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| Number | Title | Issue Date |
| 8093288 | Genipin derivatives and uses thereof Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed. | 01/10/2012 |
| 8071642 | Dimethyl amino ethyl ether psoralens and methods for their production and use Water-soluble dimethyl amino ethyl ether psoralens useful in the treatment of proliferative skin disorders, microbial infections and diseases, disorders of the blood and bone marrow of mammals and in microbiocidal compositions for sterilization of blood and blood pr... | 12/06/2011 |
| 8067460 | 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated Kv1.3 potassium channel Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, ... | 11/29/2011 |
| 8017648 | Methods of use of cyclopamine analogs The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula: ... | 09/13/2011 |
| 7977377 | Treatment of depressive disorders The invention provides for the use of carbonic anhydrase activators; protein kinase C activators and FGF-18 to treat depressive disorders. The invention also relates to improved animal models and methods for screening and identifying compounds the treatment of depre... | 07/12/2011 |
| 7935726 | Tricyclic pyrones Provided are compounds of formula IA or IB: wherein R1 and R8 are independently optionally substituted hydrocarbyl groups; wherein (a) R1 contains a carbonyl group and a phenyl group,... | 05/03/2011 |
| 7863322 | Anti-cancer combinations The present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from platinum compounds, vinca alkaloids, alkylating agents, anthracyclines, topoisomerase I inhibitors, antimetabolites an... | 01/04/2011 |
| 7846965 | Compound A compound is described. In particular, a non-steroidal sulphamate compound is described. The compound is suitable for use as an inhibitor of oestrone sulphatase. The compound is of general Formula (A), wherein R1 | 12/07/2010 |
| 7842721 | Composition for treating cancer cells and synthetic method for the same A pharmaceutical composition having a cytotoxic effect to a cancer cell is provided. The pharmaceutical composition includes a flavonoid compound having a formula as wherein B ring is a 4-oxo-cyclohexa-2,5-dienyl group, and... | 11/30/2010 |
| 7825157 | Methods for improving the aesthetic appearance of skin There are provided methods and compositions for improving the aesthetic appearance of akin, treating rosacea and/or telangiectasia, and treating the signs of dermatological aging. The method is directed to topically applying to an affected area an effective amount o... | 11/02/2010 |
| 7741365 | Peripheral cannabinoid receptor (CB2) selective ligands Novel polycyclic cannabinoid analogs are presented which have preferentially high affinities for the cannabinoid CB2 receptor sites. ... | 06/22/2010 |
| 7705040 | Reagents for highly specific detection of peroxynitrite This invention provides compositions which specifically reacts with peroxynitrite rather than other reactive oxygen species and reactive nitrogen species. This invention also provides related agents for measuring peroxynitrite. This invention also provides related m... | 04/27/2010 |
| 7705039 | Method for treating sleep apnea A method of ameliorating a sleep-related breathing disorder via administration of at least one cannabimimetic agent, such as oleamide or Δ9THC, to an individual in need of treatment. ... | 04/27/2010 |
| 7687538 | Agents with selective κ-opioid receptor affinity Compounds and compositions that are salvinorin A and salvinorin B derivatives that demonstrate selectivity and/or potency for the k-opioid receptor (KOR), allowing for their use as medicines, as well as chemical probes (both radiolabeled and cold) for fields utilizi... | 03/30/2010 |
| 7649013 | Methods of protecting against radiation injury Administration of a modulator of cell cycle checkpoint activation, which is preferably β-lapachone, or a pharmaceutically acceptable salt, prodrug, metabolite, analog or derivative thereof, protects normal cells against radiation injury. The invention includes meth... | 01/19/2010 |
| 7649014 | Genipin derivatives and uses thereof Genipin derivatives and pharmaceutical compositions thereof that inhibit the activity of uncoupling protein-2 (UCP2) and are useful in treating deficient first-phase insulin secretion, non-insulin dependent diabetes mellitus, and ischemia in a mammal are disclosed. | 01/19/2010 |
| 7638554 | Flavanoids as chemotherapeutic, chemopreventive, and antiangiogenic agents Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I) wh... | 12/29/2009 |
| 7618997 | Diaminofluorescein derivatives A compound represented by the following formula (I): wherein R1 and R2 represent amino groups that substitute at adjacent positions on the phenyl ring, provided that either of R1 and R2... | 11/17/2009 |
| 7601754 | Flavonoid compounds as therapeutic antioxidants Novel flavonoid compounds having anti-oxidant activity are described. Formula 1. The compounds have been shown to exhibit anti-oxidative properties in biological systems and their utility in a sunscreen or skincare composition or to treat conditions involving oxidat... | 10/13/2009 |
| 7557138 | 5-phenoxyalkoxypsoralens and methods for selective inhibition of the voltage gated 1.3 potassium channel Compositions of matter comprising 5-phenoxyalkoxypsoralen compounds and their method of synthesis and use. The compounds are useable to treat diseases or disorders in human or animal subjects, including autoimmune diseases. The compounds inhibit potassium channels, ... | 07/07/2009 |
