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| Number | Title | Issue Date |
| 7671086 | Pharmaceutical compositions comprising flavonoids and menthol The present invention relates to use of certain antiviral fragrances for reduction of viruses, in particular vira causing common cold. In one embodiment, the invention relates to pharmaceutical compositions comprising an antiviral fragrance, preferably menthol. Said... | 03/02/2010 |
| 7671085 | Non-steroidal farnesoid X receptor modulators and methods for the use thereof The efficient regulation of cholesterol synthesis, metabolism, acquisition, and transport is an essential component of lipid homeostasis. The farnesoid X receptor (FXR) is a transcriptional sensor for bile acids, the primary product of cholesterol metabolism. Accord... | 03/02/2010 |
| 7655694 | Phytoestrogenic isoflavone compositions, their preparation and use thereof for protection against and treatment of radiation injury The present invention provides compositions and methods for the prophylactic and therapeutic treatment of animals, including humans from radiation injury. In particular, the present invention provides methods and compositions comprising the isoflavone genistein (4â€... | 02/02/2010 |
| 7642283 | Mitochrondrial permeability transition pore affinity labels and modulators Methods of utilizing compounds of general formulas I and II as modulators and affinity labels of the MPTP complex are elucidated. Furthermore, methods for modulating the activity of the MPTP complex, methods for determining the presence of a component of the MPTP co... | 01/05/2010 |
| 7629379 | Substituted phosphonate fluorescent sensors and use thereof The invention relates to new compounds of formula (1) wherein R is hydrogen or a linear or branched C1-40alkyl; where X is O, S, or NR1 where R1 is a hydrogen, a linear or branched C1-40 alkyl, C2-40 alkenyl or ... | 12/08/2009 |
| 7625943 | 5-alkyl-7-alkylcarbonate-isoflavone ester and related method A compound is provided for increasing the concentration of a parent isoflavone in a subject in vivo. The parent isoflavone has a skeletal structure including a 5 position and a 7 position, a 5 alkyl group, and a 7-hydroxy group with a 7-hydroxy oxygen appended to th... | 12/01/2009 |
| 7622499 | β-Benzyloxyaspartate derivatives with photosensitive groups The present invention relates to photosensitive derivatives of optically active L-threo-β-benzyloxyaspartate or its benzene ring-substituted analogs, represented by the following formula (1) or (2): (1) (2) wherein R1 represents hydrogen atom, amino grou... | 11/24/2009 |
| 7618998 | Isoflavone derivatives and pharmaceutical compositions comprising the same An isoflavone derivative is provided. The isoxazole derivative has following formula: wherein R1 and R2, independently, include C1-C12 alkyl optionally substituted with oxirane, thi... | 11/17/2009 |
| 7598291 | Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an... | 10/06/2009 |
| 7585892 | Compound for promoting the growth of neural cells Disclosed is a compound capable of promoting the growth and development of neurons, the proliferation of neural stem cells and inducing the neural stem cells to differentiate into neurons, which is represented by a general formula as (I). | 09/08/2009 |
| 7585891 | Pesticidal (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxole derivatives Certain novel (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula I: where R through R10, inclusively, x, A, B, y, D, E, G and M are... | 09/08/2009 |
| 7585890 | Pharmaceutical compositions comprising flavonoids and menthol The present invention relates to use of certain antiviral fragrances for reduction of viruses, in particular vira causing common cold. In one embodiment, the invention relates to pharmaceutical compositions comprising an antiviral fragrance, preferably menthol. Said... | 09/08/2009 |
| 7582675 | Flavonoid compound and process for producing the same A preparation process is provided for preparing a novel flavonoid compound having a high level of antioxidative action. The flavonoid compound is obtained by subjecting hesperidin to microbial fermentation treatment with Aspergillus saitoi. ... | 09/01/2009 |
| 7582674 | Nutraceutical compositions and use thereof Compositions including, as the active ingredients, resveratrol, a derivative, metabolite or analogue thereof, and at least one additional component selected from epigallocatechin gallate (EGCG), genestein, vitamin E, polyunsaturated fatty acids, gamma-linolenic acid... | 09/01/2009 |
| 7553869 | Protein probe compounds, compositions, and methods Coumarine/chinolone and Martina-type compounds, compositions, and method of using the compounds and compositions for protein detection, assay, quantitation, etc. are disclosed. The composition, also referred to as a dye, has enhanced sensitivity over commercially av... | 06/30/2009 |
| 7544711 | Use of nitroderivatives in urinary incontinence The present invention relates to the use of the following compounds, their compositions, and their salts for the preparation of medicaments for the treatment of urinary incontinence and other diseases, the compounds having the general formula: A-X1 | 06/09/2009 |
| 7538137 | 1-O-β-D-glucopyranosylgeraniol-10,5-olide and use thereof A novel natural compound having various therapeutically effects is provided. The compound is obtainable from Sibiraea leaves by aqueous extraction and is represented by a formula (1) as follows. ... | 05/26/2009 |
| 7534812 | Process for preparation of isochroman and derivatives thereof The present invention relates to an improved process for preparing compounds of formula 1 on an industrial scale, wherein R1, R2 and R3 are independently C1-6-alkyl, C2-6 | 05/19/2009 |
