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| Number | Title | Issue Date |
| 5935996 | Composition for stimulating osteogenesis and preventingreduction of bone salt It is an object of this invention to provide a composition capable of being used for foods and pharmaceuticals, which stimulates osteogenesis and has an effect for preventing reduction of a bone salt content, and which is useful for therapy and prevention... | 08/10/1999 |
| 5932196 | Buffered emulsion compositions containing actives subject to acid or base hydrolysis The present invention are for emulsion compositions and the process for making such compositions containing biological and cosmetic actives subject to hydrolysis of actives during processing and storage of the emulsion composition. Buffers are incorporate... | 08/03/1999 |
| 5929101 | Use of insulin sensitizing agents to treat hypertension The present invention provides a method for treatin hypertension in insulin resistant patients comprising the administration of an insulin sensitizing agent, particularly ciglitazone or pioglitazone.... | 07/27/1999 |
| 5925616 | Treatment of fungal infections using a combination of an anti-fungal compound and an H-alkyl heterocyclic compound A method for increasing the effectiveness of an anti-fungal compound is described. In the method, an anti-fungal compound and an N-alkyl heterocyclic compound or a salt thereof are administered to a mammal in a combined amount effective to treat a fungal ... | 07/20/1999 |
| 5925672 | Methods of treating mental diseases, inflammation and pain Methods are disclosed for treating or preventing disorders such as mental diseases, inflammation and pain by inhibiting the enzyme anandamide amidohydrolase. A therapeutically effective level of an anandamide amidohydrolase inhibitor is administered such ... | 07/20/1999 |
| 5919816 | Formulations and methods of reducing toxicity of antineoplastic agents This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineopl... | 07/06/1999 |
| 5919768 | Di- and trivalent small molecule selectin inhibitors The present invention provides compounds having structure (II), and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof.... | 07/06/1999 |
| 5912019 | Compounds for reducing ischemia/reperfusion injury Disclosed herein are compositions containing NO donors, inhibitors of iNOS induction, and endopeptidase inhibitors, and methods for their use for combating injury induced by ischemia and reperfusion following ischemic episodes.... | 06/15/1999 |
| 5912266 | Beta2 integrin cell adhesion molecule inhibitors This invention concerns compositions and methods utilizing a compound of the formula: ##STR1## for reducing or controlling inflammation and treating pathological conditions mediated by intercellular adhesion. More particularly, the present inven... | 06/15/1999 |
| 5902805 | Method for treatment of acne and/or the effects of ageing using HMG-coenzyme A-reductase inhibitor and compositions for performing the same A method for the treatment of acne and/or the effects of ageing, by administering, to a subject in need thereof, a composition containing an effective amount of at least one HMG-Coenzyme A-reductase inhibitor in a carrier that is selected from the group c... | 05/11/1999 |
| 5885992 | Triterpene derivative and medicinal composition The invention is composed of a hederagenin derivative of the following formula or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising of this compound as an active ingredient. ##STR1## (wherein R1 r... | 03/23/1999 |
| 5876763 | Glycerol enhanced rehydration formulation A rehydration formulation which enhances a subjects ability to quickly recover from dehydration. The rehydration formulation includes a glycerol solution combined with a carbohydrate or sodium to produce a desired result. The glycerol solution combats the... | 03/02/1999 |
| 5877212 | Molecular complex and control-release of alpha hydroxyacids Compositions comprising an alpha hydroxyacid or related acid and organic complexing agent having a molecular weight ranging preferably between about 100 and about 600 can form a control-release molecular complex. Such complexing agent preferably possesses... | 03/02/1999 |
| 5874103 | Ionophore antibiotic formulations An aqueous base suspension concentrate of an ionophore antibiotic or ionophore antibiotics capable of aqueous dilution (if desired) and capable (with or without such aqueous dilution) of being orally administered to an animal (eg; by drenching), said conc... | 02/23/1999 |
| 5874463 | Hydroxy-kojic acid skin peel The subject of the present invention is a hydroxy-kojic acid skin peel.... | 02/23/1999 |
| 5869523 | Process for the preparation of 6-(substitutedaminopropionyl)-derivatives of forskolin Process for the preparation of 6-(substitutedaminopropionyl)-derivatives of forskolin Process for the manufacture of 6ଲ-(3-substitutedamino) propionyloxy forskolin derivatives of the general formula ##STR1##... | 02/09/1999 |
| 5863773 | Antifungal corynecandin Disclosed are novel antifungal agents having the formula: ##STR1## as well as a pharmaceutically acceptable salt, ester of prodrug thereof, wherein R is: ##STR2## --C(O)--R1 wherein R1 is alkyl, alkenyl, aryl, arylalkenyl, ... | 01/26/1999 |
| 5863912 | Method of treatment of hormone-unresponsive metastiatic prostate cancer Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity and amelioration of cyclophosphamide-associated toxicity ... | 01/26/1999 |
| 5861399 | Methods and compositions for the rapid and enduring relief of inadequate myocardial function Disclosed are methods and compositions for reducing coronary artery stenosis, restoring blood flow to infarcted myocardium, improving myocardial perfusion, reducing heart attacks or other adverse cardiovascular events, or treating symptoms of inadequate m... | 01/19/1999 |
| 5859049 | Calanolide and related antiviral compounds, compositions, and uses thereof The present invention provides novel antiviral compounds, refered to as calanolides, related compounds, and their derivatives, which may be isolated from plants, or derived from compounds from plants, of the genus Calophyllum in accordance with the presen... | 01/12/1999 |
