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| Number | Title | Issue Date |
| 8273789 | Biologically active taxane analogs and methods of treatment by oral administration The present invention relates to a novel chemical compound of formula S-(1): for use in the treatment of cancer, to compositions containing said compound, methods of manufacture and combinations with other therapeutic agent... | 09/25/2012 |
| 8263643 | Polyphenol compounds with modulating neurotransmitter release Disclosed is a composition for modulating the release of a neurotransmitter, which includes naturally extracted polyphenols as an active ingredient. The disclosed composition suppresses the formation of a SNARE complex, thereby modulating the release of a neurotrans... | 09/11/2012 |
| 8263644 | Cytotoxic xanthone compounds The present invention relates to xanthone compounds isolated from the plant Psorospermum molluscum Hochr. (Clusiaceae), a Madagascar plant, which are potent cytotoxic agents. ... | 09/11/2012 |
| 8227508 | Dietary and pharmaceutical compositions containing carnosol and/or rosmanol and their uses The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical co... | 07/24/2012 |
| 8193240 | Compositions and methods for reducing or preventing obesity Compositions useful for weight management in an animal are disclosed. The compositions comprise one or more isoflavones or isoflavone metabolites, and in some embodiments include conjugated linoleic acid, and/or L-carnitine. Also disclosed are methods useful for wei... | 06/05/2012 |
| 8071640 | Urea oligomers, their preparation process and pharmaceutical compositions containing them A method for treating a cytotoxic disease by administrating compounds having a general formula X-(A)n-Y, wherein: n varies between 6 and 20; X denotes a hydrogen atom, an RaCO, RaOCO, RaNHCO or RaSO2 group, Ra being an alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroa... | 12/06/2011 |
| 8039509 | Composition comprising (−)-Δ-trans-tetrahydrocannabinol A composition comprising a tetrahydrocannabinol compound, a solvent and an acid, wherein the tetrahydrocannabinol compound may be Δ8 tetrahydrocannabinol, (−)-Δ9-trans-tetrahydrocannabinol or a side chain alkyl derivative of either compound... | 10/18/2011 |
| 7994215 | High purity phthalein derivatives and method for preparing same High purity phthalein derivatives are useful for medical applications and/or in the field of biotechnology. The phthalein derivatives are prepared by a method whereby a phthalic anhydride derivative is condensed with a naphthol or phenol derivative in an organic aci... | 08/09/2011 |
| 7981927 | Steroids derivatives as selective progesterone receptor modulators The present invention is directed to novel steroid derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by at least one progesterone or glucocorticoid receptor. ... | 07/19/2011 |
| 7820713 | Cocoa extracts as antioxidants Disclosed and claimed are cocoa extracts such as polyphenols or procyanidins, methods for preparing such extracts, as well as uses for them, especially as antineoplastic agents and antioxidants. Disclosed and claimed are antineoplastic compositions containing cocoa ... | 10/26/2010 |
| 7795299 | Neo-tanshinlactone and analogs as potent and selective anti-breast cancer agents Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmaceutical formulations thereof. ... | 09/14/2010 |
| 7776911 | Antimalarial drug containing synergistic combination of curcumin and artemisinin A pharmaceutical composition for the treatment of malaria in mammals is disclosed. The composition comprises of a synergistic combination of curcumin and artemisinin. ... | 08/17/2010 |
| 7763648 | Oxa-steroids derivatives as selective progesterone receptor modulators The present invention is directed to 7 oxa-estra-4,9-diene-3,17-dione derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by at least one progesterone or glucocorticoid receptor. ... | 07/27/2010 |
| 7700644 | Isoflavonoid dimers Novel compounds based on phenyl-substituted naphtho[1,2-g]chrysene compounds (A) are described. The compounds are obtainable by dimerisation of 3-phenylchroman (isoflavonoid) ring systems (B). Methods of synthesis of the novel dimeric compounds, compositions contain... | 04/20/2010 |
| 7691899 | Urea oligomers, the preparation method thereof and pharmaceutical composition containing same Compounds having a general formula X-(A)n-Y, wherein: n varies between 6 and 20; X denotes a hydrogen atom, an RaCO, RaOCO, RaNHCO or RaSO2 group, Ra being an alkyl, alkenyl, alkynyl, aryl, aralkyl, heteroaryl group, the groups being substituted or not, on condition... | 04/06/2010 |
| 7671084 | Dibenzo chromene derivatives and their use as ERβ selective ligands This invention provides estrogen receptor modulators of formula I having the structure where R1, R2, R3, R4, R5, R6, R7 and R8 are as d... | 03/02/2010 |
| 7666901 | Analogs of 17-hydroxywortmannin as PI3K inhibitors The present invention relates to compounds of formula I: wherein R1, R2, R3, and R8 are defined herein. ... | 02/23/2010 |
| 7592367 | Compounds from , their use in treating cancer and method of separating epimers thereof Three pairs of C-2 epimeric xanthones isolated from Garcinia hanburyi and method for efficiently separating the xanthone compounds into individual epimers, each of which possesses varying biological effects. The compounds are useful for their anticancer effec... | 09/22/2009 |
| 7576124 | Anti-first-pass effect compounds Safe, effective first-pass inhibiting compounds and citrus-derived substances are provided. Formulations containing the compounds are also provided as are methods for their preparation and for inhibiting the first pass effect. ... | 08/18/2009 |
