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Apparatus for Simulating a High Five
A self-righting hand-arm configuration which is adapted to pivot when struck by a user, thereby simulating a "high five."
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| Number | Title | Issue Date |
| 7553869 | Protein probe compounds, compositions, and methods Coumarine/chinolone and Martina-type compounds, compositions, and method of using the compounds and compositions for protein detection, assay, quantitation, etc. are disclosed. The composition, also referred to as a dye, has enhanced sensitivity over commercially av... | 06/30/2009 |
| 7544711 | Use of nitroderivatives in urinary incontinence The present invention relates to the use of the following compounds, their compositions, and their salts for the preparation of medicaments for the treatment of urinary incontinence and other diseases, the compounds having the general formula: A-X1 | 06/09/2009 |
| 7538137 | 1-O-β-D-glucopyranosylgeraniol-10,5-olide and use thereof A novel natural compound having various therapeutically effects is provided. The compound is obtainable from Sibiraea leaves by aqueous extraction and is represented by a formula (1) as follows. ... | 05/26/2009 |
| 7534812 | Process for preparation of isochroman and derivatives thereof The present invention relates to an improved process for preparing compounds of formula 1 on an industrial scale, wherein R1, R2 and R3 are independently C1-6-alkyl, C2-6 | 05/19/2009 |
| 7521475 | Chondropsin-class antitumor V-ATPase inhibitor compounds, compositions and methods of use thereof A composition comprising a substantially purified compound of the formula: in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a condition treatable by the inhibit... | 04/21/2009 |
| 7514469 | Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways... | 04/07/2009 |
| 7507761 | Benzopyran derivatives, method of production and use thereof The invention relates to novel benzopyran derivatives of formula I, to their method of production, to composition comprising the derivatives and use thereof. wherein: R1, R2, R3 an... | 03/24/2009 |
| 7507762 | Substituted 4-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, Z and R5 are defined herein. The present invention also relates to the d... | 03/24/2009 |
| 7488751 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan Compounds of the Formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, p... | 02/10/2009 |
| 7470722 | Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central n... | 12/30/2008 |
| 7470721 | Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling. ... | 12/30/2008 |
| 7456214 | Chromene-containing compounds with anti-tubulin and vascular targeting activity Chrome compounds have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. ... | 11/25/2008 |
| 7439265 | Irciniastatins a and b The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 0.001 to | 10/21/2008 |
| 7435705 | Environmentally safe anti-fungal composition and methods of using same Disclosed herein or novel, environmentally friendly compositions and methods for treating or preventing fungal growth, such as molds and mildew, on surfaces and in objects. Specifically exemplified herein are compositions containing nepetalactone, and methods of usi... | 10/14/2008 |
| 7435722 | Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and ... | 10/14/2008 |
| 7432297 | Reaction product of resorcin and methyl ethyl ketone A compound of the following formula (I) or (II) (in the formula (I), n represents an integer of 0 to 2) (in the formula (II), m represents an integer of 0 to 2). ... | 10/07/2008 |
| 7429576 | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors Novel methods for the medical treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans involving administration of selective estrogen r... | 09/30/2008 |
| 7427686 | (3R, 4R)-trans-3, 4-diarylchroman derivatives and a method for the prevention and/or treatment of estrogen dependent diseases The present invention relates to compounds of the formula I in which substituents R2 and R3 are arranged in trans-configuration: wherein: R1 is H or C1-C6 ... | 09/23/2008 |
| 7419998 | Therapeutic methods and compositions involving isoflavones Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R | 09/02/2008 |
| 7417067 | Composition and method for stabilizing the same Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride. ... | 08/26/2008 |
| 7405227 | Treatment of cancer Methods of treating ovarian cancer, endometrium cancer, cervical cancer, pancreatic cancer, bladder cancer, eve cancer, central nervous system cancer, thyroid cancer and lung cancer are disclosed. Specifically disclosed are methods of treating ovarian adenocarcinoma... | 07/29/2008 |
| 7399784 | Tocopherol and tocotrienol anti-obesity medicaments Anti-obesity compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and an obesity-promoting drug, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl substituted chroma... | 07/15/2008 |
| 7399783 | Methods for the treatment of scar tissue A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids formulated in a pharmaceutically acceptable topical carrier. The method incl... | 07/15/2008 |
