"What can be more palpably absurd than the prospect held out of locomotives traveling twice as fast as stagecoaches?"
The Quarterly Review ; March edition, 1825
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| Number | Title | Issue Date |
| 5134140 | Psychotropic benzofuran derivatives The antipsychotic, antidepressant, anxiolytic compounds of the formula: ##STR1## wherein Z is phenyl or phenyl substituted with alkyl, alkoxy, hydroxy, halogen or methylenedioxy or Z is one of the structures ##STR2## in which m is one of the int... | 07/28/1992 |
| 5132322 | Etoposide analogues Compounds that are analogs of etoposide and exhibit antitumor activity are disclosed. The compounds of the present invention have the following formula: ##STR1## where: R1 is ଲ-OCH2 CH2 NH2 ... | 07/21/1992 |
| 5093360 | Retinal, derivatives and their therapeutic use Therapeutic as well as preventive measures to improve cosmetic conditions and to alleviate the symptoms of dermatologic disorders with retinal and its derivatives is disclosed. Cosmetic conditions and dermatologic disorders in humans and domestic animals ... | 03/03/1992 |
| 5086071 | 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivatives Pharmaceutically useful compounds are 2,5,6,7-tetranor-4,8-inter-m-phenylene PGI2 derivatives which are excellently stable and potent in vivo.... | 02/04/1992 |
| 5075331 | Benzofuran compounds, compositions containing them and processes for using the compositions A benzofuran compound of the formula ##STR1## wherein A represents ##STR2## wherein R1, R2, R3, B and D have various meanings. The benzofuran compound is usefully employed in pharmaceutical and cosmetic comp... | 12/24/1991 |
| 5071853 | Polycyclic amines useful as cerebrovascular agents A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.... | 12/10/1991 |
| 5066669 | Benzofuran derivatives A novel biphenyl derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted sulfur-containing or oxygen-containing heteromonocyclic ring; Ring B is a ring of the formula: ##STR2## each of R1 and R3... | 11/19/1991 |
| 5055452 | Medicinal and cosmetic compositions A benzofuran derivative which is a compound of formula (I): ##STR1## wherein a to d each are 0 or 1, with a+b+c+dࣙ2; R1 to R6 are each H or C1 -C6 alkyl; R7 is --CH2 OR8 (... | 10/08/1991 |
| 5051132 | Lyophilized preparation of 6-(3-dimethylaminopropionyl)forskolin A lyophilized preparation comprising 6-(3-dimethylaminopropionyl)forskolin, a buffer agent having a pH value of about 3 to about 6 when dissolved, and, as an optional ingredient, a sugar. The lyophilized preparation is excellent in resolubility and stable... | 09/24/1991 |
| 5049581 | Dibenzofurans having anti-tumor activity The present invention relates to compounds of formula (I) ArCh2 R or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid additio... | 09/17/1991 |
| 5026726 | Gossylic iminolactones and gossylic lactones and their anti-viral activities A compound of the chemical formula ##STR1## wherein n is 1 or 2, X is NH and O, and R1 and R2 are H, (C1 -C12) alkyl, (C2 -C12)alkenyl, (C2 -C12)alkynyl, (C2... | 06/25/1991 |
| 5021448 | Method of reducing serum uric acid and/or increasing renal uric acid clearance with thromboxane synthetase inhibitor inhibitor and/or thromboxane receptor antagonist A method of reducing serum uric acid and/or increasing renal clearance of uric acid in a mammal in need thereof comprising administering to such mammal a uricosuric effective amount of a thromboxane synthetase inhibitor, a thromboxane receptor antagonist,... | 06/04/1991 |
| 5019573 | Substituted dibenzofurans and methods of using same Novel substituted dibenzofuran compounds are disclosed. The compounds exhibit activity in antagonizing the effects of leukotriene B4 (LTB4). Pharmaceutical compositions containing the novel compounds and methods of treatment employin... | 05/28/1991 |
| 5017603 | Xanthomegnin, a known compound, is an antiparasitic agent The controlled aerobic fermentation of the fungal organism Fusarium lateritium var. longum produces xanthomegnin. Xanthomegnin has been discovered to have potent parasiticidal, anthelminthic, and insecticidal activity.... | 05/21/1991 |