| 7576123 | Anti-first-pass effect compounds Compositions, methods, etc. for addressing the first-pass effect. ... | 08/18/2009 |
| 7572827 | Use of angelicin and of its structural analogues for the treatment of thalassemia The use of angelicin and its structural analogues for the preparation of a medicament for the therapeutic treatment of beta-thalassaemia is described. A structural analogue which is particularly preferred for this purpose is bergapten. ... | 08/11/2009 |
| 7495026 | Neo-tanshinlactone and analogs as potent and selective anti-breast cancer agents Compounds of Formulas I-II are described, along with methods of using such compounds for the treatment of cancer and pharmeutical formulations thereof. ... | 02/24/2009 |
| 7399783 | Methods for the treatment of scar tissue A topical composition and method for the reduction of scar tissue and/or improving the appearance of scar tissue after it has formed. The topical composition includes one or more flavonoids formulated in a pharmaceutically acceptable topical carrier. The method incl... | 07/15/2008 |
| 7396828 | PI-3 kinase inhibitor prodrugs The invention provides prodrugs of inhibitors of PI-3 kinase. The compounds are LY294002 and analogs thereof comprising a reversibly quaternized amine. ... | 07/08/2008 |
| 7384975 | Substituted furochromenes, preparation thereof and their antiinflammatory action The invention relates to novel compounds of the formula (I) including all their tautomers, to pharmaceutically acceptable salts and solvates thereof, to processes and reactive intermediates for the preparation thereof, and ... | 06/10/2008 |
| 7368474 | Radiofluorination methods The present invention relates to methods and reagents for [18F]-fluorination, particularly of peptides. The resultant 18F-labelled compounds are useful as radiopharmaceuticals, specifically for use in Positron Emission Tomography (PET). Thus, a... | 05/06/2008 |
| 7335682 | Pharmaceutical compositions and methods for treating immune-response associated diseases of the surface and the anterior segment of the eye A pharmaceutical composition for the treatment of immune-related diseases of ocular surface and the anterior segment of the eye. More specifically, the invention relates to a composition comprising tacrolimus in a pharmaceutically acceptable formulation, particularl... | 02/26/2008 |
| 7329654 | Heteroatom containing tetracyclic derivatives as selective estrogen receptor modulators The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them, their use in the treatment and/or prevention of disorders mediated by one or more estrogen receptors and processes for their prepar... | 02/12/2008 |
| 7323452 | Method for the accelerated in vivo removal of ethanol A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives... | 01/29/2008 |
| 7306789 | Method of stimulating hair growth using benzopyrans The present invention is directed to methods of stimulating hair growth by administering particular benzopyran compounds. ... | 12/11/2007 |
| 7285293 | Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from and related plants Assay-guided affinity fractionation and reverse phase high pressure liquid chromatography (HPLC) methodology to isolate, test and characterize the most active water-soluble ingredients within Cat's Claw, or Uncaria tomentos. These components appear to account... | 10/23/2007 |
| 7285683 | Bicyclic and tricyclic cannabinoids Novel bicyclic-cannabinoids and hexahydrocannabinol analogs are presented. These compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause... | 10/23/2007 |
| 7282598 | Synthetic methods for preparing procyanidin oligomers Processes are disclosed for the production of linear and branched procyanidin oligomers having “n” procyanidin monomeric units where n is 2 to 18. The processes include coupling protected, activated monomers with an unprotected monomer to produce a partially pro... | 10/16/2007 |
| 7268240 | Synthetic methods for polyphenols A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphe... | 09/11/2007 |
| 7253206 | Phenalenone derivatives, processes for preparation and use thereof The present invention provides novel phenalenone derivatives of formula (I) which are formed by the microorganism Penicillium herquei Bainer & Sartory, DSM 14142, during fermentation. A process for their preparation, their use as pharmaceutical compositions, ... | 08/07/2007 |
| 7244855 | Synthesis of oligomeric epicatechin and catechin-derived procyanidins Various processes are disclosed for preparing procyanidin oligomers having (4,8)-interflavan linkages. In an improved process, a tetra-O-protected-epicatechin or -catechin monomer or oligomer is coupled with a protected, C-4 alkoxy-activated-epicatechin or -catechin... | 07/17/2007 |
| 7238726 | Synergistic and residual pesticidal compositions containing plant essential oils with enzyme inhibitors Synergistic and residual pesticidal compositions containing synergistic and residual mixtures of plant essential oils in admixture with enzyme inhibitors, with or without other compounds not previously used as active ingredients in pesticidal formulations. In additi... | 07/03/2007 |
| 7235584 | Non-psychotropic cannabinoids Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) ... | 06/26/2007 |
| 7230027 | Anti-first-pass effect compounds Compositions, methods, etc. for addressing the first-pass effect. ... | 06/12/2007 |
| 7208518 | Substituted furochromene compounds of antiinflammatory action The present invention relates to novel compounds of the formula (I) including all stereoisomers and tautomers thereof, to the pharmaceutically acceptable salts and solvates thereof, to the processes and reactive ... | 04/24/2007 |