| 7521475 | Chondropsin-class antitumor V-ATPase inhibitor compounds, compositions and methods of use thereof A composition comprising a substantially purified compound of the formula: in combination with at least one additional therapeutic agent, and methods of preventing or treating cancer and a condition treatable by the inhibit... | 04/21/2009 |
| 7514469 | Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways... | 04/07/2009 |
| 7507761 | Benzopyran derivatives, method of production and use thereof The invention relates to novel benzopyran derivatives of formula I, to their method of production, to composition comprising the derivatives and use thereof. wherein: R1, R2, R3 an... | 03/24/2009 |
| 7507762 | Substituted 4-chromene and analogs as activators of caspases and inducers of apoptosis and the use thereof The present invention is directed to substituted 4H-chromene and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, Z and R5 are defined herein. The present invention also relates to the d... | 03/24/2009 |
| 7488751 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan Compounds of the Formula I: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, p... | 02/10/2009 |
| 7470721 | Compositions and methods for identifying agents which modulate PTEN function and PI-3 kinase pathways Methods are provided for the identification, biochemical characterization and therapeutic use of agents which impact PTEN, p53, PI-kinase and AKT mediated cellular signaling. ... | 12/30/2008 |
| 7470722 | Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease Disclosed herein are carbonyl compounds of Formula I as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central n... | 12/30/2008 |
| 7456214 | Chromene-containing compounds with anti-tubulin and vascular targeting activity Chrome compounds have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. ... | 11/25/2008 |
| 7439265 | Irciniastatins a and b The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 0.001 to | 10/21/2008 |
| 7435722 | Non-toxic crosslinking reagents to resist curve progression in scoliosis and increase disc permeability A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and ... | 10/14/2008 |
| 7435705 | Environmentally safe anti-fungal composition and methods of using same Disclosed herein or novel, environmentally friendly compositions and methods for treating or preventing fungal growth, such as molds and mildew, on surfaces and in objects. Specifically exemplified herein are compositions containing nepetalactone, and methods of usi... | 10/14/2008 |
| 7432297 | Reaction product of resorcin and methyl ethyl ketone A compound of the following formula (I) or (II) (in the formula (I), n represents an integer of 0 to 2) (in the formula (II), m represents an integer of 0 to 2). ... | 10/07/2008 |
| 7429576 | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors Novel methods for the medical treatment and/or inhibition of the development of osteoporosis, breast cancer, hypercholesterolemia, hyperlipidemia or atherosclerosis in susceptible warm-blooded animals including humans involving administration of selective estrogen r... | 09/30/2008 |
| 7427686 | (3R, 4R)-trans-3, 4-diarylchroman derivatives and a method for the prevention and/or treatment of estrogen dependent diseases The present invention relates to compounds of the formula I in which substituents R2 and R3 are arranged in trans-configuration: wherein: R1 is H or C1-C6 ... | 09/23/2008 |
| 7419998 | Therapeutic methods and compositions involving isoflavones Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described by general formula (I), in which Z is H, R1 is H, or RACO where RA is C1-10alkyl or an amino acid, R | 09/02/2008 |
| 7417067 | Composition and method for stabilizing the same Disclosed is a novel composition comprising a novel bi-cyclic compound, which is expected to be pharmaceutically active, and a glyceride. The stability of the bi-cyclic compound can be improved significantly by dissolving the same in a glyceride. ... | 08/26/2008 |
| 7405227 | Treatment of cancer Methods of treating ovarian cancer, endometrium cancer, cervical cancer, pancreatic cancer, bladder cancer, eve cancer, central nervous system cancer, thyroid cancer and lung cancer are disclosed. Specifically disclosed are methods of treating ovarian adenocarcinoma... | 07/29/2008 |
| 7399783 | Methods for the treatment of scar tissue A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids formulated in a pharmaceutically acceptable topical carrier. The method incl... | 07/15/2008 |
| 7399784 | Tocopherol and tocotrienol anti-obesity medicaments Anti-obesity compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and an obesity-promoting drug, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl substituted chroma... | 07/15/2008 |
| 7396855 | Compositions and products containing S-equol, and methods for their making A composition for use in making commercial food and skin products comprising S-equol or mixtures, including both a non-racemic mixture and a racemic mixture, of S-equol and R-equol. The composition can be used to make articles of commerce such as food supplements, p... | 07/08/2008 |
| 7384976 | Nebivolol and its metabolites in combination with nitric oxide donors, compositions and methods of use The invention describes novel compositions comprising nebivolol and/or at least one metabolite of nebivolol and at least one nitric oxide donor, and, optionally, at least one antioxidant or a pharmaceutically acceptable salt thereof, and/or at least one compound use... | 06/10/2008 |
| 7384919 | Increased solubility flavanolignan preparations The inventors have devised novel approaches for the preparation of flavanolignan compositions of enhanced solubility and substantially free of toxic contaminants. Such novel approaches are based on spray drying or lyophilizing to dry a diluted preparation of flavano... | 06/10/2008 |