| 5008286 | Certain substituted naphthofurans with anti-tumor properties The present invention relates to compounds of formula (I) ArCH2 R1 (I) or a monomethyl or monethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon ato... | 04/16/1991 |
| 5002965 | Use of ginkgolides to prevent reperfusion injury in organ transplantation A living tissue or living cell preservation solution comprising an effective amount of a ginkgolide to reduce reperfusion injury in living tissue which has been stored therein and a substance or mixture or substances present in an amount sufficient to pro... | 03/26/1991 |
| 5001149 | Azadirachtin derivative insecticides Derivatives of azadirachtin are described which should facilitate their synthesis and provide greater stability than their naturally-occurring counterpart. The derivative 2',3',22,-23-tetraydroanzadirachtin is also described, that derivative retaining ful... | 03/19/1991 |
| 4999376 | Pharmaceutical composition for treating and preventing cardiovasular disease The new pharamaceutical composition (PTC) and process are provided for treating and preventing cardiovascular disease. The fine-PTC is composed of following ingredients: Puerarin or derivate of Puerarin; Danshensu or Danshenketone; Tetramethyl pyrazine; P... | 03/12/1991 |
| 4999343 | Production of polysaccharides and saponin of dangshen The new pharmaceutical composition (PTC) and process are provided for treating and preventing cardiovascular disease. The fine-PTC is composed of following ingredients: Puerarin or derivative of Puerarin; Danshensu or Danshenketone; Tetramethyl pyrazine; ... | 03/12/1991 |
| 4983587 | Dihydrodibenzofuran derivatives and fungicides containing these compounds Substituted benzofuran derivatives of the formula ##STR1## where R1, R2 and R3 are hydrogen, an alkali or alkaline earth metal, alkyl, aralkyl, alkanoyl, halogen-substituted alkanoyl, benzoyl or a radical R4 | 01/08/1991 |
| 4978679 | 6- and/or 7-substituted-1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis Positions 7- and/or 6-substituted 1,2,3,4,4a,9b-Hexahydro-8-hydroxydibenzofuran-3-ols and analogs of that general structure are described. These compounds are found to be potent inhibitors of 5-lipoxygenase, an enzyme crucial to the biosynthesis of leukot... | 12/18/1990 |
| 4970199 | Steroidal glycolipids as host resistance stimulators against viral infection Disclosed are steroidal derivatives of glycolipids, in which steroids are bridged, via a medium length hydrocarbon chain, to 1-thio-D-mannopyranoses or 1-thio-L-fucopyranoses in combination with an anti-AIDS drug, that protect an immunocomprimised hot, pa... | 11/13/1990 |
| 4970212 | Method of treating human illnesses which compromise the ability to mount an effective immunological response A method is disclosed for treating human patients suffering from illnesses, including AIDS, which compromise their ability to mount an effective immunological response. This method comprises administering to the patient a pharmaceutically acceptable cytos... | 11/13/1990 |
| 4963526 | Oral insulin and a method of making the same The present invention provides for a composition of matter useful as an oral dosage form of insulin based upon a two phase liquid aqueous system in which insulin component or components are incorporated. The invention also provides for a method of prepari... | 10/16/1990 |
| 4960791 | Salannin derivative insect control agents Derivatives of salannin, including 2',3',20,21,22,23-hexahydro salannin and 20,21,22,23-tetrahydro salannin derivatives, having up to 40-fold greater insect antifeedant activity than native salannin.... | 10/02/1990 |
| 4943589 | Anthelmintic dysinins of marine origin This invention is directed to a method for treating helminthiasis which comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of Formula (I): ##STR1## where R1 is hydrogen or --SR2 | 07/24/1990 |
