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| Number | Title | Issue Date |
| 5109018 | Use of heterocyclic inhibitors of serine proteases Certain novel heterocyclic compounds, their preparation, and their use in inhibiting serine proteases with chymotrypsin-like, elastase-like, and trypsin-like specificity and in the treatment of diseases such as emphysema which involve tissue proteolysis.... | 04/28/1992 |
| 5098930 | Heterocyclic derivatives The invention concerns a heterocyclic derivative of the formula I, ##STR1## wherein Ar1 is optionally substituted phenyl or naphthyl; A1 is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo-(3-6C)alkylene; Ar2 is... | 03/24/1992 |
| 5059623 | Substituted cycloalkyl- and heterocyclyl-carboxanilides A substituted cycloalkyl- or heterocyclyl-carboxanilide of the formula (I) ##STR1## in which X stands for an unsubstituted or an alkyl-substituted cycloalkyl or an unsubstituted or an alkyl-substituted heterocyclic, Hal stands for halogen and Y1 | 10/22/1991 |
| 5055471 | Fungicides This invention relates to derivatives of propanoic acid of the formula ##STR1## Useful as fungicides, insecticides and miticides, to processes for preparing them, to compositions containing them, and to methods of using them to combat fungi, especial... | 10/08/1991 |
| 5051445 | 3-amino-propyloxyphenyl derivatives, their preparation and pharmaceutical compositions containing them (a) R1 and R5 are hydrogen and R3 is n-propyl, isobutyl, cyclopentylmethyl, benzyl or 2-(p-fluorophenyl)ethyl; (b) R1 is fluorine and R5 is hydrogen and R3 is n-propyl; (c) R1 is methyl an... | 09/24/1991 |
| 5049561 | Anthelmintic acylhydrazones, method of use and compositions This invention concerns a process for killing internal parasites, especially nematodes, trematodes and cestodes affecting warm blooded animals such as sheep, cattle, swine, goats, dogs, cats, horses and humans as well as poultry by administering an effect... | 09/17/1991 |
| 5047419 | Photodynamic therapy of glioma or mammary carcinoma using seleno- or telluropyrylium salts There are disclosed pyrylium salts and a method of using them medicinally in photodynamic therapy for increasing the survival time of animals affected with glioma or mammary carcinoma. The salts are seleno- or telluropyrylium compounds having a singlet ox... | 09/10/1991 |
| 5047412 | Alkene derivatives The invention describes novel (2-styryl-, 2-naphthyl- and 2-phenethyl-4-o-hydroxyphenyl-1,3-dioxan-5-yl)alkenoic acids and related tetrazoles and sulphonamides, of the formula I wherein Q completes a benzene or pyridine ring, Y is vinylene, Z is carboxy, ... | 09/10/1991 |
| 5026857 | Substituted basic 2-aminotetralin in pharmaceuticals For treatment of disorders of the central nervous system, the cardiovascular system or the intestinal tract, the new substituted basic 2-aminotetralins of the formula ##STR1## in which R1 represents hydrogen or alkyl, R2 represe... | 06/25/1991 |
| 5010099 | Discodermolide compounds, compositions containing same and method of preparation and use Novel lactone compounds having remarkable immunomodulatory and antitumor activities, pharmaceutical compositions comprising such compounds, methods for the preparation of the novel compounds and compositions and methods of their use for therapeutic purpos... | 04/23/1991 |
| 5001148 | Mevinic acid derivatives Antihypercholesterolemic activity, due to competitive inhibition of HMG CoA reductase, has been found in compounds of the formula ##STR1## wherein: R1, R2 and R3 are independently selected from: (1) alkyl, (2) substituted ... | 03/19/1991 |
| 4999374 | Veterinary treatment The antibiotic compound M139603 (tetronasin), disclosed in GB-A-2027013 as a growth-promotant in farm animals with activity against Gram-positive bacteria, has now been found to prevent and treat Treponem a hyodysenteriae infections in pigs (swine dysente... | 03/12/1991 |
| 4988729 | Pesticides based on substituted aminomethylheterocyclic compounds Combattting fungi and bacteria with aminomethylheterocyclic compounds of the formula ##STR1## in which R1 represents hydrogen, alkyl, alkenyl, in each case optionally substituted tetrahydronaphthyl, decahydronaphthyl, cycloalkyl or cy... | 01/29/1991 |
| 4987132 | Saturated heterocyclic carboxamide derivatives A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity. ##STR1##... | 01/22/1991 |
| 4977153 | 3-aminopropyloxyphenyl derivatives, pharmaceutical compositions containing them and method for the therapy of diseases Compounds of formula (I), ##STR1## characterized in that R signifies optionally substituted heteroaryl-, heteroarylakyl or heteroarylalkenyl, R1 signifies hydrogen or a substituent, R2 is hydroxy or a group --z--(CH2)... | 12/11/1990 |
| 4970231 | 4-substituted HMG-CoA reductase inhibitors HMG-CoA reductase inhibitors of formulae (I) and (II) are disclosed. ##STR1##... | 11/13/1990 |
| 4968693 | 3-keto HMG-COA reductase inhibitors Compounds of formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.... | 11/06/1990 |
| 4952604 | Antifungal agent Pyranyl ester compounds isolated from the fermentation of the species Penicillium are described. The compounds are useful as antifungal agents.... | 08/28/1990 |
| 4946852 | 4(R)-substituted 6(S)-phenoxymethyl-, 6(S)-ଲ-phenylethyl- and 6(S)-ଲ-styryl-tetrahydropyran-2-ones, a highly stereoselective process for their preparation, pharmaceutical products based on these compounds, and their use 4(R)-Substituted 6(S)-phenyloxymethyl-, 6(S)-ଲ-phenylethyl- and 6(S)-ଲ-styryl-tetrahydropyran-2-ones of the general formula V ##STR1## in which R7, R8 and A have the meanings given, and the corresponding open-chain h... | 08/07/1990 |