| 7462642 | Anti-cancer combinations The present invention relates to synergistic combinations of the compounds of formula I such as compounds of the xanthenone acetic acid class such as 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and NSAIDs, in particular diclofenac, which have anti-tumor activity. M... | 12/09/2008 |
| 7435754 | Laulimalide microtubule stabilizing agents A method of inhibiting the proliferation of a hyperproliferative mammalian cell having a multiple drug resistant phenotype utilizing an amount of a laulimalide compound effective to disrupt the dynamic state of microtubule polymerization and depolymerization to arre... | 10/14/2008 |
| 7423026 | Methylated cyclodextrin complexes The present invention is directed to novel complexes of cyclodextrin. In particular the invention is directed to a complex of a cyclodextrin selected from the group consisting of RM-β-cyclodextrin, DM-β-cyclodextrin and TM-β-cyclodextrin, and a cannabinoid select... | 09/09/2008 |
| 7338971 | Treatment of inflammatory, cancer, and thrombosis disorders This invention provides for the treatment of inflammatory, cancer and thrombotic disorders through the administration, in combination, of a COX2 inhibitor, low dose aspirin, and antioxidant flavanoids, flavonoids or isoflavones and at least one of these combinations... | 03/04/2008 |
| 7329687 | Flavanoid compounds as chemotherapeutic, chemopreventive, and antiangiogenic agents Compounds useful as chemotherapeutic, chemopreventive, and antiangiogenic agents are provided. The compounds are flavanoids, including flavanones, flavanols, and chalcones. The compounds have the structure of formula (I) | 02/12/2008 |
| 7326734 | Treatment of bladder and urinary tract cancers Compositions of matter and methods wherein chalcone and flavone derivatives are administered to human or veterinary patients for the treatment of bladder or urinary tract cancer. Compounds of the invention include 2′-hydroxy-4,4′,6′-trimethoxychalcone (Flavoka... | 02/05/2008 |
| 7317038 | Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regene... | 01/08/2008 |
| 7253207 | Quinones as disease therapies Novel quinones are provided, as well as compositions comprising these novel quinones. Methods of using the novel quinones in treatment of various indications including cancer are also provided. ... | 08/07/2007 |
| 7244761 | Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regene... | 07/17/2007 |
| 7244760 | Methods for preparation and use of psorospermin analogs Psorospermin is a cytotoxic dihydroflranoxanthone that has found to exhibit significant activity against various tumor cell lines. Unfortunately, psorospermin is no longer readily available from its natural plant source. The present invention is directed to a method... | 07/17/2007 |
| 7238725 | Tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel tricyclic compounds useful for the treatment of inflammatory conditions, diseases of the central nervous and insulin resistant diabetes. ... | 07/03/2007 |
| 7230027 | Anti-first-pass effect compounds Compositions, methods, etc. for addressing the first-pass effect. ... | 06/12/2007 |
| 7223789 | Heterocyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate N-oxides, the... | 05/29/2007 |
| 7220747 | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer This invention provides methods for treating cellular blood components and other cells containing mitochondria to improve vital qualities of the cells by contacting the cells with a mitochondrial enhancer to the cells. Mitochondrial enhancers prevent damage to and r... | 05/22/2007 |
| 7208518 | Substituted furochromene compounds of antiinflammatory action The present invention relates to novel compounds of the formula (I) including all stereoisomers and tautomers thereof, to the pharmaceutically acceptable salts and solvates thereof, to the processes and reactive ... | 04/24/2007 |
| 7208594 | Isoflavone concentrates as well as methods for their production Isoflavone concentrates are described, which contain at least about ten to about twenty weight parts of polysorbate to one weight part of isoflavone containing a genistein, and/or daidcein, and/or glycitein. Further, a method for the production of an isoflavone conc... | 04/24/2007 |
| 7205333 | Multivalent neuraminidase inhibitor conjugates The invention relates to a multimeric compound or a pharmaceutically acceptable salt or derivative thereof which comprises three or more neuraminidase-binding groups attached to a spacer or linking group, in which the neuraminidase-binding group is a compound which ... | 04/17/2007 |
| 7202272 | Compound A compound is described. In particular, a non-steroidal sulphamate compound is described. The compound is suitable for use as an inhibitor of oestrone sulphatase. The compound is of general Formula (A), wherein R... | 04/10/2007 |
| 7183313 | Keto cannabinoids with therapeutic indications Novel tricyclic cannabinoid compounds are presented. Some of these compounds exhibit fluorescence properties. The fluorescent cannabinoid compounds are typically endogenously fluorescent. Some of these compounds, when administered in a therapeutically effective amou... | 02/27/2007 |
| 7182964 | Dissolving thin film xanthone supplement A nutraceutical composition containing xanthones for oral ingestion is disclosed. The composition is a rapidly dissolving film comprising water soluble polymers and xanthones. The xanthones are, preferably, derived from natural plant sources, especially from fruit o... | 02/27/2007 |