| 4918101 | Tetracyclic phenanthro furan heterocyclic derivatives compositions and use The present invention relates to antitumor compounds of formula (I) ArCH2 R1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29... | 04/17/1990 |
| 4908207 | Method of treatment of a person having a compromised human immune system A method of producing a composition for use in the treatment of a compromised human immune system is described. The active ingredient in the ingredient in the composition is a mixture of terpenoids derived from an extract of the tubers of the plant Cyperu... | 03/13/1990 |
| 4906470 | Pharmaceutical composition for treating and preventing cardiovascular disease The new pharmaceutical composition (PTC) and process are provided for treating and preventing cardiovascular disease. The fine-PTC is composed of following ingredients: Puerarin or derivative of Puerarin; Danshensu or Danshenketone; Tetramethyl pyrazine; ... | 03/06/1990 |
| 4904693 | Octahydro indenofuran derivatives and their therapeutic compositions This invention relates to indenofuran derivatives of the formula: ##STR1## wherein R stands for H or for a ##STR2## group optionally substituted on the phenyl ring by Alk, OH or OAlk, Alk being a lower straight or branched alkyl group up to C | 02/27/1990 |
| 4897418 | Novel naphthalene derivative Naphthalene derivative of the formula: ##STR1## wherein R1 is hydrogen atom or a lower alkoxycarbonyl and R2 is a lower alkoxycarbonyl, or R1 and R2 are combined together to form a group of the formula: ... | 01/30/1990 |
| 4883808 | Condensation products of cyclic diketones and ascorbic acid as immunomodulatory agents It has now been discovered that the acid catalyzed Michael reaction products of ascorbic acid and certain selected ketones are useful for their therapeutic activity. More specifically the useful reaction products of the invention are those obtained by rea... | 11/28/1989 |
| 4866073 | Acridinylmethylamino derivatives and pharmaceutical compositions containing them The present invention relates to compounds of formula (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wh... | 09/12/1989 |
| 4866070 | Acenaphtho[1,2b]quinolinylmethylamino derivatives and pharmaceutical compositions containing them The present invention relates to compounds of formula (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wh... | 09/12/1989 |
| 4863951 | Pharmacologically active amino-5,6,7,8-tetrahydronaphtho [2,3-B] furan compounds Compounds of general formula I, ##STR1## in which: R1 denotes a hydrogen atom or, with the proviso, however, that the amino radical is at the 7-position, a linear or branched alkyl radical containing 1 to 4 carbon atoms, R2 deno... | 09/05/1989 |
| 4861767 | Pharmaceutical compositions Pharmaceutical compositions containing an iron complex of 3-hydroxy-4-pyrone or of a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms are of v... | 08/29/1989 |
| 4857516 | Coumaran derivatives and their pharmaceutical use A compound of the formula ##STR1## wherein R is a lower alkyl group, R0 is hydrogen or an acyl group, R1 and R2 are lower alkyl groups which may optionally be substituted or wherein R1 and R2 are... | 08/15/1989 |
| 4851429 | Pharmaceutically useful tricyclic amines derived from 2,3,5,6,7,8-hexahydronaphtho(2,3-B)furan and from 2,3,6,7,8,9-hexahydro-5H-benzocyclohepta(2,3-B)furan Compound of general formula I ##STR1## in which R1 and R2, which may be identical or different, each denote a hydrogen atom, a benzyl radical, a cyclohexylmethyl radical or a linear or branched alkyl radical containing from 1 to... | 07/25/1989 |
| 4840951 | Novel naphthalene derivative Naphthalene derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted benzene ring; each of R1 and R2 is a group of the formula: --OR5, --NHR5 or ##STR2## or either one of R | 06/20/1989 |
| 4837226 | Polycyclic amine derivatives useful as cerebrovascular agents A method for the treatment of cerebrovascular disorders by administering a fluorenamine, dibenzofuranamine, or dibenzothiophenamine derivative.... | 06/06/1989 |