| 4939169 | 1,4-naphthalenediol and 1,4-hydroquinone derivatives Novel 1,4-naphthalenediol and 1,4-hydroquinone derivatives of formula I, II, III and IV and their therapeutic uses as 5-lipoxygenase inhibitors, leukotriene inhibitors, antiinflammatory and/or inhibitors of mucus secretion agents are described. Also provi... | 07/03/1990 |
| 4937259 | Antihypercholesterolemic compounds Compounds of Formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.... | 06/26/1990 |
| 4935409 | Aminophenylethylamine yield promoters Animal growth promoters of the formula ##STR1## The intermediates of the formula ##STR2## are also new.... | 06/19/1990 |
| 4925831 | Aminoalkyl naphthalenediols as host resistance enhancers against viral infection Disclosed are specific aminoalkyl naphthalenediol derivatives that enhance natural human host resistance to viral infectious organisms and particularly AIDS-related viruses. Such agents are also administered prophylactically to individuals whose resistanc... | 05/15/1990 |
| 4923852 | Aminoalkyl naphthalenediols as host resistance enhancers against viral infections Disclosed are specific aminoalkyl naphthalenediol derivatives that enhance natural human host resistance to viral infectious organisms and particularly AIDS-related viruses. Such agents are also administered prophylactically to individuals whose resistanc... | 05/08/1990 |
| 4904691 | Novel HMG-CoA reductase inhibitors Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids and esters derived therefrom and pharmac... | 02/27/1990 |
| 4904692 | Novel HMG-CoA reductase inhibitors Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically a... | 02/27/1990 |
| 4902714 | Pharmaceutical compositions Compounds of the formula (II) ##STR1## wherein R1 and R2 are each separately selected from hydrogen, alkyl, alkenyl and alkynyl groups having up to a maximum of four carbon atoms and being unsubstituted, and alkyl, alkenyl and a... | 02/20/1990 |
| 4900754 | HMG-COA reductase inhibitors Disclosed are novel 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors useful as antihypercholesterolemic agents represented by the formula ##STR1## and the corresponding ring-opened hydroxy acids derived therefrom and pharmaceutically a... | 02/13/1990 |
| 4897397 | Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed.... | 01/30/1990 |
| 4894392 | Aminoalkyl naphthalenediols as host resistance enhancers Disclosed are specific aminoalkyl naphthalenediol derivatives that enhance host resistance to infectious organisms. Such agents are administered prophylactically to individuals whose resistance to infection is comprised by chemotherapy, surgery, burns or ... | 01/16/1990 |
| 4891363 | Cyclic ether derivatives and their use Compounds of formula (I): ##STR1## (wherein: l is 2-4; A and B are oxygen or sulfur; one of R1 and R2 represents a long chain alkyl, alkylcarbamoyl or aliphatic acyl group and the other of R1 and R2 represe... | 01/02/1990 |
| 4871756 | Leukotriene antagonists Compounds having the formula: ##STR1## are antagonists of leukotrienes of C4, D4, E4 and the slow reacting substance of anaphylaxis. As such, these compounds will be useful as anti-asthmatic, anti-allergic, anti-infla... | 10/03/1989 |
| 4871761 | Substituted propylamine pesticides Novel pesticides of the formula ##STR1## in which R1 represents in each case optionally substituted cycloalkyl, cycloalkenyl, tetrahydronaphthyl, decahydronaphthyl, phenyl, naphthyl or thienyl, R2 represents alkyl, R3... | 10/03/1989 |
| 4857522 | Derivatives of pravastatin for inhibiting cholesterol biosynthesis Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the struc... | 08/15/1989 |
| 4847301 | Methods of use of -(aminoalkyl)-arylacetic acid derivatives Novel -aryl--(ω-aminoalkyl)--[hydroxy(aralkyl and cycloalkyl)]acetic acid derivatives and -aryl--(ω-aminoalkyl)-[alkanoyloxy(aralkyl and cycloalkyl)]acetic acid derivatives, such as N,N-dimethyl-2-(hydroxyp... | 07/11/1989 |
| 4835177 | Aminoalkyl naphthalenediols as host resistance enhancers against viral infection Disclosed are specific aminoalkyl naphthalenediol derivatives that enhance natural human host resistance to viral infectious organisms and particularly AIDS-related viruses. Such agents are also administered prophylactically to individuals whose resistanc... | 05/30/1989 |
| 4814347 | Anthelmintic spiroketals and method of use This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of northern hemisphere intermediates for the synthesis of mil... | 03/21/1989 |
| 4783473 | Geminally substituted cyclic ether carboxylic acids, derivatives thereof, compositions containing same and method of use Geminally-substituted cyclic ether carboxylic acids or derivatives thereof are provided which have the structure ##STR1## wherein Z is aryl, which may be optionally substituted with one or more of the following groups: halo, lower alkyl, lower alkoxy... | 11/08/1988 |
| 4725302 | Substituted phenylhydrazines and phenyloxadiazolinones and pesticidal usage thereof Phenylhydrazines of the formula I ##STR1## wherein R1 is --A--R--Z, A is oxygen, sulfur, ##STR2## R is C1 -C6 -alkylene, C1 -C6 -haloalkyl-C1 -C6 -alkylene, C1 | 02/16/1988 |
| 4722925 | Bicyclic benzo-oxy heterocyclic ethers and thioethers pharmaceutical compositions and use A class of bicyclic benzo-oxy heterocyclic ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of ... | 02/02/1988 |
