Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 4847290 | Delta 1-thc-7-oic acid and analgesic and anti-inflammatory agents A non-psychoactive metabolite of THC is described. The invention is based on the discovery that this metabolite has analgesic and anti-inflammatory properties. The use of the metabolite as a therapeutic agent is based upon the further discovery that it is... | 07/11/1989 |
| 4845121 | Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-dihydro benzopyan-2H-one class having antiaggregatory properties The present invention relates to novel benzopyranone aci-reductone compounds of the formula I wherein X and Y are selected from the group comprising H (except that X and Y are not both H, unless otherwise indicated) Cl or other halogen, OH, a straight or ... | 07/04/1989 |
| 4831052 | Flavone carboxylic acid derivatives Novel flavone carboxylic acid derivatives, intermediates therefor, and method for the preparation thereof, and their use in the differentiation of certain types of malignant cells, are all disclosed, certain of the novel compounds disclosed to be superior... | 05/16/1989 |
| 4816479 | Xanthone derivatives and process for producing the same Xanthone derivatives of the formula (I): ##STR1## wherein W, X, Y and Z which may be the same or different represent a hydrogen atom, a halogen atom or a lower alkyl group having 1 to 4 carbon atoms; A is a hydrogen atom B is a hydroxymethyl group, a... | 03/28/1989 |
| 4800081 | Methods and compositions for treating viral infections The disclosure demonstrates the inhibition of replication of human cytomegalovirus (HCMV) in cultured human embryo skin muscle cells by two separate subclasses of direct-acting smooth muscle relaxing agents alone or in combination with each other. These t... | 01/24/1989 |
| 4782082 | Method for treating allergic reactions with Forskolin Forskolin and its disclosed derivatives are useful as antiallergic agents. Certain of the derivatives are novel.... | 11/01/1988 |
| 4772603 | Method for treating congestive heart failure, angina, occlusive peripheral vascular disease or cerebral vascular disease in mammals A method for the treatment and/or prophylaxis of congestive heart failure, angina, occlusive peripheral vascular disease or cerebral vascular disease in mammals, such as humans, which method comprises administering to the mammal in need of such treatment ... | 09/20/1988 |
| 4771049 | Labdanes, pharmaceutical compositions and use Novel labdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.... | 09/13/1988 |
| 4751224 | Treatment of metastasis A method for reducing the incidence of metastasis in tumor victims without treating the primary tumor per se resides in the administration of forskolin or its analogs which are potent inhibitors of platelet aggregation. Forskolin compounds are generally d... | 06/14/1988 |
| 4740522 | Oxolabdanes useful as pharmaceuticals for reducing intraocular pressure Novel oxolabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.... | 04/26/1988 |
| 4724238 | Method of treating inflammatory diseases with labdan derivatives The present invention relates to a process for the isolation of labdan derivatives from the plant Coleus forskohlii, and their use as medicaments having anti-inflammatory and analgesic activity.... | 02/09/1988 |
| 4670452 | Dioxo dibenzopyrans and anti-allergic use thereof There are provided benzopyrans of formula I ##STR1## wherein R6 and R7 together form the chain --CHOCH.dbd.(A1 E1)--O-- in which --O-- is attached to R7, R5 represents hydrogen, R8 | 06/02/1987 |
| 4654323 | Method and composition for the therapeutic and prophylactic treatment of trauma to the skin A novel method and composition are disclosed for the therapeutic and prophylatic treatment of trauma to the skin. In particular, burns, sunburn and frostbite are treated with compounds that have the ability to interfere with the action of calcium calmodul... | 03/31/1987 |
| 4639446 | Aminoacyllabdanes, pharmaceutical compositions and use Novel aminoacyllabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.... | 01/27/1987 |
| 4626432 | Storage of red blood cells Use of compounds of formula (I) ##STR1## to provide a more effective delivery of oxygen to the tissues of a mammalian, including human, recipient. In vivo applications include the relief or amelioration of conditions wherein there is tissue hypoxia; ... | 12/02/1986 |
| 4598090 | Condensed benzopyrone derivatives The present invention relates to new condensed benzopyrone derivatives, to a process for their preparation and to pharmaceutical compositions containing them.... | 07/01/1986 |
| 4578399 | Use of the diterpene derivative forskolin for immunostimulation The possibility of using the diterpene derivative forskolin (1, 6ଲ, 9-trihydroxy-7ଲ-acetoxy-8,13-epoxy-14-labden-11-one) to increase the immunological responsiveness of mammals is described.... | 03/25/1986 |
| 4571405 | Anti-allergic chromone- or thiochromone-5-oxamic acid derivatives, compositions, and method of use therefor Certain 5-substituted chromones and thiochromones and pharmacologically acceptable salts thereof are disclosed. The compounds possess antiallergic properties and are represented by the formula: ##STR1## wherein: X is selected from the group consistin... | 02/18/1986 |
| 4564626 | Methods of inducing bronchodilation A method for producing bronchodilation in a mammal is disclosed. Composition for use in said method are also described.... | 01/14/1986 |
| 4556651 | Secalonic acid derivatives as antitumor agents A secalonic acid derivative of the formula (I); ##STR1## wherein R is ##STR2## wherein R1 and R2 each independently is a hydrogen atom or a C1-4 alkyl group; R3 is a hydrogen atom, a C1-4 al... | 12/03/1985 |