| 5854280 | Antifungal sordaridin derivatives A compound of formula ##STR1## wherein Z is a tetrahydro-pyrano group selected from ##STR2## having antifungal activity processes for their preparation and their use in medicines.... | 12/29/1998 |
| 5849727 | Compositions and methods for altering the biodistribution of biological agents This invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic or bioactive agents. The methods and composition of the invention can be used with several therapeutic or bioactive agents and can achieve site-... | 12/15/1998 |
| 5846966 | Combinations of hydroxy-substituted azetidinone compounds and HMG CoA Reductase Inhibitors Hydroxy-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein: Ar1 and Ar2 are aryl or R4 -substituted aryl; Ar3 is aryl or R5 | 12/08/1998 |
| 5840753 | 1,2 diarylmethylene derivatives, their methods of preparation and their uses in therapeutics The present invention relates to the derivatives of formula: ##STR1## and to their use in therapeutics, especially as drugs with anti-inflammatory and analgesic properties.... | 11/24/1998 |
| 5840752 | Reduction of hair growth Mammalian hair growth is reduced by applying to the skin an inhibitor of a cholesterol synthetic pathway enzyme.... | 11/24/1998 |
| 5834506 | Dihydropyrones with improved antiviral activity This invention pertains to improved antiviral activity of 6,6-disubstituted-5,6-dihydropyran-2-ones caused by judicious placement of certain polar substituents at the 3 and/or 6 positions. The same substituents which enhance the cellular activity also diminish... | 11/10/1998 |
| 5834473 | Method for treating coccidiosis The invention is directed to methods for the treatment of coccidiosis and compositions designed to be administered to animals infected with coccidiosis-inducing organism. The compositions contain an osmoprotectant, and especially, betaine.... | 11/10/1998 |
| 5830886 | Steroid sulphatase inhibitors Steroid sulphatase inhibitors and pharmaceutical compositions containing them for use in the treatment of oestrone dependent tumors, especially breast cancer. The steroid sulphatase are sulphamate esters of formula (I): ##STR1## where R1 | 11/03/1998 |
| 5830871 | Inhibitors of E-, P- and L-selectin binding Inhibitors of E-, P- and L-selectin binding are synthesized by an aldol addition reaction between a glycoside aldehyde precursor and dihydroxyacetone phosphate or a derivative thereof. The addition reaction is catalyzed by aldolase. The inhibitors exhibit... | 11/03/1998 |
| 5827855 | Hexahydronaphthalene ester derivatives their preparation and their therapeutic uses Compounds of formula (I): ##STR1## wherein R1 represents a group of formula (II) or (III): ##STR2## R2 is alkyl, alkenyl or alkynyl; R3 and R4 are each hydrogen, alkyl, alkenyl or alkynyl; R5 | 10/27/1998 |
| 5807834 | Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor Pharmaceutical combination compositions including certain cholesterol absorption inhibitors and cholesterol synthesis inhibitors. The compositions are useful for the treatment of hypercholesterolemia and atherosclerosis.... | 09/15/1998 |
| 5804598 | Xylomollin derivatives for use as insect feeding deterrents Synthetic derivatives or intermediates of xylomollin are identified which can be used as insect feeding deterrents. The identified derivatives or intermediates exhibiting antifeeding activity include glutaraldehyde and carbocyclic or heterocyclic dialdehy... | 09/08/1998 |
| 5798372 | Method for preventing onset of restenosis after angioplasty employing a retinoid A method is provided for preventing or reducing the risk of restenosis following angioplasty by administering a retinoid, such as an RAR-selective retinoid, e.g. the compound of the formula: ##STR1##... | 08/25/1998 |
| 5792790 | Method for improving weight gain and feed utilization in livestock Crystalline calcium pseudomonate or a hydrate thereof, in particular the dihydrate. Processes for the preparation of these salts and their use in human and veterinary medicine and as a growth promoter in animals are described.... | 08/11/1998 |
| 5789440 | 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents The present invention relates to novel 5,6-dihydropyrone derivatives and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The 5,6-dihydropyrone derivatives are useful in the development of therapies for the tre... | 08/04/1998 |
| 5786385 | Polyacetylenes A 2-(1-nonen-3,5,7-triynyl)3-hydroxy tetrahydropyran (cunaniol) particularly that having the formula: ##STR1## or a corresponding anhydrocunaniol or cunanione, for use in therapy, especially as a reversible heart blocking agent or neuromuscular activ... | 07/28/1998 |
| 5767094 | Propiophenone derivative and processes for preparing the same A propiophenone derivative the formula I!: ##STR1## wherein R' is a lower alkanoyl group and R" is a hydrogen atom, or R' is a hydrogen atom and R" is a lower alkoxycarbonyl group, or a pharmaceutically acceptable salt thereof. Said compounds have ... | 06/16/1998 |
| 5767147 | Inhibition of glutathione transferase by haloenol lactones This invention relates to novel haloenol lactone compounds. These compounds have the following general structure: ##STR1## in which Ar is an aryl group and Y is a haloenol lactone moiety. The compounds of the invention are useful for the specific mea... | 06/16/1998 |
| 5760073 | Substituted 4H-pyrans The substituted 4H-pyrans are prepared by reacting either aldehydes or ylidene compounds with suitably substituted ଲ-diketones. The substituted 4H-pyrans according to the invention are suitable as active compounds in medicaments, in particular for t... | 06/02/1998 |
| 5750563 | Preparation for epidermis A preparation for epidermis containing kojic acid and/or its derivative, which has improved preparation stability, is provided. The preparation stability is imparted by adding to the preparation at least one member selected from the group consisting of al... | 05/12/1998 |