| 7396855 | Compositions and products containing S-equol, and methods for their making A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, p... | 07/08/2008 |
| 7384919 | Increased solubility flavanolignan preparations The inventors have devised novel approaches for the preparation of flavanolignan compositions of enhanced solubility and substantially free of toxic contaminants. Such novel approaches are based on spray drying or lyophilizing to dry a diluted preparation of flavano... | 06/10/2008 |
| 7384976 | Nebivolol and its metabolites in combination with nitric oxide donors, compositions and methods of use The invention describes novel compositions comprising nebivolol and/or at least one metabolite of nebivolol and at least one nitric oxide donor, and, optionally, at least one antioxidant or a pharmaceutically acceptable salt thereof, and/or at least one compound use... | 06/10/2008 |
| 7381743 | Macrocycles for the treatment of cancer The present invention relates to new macrocycles of the general formula (I) as well as their use for the treatment of cancer diseases ... | 06/03/2008 |
| 7375132 | Compounds and methods for inhibiting cellular responses to hypoxia Compounds and compositions of the following formula: and analogs and stereoisomers thereof (and pharmaceutically acceptable carriers). Additionally disclosed is a method of inhibiting hypoxia-inducible factor-1 function in ... | 05/20/2008 |
| 7371874 | 6-Alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative as anti-inflammatory inhibitor The present invention relates to a noble 6-alkylamino-2-methyl-2′-(N-methyl substituted sulfonamido)methyl-2H-1-benzopyran derivative, a method for preparing the same with high efficiency using a parallel synthetic method, one of combinatorial chemical synthetic t... | 05/13/2008 |
| 7371775 | 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone monohydrate, the preparation method and uses thereof The present invention relates to 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone.monohydrate which is a non hygroscopic product suitable for the preparation of metered dose of 7-carboxymethyloxy-3′,4′,5-trimethoxy flavone having protective activity for gastroi... | 05/13/2008 |
| 7371776 | Methods and compositions for treating cancer This invention relates to methods of inducing dephosphorylation of a hyperphosphorylated cell cycle regulatory protein in a tumor cell in which hyperphosphorylation of said protein contributed to cell transformation, the method comprising contacting the tumor cell w... | 05/13/2008 |
| 7368593 | Method of selective esterification A method of preparing a compound of formula I wherein R is a hydrocarbon and n is an integer from 1 to 5, including the steps of: contacting a compound of formula II with a compou... | 05/06/2008 |
| 7368434 | Compounds useful for the inhibition of ALDH The present invention provides novel antidipsotropic compounds. The invention further provides methods of inhibiting ALDH-2 using the compounds described herein. Methods for modulating alcohol consumption, alcohol dependence and/or alcohol abuse by administering the... | 05/06/2008 |
| 7368134 | Herbal composition for treatment and maintenance of hormone dependent conditions and circulatory conditions, and immunostimulation A pharmaceutical or medicinal preparation comprising a mixture of herbs including Glycine max, Asparagus racemosa, Boerhavia diffusa, Withania somnifera, Saraca indica, and Coleus forskohlii, or a mixture of the active ingredients that have been extrac... | 05/06/2008 |
| 7365071 | Heterocyclic compounds, preparation process and intermediates, and use as medicaments, in particular as β-lactamase inhibitors and antibacterials The invention relates to novel heterocyclic compounds of general formula (I) and to their salts with a base or an acid: The invention also relates to processes and to intermediates for the preparation of these compounds, and ... | 04/29/2008 |
| 7365095 | Chromane and chromene derivatives and uses thereof Compounds of formula I or pharmaceutically acceptable salts thereof are provided: wherein each of R1, R2, R3, R4, y, m, n, and Ar are as defined, and described in classes and subc... | 04/29/2008 |
| 7358245 | Treatment of gastroesophageal reflux disease The administration of cannabinoid receptor agonists for inhibition of transient lower esophageal sphincter relaxations, gastroesophageal reflux disease and regurgitation is disclosed. ... | 04/15/2008 |
| 7354928 | Small molecule inhibitors targeted at Bcl-2 The present invention relates to small molecule antagonists of Bcl-2 family proteins such as Bcl-2 and/or Bcl-XL. In particular, the present invention provides non-peptide cell permeable small molecules (e.g., tricyclo-dibenzo-diazocine-dioxides) that bin... | 04/08/2008 |
| 7351737 | 4-[(8-substituted)-6-chromanoyl]-and 4-[8-substituted)-chroman-6-YL-ethynyl]-benzoic and phenylacetic acids, their esters and salts having cytochrome P450RAI inhibitory activity Compounds of the formula where the variables are defined in the specification have cytochrome P450RAI-1 and P450RAI-2 inhibitory activity, and are suitable for treatment of mammals with conditions which are treatable with r... | 04/01/2008 |
| 7351738 | Substituted ureas and carbamates The invention provides compounds of formula I: useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer... | 04/01/2008 |
