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| Number | Title | Issue Date |
| 6699860 | Di-substituted aminomethyl-chroman derivative beta-3 adrenoreceptor agonists This invention is related to novel di-substituted aminomethyl chroman derivatives which are useful in the treatment of beta-3 receptor-mediated conditions.... | 03/02/2004 |
| 6696484 | Method and compositions for regulation of 5-alpha reductase activity Pharmaceutical compositions and methods for treating androgen related disorders. The pharmaceutical compositions may include a 5-reductase inhibitor, such as natural and synthetic flavanoids, catechols, curcumin-related substances, quinones, catech... | 02/24/2004 |
| 6693094 | Biguanide and sulfonylurea formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus The invention describes formulations that include either metformin, sulfonylurea or a biguanide-sulfonylurea combination as one active ingredient in addition to specific, other active ingredients. The compositions and dosage forms of the invention are cli... | 02/17/2004 |
| 6683100 | Organic compounds Pharmaceutical formulations comprising an epothilone in the form of an infusion concentrate or a lyophilised composition, and methods of administration of an epothilone in suitable form for parenteral administration.... | 01/27/2004 |
| 6683069 | Methods and compositions for reducing UV-induced inhibition of collagen synthesis in human skin Exposure of human skin to ultraviolet (UV) radiation from the sun not only induces the production of enzymes (matrix metalloproteinases) that degrade collagen, but also inhibits the synthesis of new collagen by inhibiting the synthesis of procollagen. Thi... | 01/27/2004 |
| 6680312 | Sulfonamide derivatives, their production and use The present invention is to provide a compound or a salt thereof represented by the formula: ##STR1## wherein R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, the ring A is an optionally su... | 01/20/2004 |
| 6680381 | Recovery of isoflavones from soy molasses A health supplement composition is disclosed. The health supplement composition contains a solid health supplement material that is separated from a condensed soy molasses material. The solid health supplement material contains at least two isoflavones wh... | 01/20/2004 |
| 6677338 | Serotonin transport inhibitors The present invention relates to the therapeutic use of non-amine tropane analogues that bind to the SERT to treat neuropsychiatric disorders.... | 01/13/2004 |
| 6677371 | 4-oxybenzopyran derivative This invention relates to a 4-oxybenzopyran derivative of formula (I) wherein, R1 and R2 represent each independently a hydrogen atom, a C1-6 alkyl group or a phenyl group; R3 represents a hydroxyl group or C | 01/13/2004 |
| 6677325 | Steroid sulphatase inhibitors A method for controlling estrone or estrodiol production comprising administering a ring system compound comprising a sulphamic acid ester group; wherein said compound is an inhibitor of an enzyme having steroid sulphatase activity (EC 3.1.6.2); and where... | 01/13/2004 |
| 6673379 | Use of non-alkalized cocoa solids in a drink The present invention is directed to a method of processing a fat-containing bean, e.g., cocoa beans, for producing solids comprising active polyphenols and/or fat-containing products, comprising extracting the fat to produce solids and fat-containing pro... | 01/06/2004 |
| 6670389 | Laulimalide derivatives Laulimalide compounds, intermediates thereto and methods for their preparation, and methods for their use in the treatment of diseases characterized by cellular hyperproliferation. ##STR1##... | 12/30/2003 |
| 6670390 | Cocoa extract compounds and methods for making and using the same Disclosed and claimed are cocoa extracts, compounds, combinations thereof and compositions containing the same, such as polyphenols or procyanidins, methods for preparing such extracts, compounds and compositions, as well as uses for them, especially a po... | 12/30/2003 |
| 6670346 | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors Novel methods for the medical treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans involving administration of selective... | 12/30/2003 |
| 6667371 | Block copolymers based on poly(ortho esters) containing amine groups Block copolymers based on poly(ortho esters) containing amine groups. These block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or w... | 12/23/2003 |
| 6663850 | Inhibition of ceramide for the prevention and treatment of oral mucositis induced by antineoplastic drugs or radiation Intervention for oral mucosal injury secondary to chemotherapy or radiation based on the inhibition in the synthesis of ceramide, blockage of its activity, or its digestion.... | 12/16/2003 |
| 6652891 | Co-enzyme Q10 dietary supplement A liquid dietary supplement useful in increasing bodily levels of coenzyme Q10 is disclosed. The supplement comprises an oil in water emulsion of coenzyme Q10. The dietary supplement disclosed is pleasant tasting, is effectively absorbed into the body and... | 11/25/2003 |
| 6652890 | Tea catechins as cancer specific proliferation inhibitors The invention described herein encompasses a methods and compositions of treating cancer or solid tumors comprising the administration of a therapeutically effective amount of catechins, a group of polyphenols found in green tea, to a mammal in need of su... | 11/25/2003 |
| 6649648 | Therapeutic methods and compositions involving isoflavones Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H, or RA CO where RA is C1-10 alkyl or an a... | 11/18/2003 |
