943589Anthelmintic dysinins of marine origin
This invention is directed to a method for treating helminthiasis which comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of Formula (I): ##STR1## where R1 is hydrogen or --SR2
07/24/1990
4918101Tetracyclic phenanthro furan heterocyclic derivatives compositions and use
The present invention relates to antitumor compounds of formula (I) ArCH2 R1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29...
04/17/1990
4908207Method of treatment of a person having a compromised human immune system
A method of producing a composition for use in the treatment of a compromised human immune system is described. The active ingredient in the ingredient in the composition is a mixture of terpenoids derived from an extract of the tubers of the plant Cyperu...
03/13/1990
4906470Pharmaceutical composition for treating and preventing cardiovascular disease
The new pharmaceutical composition (PTC) and process are provided for treating and preventing cardiovascular disease. The fine-PTC is composed of following ingredients: Puerarin or derivative of Puerarin; Danshensu or Danshenketone; Tetramethyl pyrazine; ...
03/06/1990
4904693Octahydro indenofuran derivatives and their therapeutic compositions
This invention relates to indenofuran derivatives of the formula: ##STR1## wherein R stands for H or for a ##STR2## group optionally substituted on the phenyl ring by Alk, OH or OAlk, Alk being a lower straight or branched alkyl group up to C
02/27/1990
4897418Novel naphthalene derivative
Naphthalene derivative of the formula: ##STR1## wherein R1 is hydrogen atom or a lower alkoxycarbonyl and R2 is a lower alkoxycarbonyl, or R1 and R2 are combined together to form a group of the formula: ...
01/30/1990
4883808Condensation products of cyclic diketones and ascorbic acid as immunomodulatory agents
It has now been discovered that the acid catalyzed Michael reaction products of ascorbic acid and certain selected ketones are useful for their therapeutic activity. More specifically the useful reaction products of the invention are those obtained by rea...
11/28/1989
4866073Acridinylmethylamino derivatives and pharmaceutical compositions containing them
The present invention relates to compounds of formula (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wh...
09/12/1989
4866070Acenaphtho[1,2b]quinolinylmethylamino derivatives and pharmaceutical compositions containing them
The present invention relates to compounds of formula (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wh...
09/12/1989
4863951Pharmacologically active amino-5,6,7,8-tetrahydronaphtho [2,3-B] furan compounds
Compounds of general formula I, ##STR1## in which: R1 denotes a hydrogen atom or, with the proviso, however, that the amino radical is at the 7-position, a linear or branched alkyl radical containing 1 to 4 carbon atoms, R2 deno...
09/05/1989
4861767Pharmaceutical compositions
Pharmaceutical compositions containing an iron complex of 3-hydroxy-4-pyrone or of a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms are of v...
08/29/1989
4857516Coumaran derivatives and their pharmaceutical use
A compound of the formula ##STR1## wherein R is a lower alkyl group, R0 is hydrogen or an acyl group, R1 and R2 are lower alkyl groups which may optionally be substituted or wherein R1 and R2 are...
08/15/1989
4851429Pharmaceutically useful tricyclic amines derived from 2,3,5,6,7,8-hexahydronaphtho(2,3-B)furan and from 2,3,6,7,8,9-hexahydro-5H-benzocyclohepta(2,3-B)furan
Compound of general formula I ##STR1## in which R1 and R2, which may be identical or different, each denote a hydrogen atom, a benzyl radical, a cyclohexylmethyl radical or a linear or branched alkyl radical containing from 1 to...
07/25/1989
4840951Novel naphthalene derivative
Naphthalene derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted benzene ring; each of R1 and R2 is a group of the formula: --OR5, --NHR5 or ##STR2## or either one of R
06/20/1989
4837226Polycyclic amine derivatives useful as cerebrovascular agents
A method for the treatment of cerebrovascular disorders by administering a fluorenamine, dibenzofuranamine, or dibenzothiophenamine derivative....
06/06/1989
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