| 4551475 | Pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids The invention relates to pharmaceutical preparations for topical application which contain salts of alkanecarboxylic acids, in particular compounds of the formula ##STR1## wherein R1 is a group of the formula ##STR2## wherein X | 11/05/1985 |
| 4517200 | Method for treating allergic reactions with forskolin Forskolin and its disclosed derivatives are useful as antiallergic agents. Certain of the derivatives are novel.... | 05/14/1985 |
| 4476140 | Composition and method for treatment of glaucoma Topical administration of one of the polyoxygenated Labdanes of which forskolin is an example to the eyes produces lower intraocular pressure. The topical application to the eye produces no significant changes in blood pressure or pulse rate. The polyoxyg... | 10/09/1984 |
| 4454152 | Methoxsalen dosage forms This invention relates to oral dosage forms wherein the active ingredient, methoxsalen, is dispersed in a water-soluble composition containing a polyethylene glycol or mixtures of polyethylene glycols. Dissolution of methoxsalen in gastrointestinal fluids... | 06/12/1984 |
| 4382952 | Antibiotic roridin L-2 and its use The present invention relates to a novel trichothecene antibiotic, roridin L-2, and a process for the production and the method of using said compound.... | 05/10/1983 |
| 4376123 | Hexahydroazepinyloxy-chromones useful as antidepressants Basic ethers of the formula ##STR1## wherein Z is CH3 --NR2 --CH2 CH2 --CHR1 --, (1-R2 -3-piperidyl)-CHR3 --, (1-R2 -2-piperidyl)-CH2 --CHR3... | 03/08/1983 |
| 4370344 | 5'-Aminoalkyl-4'-alkylpsoralens The invention relates to 5'-aminoalkyl-4'-alkylpsoralens, having essentially no erythematic photosensitizing activity but at the same time having substantial DNA-binding photosensitizing activity, making them of especial interest from the standpoint of su... | 01/25/1983 |
| 4328239 | 8-Aminoalkylpsoralens The invention relates to 8-aminoalkylpsoralens, having essentially no erythematic photosensitizing activity but at the same time having substantial DNA-binding photosensitizing activity, making them of especial interest from the standpoint of suntanning a... | 05/04/1982 |
| 4312883 | Furocoumarin for the photochemotherapy of psoriasis and related skin diseases A class of alkyl-substituted angular flurocoumarins, sometimes termed alkylangelicins, useful in the photochemotherapy of psoriasis and in other skin diseases characterized by cellular hyperproliferation or lack of skin pigmentation is disclosed for topic... | 01/26/1982 |
| 4308210 | Nanaomycin B and therapeutic compositions containing same The present invention relates to new compound designated as nanaomycin B represented by general formula: ##STR1## Nanaomycin B is a quinone type and is active on mycoplasma, Gram-positive bacteria and trycophyton. This compound is useful as a medicam... | 12/29/1981 |
| 4298614 | 5'-Aminoalkyl-4',4-dialkylpsoralens The invention relates to 5'-aminoalkyl-4',4-dialkylpsoralens having enhanced photosensitizing activity, especially oral activity, including early onset, increased maximum, and rapid decline, as well as low toxicity, when compared with psoralens of differe... | 11/03/1981 |
| 4294847 | 8-Aminoalkyl-4-alkylisopsoralens The invention relates to 8-aminoalkyl-4-alkylisopsoralens, especially 8-aminomethyl-4-methylisopsoralen, having enhanced photosensitizing activity, especially oral and topical activity, pharmaceutical compositions thereof, and method of effecting photosen... | 10/13/1981 |
| 4294822 | 5-Aminoalkyl-4,4,8-trialkylpsoralens The invention relates to 5'-aminoalkyl-4',4,8-trialkylpsoralens having enhanced photosensitizing activity, especially oral and topical activity, as well as low toxicity, when compared with psoralens of different structure.... | 10/13/1981 |
| 4292316 | Antiglaucoma agents A method of reducing intra-ocular pressure in mammalian patients comprising administering to a glaucoma patient a therapeutically effective amount of a compound of the formula ##STR1## wherein, in the C ring, X is CH2, S, ##STR2## ... | 09/29/1981 |
| 4285963 | Novel derivatives of C-076 compounds There are disclosed certain new derivatives of C-076 compounds which have been isolated from the fermentation broth that produced the original C-076 compounds. The compounds retain the C-076 16-membered cyclic backbone, however, the groups attached theret... | 08/25/1981 |
| 4284644 | Spirobenzofuranone compounds Novel spiro compounds of the formula: ##STR1## wherein Ring A represents a benzene ring or a naphthalene ring, said rings being unsubstituted or substituted by at least one of lower alkyl, nitro, halogen, amino which may optionally be substituted, hy... | 08/18/1981 |
| 4281013 | Antiatherosclerotic use of khellin and khellinin The present specification relates to the antiatherosclerotic use of khellin and related furochromones, and further provides novel antiatherogenic 6-halofurochromones.... | 07/28/1981 |
| 4269852 | 4'-Substituted-4,5',8-trialkylpsoralens The invention relates to 4,5',8-trialkylpsoralens, having a substituent on the 4' carbon atom which is selected from hydroxyalkoxyalkyl and hydroxyalkylaminoalkyl, which are characterized by enhanced photosensitizing activity, especially oral activity, in... | 05/26/1981 |
| 4269854 | 6,7,8,9-Tetrahydro-4H-naphtho-[2,3-b]pyran-2-carboxylic acids There are described compounds of formula I, ##STR1## in which R is hydrogen, hydroxy or alkoxy C 1 to 6, and X is hydroxy, carbonyl oxygen or alkoxy C 1 to 6, and pharmaceutically acceptable derivatives thereof. There are also described methods for m... | 05/26/1981 |
| 4269853 | Composition and method for treating skin mast cells and/or delayed cellular hypersensitivity reactions There is described a pharmaceutical composition suitable for application to the skin and comprising, as active ingredient, a compound of formula I, ##STR1## in which R1 represents hydrogen, hydroxy or --NR5 R6, in whi... | 05/26/1981 |