| 6645951 | Benzopyran or thiobenzopyran derivatives The present invention provides novel benzopyran compounds, pharmaceutically acceptable salts thereof and stereoisomers thereof where the benzopyran compounds of the invention are compounds according to Formula I: ##STR1## The present invention further pro... | 11/11/2003 |
| 6645997 | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders A class of benzopyrancarboxylic acid derivatives comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, d... | 11/11/2003 |
| 6645998 | Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof The present invention provides an antiproliferative compound having the structural formula ##STR1## wherein X is oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester,... | 11/11/2003 |
| 6646000 | Method to control plant pests, improve plant productivity and other purposes A method of treating plant and animal systems and inanimate surfaces for the purposes of controlling plant pests, introducing pesticides and nutrients into plants, mitigating frost damage to plants, increasing crop yields, controlling certain plant diseas... | 11/11/2003 |
| 6642277 | Food supplements containing polyphenols Disclosed is a plant-derived flavonol-containing dry composition suitable for human consumption, wherein at least 25% of the plant-derived material in the composition comprises polyphenols, together with uses thereof.... | 11/04/2003 |
| 6641800 | Pressurized aerosol compositions comprising powdered medicament dispersed in hydrofluoroalkane Pressurized aerosol composition for administration by inhalation comprising a liquefied hydrofluoroalkane, a powdered medicament dispersed therein, and a suspending agent comprising a polymer soluble in the liquefied hydrofluoroalkane which is selected fr... | 11/04/2003 |
| 6638972 | Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor. ##STR1##... | 10/28/2003 |
| 6638970 | Substituted alkylene diamine compounds Novel compounds of the general formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subse... | 10/28/2003 |
| 6638971 | Cocoa extract compounds and methods for making and using the same Polyphenol-containing compositions, for example cocoa procyanidin monomer and/or oligomer-containing compositions, and their use inhibiting bacterial growth are disclosed. Compositions may be used for human and veterinary animal administration and may be,... | 10/28/2003 |
| 6635650 | Substituted dimeric compounds The invention relates to compounds of formula (I): wherein: A represents NR1 C(Q)R2, C(Q)NR2 R3 or NR1 C(Q)NR2 R3, B represents NR1 C(Q)R2, C(Q)NR2... | 10/21/2003 |
| 6630506 | Bicyclic acyl guanidine sodium/proton exchange inhibitors and method Acyl guanidines are provided which are sodium/proton exchange (NHE) inhibitors which have the structure ##STR1## wherein n is 0 to 4; X is a bond, O, S, SO, SO2, CO, ##STR2## or NR7 ; Y is a bond, O, S, SO, SO2, CO, #... | 10/07/2003 |
| 6627653 | Anticonvulsant derivatives useful for the treatment of depression Anticonvulsant derivatives useful for treating depression as monotherapy or combination therapy are disclosed.... | 09/30/2003 |
| 6623769 | Administration of lycopene for combating skin/mucous membrane damage Lycopene and compositions comprised thereof, for example tomato plant extracts, are uniquely suited for treating, preventively and/or curatively, cutaneous signs of aging, in particular inhibiting damage to the skin and/or mucous membranes via inhibition ... | 09/23/2003 |
| 6624188 | Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects A process and pharmaceutical compositions for treating several diseases and conditions which are normally treatable with retinoid like compounds are disclosed where the compound used for the treatment are substantially non-teratogenic and not irritant to ... | 09/23/2003 |
| 6624189 | Byrostatin analogues, synthetic methods and uses Biologically active compounds related to the bryostatin family of compounds, having simplified spacer domains and/or imroved recognition domains are disclosed, including methods of preparing and utilizing the same.... | 09/23/2003 |
| 6620819 | Anticonvulsant derivatives useful in treating psychosis The anticonvulsant derivative topiramate useful in treating dementia and/or behavioral and psychotic disturbances in dementia is disclosed.... | 09/16/2003 |
| 6620798 | Synergistic agents for enhancing tissue repair Methods for the repair, reconstruction and protection of tissue using compositions containing flavonoids and/or flavonols, including simultaneous administration of agents in order to obtain synergistic effects from the combinations taught and claimed here... | 09/16/2003 |
| 6620842 | Chalcones Disclosed are novel chalcone derivatives having the formula (I) ##STR1## The compounds possess antiproliferative activity and are useful for the manufacture of a medicament for the treatment or prevention of neoplasms, particularly those located in the ut... | 09/16/2003 |
| 6617361 | Behavior chemotherapy A protocol for prevention of Alzheimer's disease onset is described. The protocol involves stimulating the implicit memory, followed by continuing such stimulation in conjunction with psychological treatments followed by continuing said stimulation of the... | 09/09/2003 |
| 6617349 | Blends of isoflavones and flavones Blends of quercetin and isoflavones from the group consisting of genestein, daidzein and glycetin display synergistic effects when applied as anti-inflammatory agent or as skin agent in particular for anti ageing purposes.... | 09/09/2003 |
| 6613743 | Sulfonamide inhibitors of aspartyl protease The present invention relates to a novel class of sulfonamides of formula I which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and phy... | 09/02/2003 |
